KEGG   ORTHOLOGY: K03362
Entry
K03362                      KO                                     
Symbol
FBXW1_11, BTRC, beta-TRCP
Name
F-box and WD-40 domain protein 1/11
Pathway
map04114  Oocyte meiosis
map04120  Ubiquitin mediated proteolysis
map04218  Cellular senescence
map04310  Wnt signaling pathway
map04340  Hedgehog signaling pathway
map04341  Hedgehog signaling pathway - fly
map04390  Hippo signaling pathway
map04624  Toll and Imd signaling pathway
map04710  Circadian rhythm
map05131  Shigellosis
map05170  Human immunodeficiency virus 1 infection
Disease
H02460  Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04340 Hedgehog signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04341 Hedgehog signaling pathway - fly
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04390 Hippo signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   04218 Cellular senescence
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
   03036 Chromosome and associated proteins
    K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
Genes
HSA: 23291(FBXW11) 8945(BTRC)
PTR: 450685(BTRC) 462263(FBXW11)
PPS: 100976100(FBXW11) 100977066(BTRC)
GGO: 101142383(FBXW11) 101152319(BTRC)
PON: 100171847(BTRC) 100432610(FBXW11)
NLE: 100583099(BTRC) 100605260(FBXW11)
MCC: 708990(FBXW11) 711843(BTRC)
MCF: 102136827(BTRC) 102143687(FBXW11)
CSAB: 103216409(BTRC) 103244971(FBXW11)
CATY: 105581652(FBXW11) 105581859(BTRC)
PANU: 101010993(BTRC) 101025156(FBXW11)
TGE: 112626354(FBXW11) 112631652(BTRC)
RRO: 104656496(BTRC) 104670124(FBXW11)
RBB: 108513614(FBXW11) 108515136(BTRC)
TFN: 117065452(FBXW11) 117067981(BTRC)
PTEH: 111538928(BTRC) 111547216(FBXW11)
CJC: 100389218(BTRC) 100402300(FBXW11)
SBQ: 101035000(BTRC) 101044866(FBXW11)
CSYR: 103252024(BTRC) 103268136(FBXW11)
MMUR: 105871854(FBXW11) 105873891(BTRC)
LCAT: 123637962(FBXW11) 123644072 123650108(BTRC)
OGA: 100942812(BTRC) 100946977(FBXW11)
MMU: 103583(Fbxw11) 12234(Btrc)
MCAL: 110285422(Btrc) 110304634(Fbxw11)
MPAH: 110331061(Fbxw11) 110337956(Btrc)
RNO: 303024(Fbxw11) 361765(Btrc)
MCOC: 116078965(Fbxw11) 116103918(Btrc)
MUN: 110547815(Fbxw11) 110556200(Btrc)
CGE: 100750426(Btrc) 100753568 100772242(Fbxw11)
MAUA: 101831932(Fbxw11) 101832496(Btrc)
PLEU: 114683476(Fbxw11) 114708125(Btrc)
MORG: 121453901(Btrc) 121463665(Fbxw11)
AAMP: 119811932(Fbxw11) 119826523(Btrc)
NGI: 103744000(Btrc) 103748186(Fbxw11)
HGL: 101718253(Fbxw11) 101726740(Btrc)
CPOC: 100715997(Fbxw11) 100730107(Btrc)
CCAN: 109691321(Btrc) 109696980(Fbxw11)
DORD: 105986593(Btrc) 105994975(Fbxw11)
DSP: 122101862(Fbxw11) 122115762(Btrc)
OCU: 100340737(FBXW11) 100350519(BTRC)
OPI: 101532378(FBXW11) 101534601(BTRC)
TUP: 102485164(BTRC)
