KEGG   ORTHOLOGY: K04345Help
Entry
K04345                      KO                                     

Name
PKA
Definition
protein kinase A [EC:2.7.11.11]
Pathway
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04113  Meiosis - yeast
ko04114  Oocyte meiosis
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04310  Wnt signaling pathway
ko04340  Hedgehog signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04371  Apelin signaling pathway
ko04530  Tight junction
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04740  Olfactory transduction
ko04742  Taste transduction
ko04750  Inflammatory mediator regulation of TRP channels
ko04910  Insulin signaling pathway
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing's syndrome
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04962  Vasopressin-regulated water reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04976  Bile secretion
ko05012  Parkinson's disease
ko05020  Prion diseases
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05032  Morphine addiction
ko05110  Vibrio cholerae infection
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Disease
H01431  Cushing's syndrome
H01740  Macrothrombocytopenia
H02049  Bilateral macronodular adrenal hyperplasia (BMAH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04345  PKA; protein kinase A
   04010 MAPK signaling pathway
    K04345  PKA; protein kinase A
   04310 Wnt signaling pathway
    K04345  PKA; protein kinase A
   04340 Hedgehog signaling pathway
    K04345  PKA; protein kinase A
   04341 Hedgehog signaling pathway - fly
    K04345  PKA; protein kinase A
   04371 Apelin signaling pathway
    K04345  PKA; protein kinase A
   04020 Calcium signaling pathway
    K04345  PKA; protein kinase A
   04024 cAMP signaling pathway
    K04345  PKA; protein kinase A
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K04345  PKA; protein kinase A
   04138 Autophagy - yeast
    K04345  PKA; protein kinase A
  Cell growth and death
   04113 Meiosis - yeast
    K04345  PKA; protein kinase A
   04114 Oocyte meiosis
    K04345  PKA; protein kinase A
  Cellular community - eukaryotes
   04530 Tight junction
    K04345  PKA; protein kinase A
   04540 Gap junction
    K04345  PKA; protein kinase A
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04345  PKA; protein kinase A
   04062 Chemokine signaling pathway
    K04345  PKA; protein kinase A
  Endocrine system
   04911 Insulin secretion
    K04345  PKA; protein kinase A
   04910 Insulin signaling pathway
    K04345  PKA; protein kinase A
   04922 Glucagon signaling pathway
    K04345  PKA; protein kinase A
   04923 Regulation of lipolysis in adipocyte
    K04345  PKA; protein kinase A
   04912 GnRH signaling pathway
    K04345  PKA; protein kinase A
   04913 Ovarian Steroidogenesis
    K04345  PKA; protein kinase A
   04915 Estrogen signaling pathway
    K04345  PKA; protein kinase A
   04914 Progesterone-mediated oocyte maturation
    K04345  PKA; protein kinase A
   04921 Oxytocin signaling pathway
    K04345  PKA; protein kinase A
   04926 Relaxin signaling pathway
    K04345  PKA; protein kinase A
   04918 Thyroid hormone synthesis
    K04345  PKA; protein kinase A
   04919 Thyroid hormone signaling pathway
