KEGG   ORTHOLOGY: K05060
Entry
K05060                      KO                                     
Symbol
IL6ST, GP130, CD130
Name
interleukin 6 signal transducer
Pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04550  Signaling pathways regulating pluripotency of stem cells
map04630  JAK-STAT signaling pathway
map04659  Th17 cell differentiation
map05167  Kaposi sarcoma-associated herpesvirus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
Disease
H00462  Stuve-Wiedemann syndrome
H01968  Hyper-IgE syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   05203 Viral carcinogenesis
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   04090 CD molecules
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL6/12 receptor family
   K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
CD molecules [BR:ko04090]
 Proteins
  K05060  CD130, IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor)
Other DBs
GO: 0004915
Genes
HSA: 3572(IL6ST)
PTR: 461866(IL6ST)
PPS: 100992032(IL6ST)
GGO: 101153224(IL6ST)
PON: 100451191(IL6ST)
NLE: 100581824(IL6ST)
HMH: 116463892(IL6ST)
MCC: 574127(IL6ST)
MCF: 101926138(IL6ST)
MTHB: 126957544
MNI: 105499399(IL6ST)
CSAB: 103221611(IL6ST)
CATY: 105599628(IL6ST)
PANU: 100998383(IL6ST)
TGE: 112625906(IL6ST)
MLEU: 105551494(IL6ST)
RRO: 104680478(IL6ST)
RBB: 108530957(IL6ST)
TFN: 117065139(IL6ST)
PTEH: 111541627(IL6ST)
CANG: 105512469(IL6ST)
CJC: 100396729(IL6ST)
SBQ: 101029979(IL6ST)
CIMI: 108317975(IL6ST)
CSYR: 103258794(IL6ST)
MMUR: 105877286(IL6ST)
LCAT: 123647990(IL6ST)
PCOQ: 105819129(IL6ST)
OGA: 100958958(IL6ST)
MMU: 16195(Il6st)
MCAL: 110307804(Il6st)
MPAH: 110328878(Il6st)
RNO: 25205(Il6st)
MCOC: 116083943(Il6st)
ANU: 117723760(Il6st)
MUN: 110546647(Il6st)
CGE: 100767181(Il6st)
MAUA: 101842747(Il6st)
PROB: 127221151(Il6st)
PLEU: 114703579(Il6st)
MORG: 121455663(Il6st)
MFOT: 126507925
AAMP: 119808804(Il6st)
NGI: 103739911(Il6st)
HGL: 101703833(Il6st)
CPOC: 100724018(Il6st)
CCAN: 109700609(Il6st)
DORD: 105987287(Il6st)
DSP: 122117279(Il6st)
PLOP: 125367391(Il6st)
NCAR: 124986719
MMMA: 107151880(Il6st)
OCU: 100349330
OPI: 101523596(IL6ST)
TUP: 102494199(IL6ST)
GVR: 103588371(IL6ST)
CFA: 403545(IL6ST)
CLUD: 112660681(IL6ST)
VVP: 112935199(IL6ST)
VLG: 121496704(IL6ST)
NPO: 129513576(IL6ST)
AML: 100483131(IL6ST)
UMR: 103663669(IL6ST)
UAH: 113255323(IL6ST)
UAR: 123790182(IL6ST)
ELK: 111156948
LLV: 125099966
MPUF: 101691642(IL6ST)
MNP: 132028647(IL6ST)
MLK: 131832243(IL6ST)
NVS: 122889456(IL6ST)
ORO: 101368221(IL6ST)
EJU: 114220972(IL6ST)
ZCA: 113929940(IL6ST)
MLX: 118016794(IL6ST)
NSU: 110590912(IL6ST)
LWW: 102733408
FCA: 101089832(IL6ST)
PYU: 121015786(IL6ST)
PCOO: 112860883(IL6ST)
PBG: 122489075(IL6ST)
PVIV: 125155182(IL6ST)
LRUF: 124517290
PTG: 102968948(IL6ST)
PPAD: 109246341(IL6ST)
PUC: 125935635
AJU: 106975253
HHV: 120239954(IL6ST)
BTA: 522155(IL6ST)
BOM: 102280532(IL6ST)
BIU: 109574817(IL6ST)
BBUB: 102405590(IL6ST)
BBIS: 104998380(IL6ST)
CHX: 102188086(IL6ST)
OAS: 101113174(IL6ST)
BTAX: 128066072(IL6ST)
ODA: 120879525(IL6ST)
