KEGG   ORTHOLOGY: K04662
Entry
K04662                      KO                                     
Symbol
BMP4
Name
bone morphogenetic protein 4
Pathway
map04013  MAPK signaling pathway - fly
map04060  Cytokine-cytokine receptor interaction
map04341  Hedgehog signaling pathway - fly
map04350  TGF-beta signaling pathway
map04390  Hippo signaling pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map04919  Thyroid hormone signaling pathway
map05200  Pathways in cancer
map05217  Basal cell carcinoma
map05418  Fluid shear stress and atherosclerosis
Disease
H00516  Cleft lip and/or cleft palate
H02170  Microphthalmia, syndromic
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04341 Hedgehog signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04350 TGF-beta signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
   04390 Hippo signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP4; bone morphogenetic protein 4
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP4; bone morphogenetic protein 4
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04662  BMP4; bone morphogenetic protein 4
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K04662  BMP4; bone morphogenetic protein 4
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04662  BMP4; bone morphogenetic protein 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04662  BMP4; bone morphogenetic protein 4
   00536 Glycosaminoglycan binding proteins
    K04662  BMP4; bone morphogenetic protein 4
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   K04662  BMP4; bone morphogenetic protein 4
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Morphogens
   K04662  BMP4; bone morphogenetic protein 4
Other DBs
GO: 0070700
Genes
HSA: 652(BMP4)
PTR: 107968170(BMP4)
PPS: 100987443(BMP4)
GGO: 101126138(BMP4)
PON: 100449444(BMP4)
NLE: 100586277(BMP4)
MCC: 694618(BMP4)
MCF: 102132568(BMP4)
CSAB: 103229007(BMP4)
CATY: 105586635(BMP4)
PANU: 100137596(BMP4)
TGE: 112629358(BMP4)
RRO: 104669157(BMP4)
RBB: 108513693
TFN: 117069628(BMP4)
PTEH: 111555060(BMP4)
CJC: 100398270(BMP4)
SBQ: 101038031(BMP4)
CSYR: 103251761(BMP4)
MMUR: 105867695(BMP4)
OGA: 100961860(BMP4)
MMU: 12159(Bmp4)
MCAL: 110309274(Bmp4)
MPAH: 110325391(Bmp4)
RNO: 25296(Bmp4)
MCOC: 116084889(Bmp4)
MUN: 110550958(Bmp4)
CGE: 100754303(Bmp4)
PLEU: 114696047(Bmp4)
NGI: 103739231(Bmp4)
HGL: 101711207(Bmp4)
CPOC: 100733516(Bmp4)
CCAN: 109701382(Bmp4)
DORD: 105982610(Bmp4)
DSP: 122110043(Bmp4)
NCAR: 124976922
OCU: 100009569(BMP4)
OPI: 101531889(BMP4)
TUP: 102497487(BMP4)
CFA: 490695(BMP4)
VVP: 112921419(BMP4)
VLG: 121493806(BMP4)
AML: 100477715(BMP4)
UMR: 103672975(BMP4)
UAH: 113242361(BMP4)
UAR: 123800688(BMP4)
ELK: 111162047
LLV: 125105283
MPUF: 101670047(BMP4)
ORO: 101380696(BMP4)
EJU: 114204559(BMP4)
ZCA: 113910450(BMP4)
MLX: 118002167(BMP4)
FCA: 101100311(BMP4)
PYU: 121031781(BMP4)
PBG: 122469107(BMP4)
PTG: 102950088(BMP4)
PPAD: 109268456(BMP4)
AJU: 106983046(BMP4)
HHV: 120237282(BMP4)
