KEGG   Homo sapiens (human): 7082
Entry
7082              CDS       T01001                                 
Symbol
TJP1, ZO-1
Name
(RefSeq) tight junction protein 1 isoform a
  KO
K05701  tight junction protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
hsa04517  IgSF CAM signaling
hsa04519  Cadherin signaling
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04540  Gap junction
hsa05110  Vibrio cholerae infection
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
Network
nt06180  Pathogenic Escherichia coli
nt06546  IgSF CAM signaling
  Element
N01287  Tight junction-Actin signaling pathway
N01288  Escherichia EspF to Tight junction-Actin signaling pathway
N01956  JAM1 interactions
N01957  JAM2 interactions
N01958  JAM3 interactions
N01960  CLMP interactions
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    7082 (TJP1)
   04519 Cadherin signaling
    7082 (TJP1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    7082 (TJP1)
   04530 Tight junction
    7082 (TJP1)
   04540 Gap junction
    7082 (TJP1)
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    7082 (TJP1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    7082 (TJP1)
   05120 Epithelial cell signaling in Helicobacter pylori infection
    7082 (TJP1)
   05130 Pathogenic Escherichia coli infection
    7082 (TJP1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7082 (TJP1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     7082 (TJP1)
SSDB
Motif
Pfam: PDZ ZU5 PDZ_6 PDZ_2 Guanylate_kin SH3_2 SH3_1 HA_Alsin
Other DBs
NCBI-GeneID: 7082
NCBI-ProteinID: NP_003248
OMIM: 601009
HGNC: 11827
UniProt: Q07157 Q6MZU1
Structure
Position
15:complement(29699367..29969049)
AA seq 1748 aa
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC
VSVLIDHF
NT seq 5247 nt   +upstreamnt  +downstreamnt
atgtccgccagagctgcggccgccaagagcacagcaatggaggaaacagctatatgggaa
caacatacagtgacgcttcacagggctcctggatttggatttggaattgcaatatctggt
ggacgagataatcctcattttcagagtggggaaacgtcaatagtgatttcagatgtgctg
aaaggaggaccagctgaaggacagctacaggaaaatgaccgagttgcaatggttaacgga
gtttcaatggataatgttgaacatgcttttgctgttcagcaactaaggaaaagtgggaaa
aatgcaaaaattacaattagaaggaagaagaaagttcaaataccagtaagtcgtcctgat
cctgaaccagtatctgataatgaagaagatagttatgatgaggaaatacatgatccaaga
agtggccggagtggtgtggttaacagaaggagtgagaagatttggccgagggatagaagt
gcaagtagagagaggagcttgtccccgcggtcagacaggcggtcagtggcttccagccag
cctgctaaacctactaaagtcacactggtgaaatcccggaaaaatgaagaatatggtctt
cgattggcaagccatatatttgttaaggaaatttcacaagatagtttggcagcaagagat
ggcaatattcaagaaggtgatgttgtattgaagataaatggtactgtgacagaaaatatg
tcattgacagatgcaaagacattgatagaaaggtctaaaggcaaattaaaaatggtagtt
caaagagatgaacgggctacgctattgaatgtccctgatctttctgacagcatccactct
gctaatgcctctgagagagacgacatttcagaaattcagtcactggcatcagatcattct
ggtcgatcacacgataggcctccccgccgcagccggtcacgatctcctgaccagcggtca
gagccttctgatcattccaggcactcgccgcagcagccaagcaatggcagtctccggagt
agagatgaagagagaatttctaaacctggggctgtctcaactcctgtaaagcatgctgat
gatcacacacctaaaacagtggaagaagttacagttgaaagaaatgagaaacaaacacct
tctcttccagaaccaaagcctgtgtatgcccaagttgggcaaccagatgtggatttacct
gtcagtccatctgatggtgtcctacctaattcaactcatgaagatgggattcttcggccc
agcatgaaattggtaaaattcagaaaaggagatagtgtgggtttgcggctggctggtgga
aatgatgttggaatatttgtagctggcgttctagaagatagccctgcagccaaggaaggc
ttagaggaaggtgatcaaattctcagggtaaacaacgtagattttacaaatatcataaga
gaagaagccgtccttttcctgcttgacctccctaaaggagaagaagtgaccatattggct
cagaagaagaaggatgtttatcgtcgcattgtagaatcagatgtaggagattctttctat
attagaacccattttgaatatgaaaaggaatctccctatggacttagttttaacaaagga
gaggtgttccgtgttgtggataccttgtacaatggaaaactgggctcttggcttgctatt
cgaattggtaaaaatcataaggaggtagaacgaggcatcatccctaataagaacagagct
gagcagctagccagtgtacagtatacacttccaaaaacagcaggcggagaccgtgctgac
ttctggagattcagaggtcttcgcagctccaagagaaatcttcgaaaaagcagagaggat
ttgtccgctcagcctgttcaaacaaagtttccagcttatgaaagagtggttcttcgagaa
gctggatttctgaggcctgtaaccatttttggaccaatagctgatgttgccagagaaaag
