KEGG   ORTHOLOGY: K01539Help
Entry
K01539                      KO                                     

Name
ATP1A
Definition
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04911  Insulin secretion
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04960  Aldosterone-regulated sodium reabsorption
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04964  Proximal tubule bicarbonate reclamation
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04973  Carbohydrate digestion and absorption
ko04974  Protein digestion and absorption
ko04976  Bile secretion
ko04978  Mineral absorption
Disease
H00775  Familial or sporadic hemiplegic migraine
H00831  Primary dystonia
H00998  Alternating hemiplegia of childhood
H01603  Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04024 cAMP signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04022 cGMP - PKG signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04918 Thyroid hormone synthesis
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04919 Thyroid hormone signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04925 Aldosterone synthesis and secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Circulatory system
   04260 Cardiac muscle contraction
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04261 Adrenergic signaling in cardiomyocytes
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Digestive system
   04970 Salivary secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04971 Gastric acid secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04972 Pancreatic secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04976 Bile secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04973 Carbohydrate digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04974 Protein digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04978 Mineral absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04964 Proximal tubule bicarbonate reclamation
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of colorectal cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of bladder cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
BRITE hierarchy
Other DBs
GO: 0005391
TC: 3.A.3.1
Genes
HSA: 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
RRO: 104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
RBB: 108524039(ATP1A4) 108524041(ATP1A2) 108528132(ATP1A1)
CJC: 100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3) 104652875
MMU: 11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
NGI: 103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CCAN: 109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4) 103346768
TUP: 102475448(ATP1A3) 102483255(ATP1A2) 102483989 102483994(ATP1A1)
CFA: 403992(ATP1A1) 488636 612463(ATP1A3)
AML: 100477585(ATP1A3) 100477989(ATP1A1) 100480641(ATP1A2) 100480890(ATP1A4)
UMR: 103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
ORO: 101366083(ATP1A1) 101376936(ATP1A3) 101379349(ATP1A2) 101379646(ATP1A4)
FCA: 101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785
PTG: 102954810 102955336(ATP1A3) 102955398 102957431(ATP1A4) 102971148(ATP1A1)
AJU: 106969643(ATP1A1) 106978517(ATP1A4) 106985576(ATP1A2) 106987698(ATP1A3)
BTA: 282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
PHD: 102341310(ATP1A1) 102343479(ATP1A2) 102343841(ATP1A4) 102344375(ATP1A3)
CHX: 102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 101103751(ATP1A3) 101118148(ATP1A2) 101118398 443381(ATP1A1)
SSC: 100157711 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
CDK: 105089616(ATP1A1) 105090227(ATP1A3) 105100141(ATP1A2)
BACU: 102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
OOR: 101279507(ATP1A1) 101280223(ATP1A3) 101288540(ATP1A4) 101288792(ATP1A2)
ECB: 100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
EAI: 106835689(ATP1A1) 106835754(ATP1A4) 106835755(ATP1A2) 106847933(ATP1A3)
MYB: 102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2) 102260737
MYD: 102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
HAI: 109374442 109374464(ATP1A3) 109386454 109386501(ATP1A2) 109392813(ATP1A1)
RSS: 109435707(ATP1A3) 109437283(ATP1A2) 109446683(ATP1A1)
PALE: 102884868(ATP1A4) 102885125(ATP1A2) 102888359(ATP1A1) 102893697(ATP1A3)
LAV: 100661428(ATP1A1) 100667801 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 100029759(ATP1A2)
SHR: 100914130 100918637 100922123(ATP1A3) 100928210(ATP1A1)
GGA: 396530(ATP1A1)
MGP: 100303690(ATP1A1)
APLA: 101797095 101801864(ATP1A1)
ACYG: 106029333 106037472(ATP1A1)
TGU: 100190719(ATP1A1)
GFR: 102036467(ATP1A1) 102044935
PHI: 102099305 102104980 102106372(ATP1A1) 102107817(ATP1A2)
PMAJ: 107207264(ATP1A1)
CCW: 104687046(ATP1A1)
FPG: 101914787(ATP1A1) 101915017(ATP1A2)
FCH: 102050259(ATP1A1) 102059303(ATP1A2)
CLV: 102092496(ATP1A1) 102093141
EGZ: 104126505(ATP1A1)
AAM: 106490649(ATP1A1) 106500059(ATP1A2)
ASN: 102371189(ATP1A2) 102372830(ATP1A1) 102376674(ATP1A3)
AMJ: 102567591(ATP1A1) 102575084(ATP1A2) 106737151
PSS: 102460622(ATP1A1) 102462326(ATP1A2)
CMY: 102936217(ATP1A1) 102938341(ATP1A2) 102943620
CPIC: 101931556(ATP1A3) 101933418(ATP1A1) 101934511 101950302(ATP1A2)
PBI: 103051176(ATP1A2) 103054113(ATP1A1) 103058247(ATP1A3)
XLA: 108697760 108699431 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64616(atp1a1b)
LCM: 102346835 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
SPU: 404637
APLC: 110976714
SKO: 100370816(ATP1A1)
DME: Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DSI: Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
MDE: 101893028
AAG: 5575790
AME: 410913(GB10508) 411083(Rpb8) 413471(GB17873)
CEL: CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: CBG01656 CBG09434(Cbr-eat-6)
BMY: Bm1_51740
CRG: 105338008
MYI: 110459295
OBI: 106880261
PIC: PICST_60178(PMR2)
CAL: CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
CAUR: QG37_03453
SLB: AWJ20_4150(PMR1)
MBE: MBM_04409
ANI: AN8941.2
ANG: ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
PTE: PTT_00480
SMIN: v1.2.000245.t1(symbB.v1.2.000245.t1) v1.2.028598.t1(symbB.v1.2.028598.t1)
TCX: Tcr_1065
CYQ: Q91_1618
DAR: Daro_1851
GUR: Gura_3300
GEO: Geob_1849
PCA: Pcar_2279
SAT: SYN_02485
MAC: MA_4378
MBAR: MSBR2_3266
MBAK: MSBR3_3261
MMA: MM_1069
MMAC: MSMAC_0238
METM: MSMTP_0268
MHOR: MSHOH_0294
MBU: Mbur_0431
MPY: Mpsy_0778
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1328175
  Authors
Lingrel JB
  Title
Na,K-ATPase: isoform structure, function, and expression.
  Journal
J Bioenerg Biomembr 24:263-70 (1992)
DOI:10.1007/BF00768847
Reference
  Authors
Morth JP, Poulsen H, Toustrup-Jensen MS, Schack VR, Egebjerg J, Andersen JP, Vilsen B, Nissen P
  Title
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:217-27 (2009)
DOI:10.1098/rstb.2008.0201

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