KEGG   ORTHOLOGY: K04447
Entry
K04447                      KO                                     

Name
JAK2
Definition
Janus kinase 2 [EC:2.7.10.2]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04062  Chemokine signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04217  Necroptosis
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04725  Cholinergic synapse
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05164  Influenza A
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05200  Pathways in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00012  Polycythemia vera
H01433  Budd-Chiari syndrome
H01481  Myelodysplastic syndrome
H01605  Myelofibrosis
H01612  Essential thrombocytosis
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04447  JAK2; Janus kinase 2
   04151 PI3K-Akt signaling pathway
    K04447  JAK2; Janus kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04447  JAK2; Janus kinase 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04447  JAK2; Janus kinase 2
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K04447  JAK2; Janus kinase 2
   04659 Th17 cell differentiation
    K04447  JAK2; Janus kinase 2
   04062 Chemokine signaling pathway
    K04447  JAK2; Janus kinase 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04447  JAK2; Janus kinase 2
   04917 Prolactin signaling pathway
    K04447  JAK2; Janus kinase 2
   04935 Growth hormone synthesis, secretion and action
    K04447  JAK2; Janus kinase 2
  09156 Nervous system
   04725 Cholinergic synapse
    K04447  JAK2; Janus kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04447  JAK2; Janus kinase 2
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04447  JAK2; Janus kinase 2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04447  JAK2; Janus kinase 2
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K04447  JAK2; Janus kinase 2
  09172 Infectious disease: viral
   05164 Influenza A
    K04447  JAK2; Janus kinase 2
   05161 Hepatitis B
    K04447  JAK2; Janus kinase 2
   05168 Herpes simplex virus 1 infection
    K04447  JAK2; Janus kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04447  JAK2; Janus kinase 2
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04447  JAK2; Janus kinase 2
   05140 Leishmaniasis
    K04447  JAK2; Janus kinase 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04447  JAK2; Janus kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04447  JAK2; Janus kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K04447  JAK2; Janus kinase 2
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K04447  JAK2; Janus kinase 2
Other DBs
GO: 0004715
Genes
HSA: 3717(JAK2)
PTR: 464979(JAK2)
PPS: 100979742(JAK2)
GGO: 101149427(JAK2)
PON: 100172517(JAK2)
NLE: 100588880(JAK2)
MCC: 694184(JAK2)
MCF: 102119008(JAK2)
CSAB: 103219496(JAK2)
RRO: 104665700(JAK2)
RBB: 108523026
CJC: 100413251(JAK2)
MMU: 16452(Jak2)
MCAL: 110285435(Jak2)
MPAH: 110316808(Jak2)
RNO: 24514(Jak2)
MUN: 110547004(Jak2)
CGE: 100769337(Jak2)
NGI: 103740979(Jak2)
HGL: 101717708(Jak2)
CCAN: 109692635(Jak2)
OCU: 100358134(JAK2)
TUP: 102502106(JAK2)
CFA: 484185(JAK2)
VVP: 112922148(JAK2)
AML: 100481360(JAK2)
UMR: 103663212(JAK2)
UAH: 113270160(JAK2)
ORO: 101375007(JAK2)
ELK: 111153517
FCA: 101088959(JAK2)
PTG: 102950330(JAK2)
PPAD: 109275494(JAK2)
AJU: 106968145(JAK2)
BTA: 525246(JAK2)
BOM: 102278692(JAK2)
BIU: 109562906(JAK2)
BBUB: 102412645(JAK2)
CHX: 102180670(JAK2)
OAS: 101113909(JAK2)
SSC: 397201(JAK2)
CFR: 102520220(JAK2)
CDK: 105101970(JAK2)
BACU: 103016904(JAK2)
LVE: 103076804(JAK2)
OOR: 101275108(JAK2)
DLE: 111174651(JAK2)
PCAD: 102978811(JAK2)
ECB: 100051487(JAK2)
EPZ: 103554269(JAK2)
EAI: 106843620(JAK2)
MYB: 102253056(JAK2)
MYD: 102768196(JAK2)
MNA: 107538122(JAK2)
HAI: 109384506(JAK2)
DRO: 112299737(JAK2)
PALE: 102882079(JAK2)
RAY: 107507294(JAK2)
MJV: 108388836(JAK2) 108395333
LAV: 100676652(JAK2)
TMU: 101354918
MDO: 100017930(JAK2)
SHR: 100927237(JAK2)
PCW: 110221618(JAK2)
OAA: 100074305(JAK2)
GGA: 374199(JAK2)
MGP: 100548880(JAK2)
CJO: 107306093(JAK2)
NMEL: 110389515(JAK2)
APLA: 101799651(JAK2)
ACYG: 106046386(JAK2)
TGU: 100225452(JAK2)
LSR: 110471247(JAK2)
