KEGG   ORTHOLOGY: K00844
Entry
K00844                      KO                                     

Symbol
HK
Name
hexokinase [EC:2.7.1.1]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00051  Fructose and mannose metabolism
map00052  Galactose metabolism
map00500  Starch and sucrose metabolism
map00520  Amino sugar and nucleotide sugar metabolism
map00521  Streptomycin biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01250  Biosynthesis of nucleotide sugars
map04066  HIF-1 signaling pathway
map04910  Insulin signaling pathway
map04930  Type II diabetes mellitus
map04973  Carbohydrate digestion and absorption
map05131  Shigellosis
map05230  Central carbon metabolism in cancer
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
M00892  UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc
Disease
H00527  Retinitis pigmentosa
H00664  Anemia due to disorders of glycolytic enzymes
H02470  Neurodevelopmental disorder with structural brain abnormalities
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00844  HK; hexokinase
   00051 Fructose and mannose metabolism
    K00844  HK; hexokinase
   00052 Galactose metabolism
    K00844  HK; hexokinase
   00500 Starch and sucrose metabolism
    K00844  HK; hexokinase
   00520 Amino sugar and nucleotide sugar metabolism
    K00844  HK; hexokinase
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K00844  HK; hexokinase
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K00844  HK; hexokinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K00844  HK; hexokinase
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K00844  HK; hexokinase
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K00844  HK; hexokinase
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K00844  HK; hexokinase
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K00844  HK; hexokinase
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K00844  HK; hexokinase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00844  HK; hexokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     K00844  HK; hexokinase
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    K00844  HK; hexokinase
Other DBs
RN: R00299 R00760 R00867 R01326 R01600 R01786 R01961 R03920
GO: 0004396
Genes
HSA: 3098(HK1) 3099(HK2) 3101(HK3) 80201(HKDC1)
PTR: 450504(HKDC1) 450505(HK1) 462298(HK3) 741291(HK2)
PPS: 100969639(HKDC1) 100969975(HK1) 100983149(HK2) 100990081(HK3)
GGO: 101125395(HK2) 101127052(HKDC1) 101131029(HK1) 101146050(HK3)
PON: 100172246(HK1) 100433183(HKDC1) 100458288(HK3) 100460834(HK2)
