KEGG   Homo sapiens (human): 653361
Entry
653361            CDS       T01001                                 

Gene name
NCF1, CGD1, NCF1A, NOXO2, SH3PXD1A, p47phox
Definition
(RefSeq) neutrophil cytosolic factor 1
  KO
K08011  neutrophil cytosolic factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04145  Phagosome
hsa04380  Osteoclast differentiation
hsa04613  Neutrophil extracellular trap formation
hsa04666  Fc gamma R-mediated phagocytosis
hsa04670  Leukocyte transendothelial migration
hsa05020  Prion disease
hsa05140  Leishmaniasis
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06415  PI3K signaling
nt06465  Prion disease
  Element
N01204  PRNP-PI3K-NOX2 signaling pathway
N01205  Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
Disease
H00098  Chronic granulomatous disease
H01167  Granulibacter infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    653361 (NCF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    653361 (NCF1)
   04666 Fc gamma R-mediated phagocytosis
    653361 (NCF1)
   04670 Leukocyte transendothelial migration
    653361 (NCF1)
   04062 Chemokine signaling pathway
    653361 (NCF1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    653361 (NCF1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    653361 (NCF1)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    653361 (NCF1)
  09164 Neurodegenerative disease
   05020 Prion disease
    653361 (NCF1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    653361 (NCF1)
   05418 Fluid shear stress and atherosclerosis
    653361 (NCF1)
   05415 Diabetic cardiomyopathy
    653361 (NCF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    653361 (NCF1)
Membrane trafficking [BR:hsa04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    653361 (NCF1)
Motif
Pfam: SH3_1 NECFESHC SH3_9 p47_phox_C PX SH3_2 hSH3 SH3_6
Other DBs
NCBI-GeneID: 653361
NCBI-ProteinID: NP_000256
OMIM: 608512
HGNC: 7660
Ensembl: ENSG00000158517
Vega: OTTHUMG00000149965
Pharos: P14598(Tbio)
UniProt: P14598
Structure
PDB: 

Position
7q11.23
AA seq 390 aa
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgggggacaccttcatccgtcacatcgccctgctgggctttgagaagcgcttcgtaccc
agccagcactatgtgtacatgttcctggtgaaatggcaggacctgtcggagaaggtggtc
taccggcgcttcaccgagatctacgagttccataaaaccttaaaagaaatgttccctatt
gaggcaggggcgatcaatccagagaacaggatcatcccccacctcccagctcccaagtgg
tttgacgggcagcgggccgccgagaaccgccagggcacacttaccgagtactgcagcacg
ctcatgagcctgcccaccaagatctcccgctgtccccacctcctcgacttcttcaaggtg
cgccctgatgacctcaagctccccacggacaaccagacaaaaaagccagagacatacttg
atgcccaaagatggcaagagtaccgcgacagacatcaccggccccatcatcctgcagacg
taccgcgccattgccaactacgagaagacctcgggctccgagatggctctgtccacgggg
gacgtggtggaggtcgtagagaagagcgagagcggttggtggttctgtcagatgaaagca
aagcgaggctggatcccagcgtccttcctcgagcccctggacagtcctgacgagacggaa
gaccctgagcccaactatgcaggtgagccatacgtcgccatcaaggcctacactgctgtg
gagggggacgaggtgtccctgctcgagggtgaagctgttgaggtcattcacaagctcctg
gacggctggtgggtcatcaggaaagacgacgtcacaggctacttcccgtccatgtacctg
caaaagtcagggcaagacgtgtcccaggcccaacgccagatcaagcggggggcgccgccc
cgcaggtcgtccatccgcaacgcgcacagcatccaccagcggtcgcggaagcgcctcagc
caggacgcctatcgccgcaacagcgtccgttttctgcagcagcgacgccgccaggcgcgg
ccgggaccgcagagccccgggagcccgctcgaggaggagcggcagacgcagcgctctaaa
ccgcagccggcggtgcccccgcggccgagcgccgacctcatcctgaaccgctgcagcgag
agcaccaagcggaagctggcgtctgccgtctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (12)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (14)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
Protein domain (8)   
   Pfam (8)   
All databases (96)   

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