KEGG ORTHOLOGY: K04662

ORTHOLOGY: K04662

Entry

K04662                      KO

Symbol

BMP4

Name

bone morphogenetic protein 4

Pathway

map04013

MAPK signaling pathway - fly

map04060

Cytokine-cytokine receptor interaction

map04341

Hedgehog signaling pathway - fly

map04350

TGF-beta signaling pathway

map04390

Hippo signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04919

Thyroid hormone signaling pathway

map05200

Pathways in cancer

map05217

Basal cell carcinoma

map05418

Fluid shear stress and atherosclerosis

Disease

H00516

Cleft lip and/or cleft palate

H02170

Microphthalmia, syndromic

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04341 Hedgehog signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04350 TGF-beta signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
   04390 Hippo signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP4; bone morphogenetic protein 4
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP4; bone morphogenetic protein 4
09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04662  BMP4; bone morphogenetic protein 4
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K04662  BMP4; bone morphogenetic protein 4
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04662  BMP4; bone morphogenetic protein 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04662  BMP4; bone morphogenetic protein 4
   00536 Glycosaminoglycan binding proteins
    K04662  BMP4; bone morphogenetic protein 4
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Transforming growth factors (RSTK binding)
   K04662  BMP4; bone morphogenetic protein 4
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Morphogens
   K04662  BMP4; bone morphogenetic protein 4

Other DBs

GO:

0070700

Genes

HSA:

652(BMP4)

PTR:	107968170(BMP4)

PPS:	100987443(BMP4)

GGO:	101126138(BMP4)

PON:	100449444(BMP4)

PPYG:

129012077(BMP4)

NLE:	100586277(BMP4)

HMH:	116485021(BMP4)

SSYN:

129487872(BMP4)

MCC:	694618(BMP4)

MCF:	102132568(BMP4)

MTHB:

126959339

MNI:	105481800(BMP4)

CSAB:

103229007(BMP4)

CATY:

105586635(BMP4)

PANU:

100137596(BMP4)

TGE:	112629358(BMP4)

MLEU:

105553593(BMP4)

RRO:	104669157(BMP4)

RBB:

108513693

TFN:	117069628(BMP4)

PTEH:

111555060(BMP4)

CANG:

105525983(BMP4)

CJC:	100398270(BMP4)

SBQ:	101038031(BMP4)

CIMI:

108289624(BMP4)

ANAN:

105716410(BMP4)

CSYR:

103251761(BMP4)

MMUR:

105867695(BMP4)

LCAT:

123649038(BMP4)

PCOQ:

105825859(BMP4)

OGA:	100961860(BMP4)

MMU:	12159(Bmp4)

MCAL:

110309274(Bmp4)

MPAH:

110325391(Bmp4)

RNO:	25296(Bmp4)

MCOC:

116084889(Bmp4)

ANU:	117706351(Bmp4)

MUN:	110550958(Bmp4)

CGE:	100754303(Bmp4)

MAUA:

101828063(Bmp4)

PROB:

127216408(Bmp4)

PLEU:

114696047(Bmp4)

MORG:

121434984(Bmp4)

MFOT:

126513813

AAMP:

119800048(Bmp4)

NGI:	103739231(Bmp4)

HGL:	101711207(Bmp4)

CPOC:

100733516(Bmp4)

CCAN:

109701382(Bmp4)

DORD:

105982610(Bmp4)

DSP:	122110043(Bmp4)

PLOP:

125363324(Bmp4)

NCAR:

124976922

MMMA:

107138284(Bmp4)

OCU:	100009569(BMP4)

OPI:	101531889(BMP4)

TUP:	102497487(BMP4)

GVR:	103588444(BMP4)

CFA:	490695(BMP4)

CLUD:

112657550(BMP4)

VVP:	112921419(BMP4)

VLG:	121493806(BMP4)

NPO:	129496358(BMP4)

AML:	100477715(BMP4)

UMR:	103672975(BMP4)

UAH:	113242361(BMP4)

UAR:	123800688(BMP4)

ELK:

111162047

LLV:

125105283

MPUF:

101670047(BMP4)

MNP:	131999957(BMP4)

MLK:	131836584(BMP4)

NVS:	122893660(BMP4)

ORO:	101380696(BMP4)

EJU:	114204559(BMP4)

ZCA:	113910450(BMP4)

MLX:	118002167(BMP4)

NSU:	110590602(BMP4)

LWW:	102740547(BMP4)

FCA:	101100311(BMP4)

PYU:	121031781(BMP4)

PCOO:

112855771(BMP4)

PBG:	122469107(BMP4)

PVIV:

125168872(BMP4)

LRUF:

124512337

PTG:	102950088(BMP4)

PPAD:

