KEGG T01001: 883

Homo sapiens (human): 883

Entry

883 CDS T01001

Gene name

KYAT1, CCBL1, GTK, KAT1, KATI

Definition

(RefSeq) kynurenine aminotransferase 1

K00816

kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]

Organism

hsa Homo sapiens (human)

Pathway

hsa00270

Cysteine and methionine metabolism

hsa00380

Tryptophan metabolism

hsa00450

Selenocompound metabolism

hsa01100

Metabolic pathways

hsa05204

Chemical carcinogenesis

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    883 (KYAT1)
   00380 Tryptophan metabolism
    883 (KYAT1)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    883 (KYAT1)
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    883 (KYAT1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    883 (KYAT1)
Enzymes [BR:hsa01000]
2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.7  kynurenine---oxoglutarate transaminase
     883 (KYAT1)
    2.6.1.64  glutamine---phenylpyruvate transaminase
     883 (KYAT1)
4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.13  cysteine-S-conjugate beta-lyase
     883 (KYAT1)
Amino acid related enzymes [BR:hsa01007]
Aminotransferase (transaminase)
  Class I
   883 (KYAT1)

SSDB

Motif

Pfam:

Aminotran_1_2 Cys_Met_Meta_PP DegT_DnrJ_EryC1 Beta_elim_lyase

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

ENSG00000171097 ENSG00000286112

Vega:

OTTHUMG00000020767

Pharos:

Q16773(Tbio)

UniProt:

Q16773 A8K563

Structure

PDB:

4WLH 3FVS 3FVX 4WLJ 3FVU 4WP0 1W7L 1W7M 1W7N

Position

9q34.11

AA seq 422 aa
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL

NT seq 1269 nt +upstreamnt +downstreamnt
atggccaaacagctgcaggcccgaaggctagacgggatcgactacaacccctgggtggag
tttgtgaaactggccagtgagcatgacgtcgtgaacttgggccagggcttcccggatttc
ccaccaccagactttgccgtggaagcctttcagcacgctgtcagtggagacttcatgctt
aaccagtacaccaagacatttggttacccaccactgacgaagatcctggcaagtttcttt
ggggagctgctgggtcaggagatagacccgctcaggaatgtgctggtgactgttggtggc
tatggggccctgttcacagccttccaggccctggtggacgaaggagacgaggtcatcatc
atcgaacccttttttgactgctacgagcccatgacaatgatggcagggggtcgtcctgtg
tttgtgtccctgaagccgggtcccatccagaatggagaactgggttccagcagcaactgg
cagctggaccccatggagctggccggcaaattcacatcacgcaccaaagccctggtcctc
aacacccccaacaaccccctgggcaaggtgttctccagggaagagctggagctggtggcc
agcctttgccagcagcatgacgtggtgtgtatcactgatgaagtctaccagtggatggtc
tacgacgggcaccagcacatcagcattgccagcctccctggcatgtgggaacggaccctg
accatcggcagcgccggcaagaccttcagcgccactggctggaaggtgggctgggtcctg
ggtccagatcacatcatgaagcacctgcggaccgtgcaccagaactccgtcttccactgc
cccacgcagagccaggctgcagtagccgagagctttgaacgggagcagctgctcttccgc
caacccagcagctactttgtgcagttcccgcaggccatgcagcgctgccgtgaccacatg
atacgtagcctacagtcagtgggcctgaagcccatcatccctcagggcagctacttcctc
atcacagacatctcagacttcaagaggaagatgcctgacttgcctggagctgtggatgag
ccctatgacagacgcttcgtcaagtggatgatcaagaacaagggcttggtggccatccct
gtctccatcttctatagtgtgccacatcagaagcactttgaccactatatccgcttctgt
tttgtgaaggatgaagccacgctccaggccatggacgagaagctgcggaagtggaaggtg
gaactctag

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