    K04345  PKA; protein kinase A
   04928 Parathyroid hormone synthesis, secretion and action
    K04345  PKA; protein kinase A
   04916 Melanogenesis
    K04345  PKA; protein kinase A
   04924 Renin secretion
    K04345  PKA; protein kinase A
   04925 Aldosterone synthesis and secretion
    K04345  PKA; protein kinase A
   04927 Cortisol synthesis and secretion
    K04345  PKA; protein kinase A
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04345  PKA; protein kinase A
   04270 Vascular smooth muscle contraction
    K04345  PKA; protein kinase A
  Digestive system
   04970 Salivary secretion
    K04345  PKA; protein kinase A
   04971 Gastric acid secretion
    K04345  PKA; protein kinase A
   04976 Bile secretion
    K04345  PKA; protein kinase A
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04345  PKA; protein kinase A
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04345  PKA; protein kinase A
  Nervous system
   04724 Glutamatergic synapse
    K04345  PKA; protein kinase A
   04727 GABAergic synapse
    K04345  PKA; protein kinase A
   04725 Cholinergic synapse
    K04345  PKA; protein kinase A
   04728 Dopaminergic synapse
    K04345  PKA; protein kinase A
   04726 Serotonergic synapse
    K04345  PKA; protein kinase A
   04720 Long-term potentiation
    K04345  PKA; protein kinase A
   04723 Retrograde endocannabinoid signaling
    K04345  PKA; protein kinase A
  Sensory system
   04740 Olfactory transduction
    K04345  PKA; protein kinase A
   04742 Taste transduction
    K04345  PKA; protein kinase A
   04750 Inflammatory mediator regulation of TRP channels
    K04345  PKA; protein kinase A
  Aging
   04211 Longevity regulating pathway - mammal
    K04345  PKA; protein kinase A
   04213 Longevity regulating pathway - multiple species
    K04345  PKA; protein kinase A
  Environmental adaptation
   04713 Circadian entrainment
    K04345  PKA; protein kinase A
   04714 Thermogenesis
    K04345  PKA; protein kinase A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04345  PKA; protein kinase A
   05205 Proteoglycans in cancer
    K04345  PKA; protein kinase A
   05203 Viral carcinogenesis
    K04345  PKA; protein kinase A
  Neurodegenerative diseases
   05012 Parkinson's disease
    K04345  PKA; protein kinase A
   05020 Prion diseases
    K04345  PKA; protein kinase A
  Substance dependence
   05030 Cocaine addiction
    K04345  PKA; protein kinase A
   05031 Amphetamine addiction
    K04345  PKA; protein kinase A
   05032 Morphine addiction
    K04345  PKA; protein kinase A
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04345  PKA; protein kinase A
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04345  PKA; protein kinase A
  Infectious diseases
   05110 Vibrio cholerae infection
    K04345  PKA; protein kinase A
   05166 HTLV-I infection
    K04345  PKA; protein kinase A
   05169 Epstein-Barr virus infection
    K04345  PKA; protein kinase A
   05165 Human papillomavirus infection
    K04345  PKA; protein kinase A
   05146 Amoebiasis
    K04345  PKA; protein kinase A
  Drug resistance
   01522 Endocrine resistance
    K04345  PKA; protein kinase A
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04345  PKA; protein kinase A