109268456(BMP4)

PUC:

125909500

AJU:

106983046

HHV:	120237282(BMP4)

BTA:	407216(BMP4)

BOM:	102266106(BMP4)

BIU:	109565174(BMP4)

BBUB:

102398788(BMP4)

BBIS:

104994225(BMP4)

CHX:	100860789(BMP4)

OAS:	443502(BMP4)

BTAX:

128054087(BMP4)

ODA:	120852924(BMP4)

CCAD:

122443659(BMP4)

MREE:

136171949(BMP4)

MBEZ:

129563172(BMP4)

SSC:	100113425(BMP4)

CFR:	102509507(BMP4)

CBAI:

105074585(BMP4)

CDK:	105091431(BMP4)

VPC:	102531340(BMP4) 102544403

BACU:

103010740(BMP4)

BMUS:

118891260(BMP4)

LVE:	103072786(BMP4)

OOR:	101278431(BMP4)

DLE:	111173145(BMP4)

PCAD:

102981535(BMP4)

PSIU:

116749741(BMP4)

NASI:

112392905(BMP4)

ECB:	100034048(BMP4)

EPZ:	103558707(BMP4)

EAI:	106846123(BMP4)

MYB:	102262406(BMP4)

MYD:	102769625(BMP4) 102770741

MMYO:

118655552(BMP4)

MLF:	102436795(BMP4)

MDT:	132234482(BMP4)

PKL:	118718012(BMP4)

EFUS:

103283730(BMP4)

MNA:	107525879(BMP4)

DRO:	112311413(BMP4)

SHON:

118992410(BMP4)

AJM:	119057110(BMP4)

PDIC:

114491821(BMP4)

PHAS:

123808240(BMP4)

MMF:	118618825 118633302(BMP4)

PPAM:

129066024(BMP4)

HAI:	109384420(BMP4)

RFQ:	117024157(BMP4)

PALE:

102881920(BMP4)

PGIG:

120604412(BMP4)

PVP:	105309232(BMP4)

RAY:	107509544(BMP4)

MJV:	108407678(BMP4)

TOD:	119239102(BMP4)

SARA:

101540080(BMP4)

SETR:

125999250(BMP4)

LAV:	100654115(BMP4)

TMU:

101356019

ETF:	101653730(BMP4)

DNM:	101420561(BMP4)

MDO:	100010652(BMP4)

GAS:	123235751(BMP4)

SHR:	100916609(BMP4)

AFZ:

127549714

PCW:	110199877(BMP4)

TVP:	118840791(BMP4)

OAA:	100089255(BMP4)

GGA:	396165(BMP4)

PCOC:

116234629(BMP4)

MGP:	100544182(BMP4)

CJO:	107315532(BMP4)

TPAI:

128087220(BMP4)

LMUT:

125695096(BMP4)

NMEL:

110401682(BMP4)

APLA:

101803077(BMP4)

ACYG:

136791007(BMP4)

CATA:

118250336(BMP4)

AFUL:

116490007(BMP4)

TGU:	100221891(BMP4)

LSR:	110474762(BMP4)

SCAN:

103826326(BMP4)

PMOA:

120503839(BMP4)

OTC:	121340676(BMP4)

PRUF:

121354039(BMP4)

GFR:	102044724(BMP4)

FAB:	101816834(BMP4)

OMA:	130254291(BMP4)

PHI:	102110411(BMP4)

PMAJ:

107205267(BMP4)

CCAE:

111929526(BMP4)

CCW:	104687658(BMP4)

CBRC:

103618849(BMP4)

ETL:	114067429(BMP4)

ZAB:	102075485(BMP4)

ZLE:	135448438(BMP4)

ACHL:

103798768(BMP4)

SVG:	106850263(BMP4)

MMEA:

130582325(BMP4)

HRT:	120754053(BMP4)

SATI:

136362743(BMP4)

FPG:	101923141(BMP4)

FCH:	102047171(BMP4)

CCRI:

104168548(BMP4)

SHAB:

115607389(BMP4)

TALA:

116965637(BMP4)

ACHC:

115338579(BMP4)

HLE:	104839481(BMP4)

AGEN:

126050616

GCL:

127016740

LDI:	104341680(BMP4)

DPUB:

104299364(BMP4)

AVIT:

104271994(BMP4)

BRHI:

104491584(BMP4)

EGZ:	104122989(BMP4)

NNI:	104019440(BMP4)

PCRI:

104026570(BMP4)

PADL:

103915984(BMP4)

AFOR:

103907630(BMP4)

FGA:

104077613

CLV:	102098788(BMP4)

MUI:	104541294(BMP4)

PGUU:

104464124(BMP4)

PLET:

104618873(BMP4)