NLE: 100591401(HK3) 100593006(HK2) 100595352(HKDC1) 100595917(HK1)
MCC: 698120(HK3) 710479(HK2) 711922(HK1) 711995(HKDC1)
MCF: 102121518(HK2) 102145864(HK1) 102147228(HKDC1) 107126374(HK3)
CSAB: 103216074(HK1) 103216076(HKDC1) 103220012(HK2) 103245036(HK3)
CATY: 105581709(HK3) 105596876(HK2) 105597256(HKDC1) 105597257(HK1)
PANU: 101022816(HK3) 101024623(HK2) 101025527(HK1) 101026703(HKDC1)
RRO: 104661961(HKDC1) 104661963(HK1) 104674833(HK2) 104680441(HK3)
RBB: 108530364(HK1) 108530366(HKDC1) 108531690(HK2) 108544799(HK3)
TFN: 117062074(HK2) 117065352(HK3) 117082732(HKDC1) 117082733(HK1) 117099756
CJC: 100385141(HKDC1) 100396473(HK2) 100413117(HK1) 100415061(HK3)
SBQ: 101029285(HK3) 101047051(HK1) 101047634(HK2) 101049162(HKDC1)
MMUR: 105870209(HK1) 105870210(HKDC1) 105883841(HK3) 105884567(HK2)
MMU: 15275(Hk1) 15277(Hk2) 212032(Hk3) 216019(Hkdc1)
MCAL: 110296267(Hk2) 110302692(Hk1) 110303354(Hkdc1) 110307543(Hk3)
MPAH: 110314383(Hk2) 110326557(Hkdc1) 110326866(Hk1) 110334200(Hk3)
RNO: 100364027(Hkdc1) 25058(Hk1) 25059(Hk2) 25060(Hk3)
MCOC: 116074509(Hkdc1) 116075501(Hk1) 116081619(Hk3) 116099117(Hk2)
MUN: 110549757(Hk3) 110561607(Hk2) 110563779(Hk1) 110563780(Hkdc1)
CGE: 100765413(Hk1) 100765703(Hkdc1) 100765901(Hk3) 100772205(Hk2)
PLEU: 114689452(Hk3) 114694430(Hk2) 114704759(Hk1) 114704760(Hkdc1)
NGI: 103726981(Hk2) 103729731(Hk1) 103729733(Hkdc1) 103745389(Hk3)
HGL: 101706410(Hk3) 101708521(Hkdc1) 101709130(Hk1) 101722401(Hk2)
CCAN: 109684938(Hkdc1) 109685239(Hk1) 109685772(Hk3) 109697922(Hk2)
OCU: 100338214(HK2) 100340945(HK1) 100340994(HK3) 100345105(HKDC1)
TUP: 102479777(HK3) 102493365(HK1) 102494607(HKDC1) 102499175(HK2)
CFA: 100856448(HK2) 479234(HK1) 489019(HKDC1) 489096(HK3)
VVP: 112916701(HK2) 112923912(HKDC1) 112923920(HK1) 112925741(HK3)
VLG: 121486269(HKDC1) 121486645(HK3) 121486953(HK1) 121491114(HK2)
AML: 100470774(HK2) 100475939(HKDC1) 100483014(HK3) 100483319(HK1)
UMR: 103664456(HK3) 103667783(HKDC1) 103668004(HK1) 103671429(HK2)
UAH: 113243430(HK2) 113259127(HKDC1) 113259128(HK1) 113264133(HK3)
ORO: 101373969(HK1) 101374267(HKDC1) 101383196(HK3) 101384043(HK2)
MPUF: 101671479(HK1) 101671950(HK3) 101672779(HKDC1) 101685139(HK2)
EJU: 114208634(HK3) 114214114(HK1) 114214160(HKDC1) 114218963(HK2)
FCA: 101080358(HK3) 101089344(HK2) 101094295(HKDC1) 101098403(HK1)
PYU: 121011516(HK3) 121019208(HK2) 121036725(HK1) 121036727(HKDC1)
PTG: 102952730(HK3) 102955671(HK1) 102956632(HKDC1) 102962533(HK2)
PPAD: 109263394(HK2) 109264349(HK1) 109264350(HKDC1) 109267563(HK3)
AJU: 106967150(HKDC1) 106967151(HK1) 106972962(HK2) 106975401(HK3)
