Entry |
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Symbol |
DPH5
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Name |
diphthine methyl ester synthase [EC: 2.1.1.314]
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Reaction |
R11165 | S-adenosyl-L-methionine:2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] methyltransferase (diphthine methyl ester-[translation elongation factor 2]-forming) |
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Disease |
H02460 | Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03012 Translation factors
K00586 DPH5; diphthine methyl ester synthase
Enzymes [BR:ko01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.314 diphthine methyl ester synthase
K00586 DPH5; diphthine methyl ester synthase
Translation factors [BR:ko03012]
Eukaryotic type
Elongation factors
Elongation associated factors
K00586 DPH5; diphthine methyl ester synthase
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Other DBs |
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Genes |
» show all
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Reference |
|
Authors |
Mattheakis LC, Shen WH, Collier RJ |
Title |
DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae. |
Journal |
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Sequence |
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Reference |
|
Authors |
Zhu X, Kim J, Su X, Lin H |
Title |
Reconstitution of diphthine synthase activity in vitro. |
Journal |
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Reference |
|
Authors |
Lin Z, Su X, Chen W, Ci B, Zhang S, Lin H |
Title |
Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. |
Journal |
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Sequence |
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