KEGG ORTHOLOGY: K04447

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04447  JAK2; Janus kinase 2
   04151 PI3K-Akt signaling pathway
    K04447  JAK2; Janus kinase 2
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04447  JAK2; Janus kinase 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04447  JAK2; Janus kinase 2
09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K04447  JAK2; Janus kinase 2
   04659 Th17 cell differentiation
    K04447  JAK2; Janus kinase 2
   04062 Chemokine signaling pathway
    K04447  JAK2; Janus kinase 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04447  JAK2; Janus kinase 2
   04917 Prolactin signaling pathway
    K04447  JAK2; Janus kinase 2
   04935 Growth hormone synthesis, secretion and action
    K04447  JAK2; Janus kinase 2
  09156 Nervous system
   04725 Cholinergic synapse
    K04447  JAK2; Janus kinase 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04447  JAK2; Janus kinase 2
   05207 Chemical carcinogenesis - receptor activation
    K04447  JAK2; Janus kinase 2
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04447  JAK2; Janus kinase 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04447  JAK2; Janus kinase 2
   05164 Influenza A
    K04447  JAK2; Janus kinase 2
   05168 Herpes simplex virus 1 infection
    K04447  JAK2; Janus kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04447  JAK2; Janus kinase 2
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K04447  JAK2; Janus kinase 2
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04447  JAK2; Janus kinase 2
   05140 Leishmaniasis
    K04447  JAK2; Janus kinase 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04447  JAK2; Janus kinase 2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04447  JAK2; Janus kinase 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04447  JAK2; Janus kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04447  JAK2; Janus kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K04447  JAK2; Janus kinase 2
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  JAK family [OT]
   K04447  JAK2; Janus kinase 2

Other DBs

GO:

0004715

Genes

HSA:	3717(JAK2)

PTR:	464979(JAK2)

PPS:	100979742(JAK2)

GGO:	101149427(JAK2)

PON:	100172517(JAK2)

NLE:	100588880(JAK2)

MCC:	694184(JAK2)

MCF:	102119008(JAK2)

CSAB:

103219496(JAK2)

CATY:

105584100(JAK2)

RRO:	104665700(JAK2)

RBB:

108523026

TFN:	117098543(JAK2)

CJC:	100413251(JAK2)

MMUR:

105856276(JAK2)

MMU:	16452(Jak2)

MCAL:

110285435(Jak2)

MPAH:

110316808(Jak2)

RNO:	24514(Jak2)

MCOC:

116103711(Jak2)

MUN:	110547004(Jak2)

CGE:	100769337(Jak2)

PLEU:

114710385(Jak2)

NGI:	103740979(Jak2)

HGL:	101717708(Jak2)

CCAN:

109692635(Jak2)

OCU:	100358134(JAK2)

TUP:	102502106(JAK2)

CFA:	484185(JAK2)

VVP:	112922148(JAK2)

VLG:	121483167(JAK2)

AML:	100481360(JAK2)

UMR:	103663212(JAK2)

UAH:	113270160(JAK2)

ORO:	101375007(JAK2)

ELK:

111153517

MPUF:

101671881(JAK2)

EJU:	114219748(JAK2)

FCA:	101088959(JAK2)

PTG:	102950330(JAK2)

PPAD:

109275494(JAK2)

AJU:	106968145(JAK2)

HHV:	120230974(JAK2)

BTA:	525246(JAK2)

BOM:	102278692(JAK2)

BIU:	109562906(JAK2)

BBUB:

102412645(JAK2)

CHX:	102180670(JAK2)

OAS:	101113909(JAK2)

ODA:	120860228 120865363(JAK2)

SSC:	397201(JAK2)

CFR:	102520220(JAK2)

CDK:	105101970(JAK2)

BACU:

103016904(JAK2)

LVE:	103076804(JAK2)

OOR:	101275108(JAK2)

DLE:	111174651(JAK2)

PCAD:

102978811(JAK2)

ECB:	100051487(JAK2)

EPZ:	103554269(JAK2)

EAI:	106843620(JAK2)

MYB:	102253056(JAK2)

MYD:	102768196(JAK2)

MMYO:

118667512(JAK2)

MNA:	107538122(JAK2)

HAI:	109384506(JAK2)

DRO:	112299737(JAK2)

AJM:	119048039(JAK2)

MMF:	118629676(JAK2)

PALE:

102882079(JAK2)

RAY:	107507294(JAK2)

MJV:	108388836(JAK2) 108395333

LAV:	100676652(JAK2)

TMU:

101354918

MDO:	100017930(JAK2)

SHR:	100927237(JAK2)

PCW:	110221618(JAK2)

OAA:	100074305(JAK2)

GGA:	374199(JAK2)

PCOC:

116237171(JAK2)

MGP:	100548880(JAK2)

CJO:	107306093(JAK2)

NMEL:

110389515(JAK2)

APLA:

101799651(JAK2)

ACYG:

106046386(JAK2)

TGU:	100225452(JAK2)

LSR:	110471247(JAK2)

SCAN:

103823830(JAK2)

PMOA:

120511959(JAK2)

GFR:	102037786(JAK2)

FAB:	101808382(JAK2)

PHI:	102110768(JAK2)

PMAJ:

107216082(JAK2)

CCAE:

111940605(JAK2)

CCW:	104685173(JAK2)

ETL:	114056124(JAK2)

FPG:	101916887(JAK2)

FCH:	102051463(JAK2)

