KEGG ORTHOLOGY: K00079

ORTHOLOGY: K00079

Entry

K00079                      KO

Symbol

CBR1

Name

carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]

Pathway

map00590

Arachidonic acid metabolism

map00790

Folate biosynthesis

map00980

Metabolism of xenobiotics by cytochrome P450

map01100

Metabolic pathways

map05204

Chemical carcinogenesis - DNA adducts

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R02581

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase

R02975

7,8-dihydrobiopterin:NADP+ oxidoreductase

R04285

6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase

R09420

carbonyl reductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00079  CBR1; carbonyl reductase 1
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00079  CBR1; carbonyl reductase 1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00079  CBR1; carbonyl reductase 1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K00079  CBR1; carbonyl reductase 1
   05208 Chemical carcinogenesis - reactive oxygen species
    K00079  CBR1; carbonyl reductase 1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.184  carbonyl reductase (NADPH)
     K00079  CBR1; carbonyl reductase 1
    1.1.1.189  prostaglandin-E2 9-reductase
     K00079  CBR1; carbonyl reductase 1
    1.1.1.197  15-hydroxyprostaglandin dehydrogenase (NADP+)
     K00079  CBR1; carbonyl reductase 1

Other DBs

GO:	0004090 0050221 0047021

Genes

HSA:

873(CBR1)

PTR:	473983(CBR1)

PPS:	100984486(CBR1)

GGO:	101128365(CBR1)

PON:	100172097(CBR1)

NLE:	100595150(CBR1)

HMH:	116481448(CBR1)

MCC:

MCF:

MTHB:

MNI:

CSAB:

103218526(CBR1)

CATY:

105575413(CBR1)

PANU:

101016017(CBR1)

TGE:

112620389

MLEU:

105544992

RRO:

104680046

RBB:	108536876(CBR1)

TFN:

117095746

PTEH:

111525655

CANG:

105517486

CJC:	100385429(CBR1)

SBQ:	101053953(CBR1)

CIMI:

108302554

CSYR:

103260442

MMUR:

105881306 105881307 105881308

LCAT:

123630719 123630720 123630721 123630722

PCOQ:

105806875 105824395 105824399 105824400 105824401

OGA:	100956096 100957684 100963998 100966702

MMU:	12408(Cbr1)

MCAL:

110288679 110311495 110311943

MPAH:

110329855 110329915

RNO:	100360601(Cbr1l3) 102556347(Cbr1l2) 120093083(Cbr1l1) 29224(Cbr1)

MCOC:

116086159

ANU:	117717490 117717920 117717929 117718132

MUN:	110553070 132648611

CGE:	100689019(Chcr1) 100689020(Chcr2) 100752270 100753466 113835641

MAUA:

121141872 121141873 121141874

PROB:

127227536 127227537 127227539

PLEU:

114689098 114700346 119088843

MORG:

121461792 121461815 121461961

MFOT:

126513574 126513575 126513576

AAMP:

119824712 119824713 119824714

NGI:	103736428(Cbr1)

HGL:	101707305 101709698

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100009528(CBR1) 100344189 100344692 100344949 100345202 100345716 100348276

OPI:	101524741 101525632

TUP:	102493488(CBR1)

GVR:	103592861(CBR1)

CFA:	100688446 610164

CLUD:

112661582 112661739 112661740

VVP:	112910256 112910259 112910262 112910266

VLG:	121479475 121479477 121479478

NPO:	129502220 129502221 129502222 129502223 129502225 129516679

AML:	100463727 100482421 100482670

UMR:	103673139 103673143 103673144 103673226 103673228

UAH:	113260781 113260850

UAR:	123775789 123784231 123784232 123784385 123786548 123786550 123786552 123786553 123786554 123802675 123802676 123804157

ELK:	111155701 111155789

LLV:	125082494 125094720 125094726

MPUF:

101678900 101693597

MNP:	132012378(CBR1) 132012380

MLK:	131825351 131825352

NVS:	122908308 122908309 122908310

ZCA:

113918461

MLX:

118018856

NSU:	110570003 110570075

LWW:	102728673 102729772

FCA:	101083875 101084134 101084388 102901316 105260891

PYU:	121026601 121026604 121026606 121026608 121026610 121035958 121035960 121036456

PCOO:

112849494 112849533 112849540 112849541

PBG:	122491188 122491190 122491191 122491194 122491195 122492251 122492252 122492253

PVIV:

125174566 125174567 125175206 125175207 125175544 125175545

LRUF:

124526450 124526858 124526871 124526872 124526890

PTG:	102951798 102962462 102963221 107180402

PPAD:

109249662 109249663 109249756 109249757 109249758 109249759 109249762 109249763 109249764

PUC:	125920757 125920758 125920759

AJU:	106966975 106966977 106966978 106966979 106967000 106967001

HHV:	120229760 120229888 120229905 120229943

BTA:	112441473 510180(MGC127133) 515946(CBR1)

BOM:	102280157 102280721

BIU:	109561438 109561446 109561452 109564723

BBUB:

102389721 102414811 102415914 112577647 112577706 112586983 123464543 123464567 123466176 123466179

BBIS:

104984897 104984898

CHX:	102172669 102178311 108633281

OAS:	101114408 101114663 101115172 114110594

BTAX:

