KEGG   Homo sapiens (human): 8879
Entry
8879              CDS       T01001                                 
Symbol
SGPL1, NPHS14, RENI, S1PL, SPL
Name
(RefSeq) sphingosine-1-phosphate lyase 1
  KO
K01634  sphinganine-1-phosphate aldolase [EC:4.1.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00600  Sphingolipid metabolism
hsa01100  Metabolic pathways
hsa04071  Sphingolipid signaling pathway
Module
hsa_M00100  Sphingosine degradation
Disease
H01657  Nephrotic syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    8879 (SGPL1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    8879 (SGPL1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.27  sphinganine-1-phosphate aldolase
     8879 (SGPL1)
SSDB
Motif
Pfam: Pyridoxal_deC Aminotran_5 Aminotran_1_2 DegT_DnrJ_EryC1 SepSecS Cys_Met_Meta_PP
Other DBs
NCBI-GeneID: 8879
NCBI-ProteinID: NP_003892
OMIM: 603729
HGNC: 10817
Ensembl: ENSG00000166224
UniProt: O95470
Structure
Position
10:70815948..70881184
AA seq 568 aa
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
NT seq 1707 nt   +upstreamnt  +downstreamnt
atgcctagcacagaccttctgatgttgaaggcctttgagccctacttagagattttggaa
gtatactccacaaaagccaagaattatgtaaatggacattgcaccaagtatgagccctgg
cagctaattgcatggagtgtcgtgtggaccctgctgatagtctggggatatgagtttgtc
ttccagccagagagtttatggtcaaggtttaaaaagaaatgttttaagctcaccaggaag
atgcccattattggtcgtaagattcaagacaagttgaacaagaccaaggatgatattagc
aagaacatgtcattcctgaaagtggacaaagagtatgtgaaagctttaccctcccagggt
ctgagctcatctgctgttttggagaaacttaaggagtacagctctatggacgccttctgg
caagaggggagagcctctggaacagtgtacagtggggaggagaagctcactgagctcctt
gtgaaggcttatggagattttgcatggagtaaccccctgcatccagatatcttcccagga
ctacgcaagatagaggcagaaatcgtgaggatagcttgttccctgttcaatgggggacca
gattcgtgtggatgtgtgacttctgggggaacagaaagcatactgatggcctgcaaagca
tatcgggatctggcctttgagaaggggatcaaaactccagaaattgtggctccccaaagt
gcccatgctgcatttaacaaagcagccagttactttgggatgaagattgtgcgggtccca
ttgacgaagatgatggaggtggatgtgcgggcaatgagaagagctatctccaggaacact
gccatgctcgtctgttctaccccacagtttcctcatggtgtaatagatcctgtccctgaa
gtggccaagctggctgtcaaatacaaaataccccttcatgtcgacgcttgtctgggaggc
ttcctcatcgtctttatggagaaagcaggatacccactggagcacccatttgatttccgg
gtgaaaggtgtaaccagcatttcagctgacacccataagtatggctatgccccaaaaggc
tcatcattggtgttgtatagtgacaagaagtacaggaactatcagttcttcgtcgataca
gattggcagggtggcatctatgcttccccaaccatcgcaggctcacggcctggtggcatt
agcgcagcctgttgggctgccttgatgcacttcggtgagaacggctatgttgaagctacc
aaacagatcatcaaaactgctcgcttcctcaagtcagaactggaaaatatcaaaggcatc
tttgtttttgggaatccccaattgtcagtcattgctctgggatcccgtgattttgacatc
taccgactatcaaacctgatgactgctaaggggtggaacttgaaccagttgcagttccca
cccagtattcatttctgcatcacattactacacgcccggaaacgagtagctatacaattc
ctaaaggacattcgagaatctgtcactcaaatcatgaagaatcctaaagcgaagaccaca
ggaatgggtgccatctatggcatggcccagacaactgttgacaggaatatggttgcagaa
ttgtcctcagtcttcttggacagcttgtacagcaccgacactgtcacccagggcagccag
atgaatggttctccaaaaccccactga

  All links  
Disease (2)   
   OMIM (2)   
Gene (18)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (44)   
   RefSeq(nuc) (20)   
   GenBank (12)   
   EMBL (12)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   Pfam (6)   
All databases (93)   

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