CLV:	102095126(JAK2)

EGZ:	104135381(JAK2)

NNI:	104021434(JAK2)

ACUN:

113490376(JAK2)

PADL:

103924940(JAK2)

AAM:	106496764(JAK2)

ASN:	102370961(JAK2)

AMJ:	102569112(JAK2)

CPOO:

109323526(JAK2)

GGN:	109297662(JAK2)

PSS:	102455115(JAK2)

CMY:	102932830(JAK2)

CPIC:

101952589(JAK2)

TST:	117878774(JAK2)

CABI:

116823393(JAK2)

ACS:	100552375(jak2)

PVT:	110083245(JAK2)

PBI:	103049657(JAK2)

PMUR:

107291603(JAK2)

TSR:	106545685(JAK2)

PGUT:

117661493(JAK2)

PMUA:

114587533(JAK2)

ZVI:	118097550(JAK2)

GJA:	107107201(JAK2)

XLA:	108705365(jak2.S) 443637(jak2.L)

XTR:	100036599(jak2)

NPR:	108798500(JAK2)

DRE:	30298(jak2b) 30307(jak2a)

SRX:	107717749 107720250 107734396(jak2) 107756327

SANH:

107672564 107693475 107694534(jak2) 107699758

SGH:	107567125 107574844 107575237(jak2) 107587486

CCAR:

109062878 109111703

CAUA:

113049659 113080782 113083589 113088778

IPU:	108255897 108278781(jak2)

PHYP:

113535539 113537047

AMEX:

103030056 103042604(jak2)

EEE:	113572915 113584566

TRU:	101065198 101068778

TNG:	GSTEN00008670G001 GSTEN00028984G001

LCO:	104918982 104923637

NCC:	104948816(jak2) 104963993

ELY:	117252761(jak2b) 117269941(jak2a)

PLEP:

121943967(jak2b) 121959857(jak2a)

SLUC:

116034923(jak2a) 116054059(jak2b)

GAT:	120830370(jak2b) 120832213(jak2a)

MSAM:

119891934(jak2b) 119914925(jak2a)

MZE:	101468325 101469715

ONL:	100692564 100710044

OAU:	116312194 116312304(jak2b)

OLA:	101157629 101168468

OML:	112148412(jak2b) 112163270(jak2a)

XMA:	102224189 102230010

XCO:	114149322 114154475

XHE:	116724107 116730221

PRET:

103469946 103473642(jak2)

CVG:	107085172 107088703(jak2)

NFU:	107372526 107394328

KMR:	108232754(jak2a) 108233764(jak2b)

ALIM:

106514545(jak2) 106528942

AOCE:

111571538 111573731

CSEM:

103389123(jak2) 103397589

POV:	109626499 109637124

LCF:	108879242 108879492

SDU:	111234160(jak2) 111236466

SLAL:

111651535 111665981(jak2)

XGL:	120804991(jak2b) 120806138(jak2a)

HCQ:	109517077(jak2) 109519569

BPEC:

110155263 110174127

MALB:

109959140 109963449

SASA:

106561486(jak2) 106568442 106585396

OTW:	112219669 112232816(jak2) 112257378

OMY:	110523953 110525449(jak2b) 110536972

SALP:

111961256 111973842 111980849

ELS:	105014676 105023553(jak2)

SFM:	108930978 108934741(jak2)

PKI:	111838479 111854178(jak2)

LOC:	102687473(jak2)

PSPA:

121303536 121319776(jak2b)

ARUT:

117409044 117421267

LCM:	102352797(JAK2)

CMK:	103177704(jak2) 103181975

RTP:	109911828 109934192

BFO:

118409800

CIN:	100181410 778659(jak)

SCLV:

120338196 120338197

SPU:

590852

APLC:

110989207

DME:	Dmel_CG1594(hop)

DER:

6551607

DSE:

6617663

DSI:	Dsimw501_GD15992(Dsim_hop)

DYA:	Dyak_GE17301

DSR:

110182018

DPO:	Dpse_GA14036

DPE:

6599164

DMN:

108161463

DWI:	6648465 6648759

DGR:	Dgri_GH12542

DMO:	Dmoj_GI14899

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP008354

ACOZ:

AARA:

AAG:

AALB:

CPII:

AME:

BIM:

BTER:

CCAL:

OBB:

MGEN:

NMEA:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:	663273(Hop)

DPA:

ATD:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210157

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

TNL:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

NLU:

PHU:	Phum_PHUM202560

ZNE:

110840562

FCD:

110850062

DPX:	DAPPUDRAFT_299747(HOP)

PVM:

113812472

EAF:

111701065

ISC:	IscW_ISCW016158

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

CSCU:

PTEP:

PCAN:

BGT:	106079295 106079296

CRG:

105333485

MYI:

110446410

LAK:

106165712

TAD:	TRIADDRAFT_61274

SRE:	PTSG_13074

» show all

Reference

PMID:16456223

Authors

Wallace TA, Sayeski PP

Title

Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?

Journal

Cell Biochem Biophys 44:213-22 (2006)
DOI:10.1385/CBB:44:2:213

Reference

PMID:9618263

Authors

Saltzman A, Stone M, Franks C, Searfoss G, Munro R, Jaye M, Ivashchenko Y

Title

Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.

Journal

Biochem Biophys Res Commun 246:627-33 (1998)
DOI:10.1006/bbrc.1998.8685

Sequence

[hsa:3717]

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