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K04345  PKA; protein kinase A
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  PKA family
   K04345  PKA; protein kinase A
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K04345  PKA; protein kinase A
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K04345  PKA; protein kinase A
BRITE hierarchy
Other DBs
GO: 0004691
Genes
HSA: 5566(PRKACA) 5567(PRKACB) 5568(PRKACG)
PTR: 107966260(PRKACA) 469367(PRKACB) 472944(PRKACG)
PPS: 100968237(PRKACA) 100970917(PRKACB) 100982589(PRKACG)
GGO: 101133536(PRKACA) 101134260(PRKACB) 101151469(PRKACG)
PON: 100174748(PRKACB) 100431906(PRKACG) 100437102(PRKACA)
NLE: 100579779(PRKACA) 100583577(PRKACB) 100607741(PRKACG)
MCC: 700652(PRKACG) 709728(PRKACB) 718632(PRKACA)
MCF: 101926461(PRKACB) 102117414(PRKACG) 102142443(PRKACA)
CSAB: 103219549(PRKACG) 103224540(PRKACB) 103234377
RRO: 104661051(PRKACA) 104662061(PRKACG) 104677489(PRKACB)
RBB: 108514761(PRKACA) 108527683(PRKACB) 108530264(PRKACG) 108540003
CJC: 100392123(PRKACG) 100400737(PRKACA) 100407692(PRKACB) 100407753 100408115
SBQ: 101034152 101036705(PRKACA) 101043989(PRKACG) 101047300(PRKACB)
MMU: 18747(Prkaca) 18749(Prkacb)
RNO: 25636(Prkaca) 293508(Prkacb)
CGE: 100767097(Prkacb) 100768997(Prkaca)
NGI: 103728095(Prkacb) 103751850(Prkaca)
HGL: 101707235(Prkaca) 101721558(Prkacb)
OCU: 100008815(PRKACA) 100342212(PRKACB)
TUP: 102478525(PRKACA) 102502506(PRKACB)
CFA: 403556(PRKACA) 479975(PRKACB)
AML: 100468252(PRKACA) 100469628(PRKACB)
UMR: 103662972(PRKACB) 103682183(PRKACA)
ORO: 101367408(PRKACB) 101383001(PRKACA)
FCA: 101090494(PRKACA) 101095353(PRKACB)
PTG: 102948983(PRKACA) 102972158(PRKACB)
AJU: 106973352(PRKACB) 106985791(PRKACA)
BTA: 282322(PRKACA) 282323(PRKACB)
BOM: 102269124(PRKACB) 102281757(PRKACA)
BIU: 109556827(PRKACB) 109561498(PRKACA)
PHD: 102315955(PRKACA) 102332024(PRKACB)
CHX: 102168790(PRKACB) 102173379(PRKACA)
OAS: 101108785(PRKACB) 443094(PRKACA)
SSC: 100623628(PRKACB) 397652(PRKACA)
CFR: 102506255(PRKACB) 102508985(PRKACA)
CDK: 105095035(PRKACB) 105100776(PRKACA)
BACU: 103000011(PRKACA) 103008319(PRKACB)
LVE: 103074112(PRKACA) 103077464(PRKACB)
OOR: 101272376(PRKACA) 101273911(PRKACB)
ECB: 100052828(PRKACB) 100064302(PRKACA)
EPZ: 103557289(PRKACB) 103565953(PRKACA)
EAI: 106824036(PRKACB) 106844316(PRKACA)
MYB: 102244919(PRKACB) 102252927(PRKACA)
MYD: 102772218(PRKACA) 102773780(PRKACB)
HAI: 109385440(PRKACB) 109394225(PRKACA)
RSS: 109436571(PRKACB) 109454934(PRKACA)
PALE: 102877853(PRKACB) 102886679(PRKACA)
LAV: 100656966(PRKACB) 100674245(PRKACA)
MDO: 100011211(PRKACB) 100026861(PRKACA) 100032298
SHR: 100913731 100915481(PRKACA) 100929360 100934183(PRKACB)
OAA: 100078846(PRKACB) 100088079
GGA: 424542(PRKACB)
MGP: 100548554(PRKACB)
CJO: 107317471(PRKACB)
APLA: 101791856(PRKACB)
ACYG: 106034038(PRKACB)
TGU: 100226105(PRKACB) 100227397
GFR: 102039982(PRKACB)
FAB: 101821736(PRKACB)
PHI: 102112800(PRKACB)
PMAJ: 107208204(PRKACB)
CCW: 104695299(PRKACB)
FPG: 101921803(PRKACB)
FCH: 102052736(PRKACB)
CLV: 102094181(PRKACB)
EGZ: 104122904(PRKACB)
AAM: 106499821(PRKACB)
ASN: 102369602(PRKACA) 102373080(PRKACB)
AMJ: 102572143(PRKACB) 106737076
PSS: 102454969(PRKACB) 102458631(PRKACA)
