Entry |
|
Symbol |
leuB, IMDH
|
Name |
3-isopropylmalate dehydrogenase [EC: 1.1.1.85]
|
Pathway |
map00290 | Valine, leucine and isoleucine biosynthesis |
map00660 | C5-Branched dibasic acid metabolism |
map01110 | Biosynthesis of secondary metabolites |
map01210 | 2-Oxocarboxylic acid metabolism |
|
Module |
M00432 | Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate |
M00535 | Isoleucine biosynthesis, pyruvate => 2-oxobutanoate |
|
Reaction |
R00994 | (2R,3S)-3-methylmalate:NAD+ oxidoreductase |
R04426 | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase |
R10052 | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
K00052 leuB, IMDH; 3-isopropylmalate dehydrogenase
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
K00052 leuB, IMDH; 3-isopropylmalate dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.85 3-isopropylmalate dehydrogenase
K00052 leuB, IMDH; 3-isopropylmalate dehydrogenase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
2-Oxoacid chain elongation
K00052
|
Other DBs |
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Genes |
» show all
|
Reference |
|
Authors |
Parsons SJ, Burns RO |
Title |
Purification and properties of beta-isopropylmalate dehydrogenase. |
Journal |
J Biol Chem 244:996-1003 (1969) |
Sequence |
|
Reference |
|
Authors |
Howell DM, Graupner M, Xu H, White RH |
Title |
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea. |
Journal |
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Sequence |
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