KEGG T01001: 695

Homo sapiens (human): 695

Entry

695 CDS T01001

Symbol

BTK, AGMX1, AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA

Name

(RefSeq) Bruton tyrosine kinase

K07370

Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa04064

NF-kappa B signaling pathway

hsa04380

Osteoclast differentiation

hsa04611

Platelet activation

hsa04662

B cell receptor signaling pathway

hsa04664

Fc epsilon RI signaling pathway

hsa05169

Epstein-Barr virus infection

hsa05340

Primary immunodeficiency

Network

nt06120  Calcium signaling (viruses and bacteria)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06165  Epstein-Barr virus (EBV)
nt06220  Calcium signaling

Element

N00487

BCR-PLCG-Calcineurin signaling pathway

Disease

H00085

Agammaglobulinemias

H00254

Growth hormone deficiency

H02035

Isolated growth hormone deficiency

Drug target

Acalabrutinib (DG03089):

D10893<JP/US> D11720

Branebrutinib:

D11478

Elsubrutinib:

D12158

Fenebrutinib:

D11457

Ibrutinib:

D10223<JP/US>

Luxeptinib:

Orelabrutinib:

Pirtobrutinib:

Rilzabrutinib:

Spebrutinib (DG01863):

D10730 D10731

Tirabrutinib hydrochloride:

D11070<JP>

Tolebrutinib:

D12213

Vecabrutinib (DG03023):

D11428 D11502

Zanubrutinib:

D11422<US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    695 (BTK)
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    695 (BTK)
   04662 B cell receptor signaling pathway
    695 (BTK)
   04664 Fc epsilon RI signaling pathway
    695 (BTK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    695 (BTK)
09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    695 (BTK)
  09163 Immune disease
   05340 Primary immunodeficiency
    695 (BTK)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    695 (BTK)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     695 (BTK)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
  TEC family
   695 (BTK)

SSDB

Motif

Pfam:

PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 PH BTK SH3_9 SH3_2 Kinase-like SH3_3 SH3_10 Pkinase_fungal Kdo APH SH3_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q06187(Tclin)

UniProt:

Q06187 Q5JY90

Structure

PDB:

5P9J 6DI1 5P9I 6HRP 6E4F 4RFZ 6J6M 6DI9 5P9L 5P9K 6DI0 6BLN 5U9D 6HRT 4RX5 5KUP 6NFH 6OMU 5P9M 6O8I 6DI5 6BKW 5T18 4OTQ 4OT5 5BQ0 5VFI 5J87 4Z3V 3GEN 1BTK 5VGO 6AUB 4ZLY 6AUA 4RFY 5P9F 6NZM 5P9G 3PJ2 6BKH 5FBN 3OCS 6S90 3PIX 3PJ3 5FBO 6BIK 3K54 6BKE 5P9H 4OTR 4OTF 3OCT 5JRS 6DI3 4ZLZ 3PJ1 6EP9 4NWM 4OT6 1K2P 1BWN 4YHF 3PIZ 6N9P 3P08 5BPY 1B55 6NFI 4RG0 3PIY 2Z0P 5XYZ 5ZZ4 2GE9 1QLY 1AWW 1AWX

Position

Xq22.1

AA seq 659 aa
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES

NT seq 1980 nt +upstreamnt +downstreamnt
atggccgcagtgattctggagagcatctttctgaagcgatcccaacagaaaaagaaaaca
tcacctctaaacttcaagaagcgcctgtttctcttgaccgtgcacaaactctcctactat
gagtatgactttgaacgtgggagaagaggcagtaagaagggttcaatagatgttgagaag
atcacttgtgttgaaacagtggttcctgaaaaaaatcctcctccagaaagacagattccg
agaagaggtgaagagtccagtgaaatggagcaaatttcaatcattgaaaggttcccttat
cccttccaggttgtatatgatgaagggcctctctacgtcttctccccaactgaagaacta
aggaagcggtggattcaccagctcaaaaacgtaatccggtacaacagtgatctggttcag
aaatatcacccttgcttctggatcgatgggcagtatctctgctgctctcagacagccaaa
aatgctatgggctgccaaattttggagaacaggaatggaagcttaaaacctgggagttct
caccggaagacaaaaaagcctcttcccccaacgcctgaggaggaccagatcttgaaaaag
ccactaccgcctgagccagcagcagcaccagtctccacaagtgagctgaaaaaggttgtg
gccctttatgattacatgccaatgaatgcaaatgatctacagctgcggaagggtgatgaa
tattttatcttggaggaaagcaacttaccatggtggagagcacgagataaaaatgggcag
gaaggctacattcctagtaactatgtcactgaagcagaagactccatagaaatgtatgag
tggtattccaaacacatgactcggagtcaggctgagcaactgctaaagcaagaggggaaa
gaaggaggtttcattgtcagagactccagcaaagctggcaaatatacagtgtctgtgttt
gctaaatccacaggggaccctcaaggggtgatacgtcattatgttgtgtgttccacacct
cagagccagtattacctggctgagaagcaccttttcagcaccatccctgagctcattaac
taccatcagcacaactctgcaggactcatatccaggctcaaatatccagtgtctcaacaa
aacaagaatgcaccttccactgcaggcctgggatacggatcatgggaaattgatccaaag
gacctgaccttcttgaaggagctggggactggacaatttggggtagtgaagtatgggaaa
tggagaggccagtacgacgtggccatcaagatgatcaaagaaggctccatgtctgaagat
gaattcattgaagaagccaaagtcatgatgaatctttcccatgagaagctggtgcagttg
tatggcgtctgcaccaagcagcgccccatcttcatcatcactgagtacatggccaatggc
tgcctcctgaactacctgagggagatgcgccaccgcttccagactcagcagctgctagag
atgtgcaaggatgtctgtgaagccatggaatacctggagtcaaagcagttccttcaccga
gacctggcagctcgaaactgtttggtaaacgatcaaggagttgttaaagtatctgatttc
ggcctgtccaggtatgtcctggatgatgaatacacaagctcagtaggctccaaatttcca
gtccggtggtccccaccggaagtcctgatgtatagcaagttcagcagcaaatctgacatt
tgggcttttggggttttgatgtgggaaatttactccctggggaagatgccatatgagaga
tttactaacagtgagactgctgaacacattgcccaaggcctacgtctctacaggcctcat
ctggcttcagagaaggtatataccatcatgtacagttgctggcatgagaaagcagatgag
cgtcccactttcaaaattcttctgagcaatattctagatgtcatggatgaagaatcctga

DBGET integrated database retrieval system