ctggcaagagaagaaccagatatttatcaaattgcaaagagtgaaccacgagacgctgga
actgaccaacgtagctctggcattattcgcctgcatacaataaagcaaatcatagatcaa
gacaaacatgctttattagatgtaacaccaaatgcagttgatcgtcttaactatgcccag
tggtatccaattgttgtatttcttaaccctgattctaagcaaggagtaaaaacaatgaga
atgaggttatgtccagaatctcggaaaagtgccaggaagttatacgagcgatctcataaa
cttcgtaaaaataatcaccatctttttacaactacaattaacttaaattcaatgaatgat
ggttggtatggtgcgctgaaagaagcaattcaacaacagcaaaaccagctggtatgggtt
tccgagggaaaggcggatggtgctacaagtgatgaccttgatttgcatgatgatcgtctg
tcctacctgtcagctccaggtagtgaatactcaatgtatagcacggacagtagacacact
tctgactatgaagacacagacacagaaggcggggcctacactgatcaagaactagatgaa
actcttaatgatgaggttgggactccaccggagtctgccattacacggtcctctgagcct
gtaagagaggactcctctggaatgcatcatgaaaaccaaacatatcctccttactcacca
caagcgcagccacaaccaattcatagaatagactcccctggatttaagccagcctctcaa
cagaaagcagaagcttcatctccagtcccttacctttcgcctgaaacaaacccagcatca
tcaacctctgctgttaatcataatgtaaatttaactaatgtcagactggaggagcccacc
ccagctccttccacctcttactcaccacaagctgattctttaagaacaccaagtactgag
gcagctcacataatgctaagagatcaagaaccatcattgtcgtcgcatgtagatccaaca
aaggtgtatagaaaggatccatatcccgaggaaatgatgaggcagaaccatgttttgaaa
cagccagccgttagtcacccagggcacaggccagacaaagagcctaatctgacctatgaa
ccccaactcccatacgtagagaaacaagccagcagagacctcgagcagcccacatacaga
tacgagtcctcaagctatacggaccagttttctcgaaactatgaacatcgtctgcgatac
gaagatcgcgtccccatgtatgaagaacagtggtcatattatgatgacaaacagccctac
ccatctcggccaccttttgataatcagcactctcaagaccttgactccagacagcatccc
gaagagtcctcagaacgagggtactttccacgttttgaagagccagcccctctgtcttac
gacagcagaccacgttacgaacaggcacctagagcatccgccctgcggcacgaagagcag
ccagctcctgggtatgacacacatggtagactcagaccggaagcccagccccacccttca
gcagggcccaagcctgcagagtccaagcagtattttgagcaatattcacgcagttacgag
caagtaccaccccaaggatttacctctagagcaggtcattttgagcctctccatggtgct
gcagctgtccctccgctgataccttcatctcagcataagccagaagctctgccttcaaac
accaaaccactgcctccacccccaactcaaaccgaagaagaggaagatccagcaatgaag
ccacagtctgtactcaccagagttaagatgtttgaaaacaaaagatctgcatccttagag
accaagaaggatgtaaatgacactggcagttttaagcctccagaagtagcatctaaacct
tcaggtgctcccatcattggtcccaaacccacttctcagaatcaattcagtgaacatgac
aaaactctgtacaggatcccagaacctcaaaaacctcaactgaagccacctgaagatatt
gttcggtccaatcattatgaccctgaagaagatgaagaatattatcgaaaacagctgtca
tactttgaccgaagaagttttgagaataagcctcctgcacacattgccgccagccatctc
tccgagcctgcaaagccagcgcattctcagaatcaatcaaatttttctagttattcttca
aagggaaagcctcctgaagctgatggtgtggatagatcatttggcgagaaacgctatgaa
cccatccaggccactccccctcctcctccattgccctcgcagtatgcccagccatctcag
cctgtcaccagcgcgtctctccacatacattctaagggagcacatggtgaaggtaattca
gtgtcattggattttcagaattccttagtgtccaaaccagacccacctccatctcagaat
aagccagcaactttcagaccaccaaaccgagaagatactgctcaggcagctttctatccc
cagaaaagttttccagataaagccccagttaatggaactgaacagactcagaaaacagtc
actccagcatacaatcgattcacaccaaaaccatatacaagttctgcccgaccatttgaa
cgcaagtttgaaagtcctaaattcaatcacaatcttctgccaagtgaaactgcacataaa
cctgacttgtcttcaaaaactcccacttctccaaaaactcttgtgaaatcgcacagtttg
gcacagcctcctgagtttgacagtggagttgaaactttctctatccatgcagagaagcct
aaatatcaaataaataatatcagcacagtgcctaaagctattcctgtgagtccttcagct
gtggaagaggatgaagatgaagatggtcatactgtggtggccacagcccgaggcatattt
aacagcaatgggggcgtgctgagttccatagaaactggtgttagtataattatccctcaa
ggagccattcccgaaggagttgagcaggaaatctatttcaaggtctgccgggacaacagc
atccttccacctttagataaagagaaaggtgaaacactgctgagtcctttggtgatgtgt
ggtccccatggcctcaagttcctgaagcctgtggagctgcgcttaccacactgtgatcct
aaaacctggcaaaacaagtgtcttcccggagatccaaattatctcgttggagcaaactgt
gtttctgtccttattgaccacttttaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (24)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   OC (1)   
Protein sequence (124)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (121)   
DNA sequence (177)   
   RefSeq(nuc) (121)   
   GenBank (28)   
   EMBL (28)   
3D Structure (19)   
   PDB (19)   
Protein domain (8)   
   Pfam (8)   
All databases (353)   

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