HHV: 120232483(HK1) 120232497(HKDC1) 120236784(HK3) 120237003(HK2)
BTA: 280817(HK1) 614824(HKDC1) 788926(HK2)
BOM: 102268099(HKDC1) 102270322(HK1) 102274810(HK2) 102275095(HK3)
BBUB: 102406489(HK1) 102407034(HKDC1) 102408948(HK3) 102414046(HK2)
CHX: 102168356(HK2) 102182403(HK3) 102189736(HKDC1) 102190759(HK1)
OAS: 100036759(HK1) 101107690(HK2) 101107841(HKDC1) 101119209(HK3)
ODA: 120851230(HK2) 120863872(HK3) 120865186(HK1) 120865189(HKDC1)
CCAD: 122440049(HK3) 122441464(HK2) 122446471(HK1) 122446730(HKDC1)
SSC: 100152344(HK1) 100153520(HKDC1) 100522855(HK3) 494561(HK2)
CFR: 102509660(HK1) 102509897(HKDC1) 102511221(HK3) 102518387(HK2)
CBAI: 105062047(HK3) 105066353(HK1) 105066355(HKDC1) 105067752(HK2)
CDK: 105085304(HK2) 105099579(HK3) 105099882(HK1) 105099884(HKDC1)
BACU: 103000123(HK1) 103000583(HKDC1) 103005558(HK2) 103011120(HK3)
LVE: 103077114(HK3) 103078924(HK2) 103085238(HK1) 103085507(HKDC1)
OOR: 101271458(HK1) 101271708(HKDC1) 101278255(HK2) 101281461(HK3)
DLE: 111169081(HK2) 111169843(HK3) 111183455(HKDC1) 111183456(HK1)
ECB: 100009677(HK2) 100068725(HK3) 100072686(HKDC1) 100072687(HK1)
EPZ: 103549373(HK1) 103549388(HKDC1) 103557323(HK3) 103557674(HK2)
EAI: 106821924(HK3) 106835132(HK2) 106845014(HKDC1) 106845016(HK1)
MYB: 102243213(HK1) 102246049(HK2) 102259488(HK3) 102263651(HKDC1)
MYD: 102760926(HK3) 102762722(HKDC1) 102763004(HK1) 102767710(HK2)
MMYO: 118658712(HK3) 118668817(HK2) 118670089(HK1) 118670090(HKDC1)
MNA: 107525054(HK3) 107526031(HK1) 107526078(HKDC1) 107529247(HK2)
HAI: 109371220(HK2) 109372136(HKDC1) 109372148(HK1) 109389785(HK3)
DRO: 112302963(HK2) 112305499(HK1) 112305506(HKDC1) 112320357(HK3)
SHON: 118975417(HK1) 118975418(HKDC1) 118999734(HK3) 119000113(HK2)
AJM: 119038115(HK1) 119038131(HKDC1) 119038386(HK2) 119062960(HK3)
MMF: 118630629(HK2) 118632470(HKDC1) 118632471(HK1) 118644012(HK3)
PALE: 102878115(HK3) 102892478(HK2) 102894665(HKDC1) 102898766(HK1)
PGIG: 120594630(HK2) 120609468(HKDC1) 120609469(HK1) 120616551(HK3)
RAY: 107502916(HK2) 107504088(HK1) 107504095(HKDC1) 107517523(HK3)
TOD: 119234296(HKDC1) 119234535(HK1) 119236182(HK3) 119259107(HK2)
LAV: 100660114(HK2) 100661681(HK3) 100669094(HK1) 100677445(HKDC1)
MDO: 100015984(HKDC1) 100031311(HK1) 100031793(HK3) 100032849(HK2)
SHR: 100919294(HK3) 100926799(HK1) 100930478 116421983(HKDC1)
PCW: 110200049(HK1) 110200090(HKDC1) 110207611(HK2) 110216727(HK3)
OAA: 100074718(HK2) 100079843(HK3) 100085443(HK1) 100088018(HKDC1)
GGA: 373889(HK1) 374044(HK2) 423698(HKDC1) 768421(HK3)
SCAN: 103817507(HK3) 103822724 103823724(HKDC1) 103823725(HK1)
