KEGG   ORTHOLOGY: K00512Help
Entry
K00512                      KO                                     

Name
CYP17A
Definition
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Pathway
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
ko04913  Ovarian steroidogenesis
ko04917  Prolactin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04934  Cushing's syndrome
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Disease
H00216  Congenital adrenal hyperplasia (CAH)
H00608  46,XY disorders of sex development (Disorders in androgen synthesis or action)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04927 Cortisol synthesis and secretion
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 Human Diseases
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
BRITE hierarchy
Other DBs
RN: R02211 R03783 R04852 R04853 R08517 R08518
GO: 0004508 0047442
Genes
HSA: 1586(CYP17A1)
PTR: 450141(CYP17A1)
PPS: 100989182
GGO: 101152080
PON: 100439753
NLE: 100596228
MCC: 678693(CYP17A1)
MCF: 102133235(CYP17)
CSAB: 103216445(CYP17A1)
RRO: 104656530
RBB: 108515083
CJC: 100400572(CYP17A1)
SBQ: 101048584
MMU: 13074(Cyp17a1)
RNO: 25146(Cyp17a1)
CGE: 100758683
NGI: 103744072
HGL: 101726496
CCAN: 109691327
OCU: 100346394
TUP: 102472543
CFA: 477807(CYP17A1)
AML: 100476785
UMR: 103681600
ORO: 101384623
FCA: 493967(CYP17A1)
PTG: 102966057
AJU: 106966901
BTA: 281739(CYP17A1)
PHD: 102338504
CHX: 102182376 102182663(CYP17)
OAS: 105601846(CYP17) 493968(CYP17A1)
SSC: 403330(CYP17A1)
CFR: 102519078
CDK: 105095024
BACU: 103007900
LVE: 103081477
OOR: 101283719
ECB: 100034232(CYP17A1)
EPZ: 103558137
EAI: 106838161
MYB: 102259343
MYD: 102761363
HAI: 109379659
RSS: 109444000
PALE: 102884618
LAV: 100660963
TMU: 101354636
MDO: 100028896
SHR: 100915970
OAA: 100080906
GGA: 425056(CYP17A1)
MGP: 100540331
CJO: 107316091(P-450c17)
APLA: 101792920
ACYG: 106031836
TGU: 100218933
GFR: 102038147
FAB: 101821194
PHI: 102104333
PMAJ: 107206790
CCW: 104695563
FPG: 101910363
FCH: 102054501
CLV: 102093575
EGZ: 104125602
AAM: 106494668
ASN: 102372221
AMJ: 102567971(CYP17A1)
PSS: 102457785
CMY: 102945773
CPIC: 101933089
PVT: 110077624
PBI: 103063631
GJA: 107117909
XLA: 100036774(cyp17a1.L)
XTR: 100145650(cyp17a1) 101730309
DRE: 399692(cyp17a1)
IPU: 100313515(cyp17) 108275468
TRU: 100125766(cyp17a2) 100125798(cyp17a1)
LCO: 104935158(CYP17I) 104936651(CYP17II)
OLA: 100125816(cyp17) 101170547(cyp17a2)
OBI: 106867676
BRP: 103828977
LJA: Lj0g3v0006169.1(Lj0g3v0006169.1) Lj0g3v0355859.1(Lj0g3v0355859.1) Lj0g3v0356929.1(Lj0g3v0356929.1) Lj1g3v4303210.1(Lj1g3v4303210.1) Lj6g3v0777300.1(Lj6g3v0777300.1)
PPER: 18777519
CSV: 101212735
CMO: 103502578
RCU: 8260907
SLY: 101258162
SIND: 110011731
DOSA: Os04t0101400-01(Os04g0101400) Os05t0515200-01(Os05g0515200) Os12t0640200-00(Os12g0640200)
OBR: 102709016
ATS: 109733276(LOC109733276) 109733316(LOC109733316) 109734069(LOC109734069) 109735932(LOC109735932) 109737135(LOC109737135) 109737518(LOC109737518) 109738679(LOC109738679) 109739108(LOC109739108) 109741114(LOC109741114) 109742910(LOC109742910) 109743416(LOC109743416) 109743483(LOC109743483) 109748889(LOC109748889) 109751710(LOC109751710) 109752396(LOC109752396) 109752659(LOC109752659) 109753377(LOC109753377) 109755199(LOC109755199) 109755497(LOC109755497) 109759571(LOC109759571) 109763501(LOC109763501) 109767764(LOC109767764) 109769810(LOC109769810) 109771415(LOC109771415) 109772273(LOC109772273) 109772787(LOC109772787) 109773520(LOC109773520) 109773763(LOC109773763) 109773846(LOC109773846) 109775751(LOC109775751) 109779909(LOC109779909) 109779910(LOC109779910) 109780102(LOC109780102) 109780749(LOC109780749) 109781183(LOC109781183) 109783333(LOC109783333) 109784455(LOC109784455) 109785743(LOC109785743) 109787486(LOC109787486)
MUS: 103971358
AG: AAF65823(CYP17A1) AAG02227(CYP17A1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3025870
  Authors
Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL
  Title
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
  Journal
Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407
  Sequence
[hsa:1586]
Reference
PMID:6966286
  Authors
Yoshida KI, Oshima H, Troen P
  Title
Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17 alpha-hydroxylation.
  Journal
J Clin Endocrinol Metab 50:895-9 (1980)
DOI:10.1210/jcem-50-5-895

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