128045249 128047390

ODA:	120880850 120880865 120880873

CCAD:

122445109 122445460 122445461

MBEZ:

129549057 129552260 129552383 129552388 129552395 129552403

SSC:	100622246 110256480 110256481 110256483 397143(CBR1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:	103084663(CBR1)

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100061592 100061622 100061690 100061787 100630657

EPZ:	103548815 103548838

EAI:	106831418 106831423

MYB:	102242410 102242716 106723568

MYD:	102773942(CBR1)

MMYO:

118676368 118676559 118676891

MLF:	102425094 102425398 111822969

PKL:	118723440 118723441

EFUS:

103289825 103289914 129147668

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

129074367(CBR1)

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:	108383622 108386803 108389208 108396123 108396124 108396125 108405052 108405882 108405883 108408249 118971736

TOD:	119239950 119257208

SARA:

101540843(CBR1)

SETR:

125998153 126011752 126026081 126026088

LAV:	100665833 100666118 100674470

TMU:

101361316

ETF:	101661557 101661867 105979822

DNM:

101410715

MDO:	100015103 100015187 100015233

GAS:	123239602 123239603

SHR:

100920969

AFZ:

127553846

PCW:	110214859 110214881 110214882 110214894

OAA:

100081857

GGA:	418512(CBR1)

PCOC:

116241963

MGP:	100550018(CBR1)

CJO:

107323279

TPAI:

128076389(CBR1)

LMUT:

NMEL:

APLA:

ACYG:

CATA:

118247708(CBR1)

AFUL:

116500788

TGU:

100222525

LSR:

110475373

SCAN:

103815738(CBR1)

PMOA:

120503114

OTC:

121333523

PRUF:

121357711

GFR:	102043656(CBR1)

FAB:	101809650 101821429(CBR1)

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:	114070969 114071875

ACHL:

103810634

SVG:

106863666

MMEA:

130580000

HRT:	120748797(CBR1)

FPG:	101915985(CBR1)

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

104559931(CBR1)

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:	128912623(CBR1)

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102575087(CBR1)

CPOO:

109305805

GGN:

109302951

PSS:

102454231

CMY:	102941881 102945673 119566793

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100567688 100568150

ASAO:

132771863 132771864

PVT:	110076821 110076832

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:	118085405 118085408

HCG:

GJA:

STOW:

EMC:

XLA:	108707866(cbr1.2.L) 108707867(cbr1.1.L) 108707868 496039(cbr1.1.S) 734804(cbr1.2.S)

XTR:	100145008(cbr1.3) 101735101(cbr1.2) 496612(cbr1.1)

NPR:	108791095 108791096

RTEM:

120927930 120927931

BBUF:

120994497 120994498 120994500 120994501 120994503

BGAR:

122933033 122933036 122933038 122933039 122933041 122933043

MUO:	115469487 115469491 115469493 115469494

GSH:	117362569 117363078 117363079

DRE:	337696(cbr1l) 373866(cbr1)

SRX:	107706524 107746284

SANH:

107676886(cbr1) 107681174 107692178

SGH:	107560976 107573060 107589305

CCAR:

109096114(cbr1)

CAUA:

113038637 113038652 113068667 113075683 113098224

CGIB:

127949742 127985943 128018510

PTET:

122326921(cbr1l) 122342608(cbr1)

LROH:

127152301(cbr1l) 127164852(cbr1)

OMC:	131528706(cbr1l) 131545739(cbr1)

PPRM:

120490784(cbr1) 120490865(cbr1l)

RKG:	130085515(cbr1) 130096466(cbr1l)

MAMB:

125252547(cbr1l) 125271973(cbr1)

CIDE:

127503586 127513696

MASI:

127430734 127443527 127445316

TROS:

130553394(cbr1) 130570251(cbr1l)

TDW:	130407914(cbr1l) 130435123(cbr1)

MANU:

129424220(cbr1l) 129444179(cbr1)

IPU:	108258607 108279390(cbr1l)

IFU:	128602387(cbr1) 128622786(cbr1l)

PHYP:

113537332(cbr1) 113541450

SMEO:

124377931(cbr1) 124398406 124398407

TFD:	113648799(cbr1) 113651966(cbr1l)

TVC:	132839121(cbr1) 132860474(cbr1l)

AMEX:

103025086(cbr1) 103044035 103044320

CMAO:

118802947 118802991(cbr1) 118819847 118820309

EEE:

113577487

CHAR:

105904445 105904453(cbr1l) 105911897(cbr1)

TRU:	101070504(cbr1)

TFS:	130534035(cbr1)

TNG:	GSTEN00018781G001

LCO:	104925597(cbr1)

TBEN:

117487226(cbr1)

CGOB:

115019870(cbr1)

PGEO:

117443309(cbr1)

GACU:

117553824

EMAC:

134859095(cbr1)

ELY:	117271559(cbr1)

EFO:	125903187 125903188

PLEP:

121954458(cbr1)

SLUC:

116061672(cbr1)

ECRA:

117960675(cbr1)

ESP:	116705075(cbr1)

PFLV:

114571677 114571914(cbr1)

GAT:	120821041(cbr1)

PPUG:

119214205(cbr1)

AFB:	129092038(cbr1)

CLUM:

117743852(cbr1)

PSWI:

130206918(cbr1)

MSAM:

119889598 119889599 119889600 119912980 119913181 119913216

SCHU:

122884502(cbr1)

CUD:	121510925(cbr1)

ALAT:

119033818(cbr1)

MZE:	101465189 101465758(cbr1) 101466994 101467487

ONL:	100534432 100694465 100694734 100694993

OAU:	116318414 116318415 116318416

OLA:	100125494(cbr1)

OML:	112161544(cbr1)

CSAI:

133463793(cbr1) 133463815

XMA:	102228388(cbr1) 102228648

XCO:	114137930 114137931

XHE:	116713164 116713166

PRET:

103476570 108166972

PFOR:

103151904 103151905

PLAI:

106938651 106962559 106962563

PMEI:

106908896(cbr1)

GAF:	122842620(cbr1)

PPRL:

129353950 129353951

CVG:

107105240

CTUL:

119777760(cbr1)

GMU:	124859072 124859372(cbr1)

NFU:	107376130 107376131(cbr1)

KMR:	108250748 108250751

ALIM:

106527744(cbr1)

NWH:	119420158(cbr1)

AOCE:

111579487 111579488 111579490

MCEP:

125018685 125018686 125018687 125018688

CSEM:

103387805(cbr1)

POV:	109644021(cbr1)

SSEN:

122782161(cbr1)

HHIP:

117775513(cbr1)

HSP:	118119006 118119007

SMAU:

118283375 118283932

LCF:

108872922

SDU:	111223859(cbr1)

SLAL:

111645450(cbr1)

XGL:	120796209(cbr1)

HCQ:	109510228 109515209

SSCV:

125978214

SBIA:

133510056(cbr1)

PEE:	133409380(cbr1)

PTAO:

133485480(cbr1)

BPEC:

110156802 110156828 110156944 110171218 110175574

MALB:

109963832(cbr1)

BSPL:

114870369 114870370

SJO:	128373378(cbr1)

SASA:

106563564(DHCA) 106563565(DHCA) 106563632 106575082(cbr1) 106586631

STRU:

115161139 115179191(cbr1) 115204366 115204367

OTW:	112231245 112231246 112240976 112253987(cbr1)

OMY:	100135879 100136606 110520445 110527555(cbr1)

OGO:	124007541 124007542 124007744(cbr1) 124044125

ONE:	115101395 115101396 115112530 115134204(cbr1)

OKI:	109874436 109890688(cbr1) 109903150 116358250

OKE:	118366794 118370151(cbr1) 118385059 118385060

SALP:

111964260 111979044 112068582(cbr1)

SNH:	120021222 120021448 120033387(cbr1) 120058440

CCLU:

121536847 121541908 121541910 121554570(cbr1)

ELS:	105010857 109614572(cbr1)

SFM:	108924735 108938298

PKI:	111835840 111837929

AANG:

118222361(cbr1) 118234863(cbr1l)

LOC:

102683960

PSPA:

121320717 121328171

ARUT:

117406814(cbr1) 117418842(cbr1l)

PSEX:

120522976(cbr1) 120540359(cbr1l)

LCM:	102349061 102367136(CBR1)

CMK:	103186742 103186743

RTP:	109933230(cbr1)

CPLA:

122555345(cbr1)

HOC:	132821160(cbr1)

LERI:

129703025 129703026 129703027

PMRN:

116940210(CBR1)

LRJ:

133350722

BFO:	118406581 118415952 118423977 118423978 118423979 118423980 118423984 118432795

BBEL:

109476673 109478761

CIN:

100182286

SCLV:

120328719 120328720 120328721 120328722

SPU:	100889317 100892458 105447311 115926118 115926133 574551 574612 579824 592403

LPIC:

129273920 129273921 129274424 129274565 129274639 129274661 129275058 129275059 129275061 129275063 129275223 129281760

APLC:

110973484 110973485 110973486

SKO:	100366455 100366603 100366755 100367363 100367671 100372039

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105144039 105150971

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

DSM:	124413804 124413805 124414096 124414198

NPT:	124223802 124223803 124223806 124223807

NFB:	124186724 124186725 124186726

NLO:	107223515 107223521 107223522

NVG:	124309150 124309152 124309153

AROA:

105685315

TCA:

661972

DPA:	109534143 109543822

AGRG:

126734927

ATD:	109597522 109597585

CSET:

123307980 123308228

AGB:	108905046 108905085 108905086 111691295

LDC:	111514598 111516230

NVL:

108565934

APLN:

108738812 108739399 112905382

PPYR:

116159572 116168692 116176766

OTU:	111422276 111424546

BMOR:

101741781 101741955 101742796 101745818

BMAN:

114240454 114247724 114248343 114248943 114251689

MSEX:

115442558 115443816 115446743 115449633 115449637 115449710 115452803

DPL:	KGM_201906 KGM_201907 KGM_203730 KGM_205942 KGM_211104

BANY:

112048752 112048754 112048756 112049359 112049367 112049400 112049410 112049505 112050045 112056203 112056413

MJU:	123864861 123864868 123865090 123868784 123874389 123874639 123874640 123874641 123877210 123881068

NIQ:	126770057 126777101 126777991 126780926 126780949 126781085

VCD:	124530885 124530902 124531080 124531170 124533591 124534711 124540058 124540491 124540502 124540546

MCIX:

123653837 123665344 123666602 123666603 123666605 123666606 123666607 123666608 123666644 123668696 123668707 123669182

PMAC:

106710022 106711291 106711292 106711293 106712788 106712790 106718276 106718996 106719907 106719988

PPOT:

106099829 106102836 106104444 106105570 106109991 106109996 106110052 106110053 106111299

PXU:	106113085 106113086 106113087 106113089 106116177 106118128 106119339 106123086 106123179 106128545

PRAP:

110991285 110994263 110999668 111000886 111001160 111002340 123689188 123689621

PBX:	123708258 123708973 123711807 123715135

PNAP:

125049841 125051211 125056918 125057280

ZCE:	119831361 119836954 119837664 119839804 119839805 119839806 119839807 119840658

CCRC:

123703555 123705822 123705823 123705855

LSIN:

126965793 126968631 126968831 126968989 126970098 126970183 126979796

AAGE:

121725695 121725730 121729544 121731957 121732358 121734076 121736368

HAW:	110369634 110371928 110372428 110372664 110374859 110376990 110376991 110381163

HZE:	124631494 124641344 124642578 124643295 124646255 124646320 124646346

TNL:	113493465 113494468 113497934 113497936 113501185 113501186 113504446

SLIU:

111350869 111351692 111352484 111352733 111352744 111361909 111361916 111364424

OFU:	114352318 114354516 114357079 114362201 114362202 114362540 114362541 114362542 114364988

PXY:	105381161 105382647 105382918 105384073 105384527 105389704

PGW:	126367363 126369804 126370602 126376671 126377902

CCRN:

123292278 123292391 123302379

API:	100573774 103310702

DNX:

AGS:

RMD:

ACOO:

DCI:

CLEC:

HHAL:

HVI:	124356882 124356884 124358221

MQU:	128983966 128985425 128986867

FOC:

ZNE:

SGRE:

BROR:

IEL:	124160248 124160249 124160250 124160371

FCD:	110844332 110844333 110855694

DPX:	DAPPUDRAFT_301515 DAPPUDRAFT_303686

DMK:	116916523 116916949

DPZ:

124314469

PVM:	113803519 113803522

PJA:

PCHN:

PMOO:

HAME:

MNZ:	135208598 135208600 135208601

HAZT:

108670470

EAF:	111699123 111713161

TCF:

131890626

ISC:

8043197

DSV:	119442254 119442255 119442256

RSAN:

119377677 119387053

RMP:	119159646 119159647 119166953

VDE:	111250985 111251180 111252026

VJA:	111259823 111259829 111272049

TUT:

107369493

CSCU:

111618019 111618020 111618039 111618040

PTEP:

107443485 107443486 107443500 107449446

ABRU:

129981925

UDV:	129222591 129222592

SDM:

118186353

LPOL:

106473861

PMEO:

129583559 129599447 129599448

HRO:	HELRODRAFT_70715

LGI:	LOTGIDRAFT_191692

PVUL:

126829790

PCAN:

112560870 112560871

BGT:	106057936 106063805 106063807 106069432

GAE:	121375962 121376118

HRF:	124114997 124132940 124146840 124147500 124147533 124147534 124147536

HRJ:	124261748 124263526 124268778 124274024 124276034 124276035 124276069 124276070

CRG:	105325714 105340670 105348587 117685070

CVN:	111133008 111133134 111133483 111133534 111136236 111136237

CANU:

128187740 128187742 128187743 128187744 128189888

MYI:	110449544 110449545 110449546 110458931 110466215 110466238 110466244 110466251

PMAX:

117329379 117329504 117329572 117329573 117329574 117329575 117336322

MCAF:

127704674 127714250 127726702

DPOL:

127842014 127842015 127843653 127844376 127849219

OBI:

106869220

OSN:	115215080 115215214

SMM:	Smp_033530.1 Smp_033540 Smp_140270

SHX:	MS3_00009793(CBR3_1) MS3_00009794(CBR3_3)

OVI:	T265_10122 T265_13980

EGL:	EGR_04035 EGR_04036 EGR_04038 EGR_04039

NVE:	5509101 5521730

EPA:	110245171 110252725 110254732

ATEN:

116296802 116298141

ADF:	107331745 107355632 107355635

AMIL:

114955216 114965043

PDAM:

113670231 113670238 113670240

SPIS:

111327394 111327400 111327401

DGT:	114523105 114527152

HMG:	100200320 100209766 100215805

HSY:	130655920 130655922

AQU:

100637791

ATH:	AT3G59710 AT5G51030 AT5G61830

ALY:	9301912 9302530 9312590

CRB:	17875908 17876819 17885946

CSAT:

104699947 104725607 104739243 104749372 104752647 104761093 104762305 104788224

EUS:	EUTSA_v10004629mg EUTSA_v10006128mg EUTSA_v10014119mg

BRP:	103831402 103841820 103857252 103873463

BNA:	106347765 106356807 106365086 106386538 106386868 106405534 106421946 125592019

BOE:	106299694 106311381 106333536 106335608

RSZ:	108816710 108847990 108860585 108863207 130495273

THJ:	104801760 104804113 104825040

CPAP:

110820325 110821336

CIT:	102618831 102626275

CIC:	CICLE_v10021349mg CICLE_v10032162mg

PVY:	116120867 116135715

MINC:

123216649 123221223 123223115

TCC:	18602340 18605222

GRA:	105778476 105789862 105802135

GHI:	107888022 107896776 107912060 107914599 107950819 121223636

GAB:	108458604 108477329 108488644

HSYR:

120132768 120137902 120139469 120169438 120189910 120210623 120219235

DZI:	111290989 111307228 111318032

EGR:	104416142 104427637

GMX:	100790340 100793649 100795540 100801160 100811138 100813783 100814467

GSJ:	114389247 114410892 114411566 114414083 114421948 114425636

PVU:	PHAVU_002G280700g PHAVU_003G033300g PHAVU_003G060100g

VRA:	106765992 106768075 106777158

VAR:	108323779 108335170 108337975

VUN:	114169512 114178882 114179349

VUM:	124827144 124841266 124841634

CCAJ:

109791749 109791751 109805547 109813662 109813686 109815595

APRC:

113853206 113856532 113868681

MTR:	11411593 11421284 11444609

TPRA:

123897153 123916046 123917958 123922229 123924265

CAM:	101490621 101500438 101502987 101507622

PSAT:

127085995 127096759 127105787 127107098

VVO:	131595958 131600317 131607995 131623575 131661028

LJA:	Lj1g3v4457750.1(Lj1g3v4457750.1) Lj2g3v0126340.1(Lj2g3v0126340.1) Lj4g3v0510200.1(Lj4g3v0510200.1)

ADU:	107458870 107463386 107480845

AIP:	107612497 107613511 107634669

AHF:	112703021 112708036 112733602 112771091 112771254 112791563

LANG:

109326482 109337255 109340831 109340991 109349784 109361997 109362223

PCIN:

129298028 129300169 129307859 129314876 129320457

QSA:	O6P43_023489 O6P43_028061 O6P43_030305

FVE:	101295293 101306684 105351700

RCN:	112180155 112199948

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103418483 103420529 103438784 103454871

MSYL:

126598809 126610100 126626586 126629915

PXB:	103931301 103933612 103933613 103962644

ZJU:	107406898 107423505

MNT:	21394861 21403286

CSAV:

115708043 115708227

CSV:	101205654 101215260

CMO:	103488873 103502267

BHJ:	120071740 120080825 120081143

MCHA:

111007240 111019666

CMAX:

111466403 111485563 111493032 111496416

CMOS:

111430094 111438126 111449752 111458888

CPEP:

111780719 111792674 111801381 111802198

RCU:	8275476 8286374

JCU:	105636688 105648706

HBR:	110633828 110658924 110658943 110659712

MESC:

110615156 110616640

POP:	18104597 7457587 7484898

PEU:	105134607 105136586 105138578

PALZ:

118028385 118044871 118050358

JRE:	109000478 109005804 109021483

CILL:

122281606 122294841 122302943

CAVE:

132167637 132176394

QSU:	111997451 112034324

QLO:	115963014 115965961

TWL:	119980214 119982707 119985928 120004762

VVI:	100254495 100264726

VRI:	117914178 117934405

SLY:	101244166 101244566 101250605 101263291

SPEN:

107006389 107013752 107014799 107023668

SOT:	102584474 102587809 102604350

SSTN:

125859828 125859839 125862321 125872317

SDUL:

129870972 129896233 129899186

CANN:

107865865 107866302 107875989

LBB:	132599331 132602341 132634319 132638465

NTA:	107769189 107772180 107780469 107781563 107793914 107810410 107820627 107821771

NSY:	104217663 104220950 104221924 104234288

NTO:	104092916 104099524 104101805 104106235

NAU:	109210588 109228161 109239914 109241815

INI:	109156765 109163117 109165567 109189929

ITR:	115996318 116011125 116026308 116033648

SIND:

105158283 105165498 105172075

OEU:	111372333 111391789 111393011 111394068 111400575

EGT:	105954544 105972437 105975882

SSPL:

121740804 121746225 121774579 121774683 121776992 121779618 121781911 121788314 121805066

SMIL:

130987997 130999746 131008546

SHIS:

125187635 125195832 125202864 125203292 125221168

APAN:

127243221 127252951 127254701 127263014

HAN:	110883647 110911119 110917661 110939842

ECAD:

122583469 122589959 122607700

LSV:	111885945 111892276 111896716

CCAV:

112510112 112511454 112514227 112519910

DCR:	108195668 108220398 108220469

CSIN:

114265933 114275413 114280100 114313253

RVL:	131300674 131312027 131335268

AEW:	130767046 130776963 130796333

BVG:	104889015 104898560 104908343

SOE:	110774690 110785380 110797137

CQI:	110698550 110704321 110709284 110717863 110738715

ATRI:

130798323 130799439 130813162

MOF:	131150502 131159435

NNU:	104586992 104598224 104602854

MING:

122069555 122076042

TSS:	122656449 122656502

PSOM:

113271415 113281310 113284641 113317971

OSA:	4326939 4329932 4336277

DOSA:

Os01t0929500-01(Os01g0929500) Os02t0607700-01(Os02g0607700) Os04t0496000-01(Os04g0496000) Os04t0496150-00(Os04g0496150)

OBR:	102715443 102718517 102720045

OGL:	127761021 127761803 127772109

BDI:	100836851 100843489 100844524

ATS:	109744526 109758873 109764067

TDC:	119270208 119278271 119317062 119326241 119355611 119364776

TAES:

123045903 123053766 123063216 123066263 123080397 123127662 123137421 123144771 123189658

TUA:	125513298 125538932 125538933 125543501

LPER:

127307172 127335394 127345497

LRD:	124666207 124667751 124675222 124678529 124687735

SBI:	8056507 8059399 8075877

ZMA:	100194367 100383092 100383687 103653744

SITA:

101764764 101766964 101768330

SVS:	117845036 117854898 117865293

PVIR:

120642504 120653612 120655284 120675989 120683293 120709157

PHAI:

112872816 112891648 112900010

PDA:	103716007 103721881

EGU:	105035155 105051634

MUS:	103981762 103995983

ZOF:	122000256 122003844 122032634 122034977

DCT:	110095551 110104782

PEQ:	110028663 110035110 110037942

AOF:	109824737 109826236 109830212

MSIN:

131240195 131246588

NCOL:

116250494 116262611 116267895

ATR:	18434512 18448661

SMO:

SELMODRAFT_107407 SELMODRAFT_110901 SELMODRAFT_111807 SELMODRAFT_112611 SELMODRAFT_112669 SELMODRAFT_117556 SELMODRAFT_126117 SELMODRAFT_138880 SELMODRAFT_143767 SELMODRAFT_173170 SELMODRAFT_270248 SELMODRAFT_271526 SELMODRAFT_271617 SELMODRAFT_404603 SELMODRAFT_419963 SELMODRAFT_443296 SELMODRAFT_78232 SELMODRAFT_78745 SELMODRAFT_83967

PPP:	112277466 112281434 112289080 112294581

CRE:	CHLRE_17g731350v5

VCN:	VOLCADRAFT_121544

MNG:	MNEG_0762 MNEG_10981 MNEG_6744 MNEG_6963 MNEG_6964

CSL:	COCSUDRAFT_55771

CME:	CYME_CMR042C

GSL:	Gasu_14740 Gasu_24590

CCP:	CHC_T00006708001

TTT:	THITE_2124387

MTM:	MYCTH_2308099

VAL:	VDBG_02730

VDA:	VDAG_03647

CFJ:	CFIO01_05935

CLUP:

CLUP02_04541

CHIG:

CH63R_03357

SAPO:

SAPIO_CDS1598

GLZ:	GLAREA_06959

PCS:	N7525_005416

PNO:	SNOG_02806

PTE:	PTT_09714 PTT_15556

BZE:	COCCADRAFT_31994 COCCADRAFT_38538

BSC:	COCSADRAFT_105489 COCSADRAFT_347261

BOR:	COCMIDRAFT_39676 COCMIDRAFT_81758

AALT:

CC77DRAFT_1013598

ARAB:

EKO05_0004753 EKO05_0006539

ZTR:	MYCGRDRAFT_36990

PFJ:	MYCFIDRAFT_100760 MYCFIDRAFT_41956

FFU:	CLAFUR5_06602 CLAFUR5_10101

CBET:

CB0940_06460 CB0940_08402

BCOM:

BAUCODRAFT_37592 BAUCODRAFT_393649

TML:	GSTUM_00010330001

SHS:	STEHIDRAFT_98222

ADL:	AURDEDRAFT_115777 AURDEDRAFT_115778 AURDEDRAFT_170147

GTR:	GLOTRDRAFT_136682

MRR:	Moror_6831

SCM:	SCHCO_02190164(SCHCODRAFT_02190164)

UMA:	UMAG_01815

PFP:	PFL1_02949

SGRA:

EX895_003895

SRE:	PTSG_00844 PTSG_09068 PTSG_09069

ACAN:

ACA1_172860 ACA1_172870 ACA1_362920

TGO:	TGME49_290890

TET:	TTHERM_00187260 TTHERM_00557790

PTM:	GSPATT00013734001 GSPATT00033729001

SMIN:

v1.2.012697.t1(symbB.v1.2.012697.t1) v1.2.027692.t1(symbB.v1.2.027692.t1) v1.2.038435.t1(symbB.v1.2.038435.t1)

FCY:	FRACYDRAFT_248070 FRACYDRAFT_261152

AAF:	AURANDRAFT_20875 AURANDRAFT_58590

EHX:	EMIHUDRAFT_100056 EMIHUDRAFT_106817 EMIHUDRAFT_114810 EMIHUDRAFT_198354 EMIHUDRAFT_199868 EMIHUDRAFT_231395 EMIHUDRAFT_239732 EMIHUDRAFT_240561 EMIHUDRAFT_250847

GTT:	GUITHDRAFT_117185

NGR:	NAEGRDRAFT_46325

HALC:

EY643_09830

AGE:	AA314_02253

AVM:	JQX13_23670

CFUS:

CYFUS_001424

SCU:	SCE1572_17400 SCE1572_20305

CCRO:

CMC5_043940

MRM:	A7982_03611

SAMY:

DB32_006871

LLU:	AKJ09_08245

HOH:	Hoch_4302 Hoch_6753

PCAY:

FRD00_05770

MMAG:

MMAD_15640

NSR:	NS506_05239(cbr1)

NOZ:	DMB37_24865

SVL:	Strvi_3397

SHY:

SHJG_1150

SHO:	SHJGH_0985

SSOI:

I1A49_44545

SBH:

SBI_00264

SCI:	B446_03320

SCX:	AS200_41755

SALU:

DC74_1011

SALL:

SAZ_05530

SNZ:	DC008_34805

SAQU:

EJC51_42710

SCHA:

CP983_41380

SCYG:

S1361_36620(fabG15)

SINE:

KI385_43255

SNIG:

HEK616_76420

SSPN:

LXH13_01475

SOV:	QZH56_32140

KQI:	F1D05_27355

NOA:	BKM31_30545

SSYI:

EKG83_20765

KAL:

KALB_4608

KPHY:

AOZ06_14020

LED:	BBK82_26850

KBS:	EPA93_36485

» show all

Reference

PMID:11279087

Authors

Ghosh D, Sawicki M, Pletnev V, Erman M, Ohno S, Nakajin S, Duax WL

Title

Porcine carbonyl reductase. structural basis for a functional monomer in short chain dehydrogenases/reductases.

Journal

J Biol Chem 276:18457-63 (2001)
DOI:10.1074/jbc.M100538200

Sequence

[ssc:397143]

All links

Ontology (5)   
   KEGG BRITE (2)   
   GO (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Chemical reaction (11)   
   KEGG ENZYME (3)   
   KEGG REACTION (4)   
   KEGG RCLASS (4)   
Gene (8111)   
   KEGG GENES (1896)   
   KEGG MGENES (337)   
   RefGene (5862)   
   OC (16)   
Literature (1)   
   PubMed (1)   
All databases (8140)   

Download RDF

ORTHOLOGY: K00084

Entry

K00084                      KO

Symbol

CBR3

Name

carbonyl reductase 3 [EC:1.1.1.184]

Pathway

map00590

Arachidonic acid metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map01100

Metabolic pathways

Reaction

R02581

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase

R09420

carbonyl reductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00084  CBR3; carbonyl reductase 3
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00084  CBR3; carbonyl reductase 3
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.184  carbonyl reductase (NADPH)
     K00084  CBR3; carbonyl reductase 3

Other DBs

GO:

0004090

Genes

HSA:

874(CBR3)

PTR:	458533(CBR3)

PPS:	100982905(CBR3)

GGO:	101128728(CBR3)

PON:	100452311(CBR3)

NLE:	100595496(CBR3)

HMH:	116482155(CBR3)

MCC:	695769(CBR3)

MCF:	102140082(CBR3)

MTHB:

126951562

MNI:	105472663(CBR3)

CSAB:

103218549(CBR3)

CATY:

105575414(CBR3)

PANU:

101015075(CBR3)

TGE:	112620706(CBR3)

RRO:	104679833(CBR3)

RBB:	108536877(CBR3)

TFN:	117095747(CBR3)

PTEH:

111525662(CBR3)

CANG:

105517520(CBR3)

CJC:	100386510(CBR3)

SBQ:

101047149

CIMI:

108302555

CSYR:

103261430(CBR3)

MMUR:

105881309

LCAT:

123630725

PCOQ:

105806880(CBR3)

OGA:	100957378(CBR3)

MMU:	109857(Cbr3)

MCAL:

110311856(Cbr3)

MPAH:

110329889(Cbr3)

RNO:	304078(Cbr3)

MCOC:

116086163(Cbr3)

ANU:

117717532

MUN:	110553069(Cbr3)

CGE:	100689021(Cbr3)

MAUA:

106021442(Cbr3)

PROB:

127227540(Cbr3)

PLEU:

114700380(Cbr3)

MORG:

121461827(Cbr3)

MFOT:

126513593

AAMP:

119825259

NGI:	103736427(Cbr3)

HGL:	101697950(Cbr3)

CPOC:

100727088(Cbr3)

CCAN:

DSP:

PLOP:

NCAR:

MMMA:

107136462(Cbr3)

OCU:

100345975

OPI:

101524267

TUP:	102493906(CBR3)

GVR:	103592860(CBR3)

CFA:	487748(CBR3)

CLUD:

112661748(CBR3)

VVP:

112910261

VLG:	121479241(CBR3)

NPO:	129502224(CBR3) 129519284

AML:

100482919

UMR:	103673146(CBR3)

UAH:

113260550

UAR:	123802641 123802686(CBR3)

ELK:

111155781

LLV:

125094716

MPUF:

101679204(CBR3)

MNP:

132012381

MLK:	131825353(CBR3)

NVS:	122908305(CBR3)

ORO:

101366810

EJU:	114219180(CBR3)

ZCA:

113918757

MLX:

118018858

NSU:	110570001(CBR3)

LWW:

102744150

FCA:	101082844(CBR3)

PYU:	121035959(CBR3)

PCOO:

112849526

PBG:	122491187(CBR3)

PVIV:

125175693(CBR3)

LRUF:

124526435

PTG:	102952382(CBR3)

PPAD:

109249766(CBR3)

PUC:

125920755

AJU:

106966981

HHV:	120229466(CBR3)

BTA:	516036(CBR3)

BOM:	102279872(CBR3)

BIU:	109561468(CBR3)

BBUB:

102389405(CBR3)

CHX:	102173507(CBR3)

OAS:

101115420

BTAX:

128047310

ODA:	120880839(CBR3)