EHS:	104509313(BMP4)

CMAC:

104481164

CUCA:

104057425(BMP4)

TEO:	104379624(BMP4)

BREG:

104642562

OHA:	104333959(BMP4)

ACAR:

104527952(BMP4)

CPEA:

104387678(BMP4)

CVF:	104294310(BMP4)

RTD:	128908746(BMP4)

AAM:	106494596(BMP4)

AROW:

112961235(BMP4)

NPD:	112957780(BMP4)

TGT:	104568228(BMP4)

DNE:	112988547(BMP4)

SCAM:

104141415(BMP4)

ASN:	102371622(BMP4)

AMJ:	102573848(BMP4)

CPOO:

109324597(BMP4)

GGN:	109287494(BMP4)

PSS:	102459846(BMP4)

CMY:	102932745(BMP4)

CCAY:

125638901(BMP4)

DCC:	119857204(BMP4)

CPIC:

101949490(BMP4)

TST:	117877057(BMP4)

CABI:

116819607(BMP4)

MRV:	120405267(BMP4)

ACS:	100567033(bmp4)

ASAO:

132760954(BMP4) 132780062

PVT:	110089746(BMP4)

SUND:

121920015(BMP4)

PBI:	103054912(BMP4)

PMUR:

107293299(BMP4)

CTIG:

120297875(BMP4)

TSR:	106539867(BMP4)

PGUT:

117675078(BMP4)

APRI:

131191966(BMP4) 131204359

PTEX:

113435122(BMP4) 113446077

NSS:	113413743(BMP4) 113426422

VKO:

123025775

PMUA:

114594877(BMP4)

PRAF:

128413754(BMP4) 128418286

ZVI:	118077290(BMP4)

HCG:	128333393 128339914(BMP4)

GJA:	107118494(BMP4)

STOW:

125425547(BMP4) 125434890

EMC:	129324388(BMP4) 129343674

XLA:	397874(bmp4.L) 399322(bmp4.S)

XTR:	549788(bmp4)

NPR:	108788625(BMP4)

RTEM:

120921208(BMP4)

BBUF:

120981976(BMP4)

BGAR:

122921246(BMP4)

MUO:	115477941(BMP4)

GSH:	117364205(BMP4)

DRE:	30612(bmp4)

SRX:	107723271 107752724

SANH:

107701526 107702232

SGH:	107565000 107565007 107577028

CCAR:

109051714 109086016

CAUA:

113060420 113116948

CGIB:

127975813 128031385

PTET:

122361543(bmp4)

LROH:

127179236(bmp4)

OMC:	131523788(bmp4)

PPRM:

120479086(bmp4)

RKG:	130076709(bmp4)

MAMB:

125268289(bmp4)

CIDE:

127498054

CERY:

137006351(bmp4)

MASI:

127410972 127455377

TROS:

130560822(bmp4)

TDW:	130436744(bmp4)

MANU:

129417753(bmp4)

IPU:

108270422

IFU:	128613048(bmp4)

PHYP:

113538966(bmp4)

SMEO:

124390596(bmp4)

TFD:	113659289(bmp4)

TVC:	132852387(bmp4)

TRN:	134324912(bmp4)

AMEX:

103024384(bmp4)

CMAO:

118823939(bmp4)

EEE:	113572633(bmp4)

CHAR:

105896020(bmp4)

TRU:	101061931(bmp4)

TFS:	130540295(bmp4)

TNG:	GSTEN00031991G001

LCO:	104922404(bmp4)

NCC:	104964390(bmp4)

TBEN:

117479100(bmp4)

CGOB:

115027803(bmp4)

PGEO:

117467331(bmp4)

GACU:

117549316(bmp4)

EMAC:

134880952(bmp4)

ELY:	117266620(bmp4)

EFO:	125901407(bmp4)

PLEP:

121954057(bmp4)

SLUC:

116057644(bmp4)

ECRA:

117936136(bmp4)

ESP:	116669659(bmp4)

PFLV:

114546704(bmp4)

GAT:	120833309(bmp4)

PPUG:

119228075(bmp4)

AFB:	129103245(bmp4)

CLUM:

117751459(bmp4)

PSWI:

130201919(bmp4)

CANA:

137787538(bmp4)

MSAM:

119910406(bmp4)

SCHU:

122861887(bmp4)

CUD:	121526798(bmp4)

ALAT:

119005123(bmp4)

ASTR:

137611334(bmp4)

MZE:	101478902(bmp4)

ONL:	100693424(bmp4)

OAU:	116326100(bmp4)

OLA:	100049354(bmp4)

OML:	112149693(bmp4)

CSAI:

133462262(bmp4)

XMA:	102236800(bmp4)

XCO:	114134479(bmp4)