BTA: 407216(BMP4)
BOM: 102266106(BMP4)
BIU: 109565174(BMP4)
BBUB: 102398788(BMP4)
CHX: 100860789(BMP4)
OAS: 443502(BMP4)
ODA: 120852924(BMP4)
CCAD: 122443659(BMP4)
SSC: 100113425(BMP4)
CFR: 102509507(BMP4)
CBAI: 105074585(BMP4)
CDK: 105091431(BMP4)
VPC: 102531340(BMP4) 102544403
BACU: 103010740(BMP4)
LVE: 103072786(BMP4)
OOR: 101278431(BMP4)
DLE: 111173145(BMP4)
PCAD: 102981535(BMP4)
PSIU: 116749741(BMP4)
ECB: 100034048(BMP4)
EPZ: 103558707(BMP4)
EAI: 106846123(BMP4)
MYB: 102262406(BMP4)
MYD: 102769625(BMP4) 102770741
MMYO: 118655552(BMP4)
MLF: 102436795(BMP4)
MNA: 107525879(BMP4)
PKL: 118718012(BMP4)
HAI: 109384420(BMP4)
DRO: 112311413(BMP4)
SHON: 118992410(BMP4)
AJM: 119057110(BMP4)
PDIC: 114491821(BMP4)
PHAS: 123808240(BMP4)
MMF: 118618825 118633302(BMP4)
RFQ: 117024157(BMP4)
PALE: 102881920(BMP4)
PGIG: 120604412(BMP4)
PVP: 105309232(BMP4)
RAY: 107509544(BMP4)
MJV: 108407678(BMP4)
TOD: 119239102(BMP4)
SARA: 101540080(BMP4)
LAV: 100654115(BMP4)
TMU: 101356019
DNM: 101420561(BMP4)
MDO: 100010652(BMP4)
GAS: 123235751(BMP4)
SHR: 100916609(BMP4)
PCW: 110199877(BMP4)
OAA: 100089255(BMP4)
GGA: 396165(BMP4)
PCOC: 116234629(BMP4)
MGP: 100544182(BMP4)
CJO: 107315532(BMP4)
NMEL: 110401682(BMP4)
APLA: 101803077(BMP4)
ACYG: 106044053(BMP4)
AFUL: 116490007(BMP4)
TGU: 100221891(BMP4)
LSR: 110474762(BMP4)
SCAN: 103826326(BMP4)
PMOA: 120503839(BMP4)
OTC: 121340676(BMP4)
PRUF: 121354039(BMP4)
GFR: 102044724(BMP4)
FAB: 101816834(BMP4)
PHI: 102110411(BMP4)
PMAJ: 107205267(BMP4)
CCAE: 111929526(BMP4)
CCW: 104687658(BMP4)
ETL: 114067429(BMP4)
ZAB: 102075485(BMP4)
FPG: 101923141(BMP4)
FCH: 102047171(BMP4)
CLV: 102098788(BMP4)
EGZ: 104122989(BMP4)
NNI: 104019440(BMP4)
TALA: 116965637(BMP4)
PADL: 103915984(BMP4)
ACHC: 115338579(BMP4)
AAM: 106494596(BMP4)
AROW: 112961235(BMP4)
NPD: 112957780(BMP4)
DNE: 112988547(BMP4)
ASN: 102371622(BMP4)
AMJ: 102573848(BMP4)
CPOO: 109324597(BMP4)
GGN: 109287494(BMP4)
PSS: 102459846(BMP4)
CMY: 102932745(BMP4)
CPIC: 101949490(BMP4)
TST: 117877057(BMP4)
CABI: 116819607(BMP4)
MRV: 120405267(BMP4)
ACS: 100567033(bmp4)
PVT: 110089746(BMP4)
SUND: 121920015(BMP4)
PBI: 103054912(BMP4)
PMUR: 107293299(BMP4)
TSR: 106539867(BMP4)
PGUT: 117675078(BMP4)
VKO: 123025775
PMUA: 114594877(BMP4)
ZVI: 118077290(BMP4)
GJA: 107118494(BMP4)
STOW: 125425547(BMP4) 125434890
XLA: 397874(bmp4.L) 399322(bmp4.S)
XTR: 549788(bmp4)
NPR: 108788625(BMP4)
RTEM: 120921208(BMP4)
BBUF: 120981976(BMP4)
BGAR: 122921246(BMP4)
DRE: 30612(bmp4)
PPRM: 120479086(bmp4)
MAMB: 125268289(bmp4)
IPU: 108270422(bmp4)
PHYP: 113538966(bmp4)
SMEO: 124390596(bmp4)
TFD: 113659289(bmp4)
AMEX: 103024384(bmp4)
EEE: 113572633(bmp4)
TRU: 101061931(bmp4)
LCO: 104922404(bmp4)
NCC: 104964390(bmp4)
CGOB: 115027803(bmp4)
ELY: 117266620(bmp4)
PLEP: 121954057(bmp4)
SLUC: 116057644(bmp4)
ECRA: 117936136(bmp4)
PFLV: 114546704(bmp4)
GAT: 120833309(bmp4)
PPUG: 119228075(bmp4)
MSAM: 119910406(bmp4)
CUD: 121526798(bmp4)
MZE: 101478902(bmp4)
ONL: 100693424(bmp4)
OAU: 116326100(bmp4)