CCAD:

122445462(CBR3)

MBEZ:

129549060

SSC:	100512990(CBR3)

CFR:	102521504(CBR3)

CBAI:

105070206(CBR3)

CDK:	105089845(CBR3)

VPC:

102540637

BACU:

103007686(CBR3)

BMUS:

118893932(CBR3)

LVE:	103084396(CBR3)

OOR:

101289932

DLE:

111163865

PCAD:

102979388(CBR3)

PSIU:

116753472

NASI:

112408619(CBR3)

ECB:

100061454

EPZ:	103550453(CBR3)

EAI:	106831421(CBR3)

MYB:	102261932(CBR3)

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

PDIC:

PHAS:

123828002(CBR3)

MMF:	118617378(CBR3)

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:	108396120(CBR3)

TOD:

119257207

SARA:

101540577(CBR3)

SETR:

126026148

LAV:

100665544

TMU:

101340783

ETF:	101661235(CBR3)

DNM:	101411585 101421659

LPIC:

APLC:

AJC:

NFB:

NLO:

NVG:

AROA:

AGB:	108905036 108905083

PPYR:

116168684

BANY:

112044047 112048753 112049432 112054070 112056207

MJU:	123874390 123877342

VCD:

124540568

PPOT:

106111411

PXU:

106113088

PRAP:

111000882 111000893 111000902 111001155 111001245 123689620

PBX:	123710747 123715695 123715707 123715756

PNAP:

125057237 125057307

SLIU:

111364465 111364486

PGW:

126377899

DCI:	103522169 103523270

HHAL:

106681026 106681027 106681030

HVI:	124356684 124356998

MQU:	128987498 128987669

FOC:

113208264

TPAL:

117648155 117648167

CSEC:

111870330

DPX:	DAPPUDRAFT_231053 DAPPUDRAFT_307155

DMK:	116920318 116936702

DPZ:	124337115 124337647 124338670

PVM:

113827259

PJA:	122266917 122266918 122266920

PCHN:

125043832

HAME:

121872744

PCLA:

123751508 123759292

CQD:	128700402 128703189

PTRU:

123516517

ESN:

126990983

HAZT:

108670465 108670466 108670469

LPOL:

PMEO:

PVUL:

BGT:

HRF:

HRJ:

MCAF:

127711028 127711454 127713926 127719612

MMER:

123557511 123558499

RPHI:

132729218

DPOL:

127843652 127844277

OSN:	115214796 115214799 115215154

PNO:	SNOG_07636

PTM:	GSPATT00022346001

HJA:	BST95_12620

MBD:	MEBOL_004511

AMYY:

YIM_30355(fabG28)

» show all

Reference

PMID:15537833

Authors

Lakhman SS, Ghosh D, Blanco JG

Title

Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3).

Journal

Drug Metab Dispos 33:254-7 (2005)
DOI:10.1124/dmd.104.002006

Sequence

[hsa:874]

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (275)   
   KEGG GENES (236)   
   KEGG MGENES (4)   
   RefGene (30)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (290)   

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ORTHOLOGY: K00081

Entry

K00081                      KO

Symbol

CBR2

Name

carbonyl reductase 2 [EC:1.1.1.184]

Pathway

map00590

Arachidonic acid metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map01100

Metabolic pathways

Reaction

R02581

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase

R09420

carbonyl reductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00081  CBR2; carbonyl reductase 2
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00081  CBR2; carbonyl reductase 2
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.184  carbonyl reductase (NADPH)
     K00081  CBR2; carbonyl reductase 2

Other DBs

GO:

0004090

Genes

MMUR:

105878069

LCAT:

123650726

PCOQ:

105820017

MMU:	12409(Cbr2)

MCAL:

110304399 110306007

MPAH:

110331898 110332341

RNO:	688320(Cbr2) 688321(Cbr2l1)

ANU:	117710926 117711341

MUN:

110548851

CGE:	100770118 100770405

MAUA:

110340860 121141594 121141595

PROB:

127220477 127221584

PLEU:

114680634 114703961

MORG:

121444134 121444140 121444651 121444652

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

MMMA:

OCU:

OPI:

TUP:	102480695 102493905

GVR:

CFA:

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:

PYU:	121026451 121026491

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	782391(DCXR)

BOM:	102279110(DCXR)

BIU:

BBUB:

CHX:

OAS:

BTAX:

CCAD:

MBEZ:

SSC:	396780(CBR2)

CFR:

116656688

CBAI:

105065772

CDK:

105102236

VPC:	107033084(DCXR)

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

MNA:	107539037 107539038

DRO:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

MJV:

TOD:	119231670 119231671

SARA:

SETR:

MDO:

GAS:

SHR:

AFZ:

PCW:

FCD:

Reference

PMID:7705352

Authors

Nakanishi M, Deyashiki Y, Ohshima K, Hara A

Title

Cloning, expression and tissue distribution of mouse tetrameric carbonyl reductase. Identity with an adipocyte 27-kDa protein.

Journal

Eur J Biochem 228:381-7 (1995)
DOI:10.1111/j.1432-1033.1995.0381n.x

Sequence

[mmu:12409]

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (123)   
   KEGG GENES (119)   
   RefGene (1)   
   OC (3)   
Literature (1)   
   PubMed (1)   
All databases (138)   

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