GFR: 102031971(HK1) 102032137(HKDC1) 102042831(HK2) 102044178(HK3)
FAB: 101810322(HK2) 101813440(HK3) 101814475(HKDC1) 101814878(HK1)
PHI: 102099289(HKDC1) 102099472(HK1) 102100727(HK3) 102107271(HK2)
FPG: 101917382(HK3) 101918504(HK1) 101918678(HKDC1) 101919932(HK2)
FCH: 102055063(HK1) 102055236(HKDC1) 102055764(HK3) 102056548
EGZ: 104124621(HK1) 104124622(HKDC1) 104128868(HK3) 104130346(HK2)
NNI: 104013489(HKDC1) 104013490(HK1) 104017587(HK2) 104018992(HK3)
PADL: 103918476(HK1) 103918477(HKDC1) 103918816(HK3) 103919658(HK2)
CPOO: 109310239(HK3) 109312472(HKDC1) 109312473(HK1) 109317350(HK2)
GGN: 109289823(HK3) 109290990(HK1) 109290991(HKDC1) 109295498(HK2)
CMY: 102930728(HK3) 102933769(HKDC1) 102934001(HK1) 102942097(HK2)
CPIC: 101931154(HK1) 101931432(HKDC1) 101943345 101948904(HK3)
TST: 117872900(HK2) 117880821(HKDC1) 117880822(HK1)
ACS: 100560089(hk3) 100564618 100566564(hkdc1) 100566756(hk1)
XLA: 100036846(hk2.L) 108696205 108697444 108710242 108711534(hkdc1.L) 108712774(hkdc1.S) 108713229(hk2.S) 394323(hk1.L)
DRE: 321224(hkdc1) 406339(hk2) 406791(hk1)
IPU: 108255852 108263365(hk1) 108263366(hkdc1)
AMEX: 103028521(hk1) 103036666(hk3) 103047009
LCM: 102359026(HK3) 102363536(HK2) 102364429(HKDC1) 102364683(HK1)
BFO: 118414727
BBEL: 109463192
DME: Dmel_CG3001(Hex-A) Dmel_CG32849(Hex-t2) Dmel_CG33102(Hex-t1) Dmel_CG8094(Hex-C)
DSI: Dsimw501_GD21281(Dsim_Hex-t1) Dsimw501_GD21282(Dsim_Hex-t2) Dsimw501_GD24777(Dsim_GD24777) Dsimw501_GD25630(Dsim_GD25630)
DYA: Dyak_GE12255(Dyak_Hex-C) Dyak_GE17799(Dyak_Hex-A) Dyak_GE23668(Dyak_Hex-t1) Dyak_GE23669(Dyak_Hex-t2)
ACOZ: 120960075
AARA: 120905053
AAG: 5571932
CPII: 120423256
OBB: 114872100
NMEA: 116432316
NVI: 100121683
CSOL: 105368881
LDC: 111507602
NVL: 108565519
APLN: 108740588
PPYR: 116162765
PPOT: 106103043
CLEC: 106661784
CEL: CELE_F14B4.2(hxk-1)
CBR: CBG19465
BMY: BM_BM12811(Bma-hxk-1.1)
TSP: Tsp_08386
NVE: 5515074
EPA: 110238574
ATEN: 116303537
ADF: 107330418
AMIL: 114975924
DGT: 114516190
HMG: 100212254
AQU: 100639704
ATH: AT1G47840(HXK3) AT1G50460(HKL1) AT2G19860(HXK2) AT3G20040(ATHXK4) AT4G29130(HXK1) AT4G37840(HKL3)
LJA: Lj0g3v0022069.1(Lj0g3v0022069.1) Lj0g3v0022669.1(Lj0g3v0022669.1) Lj0g3v0323989.1(Lj0g3v0323989.1) Lj1g3v1302660.1(Lj1g3v1302660.1) Lj2g3v0852070.1(Lj2g3v0852070.1) Lj2g3v0852070.2(Lj2g3v0852070.2) Lj2g3v2089780.3(Lj2g3v2089780.3) Lj2g3v2537560.1(Lj2g3v2537560.1) Lj3g3v2318220.1(Lj3g3v2318220.1) Lj4g3v3043790.1(Lj4g3v3043790.1) Lj4g3v3043790.2(Lj4g3v3043790.2) Lj5g3v0186690.1(Lj5g3v0186690.1)
SLY: 101249034 101256649 543638(Hxk2) 543779(hxk1) 778210(HXK3) 778211(HXK4)