CFA: 479291(FBXW11) 486851(BTRC)
CLUD: 112651235(FBXW11) 112672220(BTRC)
VVP: 112915141(BTRC) 112926170(FBXW11)
VLG: 121484364(BTRC) 121488189(FBXW11)
AML: 100470916(BTRC) 100479018(FBXW11)
UMR: 103664495(FBXW11) 103678776(BTRC)
UAH: 113251850(BTRC) 113264086(FBXW11)
UAR: 123788591(FBXW11) 123795885(BTRC)
MPUF: 101671054(FBXW11) 101692220(BTRC)
ORO: 101371793(BTRC) 101378003(FBXW11)
EJU: 114205332(BTRC) 114208616(FBXW11) 114221539
ZCA: 113914801 113920925(BTRC) 113928951(FBXW11)
MLX: 118016673(FBXW11) 118025164(BTRC)
FCA: 101094156(FBXW11) 101097596(BTRC)
PYU: 121010989(FBXW11) 121037135(BTRC)
PBG: 122492298(FBXW11) 122493158(BTRC)
PTG: 102953972(BTRC) 102962015(FBXW11)
PPAD: 109267495(FBXW11) 109272793(BTRC)
AJU: 106966878(BTRC) 106989251(FBXW11)
HHV: 120234082(FBXW11) 120243193(BTRC)
BTA: 534072(BTRC) 540642(FBXW11)
BOM: 102273208(FBXW11) 102280912(BTRC)
BIU: 109553040(BTRC) 109574833(FBXW11)
BBUB: 102402023(BTRC) 102408511(FBXW11)
CHX: 102184871(BTRC) 102187079(FBXW11)
OAS: 101101939(BTRC) 101107136(FBXW11)
ODA: 120873542(BTRC) 120879679(FBXW11)
CCAD: 122446012(BTRC) 122454491(FBXW11)
SSC: 100157842(BTRC) 100523218(FBXW11)
CFR: 102509669(BTRC) 102521888(FBXW11)
CBAI: 105081727(BTRC) 105082644(FBXW11)
CDK: 105084335(BTRC) 105089376(FBXW11)
VPC: 102528542(BTRC) 102539625(FBXW11)
BACU: 103003148(BTRC) 103005978(FBXW11)
LVE: 103070169(BTRC) 103072434(FBXW11)
OOR: 101276846(FBXW11) 101286442(BTRC)
DLE: 111172377(BTRC) 111185480(FBXW11)
PCAD: 102975666(BTRC)
PSIU: 116741721(BTRC) 116750864(FBXW11)
ECB: 100069972(FBXW11) 100070200(BTRC)
EPZ: 103542811(FBXW11) 103551399(BTRC)
EAI: 106828852(BTRC) 106837358(FBXW11)
MYB: 102250477(BTRC) 102262850(FBXW11)
MYD: 102752909(BTRC) 102759029(FBXW11)
MMYO: 118658168(FBXW11) 118669829(BTRC)
MLF: 102427664(BTRC) 102432689(FBXW11)
MNA: 107535702(FBXW11) 107542570(BTRC)
PKL: 118711555(FBXW11) 118718907(BTRC)
HAI: 109379398(FBXW11) 109379675(BTRC)
DRO: 112300376(BTRC) 112319740(FBXW11)
SHON: 118994949(FBXW11) 118999496(BTRC)
AJM: 119036231(FBXW11) 119059661(BTRC)
PDIC: 114496409(BTRC) 114509949(FBXW11)
PHAS: 123808932(FBXW11) 123828770(BTRC)
MMF: 118631987(BTRC) 118643697(FBXW11)
RFQ: 117016648(FBXW11) 117035968(BTRC)
PALE: 102893556(FBXW11) 102895058(BTRC)
PGIG: 120609176(BTRC) 120614879(FBXW11)
PVP: 105299298(FBXW11) 105304642(BTRC)
RAY: 107497788(BTRC) 107511023(FBXW11)
MJV: 108383975(FBXW11) 108408519(BTRC)
TOD: 119234284(BTRC) 119236342(FBXW11)
SARA: 101541466(BTRC) 101552907(FBXW11)
LAV: 100657114(FBXW11) 100661816(BTRC)
DNM: 101429650(FBXW11) 101441891(BTRC)
MDO: 100029508(BTRC) 100031160(FBXW11)
GAS: 123237495(FBXW11) 123238130(BTRC)
SHR: 100923383(FBXW11) 100925642(BTRC)
PCW: 110194552(BTRC) 110212306(FBXW11)