XHE:	116709359(bmp4)

PRET:

103458754(bmp4)

PFOR:

103154912(bmp4)

PLAI:

106953912(bmp4)

PMEI:

106906536(bmp4)

GAF:	122845608(bmp4)

PPRL:

129365485(bmp4)

CVG:	107096913(bmp4)

CTUL:

119775042(bmp4)

GMU:	124855391(bmp4)

NFU:	107392164(bmp4)

KMR:	108232299(bmp4)

ALIM:

106518439(bmp4)

NWH:	119427409(bmp4)

AOCE:

111573266(bmp4)

MCEP:

125024060(bmp4)

CSEM:

103378831(bmp4)

POV:	109646622(bmp4)

SSEN:

122783422(bmp4)

HHIP:

117756327(bmp4)

HSP:	118117006(bmp4)

PPLT:

128451535(bmp4)

SMAU:

118286620(bmp4)

LCF:

108875064

SDU:	111225424(bmp4)

SLAL:

111651019(bmp4)

XGL:	120795913(bmp4)

HCQ:	109509080 109517481(bmp4)

SSCV:

125980814(bmp4)

SBIA:

133513462(bmp4)

PEE:	133412948(bmp4)

PTAO:

133488099(bmp4)

BPEC:

110153633(bmp4)

MALB:

109968000(bmp4)

BSPL:

114849003(bmp4)

SJO:	128375465(bmp4)

SASA:

100194815(bmp4) 106611121

STRU:

115162164 115172445

OTW:	112256771 112261632(bmp4)

OMY:	110497765(bmp4) 110505700 118936649

OGO:	124001729 124046584

ONE:	115138632 115146089

OKI:	109894393 109904173

OKE:	118362655 118368167(bmp4)

SALP:

111963403 111968588

SNH:	120023676 120060389

CCLU:

121539447 121544776

ELS:	105015523(bmp4)

SFM:	108919383 108924036

PKI:	111859967(bmp4)

AANG:

118219736(bmp4)

LOC:	102684136(bmp4)

PSPA:

121324802 121330351

ARUT:

117395489 117421860

PSEX:

120518861(bmp4)

LCM:	102365184(BMP4)

CMK:	103175246(bmp4)

RTP:	109911221(bmp4) 109915190

CPLA:

122542790 122553612(bmp4)

HOC:	132818298(bmp4) 132836734

LERI:

129700174(bmp4)

PMRN:

103091842

LRJ:

133347370

BFO:

118427296

BBEL:

109477517 109482544 109488141

LPIC:

129264992

ARUN:

117294632

DME:	Dmel_CG9885(dpp)

DER:

6542079

DSE:

6613103

DSI:	Dsimw501_GD23157(Dsim_dpp)

DYA:	Dyak_GE18157(Dyak_dpp)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15572

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119662278 119687217

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004806

CPII:

CNS:

BCOO:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105672334(dpp)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

TCA:	654513(Dpp)

DPA:

109534820

ATD:	109598554 109606765

LDC:	111506036 111506625

NVL:	108557335 108557337

APLN:

108736677

PPYR:

116168588

OTU:

111417459

BMOR:

100270781(Dpp)

BMAN:

114248672

MSEX:

115440434

DPL:	KGM_214072

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119834728 119834729

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

LGLY:

API:	100163532 100168426 100168935 100572599

DNX:	107163146 107164798 107168331

AGS:	114122517 114123096 114128049 114129981

RMD:	113548569 113553177 113556510 113557330 113558507

ACOO:

126835553 126836191

DVT:	126895949 126896804

BTAB:

DCI:

CLEC:

NLU:

HVI:

PHU:	Phum_PHUM346320

FOC:

TPAL:

ZNE:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_347232(DPP)

DMK:	116924596 123473760

DPZ:

MNZ:

MRJ:

HAZT:

LSM:

TCF:

PPOI:

RSAN:

CSCU:

CVS:	136980674 136985827

PTEP:

ABRU:

SDM:

LPOL:

CEL:	CELE_T25F10.2(dbl-1)

CBR:	CBG_19011(Cbr-dbl-1)

CRQ:	GCK72_017989

LOA:	LOAG_01966

HRF:

HRJ:

HASI:

CRG:

CANU:

DPOL:

OSN:

LJP:	135466599 135471731

LAK:

106163298

LLON:

135485615

» show all

Reference

PMID:24362451

Authors

Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T

Title

Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.

Journal

Calcif Tissue Int 94:454-64 (2014)
DOI:10.1007/s00223-013-9828-1

Reference

PMID:17301089

Authors

Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J

Title

BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

Journal

Development 134:1221-30 (2007)
DOI:10.1242/dev.000182

Sequence

[mmu:12159]

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