DOSA: Os01t0190400-01(Os01g0190400) Os01t0722700-01(Os01g0722700) Os01t0742500-01(Os01g0742500) Os01t0940100-01(Os01g0940100) Os05t0187100-01(Os05g0187100) Os05t0375100-00(Os05g0375100) Os05t0522500-01(Os05g0522500) Os07t0446800-00(Os07g0446800)
VCN: VOLCADRAFT_67129(hxk1)
APRO: F751_3201
SCE: YCL040W(GLK1) YDR516C(EMI2) YFR053C(HXK1) YGL253W(HXK2) YLR446W
KMX: KLMA_10051(GLK1) KLMA_60412(RAG5)
NCS: NCAS_0A00340(NCAS0A00340) NCAS_0B08930(NCAS0B08930) NCAS_0E00180(NCAS0E00180) NCAS_0F04080(NCAS0F04080)
NDI: NDAI_0A00320(NDAI0A00320) NDAI_0B06350(NDAI0B06350) NDAI_0F04460(NDAI0F04460) NDAI_0I03320(NDAI0I03320) NDAI_0J02790(NDAI0J02790)
TPF: TPHA_0B01640(TPHA0B01640) TPHA_0B04850(TPHA0B04850) TPHA_0E03770(TPHA0E03770) TPHA_0G03730(TPHA0G03730)
TBL: TBLA_0A05050(TBLA0A05050) TBLA_0A07540(TBLA0A07540) TBLA_0B06320(TBLA0B06320) TBLA_0E00110(TBLA0E00110) TBLA_0I03540(TBLA0I03540)
TDL: TDEL_0C06700(TDEL0C06700) TDEL_0D06490(TDEL0D06490)
KAF: KAFR_0D00310(KAFR0D00310) KAFR_0E04210(KAFR0E04210) KAFR_0G01260(KAFR0G01260) KAFR_0J00110(KAFR0J00110) KAFR_0J02970(KAFR0J02970)
PIC: PICST_32526(NAG5) PICST_73701(GLK1) PICST_85453(HXK1)
SLB: AWJ20_2590(HXK2) AWJ20_361(GLK1) AWJ20_4024(HXK2)
NTE: NEUTE1DRAFT119084(NEUTE1DRAFT_119084) NEUTE1DRAFT126829(NEUTE1DRAFT_126829) NEUTE1DRAFT87040(NEUTE1DRAFT_87040)
ANG: ANI_1_1030104(An12g08610) ANI_1_1984024(An02g14380) ANI_1_378054(An06g00380) ANI_1_66114(An13g00510)
SPO: SPAC24H6.04(hxk1) SPAC4F8.07c(hxk2)
ABP: AGABI1DRAFT114620(AGABI1DRAFT_114620) AGABI1DRAFT57808(AGABI1DRAFT_57808)
ABV: AGABI2DRAFT184646(AGABI2DRAFT_184646) AGABI2DRAFT194802(AGABI2DRAFT_194802)
MGL: MGL_1289
MRT: MRET_2854
EHI: EHI_098290(77.t00021) EHI_098560(19.t00020)
PCB: PCHAS_112240(PC301118.00.0)
BBO: BBOV_I000860(16.m00773)
CPV: cgd6_3800
SCL: sce6033(hxk)
CCE: Ccel_3221
DRM: Dred_1810
DAE: Dtox_3946
HMO: HM1_0763
MHG: MHY_04720
PUF: UFO1_4440
PFT: JBW_00035
TPA: TP_0505
TPP: TPASS_0505(hxk)
TPB: TPFB_0505
TDE: TDE_2469
TPED: TPE_0072
BTH: BT_2430
BFR: BF2523
BXY: BXY_18040
PDI: BDI_1250
DORI: FH5T_05565
 » show all
Reference
  Authors
Kawai S, Mukai T, Mori S, Mikami B, Murata K
  Title
Hypothesis: structures, evolution, and ancestor of glucose kinases in the hexokinase family.
  Journal
J Biosci Bioeng 99:320-30 (2005)
DOI:10.1263/jbb.99.320
Reference
PMID:3207429
  Authors
Nishi S, Seino S, Bell GI
  Title
Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous.
  Journal
Biochem Biophys Res Commun 157:937-43 (1988)
DOI:10.1016/s0006-291x(88)80964-1
  Sequence
[hsa:3098]

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