OAA: 100076818(FBXW11) 100080584(BTRC)
GGA: 416181(FBXW11) 423854(BTRC)
PCOC: 116231690(BTRC) 116231968(FBXW11)
MGP: 100545331(BTRC) 100551173(FBXW11)
CJO: 107316011(BTRC) 107320428(FBXW11)
NMEL: 110399216(BTRC) 110405169(FBXW11)
APLA: 101795851(BTRC) 101796951(FBXW11)
ACYG: 106034370(FBXW11) 106034939(BTRC)
AFUL: 116491135(BTRC) 116494705(FBXW11)
TGU: 100220854(BTRC) 100227408(FBXW11)
LSR: 110473660(BTRC) 110478308(FBXW11)
SCAN: 103813867(BTRC) 103823778(FBXW11)
PMOA: 120497674(FBXW11) 120501945(BTRC)
OTC: 121341657(BTRC) 121342964(FBXW11)
PRUF: 121350043(BTRC) 121355007(FBXW11)
GFR: 102038820(BTRC) 102045368(FBXW11)
FAB: 101812833(BTRC) 101812846(FBXW11)
PHI: 102101586(BTRC) 102103643(FBXW11)
PMAJ: 107198553(FBXW11) 107206950(BTRC)
CCAE: 111931254(BTRC) 111935686(FBXW11)
CCW: 104695699(BTRC) 104696044(FBXW11)
CBRC: 103618361(FBXW11) 103624550(BTRC)
ETL: 114070460(BTRC)
ZAB: 102073627(BTRC) 102074366(FBXW11)
FPG: 101914153(FBXW11) 101920782(BTRC)
FCH: 102054729(BTRC) 102057588(FBXW11)
CLV: 102083982(BTRC) 102096361(FBXW11)
EGZ: 104125612(BTRC) 104135945(FBXW11)
NNI: 104012614(BTRC) 104016560(FBXW11)
PLET: 104614773(BTRC) 104617734(FBXW11)
PCRI: 104033487(BTRC) 104035491(FBXW11)
ACUN: 113481483(BTRC) 113485119(FBXW11)
TALA: 104359634(BTRC) 104367589(FBXW11)
PADL: 103916272(BTRC) 103921960(FBXW11)
ACHC: 115334114(FBXW11) 115347994(BTRC)
HALD: 104317823(BTRC) 104322703(FBXW11)
CCRI: 104162536(BTRC) 104169560(FBXW11)
CSTI: 104549981(BTRC) 104550695(FBXW11)
EHS: 104513568(BTRC) 104516997(FBXW11)
GSTE: 104255363(BTRC) 104261016(FBXW11)
LDI: 104343471(BTRC) 104352605
MNB: 103769681(FBXW11) 103779442(BTRC)
AAM: 106484672(BTRC) 106488073(FBXW11)
AROW: 112963846(FBXW11) 112967883(BTRC)
NPD: 112944317(FBXW11) 112957014(BTRC)
DNE: 112981802(FBXW11) 112984776(BTRC)
ASN: 102370841(FBXW11) 102381867
AMJ: 102569199(BTRC) 102572700(FBXW11)
CPOO: 109309939(FBXW11) 109324068(BTRC)
GGN: 109287546(BTRC) 109290155(FBXW11)
PSS: 102449762(BTRC) 102460007(FBXW11)
CMY: 102932779(FBXW11) 102937665(BTRC)
CPIC: 101936069(BTRC) 101936220(FBXW11)
TST: 117881050(BTRC) 117881595(FBXW11)
CABI: 116818061(FBXW11) 116833949(BTRC)
MRV: 120370453(FBXW11) 120409210(BTRC)
ACS: 100555677(btrc) 100566594(fbxw11)
PVT: 110077581(BTRC) 110078955(FBXW11)
SUND: 121924940(BTRC) 121930451(FBXW11)
PBI: 103052099(BTRC) 103055313(FBXW11)
PMUR: 107285262(BTRC)
TSR: 106549005(FBXW11) 106549208(BTRC)
PGUT: 117674329(FBXW11) 117678631(BTRC)
VKO: 123026944(BTRC) 123030344(FBXW11)
PMUA: 114593637(FBXW11) 114597556(BTRC)
ZVI: 118082518(FBXW11) 118093883(BTRC)
GJA: 107106744(FBXW11) 107114452(BTRC)
STOW: 125434532(FBXW11) 125437611(BTRC)
XLA: 394362(btrc.S) 397988(btrc.L)
XTR: 549140(btrc)