SCAN: 103823830(JAK2)
GFR: 102037786(JAK2)
FAB: 101808382(JAK2)
PHI: 102110768(JAK2)
PMAJ: 107216082(JAK2)
CCAE: 111940605(JAK2)
CCW: 104685173(JAK2)
ETL: 114056124(JAK2)
FPG: 101916887(JAK2)
FCH: 102051463(JAK2)
CLV: 102095126(JAK2)
EGZ: 104135381(JAK2)
NNI: 104021434(JAK2)
ACUN: 113490376(JAK2)
PADL: 103924940(JAK2)
AAM: 106496764(JAK2)
ASN: 102370961(JAK2)
AMJ: 102569112(JAK2)
PSS: 102455115(JAK2)
CMY: 102932830(JAK2)
CPIC: 101952589(JAK2)
ACS: 100552375(jak2)
PVT: 110083245(JAK2)
PBI: 103049657(JAK2)
PMUR: 107291603(JAK2)
TSR: 106545685(JAK2)
PMUA: 114587533(JAK2)
GJA: 107107201(JAK2)
XLA: 108705365(jak2.S) 443637(jak2.L)
XTR: 100036599(jak2)
NPR: 108798500(JAK2)
DRE: 30298(jak2b) 30307(jak2a)
SRX: 107717749 107720250 107734396(jak2) 107756327
SANH: 107672564 107693475 107694534(jak2) 107699758
SGH: 107567125 107574844 107575237(jak2) 107587486
CCAR: 109062878 109111703
IPU: 108255897 108278781(jak2)
PHYP: 113535539 113537047
AMEX: 103030056 103042604(jak2)
EEE: 113572915 113584566
TRU: 101065198 101068778
TNG: GSTEN00008670G001 GSTEN00028984G001
LCO: 104918982 104923637
NCC: 104948816(jak2) 104963993
MZE: 101468325 101469715
ONL: 100692564 100710044
OLA: 101157629 101168468
XMA: 102224189 102230010
XCO: 114149322 114154475
PRET: 103469946 103473642(jak2)
CVG: 107085172 107088703(jak2)
NFU: 107372526 107394328
KMR: 108232754 108233764
ALIM: 106514545(jak2) 106528942
AOCE: 111571538 111573731
CSEM: 103389123(jak2) 103397589
POV: 109626499 109637124
LCF: 108879242 108879492
SDU: 111234160(jak2) 111236466
SLAL: 111651535 111665981(jak2)
HCQ: 109517077(jak2) 109519569
BPEC: 110155263 110174127
MALB: 109959140 109963449
SASA: 106561486(jak2) 106568442 106585396
OTW: 112219669 112232816(jak2) 112257378
SALP: 111961256 111973842 111980849
ELS: 105014676 105023553(jak2)
SFM: 108930978 108934741(jak2)
PKI: 111838479 111854178(jak2)
LCM: 102352797(JAK2)
CMK: 103177704(jak2) 103181975
RTP: 109911828 109934192
BFO: 118409800
CIN: 100181410 778659(jak)
SPU: 590852
APLC: 110989207
DME: Dmel_CG1594(hop)
DER: 6551607
DSE: 6617663
DSI: Dsimw501_GD15992(Dsim_hop)
DYA: Dyak_GE17301
DSR: 110182018
DPO: Dpse_GA14036
DPE: 6599164
DMN: 108161463
DWI: 6648465 6648759
DGR: Dgri_GH12542
DMO: Dmoj_GI14899
DAZ: 108619353
DNV: 108656460
DHE: 111601813
DVI: 6635447
MDE: 101895610
LCQ: 111684468
AGA: AgaP_AGAP008354
AAG: 5576502
AALB: 109419906
AME: 726002
BIM: 100745315
BTER: 100642307
CCAL: 108628377
OBB: 114871541
SOC: 105202510
MPHA: 105833761
AEC: 105153063
ACEP: 105617857
PBAR: 105432888
VEM: 105559882
HST: 105190877
DQU: 106749378
CFO: 105255224
LHU: 105677920
PGC: 109854546
OBO: 105276413
PCF: 106785826
NVI: 100118996
CSOL: 105359385
MDL: 103579492
TCA: 663273(Hop)
DPA: 109542640
ATD: 109596930
NVL: 108564018
BMOR: 101746320
BMAN: 114244710
DPL: KGM_210157
PMAC: 106716494
PRAP: 110991623
HAW: 110376354
TNL: 113495033
PXY: 105395070
API: 100167312
DNX: 107166020
AGS: 114128558
RMD: 113555292
BTAB: 109033753
CLEC: 106664605
PHU: Phum_PHUM202560
ZNE: 110840562
FCD: 110850062
DPX: DAPPUDRAFT_299747(HOP)
PVM: 113812472
ISC: IscW_ISCW016158
TUT: 107371028
DPTE: 113791031
CSCU: 111630018
PTEP: 107457346
PCAN: 112553579
CRG: 105333485
MYI: 110446410
LAK: 106165712
TAD: TRIADDRAFT_61274
SRE: PTSG_13074
 » show all
Reference
  Authors
Wallace TA, Sayeski PP
  Title
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
  Journal
Cell Biochem Biophys 44:213-22 (2006)
DOI:10.1385/CBB:44:2:213
Reference
PMID:9618263
  Authors
Saltzman A, Stone M, Franks C, Searfoss G, Munro R, Jaye M, Ivashchenko Y
  Title
Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.
  Journal
Biochem Biophys Res Commun 246:627-33 (1998)
DOI:10.1006/bbrc.1998.8685
  Sequence
[hsa:3717]

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Ontology (4)   
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Pathway (44)   
   KEGG PATHWAY (44)   
Disease (8)   
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Gene (1466)   
   KEGG GENES (278)   
   KEGG MGENES (428)   
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Protein sequence (111)   
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