KEGG T01001: 993

Homo sapiens (human): 993

Entry

993 CDS T01001

Gene name

CDC25A, CDC25A2

Definition

(RefSeq) cell division cycle 25A

K06645

M-phase inducer phosphatase 1 [EC:3.1.3.48]

Organism

hsa Homo sapiens (human)

Pathway

hsa04110

Cell cycle

hsa04218

Cellular senescence

hsa04914

Progesterone-mediated oocyte maturation

hsa05206

MicroRNAs in cancer

Module

hsa_M00691

DNA damage-induced cell cycle checkpoints

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    993 (CDC25A)
   04218 Cellular senescence
    993 (CDC25A)
09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    993 (CDC25A)
09160 Human Diseases
  09161 Cancers: Overview
   05206 MicroRNAs in cancer
    993 (CDC25A)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    993 (CDC25A)
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    993 (CDC25A)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     993 (CDC25A)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein Tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    993 (CDC25A)
DNA repair and recombination proteins [BR:hsa03400]
Eukaryotic Type
  Check point factors
   Other check point factors
    993 (CDC25A)

SSDB

Motif

Pfam:

M-inducer_phosp Rhodanese

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P30304(Tchem)

UniProt:

P30304 A0A024R2S4

Structure

PDB:

1C25

Position

3p21.31

AA seq 524 aa
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE
QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK
RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP
ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL
WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK
ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI
SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT
DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY
CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL

NT seq 1575 nt +upstreamnt +downstreamnt
atggaactgggcccggagcccccgcaccgccgccgcctgctcttcgcctgcagcccccct
cccgcgtcgcagcccgtcgtgaaggcgctatttggcgcttcagccgccgggggactgtcg
cctgtcaccaacctgaccgtcactatggaccagctgcagggtctgggcagtgattatgag
caaccactggaggtgaagaacaacagtaatctgcagagaatgggctcctccgagtcaaca
gattcaggtttctgtctagattctcctgggccattggacagtaaagaaaaccttgaaaat
cctatgagaagaatacattccctacctcagaagctgttgggatgtagtccagctctgaag
aggagccattctgattctcttgaccatgacatctttcagctcatcgacccagatgagaac
aaggaaaatgaagcctttgagtttaagaagccagtaagacctgtatctcgtggctgcctg
cactctcatggactccaggagggtaaagatctcttcacacagaggcagaactctgcccca
gctcggatgctttcctcaaatgaaagagatagcagtgaaccagggaatttcattcctctt
tttacaccccagtcacctgtgacagccactttgtctgatgaggatgatggcttcgtggac
cttctcgatggagagaatctgaagaatgaggaggagaccccctcgtgcatggcaagcctc
tggacagctcctctcgtcatgagaactacaaaccttgacaaccgatgcaagctgtttgac
tccccttccctgtgtagctccagcactcggtcagtgttgaagagaccagaacgatctcaa
gaggagtctccacctggaagtacaaagaggaggaagagcatgtctggggccagccccaaa
gagtcaactaatccagagaaggcccatgagactcttcatcagtctttatccctggcatct
tcccccaaaggaaccattgagaacattttggacaatgacccaagggaccttataggagac
ttctccaagggttatctctttcatacagttgctgggaaacatcaggatttaaaatacatc
tctccagaaattatggcatctgttttgaatggcaagtttgccaacctcattaaagagttt
gttatcatcgactgtcgatacccatatgaatacgagggaggccacatcaagggtgcagtg
aacttgcacatggaagaagaggttgaagacttcttattgaagaagcccattgtacctact
gatggcaagcgtgtcattgttgtgtttcactgcgagttttcttctgagagaggtccccgc
atgtgccggtatgtgagagagagagatcgcctgggtaatgaataccccaaactccactac
cctgagctgtatgtcctgaaggggggatacaaggagttctttatgaaatgccagtcttac
tgtgagccccctagctaccggcccatgcaccacgaggactttaaagaagacctgaagaag
ttccgcaccaagagccggacctgggcaggggagaagagcaagagggagatgtacagtcgt
ctgaagaagctctga

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