NPR: 108798513
RTEM: 120932371(FBXW11) 120947011(BTRC)
BBUF: 120977159(FBXW11) 121003339(BTRC)
BGAR: 122928249(FBXW11)
DRE: 334373(fbxw11a) 406825(fbxw11b)
PPRM: 120473272(fbxw11a) 120481604(fbxw11b)
MAMB: 125259455(fbxw11b) 125275627(fbxw11a)
IPU: 108275024(fbxw11a) 108277126(fbxw11b)
SMEO: 124392450(fbxw11a) 124393351(fbxw11b)
TFD: 113650300(fbxw11b) 113654883(fbxw11a)
TRU: 101067263(fbxw11)
LCO: 104934047
NCC: 104953613
CGOB: 115014396
ELY: 117260997(fbxw11a)
EFO: 125894362(fbxw11a)
PLEP: 121947873(fbxw11a)
SLUC: 116052496(fbxw11a)
ECRA: 117951202(fbxw11a)
PFLV: 114562291
GAT: 120817401(fbxw11a)
PPUG: 119210308(fbxw11a)
MSAM: 119889150
CUD: 121516266(fbxw11a)
ALAT: 119007978(fbxw11a)
MZE: 101473198
ONL: 100703880
OAU: 116336021(fbxw11a)
OLA: 101174029(fbxw11)
OML: 112153159(fbxw11a)
XMA: 102230173(fbxw11)
XCO: 114138794
XHE: 116714245
PRET: 103471323(fbxw11)
PFOR: 103129921(fbxw11)
PLAI: 106937105(fbxw11)
PMEI: 106928122(fbxw11)
GAF: 122836598(fbxw11a)
CVG: 107088238(fbxw11)
CTUL: 119794329
GMU: 124860128(fbxw11a)
NFU: 107376245(fbxw11)
KMR: 108242388(fbxw11a)
ALIM: 106517031(fbxw11)
NWH: 119408986
AOCE: 111577455(fbxw11)
MCEP: 125008658(fbxw11a)
CSEM: 103390898(fbxw11)
POV: 109627371(fbxw11)
SSEN: 122761672
HHIP: 117769018(fbxw11a)
HSP: 118112053(fbxw11a)
LCF: 108899221(fbxw11)
SDU: 111239443(fbxw11)
SLAL: 111646646(fbxw11)
XGL: 120785405(fbxw11a)
HCQ: 109518762(fbxw11)
BPEC: 110160676(fbxw11)
MALB: 109951205(fbxw11)
BSPL: 114865037(fbxw11a)
SASA: 106568099(FBW1B) 106603254(FBW1B) 106604789 106611815(FBW1B)
LOC: 102686544 102688445(btrc)
LCM: 102350584(FBXW11) 102363698(BTRC)
CMK: 103177316
RTP: 109915133(fbxw11) 109920037
BFO: 118413023
BBEL: 109485276
CIN: 445628(betaTrCP)
SCLV: 120338929
SPU: 578954
APLC: 110983423
SKO: 100329075
DME: Dmel_CG3412(slmb)
DER: 6553494
DSE: 6620053
DSI: Dsimw501_GD20006(Dsim_GD20006)
DAN: 6501287
DSR: 110190865
DPO: 6897521
DPE: 6591415
DMN: 108155681
DWI: 6650398
DGR: 6568248
DAZ: 108621765
DNV: 115561846
DHE: 111601297
DVI: 6629648
CCAT: 101448432
BOD: 106616658
MDE: 101893248
SCAC: 106096390
LCQ: 111686993
LSQ: 119614786
HIS: 119658628
ACOZ: 120952295
AARA: 120904058
ASTE: 118506576
AAG: 5578007
CPII: 120432353
BCOO: 119075239
AME: 551517
ACER: 107996315
ALAB: 122712814
BIM: 100744475
BBIF: 117209405
BVK: 117240192
BVAN: 117164390
BTER: 100647997
BPYO: 122575816
CCAL: 108630717
OBB: 114877417
MGEN: 117221111
NMEA: 116431519
CGIG: 122394827
SOC: 105193827
MPHA: 105835128
AEC: 105152271
ACEP: 105617865
PBAR: 105432375
VEM: 105557340
HST: 105184823
DQU: 106749764
CFO: 105256506
FEX: 115240474
LHU: 105672519
PGC: 109853840
OBO: 105280109
PCF: 106785883
PFUC: 122526558
VPS: 122628490
NVI: 100122997
