KEGG   Homo sapiens (human): 8630
Entry
8630              CDS       T01001                                 
Symbol
HSD17B6, HSE, RODH, SDR9C6
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 6
  KO
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00830  Retinol metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    8630 (HSD17B6)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    8630 (HSD17B6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     8630 (HSD17B6)
    1.1.1.105  all-trans-retinol dehydrogenase (NAD+)
     8630 (HSD17B6)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     8630 (HSD17B6)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR
Other DBs
NCBI-GeneID: 8630
NCBI-ProteinID: NP_003716
OMIM: 606623
HGNC: 23316
Ensembl: ENSG00000025423
UniProt: O14756
Position
12:56763324..56787790
AA seq 317 aa
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
LADYILTRSWPKPAQAV
NT seq 954 nt   +upstreamnt  +downstreamnt
atgtggctctacctggcggccttcgtgggcctgtactaccttctgcactggtaccgggag
aggcaggtggtgagccacctccaagacaagtatgtctttatcacgggctgtgactcgggc
tttgggaacctgctggccagacagctggatgcacgaggcttgagagtgctggctgcgtgt
ctgacggagaagggggccgagcagctgaggggccagacgtctgacaggctggagacggtg
accctggatgttaccaagatggagagcatcgctgcagctactcagtgggtgaaggagcat
gtgggggacagaggactctggggactggtgaacaatgcaggcattcttacaccaattacc
ttatgtgagtggctgaacactgaggactctatgaatatgctcaaagtgaacctcattggt
gtgatccaggtgaccttgagcatgcttcctttggtgaggagagcacggggaagaattgtc
aatgtctccagcattctgggaagagttgctttctttgtaggaggctactgtgtctccaag
tatggagtggaagccttttcagatattctgaggcgtgagattcaacattttggggtgaaa
atcagcatagttgaacctggctacttcagaacgggaatgacaaacatgacacagtcctta
gagcgaatgaagcaaagttggaaagaagcccccaagcatattaaggagacctatggacag
cagtattttgatgccctttacaatatcatgaaggaagggctgttgaattgtagcacaaac
ctgaacctggtcactgactgcatggaacatgctctgacatcggtgcatccgcgaactcga
tattcagctggctgggatgctaaatttttcttcatccctctatcttatttacctacatca
ctggcagactacattttgactagatcttggcccaaaccagcccaggcagtctaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (9)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (36)   
   RefSeq(nuc) (14)   
   GenBank (11)   
   EMBL (11)   
Protein domain (3)   
   Pfam (3)   
All databases (65)   

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