ACS: 100559138(prkacb) 103279522(prkaca)
PVT: 110079750(PRKACB) 110082676(PRKACA)
PBI: 103052934 103058343(PRKACB)
GJA: 107117304(PRKACB) 107117579
XLA: 100101276(prkaca.S) 108711677 108714187 380388(prkacb.S)
XTR: 100038053(prkacb) 549157(prkaca)
NPR: 108784350(PRKACB) 108790539
DRE: 393998(prkacba) 445076(prkacab) 563147(prkacbb) 564064(prkacaa)
IPU: 100528913(kapca) 108258341(prkaca) 108267323(PRKACB) 108270713(prkacb)
LCO: 104918597 104925395(prkaca) 104931534 104931945(prkacb)
MZE: 101470440 101473852(prkacb) 101482575 101482847(prkaca)
XMA: 102225635(prkaca) 102230273(prkacb) 102230641 102237217
PRET: 103464159(prkacb) 103468785 103479663 103481100(prkaca)
NFU: 107378291 107383895 107392711(prkacb) 107395214(prkaca)
LCF: 108881271(prkacb) 108883401 108885432(prkaca) 108902709
HCQ: 109521323 109521456 109522036(prkacb) 109527435(prkaca)
BPEC: 110157202 110160084(prkacb) 110166277(prkaca) 110166288
LCM: 102359855(PRKACB) 102362951
CMK: 103174709(prkacb) 103189096(prkaca)
CIN: 100176009
SPU: 589947
APLC: 110977700
SKO: 100370476
DME: Dmel_CG12066(Pka-C2) Dmel_CG4379(Pka-C1)
DSI: Dsimw501_GD16880(Dsim_GD16880) Dsimw501_GD16891(Dsim_GD16891) Dsimw501_GD22345(Dsim_GD22345)
AAG: 5569015
AME: 409791(Co)
AEC: 105151927
ACEP: 105620881
PBAR: 105430845
NVI: 100328539(Pka-C1)
TCA: 655660 656552(Pka-C1)
ZNE: 110838038
TUT: 107366684
CEL: CELE_ZK909.2(kin-1)
CBR: CBG19814(Cbr-kin-1)
BMY: Bm1_11790
MYI: 110458440
OBI: 106874074
EPA: 110236331
ADF: 107358053
HMG: 100198292(prkaca)
PPP: 112291827
APRO: F751_6210
SCE: YJL164C(TPK1) YKL166C(TPK3) YPL203W(TPK2)
KMX: KLMA_10642(TPK2) KLMA_50248(TPK1)
NCS: NCAS_0A01100(NCAS0A01100) NCAS_0B08280(NCAS0B08280) NCAS_0I02840(NCAS0I02840)
NDI: NDAI_0A00960(NDAI0A00960) NDAI_0B00210(NDAI0B00210) NDAI_0F01650(NDAI0F01650)
TPF: TPHA_0E02840(TPHA0E02840) TPHA_0E03300(TPHA0E03300)
TBL: TBLA_0A02030(TBLA0A02030) TBLA_0C05830(TBLA0C05830)
TDL: TDEL_0C03710(TDEL0C03710) TDEL_0E05220(TDEL0E05220)
KAF: KAFR_0F01800(KAFR0F01800) KAFR_0G00480(KAFR0G00480) KAFR_0K00330(KAFR0K00330)
CDU: CD36_09610 CD36_21480(CaTPK2)
SLB: AWJ20_3189(TPK2)
NCR: NCU00682(pkac-2) NCU06240(pkac-1)
NTE: NEUTE1DRAFT149564(NEUTE1DRAFT_149564) NEUTE1DRAFT81394(NEUTE1DRAFT_81394)
ANG: ANI_1_1786064(An07g05060) ANI_1_594024(An02g04270)
CIM: CIMG_06775 CIMG_13464(CIMG05383)
SPO: SPBC106.10(pka1)
ABP: AGABI1DRAFT84160(AGABI1DRAFT_84160)
ABV: AGABI2DRAFT136405(AGABI2DRAFT_136405)
WSE: WALSEDRAFT_33262(PkaC)
MGL: MGL_3248
DDI: DDB_G0283907(pkaC)
DFA: DFA_05748 DFA_06591(pkaC)
EHI: EHI_053040(4.t00093)
PYO: PY17X_0839000(PY05235)
PCB: PCHAS_083590(PC000802.04.0)
BBO: BBOV_I004190(19.m02221) BBOV_III005740(17.m07511)
CPV: cgd3_3040
SMIN: v1.2.001047.t1(symbB.v1.2.001047.t1) v1.2.002962.t1(symbB.v1.2.002962.t1) v1.2.004161.t1(symbB.v1.2.004161.t1) v1.2.025734.t1(symbB.v1.2.025734.t1) v1.2.025734.t2(symbB.v1.2.025734.t2) v1.2.028498.t1(symbB.v1.2.028498.t1) v1.2.030862.t1(symbB.v1.2.030862.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2843813
  Authors
Maldonado F, Hanks SK
  Title
A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.
  Journal
Nucleic Acids Res 16:8189-90 (1988)
DOI:10.1093/nar/16.16.8189
  Sequence
[hsa:5566]

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