CSOL: 105367293
TPRE: 106658447
MDL: 103571718
CGLO: 123271462
FAS: 105273764
DAM: 107038705
AGIF: 122860937
CCIN: 107267545
TCA: 664308(slmb)
DPA: 109546948
SOY: 115891140
ATD: 109594444
CSET: 123318954
AGB: 108917882
LDC: 111507496
NVL: 108565276
APLN: 108733401
PPYR: 116166544
OTU: 111419675
BMOR: 101738795
BMAN: 114243504
MSEX: 115453810
BANY: 112056212
PPOT: 106110650
PXU: 106122819
PRAP: 110996174
ZCE: 119839315
HZE: 124644216
TNL: 113492310
SLIU: 111351283
API: 100166937
DNX: 107163009
AGS: 114124315
RMD: 113555913
BTAB: 109042902
CLEC: 106661820
NLU: 111049173
FOC: 113214546
ZNE: 110829662
CSEC: 111861980
FCD: 110847655
PVM: 113809160
PJA: 122259331
PCHN: 125025616
HAME: 121863506
PCLA: 123755036
PTRU: 123518542
HAZT: 108669865
DSV: 119461447
RSAN: 119379032
RMP: 119175984
VDE: 111254465
VJA: 111262322
TUT: 107359583
DPTE: 113795657
DFR: 124490595
CSCU: 111618464
CEL: CELE_K10B2.1(lin-23)
CBR: CBG_02640(Cbr-lin-23)
BMY: BM_BM4966(Bma-lin-23)
TSP: Tsp_05213
PCAN: 112563747
BGT: 106061116
GAE: 121382574
HRF: 124147224
HRJ: 124292013
CRG: 105349031
MYI: 110459150
PMAX: 117340071
OBI: 106884274
OSN: 115218865
LAK: 106160796
EGL: EGR_09165
NVE: 5521070
EPA: 110239842
ATEN: 116308969
ADF: 107351693
AMIL: 114961761
PDAM: 113676471
SPIS: 111331780
DGT: 114515968
XEN: 124444756
HMG: 100199403
AQU: 100634006
SLB: AWJ20_1162(MET30)
NCR: NCU04540(fwd-1) NCU07521(fwd-2)
NTE: NEUTE1DRAFT122582(NEUTE1DRAFT_122582) NEUTE1DRAFT147873(NEUTE1DRAFT_147873)
ANG: ANI_1_1076024(An02g07700) ANI_1_1890184(An04g05180)
SPO: SPAC29E6.01(pof11)
CNE: CNN01080
CNB: CNBN1070
ABP: AGABI1DRAFT76048(AGABI1DRAFT_76048)
ABV: AGABI2DRAFT209689(AGABI2DRAFT_209689)
MGL: MGL_2979
MRT: MRET_3585
 » show all
Reference
  Authors
Shirogane T, Jin J, Ang XL, Harper JW
  Title
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
  Journal
J Biol Chem 280:26863-72 (2005)
DOI:10.1074/jbc.M502862200
  Sequence
[hsa:23291]
Reference
  Authors
Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K
  Title
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.
  Journal
J Biol Chem 275:2877-84 (2000)
DOI:10.1074/jbc.275.4.2877
  Sequence
[hsa:8945 23291]
Reference
PMID:9859996
  Authors
Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y
  Title
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.
  Journal
Nature 396:590-4 (1998)
DOI:10.1038/25159
  Sequence
[hsa:8945]
Reference
  Authors
Koike J, Sagara N, Kirikoshi H, Takagi A, Miwa T, Hirai M, Katoh M
  Title
Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1.
  Journal
Biochem Biophys Res Commun 269:103-9 (2000)
DOI:10.1006/bbrc.2000.2241
  Sequence
[hsa:23291]

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