OLA: 100049354(bmp4)
OML: 112149693(bmp4)
XMA: 102236800(bmp4)
XCO: 114134479(bmp4)
XHE: 116709359(bmp4)
PRET: 103458754(bmp4)
PFOR: 103154912(bmp4)
PLAI: 106953912(bmp4)
PMEI: 106906536(bmp4)
GAF: 122845608(bmp4)
CVG: 107096913(bmp4)
CTUL: 119775042(bmp4)
GMU: 124855391(bmp4)
NFU: 107392164(bmp4)
KMR: 108232299(bmp4)
ALIM: 106518439(bmp4)
NWH: 119427409(bmp4)
AOCE: 111573266(bmp4)
CSEM: 103378831(bmp4)
POV: 109646622(bmp4)
SSEN: 122783422(bmp4)
HHIP: 117756327(bmp4)
LCF: 108875064(bmp4)
SDU: 111225424(bmp4)
SLAL: 111651019(bmp4)
XGL: 120795913(bmp4)
HCQ: 109509080 109517481(bmp4)
BPEC: 110153633(bmp4)
MALB: 109968000(bmp4)
SASA: 100194815(bmp4) 106611121
OTW: 112256771 112261632(bmp4)
ELS: 105015523(bmp4)
PKI: 111859967(bmp4)
AANG: 118219736(bmp4)
LOC: 102684136(bmp4)
LCM: 102365184(BMP4)
CMK: 103175246(bmp4)
RTP: 109911221(bmp4) 109915190
BFO: 118427296
DME: Dmel_CG9885(dpp)
DER: 6542079
DSE: 6613103
DSI: Dsimw501_GD23157(Dsim_dpp)
DYA: Dyak_GE18157(Dyak_dpp)
DAN: 6503287
DSR: 110184975
DPO: Dpse_GA22099(Dpse_dpp)
DPE: 6596485
DMN: 108163475
DWI: 6641621
DGR: 6561971
DAZ: 108611910
DNV: 108649930
DHE: 111599355
DVI: 6627524
CCAT: 101459049
BOD: 106623787
MDE: 101892832
SCAC: 106088715
LCQ: 111679334
ACOZ: 120957075
AARA: 120900609
AAG: 5572653
AALB: 109401713
CPII: 120420590
CNS: 116340869
AME: 727101
ACER: 108000002
ALAB: 122716953
BIM: 100748741
BBIF: 117211978
BVK: 117239127
BVAN: 117166037
BTER: 100646366
BPYO: 122576941
CCAL: 108629683
OBB: 114873881
MGEN: 117219138
NMEA: 116433811
CGIG: 122398360
SOC: 105202003
MPHA: 105835632
AEC: 105148754
ACEP: 105627064
PBAR: 105427703
VEM: 105560857
HST: 105180468
DQU: 106741356
CFO: 105252168
FEX: 115240280
LHU: 105672334
PGC: 109861453
OBO: 105284879
PCF: 106785345
PFUC: 122518750
VPS: 122635513
NVI: 100123906
CSOL: 105363714
TPRE: 106651299
MDL: 103575692
CGLO: 123266556
FAS: 105264337
DAM: 107044843
AGIF: 122857105
CCIN: 107269605
TCA: 654513(Dpp)
APLN: 108736677
PPYR: 116168588
OTU: 111417459
BMOR: 100270781(Dpp)
BMAN: 114248672
MSEX: 115440434
BANY: 112044871
PMAC: 106715051
PPOT: 106106640
PXU: 106127278
PRAP: 111000988
HAW: 110370724
TNL: 113497790
OFU: 114356593
DCI: 103520571
CLEC: 106665529
NLU: 111051496
FOC: 113208976
ZNE: 110828339
FCD: 110858354
HAZT: 108676104
LSM: 121121550
RSAN: 119388066
CSCU: 111612605
PTEP: 107442925
SDM: 118192226
CEL: CELE_T25F10.2(dbl-1)
CBR: CBG_19011(Cbr-dbl-1)
HRF: 124119106
HRJ: 124283698
CRG: 105320631
OSN: 115217374
LAK: 106163298
 » show all
Reference
  Authors
Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T
  Title
Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
  Journal
Calcif Tissue Int 94:454-64 (2014)
DOI:10.1007/s00223-013-9828-1
Reference
  Authors
Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J
  Title
BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
  Journal
Development 134:1221-30 (2007)
DOI:10.1242/dev.000182
  Sequence
[mmu:12159]

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