CCAD: 122454224(IL6ST)
MBEZ: 129553248(IL6ST)
SSC: 100037294(IL6ST)
CFR: 102511873(IL6ST)
CBAI: 105077802(IL6ST)
CDK: 105087138(IL6ST)
VPC: 102529144(IL6ST)
BACU: 103000073(IL6ST)
BMUS: 118891872(IL6ST)
LVE: 103075698(IL6ST)
OOR: 101287401(IL6ST)
DLE: 111186578(IL6ST)
PCAD: 102982237(IL6ST)
PSIU: 116751175(IL6ST)
NASI: 112413398(IL6ST)
ECB: 100051700(IL6ST)
EPZ: 103548204(IL6ST)
EAI: 106843367(IL6ST)
MYB: 102253606(IL6ST)
MYD: 102763204(IL6ST)
MMYO: 118655807(IL6ST)
MLF: 102441934 102443066(IL6ST)
PKL: 118702983(IL6ST)
EFUS: 103303119(IL6ST)
MNA: 107527134(IL6ST)
DRO: 112315251(IL6ST)
SHON: 118981655(IL6ST)
AJM: 119049182(IL6ST)
PDIC: 114502072(IL6ST)
PHAS: 123819500(IL6ST)
MMF: 118642413(IL6ST)
PPAM: 129071973(IL6ST)
HAI: 109382150(IL6ST)
RFQ: 117024735(IL6ST)
PALE: 102880415(IL6ST)
PGIG: 120608187(IL6ST)
PVP: 105299364(IL6ST)
RAY: 107509633(IL6ST) 107518627
MJV: 108393228(IL6ST)
TOD: 119261463(IL6ST)
SARA: 101551921(IL6ST)
LAV: 100669556(IL6ST)
TMU: 101353064
ETF: 101646676(IL6ST)
DNM: 101441436(IL6ST)
MDO: 100017284(IL6ST)
GAS: 123237164(IL6ST)
SHR: 100913307(IL6ST)
AFZ: 127557536
PCW: 110215675(IL6ST)
OAA: 100073530(IL6ST)
GGA: 395684(IL6ST)
PCOC: 116239417(IL6ST)
MGP: 100550313
CJO: 107305990(IL6ST)
TPAI: 128074507(IL6ST)
LMUT: 125686778(IL6ST)
NMEL: 110389606(IL6ST)
APLA: 101799928(IL6ST)
ACYG: 106035611(IL6ST)
CATA: 118251514(IL6ST)
AFUL: 116501212(IL6ST)
TGU: 100226842(IL6ST)
LSR: 110472554(IL6ST)
SCAN: 103821034(IL6ST)
PMOA: 120502492(IL6ST)
OTC: 121337736(IL6ST)
PRUF: 121355302(IL6ST)
GFR: 102036418(IL6ST)
FAB: 101807050(IL6ST)
OMA: 130264882(IL6ST)
PHI: 102107918(IL6ST)
PMAJ: 107198202(IL6ST)
CCAE: 111941441(IL6ST)
CCW: 104686676(IL6ST)
CBRC: 103623859(IL6ST)
ETL: 114065911(IL6ST)
ZAB: 102064531(IL6ST)
ACHL: 103811506
SVG: 106859619(IL6ST)
MMEA: 130588694(IL6ST)
HRT: 120765107(IL6ST)
FPG: 101911352(IL6ST)
FCH: 102051353(IL6ST)
CLV: 102094030(IL6ST)
EGZ: 104134682(IL6ST)
NNI: 104013731(IL6ST) 104014605
PCRI: 104035606(IL6ST)
PLET: 104625570(IL6ST)
EHS: 104513183
PCAO: 104046321(IL6ST)
ACUN: 113489579(IL6ST)
TALA: 104360147(IL6ST)
PADL: 103919426(IL6ST)
AFOR: 103893399(IL6ST)
ACHC: 115337289(IL6ST)
HALD: 104311316(IL6ST)
HLE: 104839948(IL6ST)
AGEN: 126036446
CCRI: 104165720
CSTI: 104556346(IL6ST)
CMAC: 104474245(IL6ST)
MUI: 104547229(IL6ST)
BREG: 104637609(IL6ST)
FGA: 104070239(CSF3R)
GSTE: 104251240(IL6ST)
LDI: 104342528(IL6ST)
MNB: 103779984(IL6ST)
OHA: 104337795(IL6ST)
NNT: 104402782(IL6ST)
SHAB: 115619787(IL6ST)
DPUB: 104296756(IL6ST)
PGUU: 104470475
ACAR: 104524582(IL6ST)
CPEA: 104395628(IL6ST)
AVIT: 104270101
CVF: 104294995(IL6ST)
RTD: 128902409(IL6ST)
CUCA: 104054806(IL6ST)
TEO: 104373318(IL6ST)
BRHI: 104500331(IL6ST)
AAM: 106496354
AROW: 112960895(IL6ST)
NPD: 112945657(IL6ST)
TGT: 104575740 104579128(IL6ST)
DNE: 112995745(IL6ST)
SCAM: 104146855(IL6ST)
ASN: 102376353(IL6ST)
AMJ: 102559273(IL6ST)
CPOO: 109307922(IL6ST)
GGN: 109297812(IL6ST)
PSS: 102460174(IL6ST)
CMY: 102933394(IL6ST)
CCAY: 125627293 125637431(IL6ST)
DCC: 119848324 119855770(IL6ST)
CPIC: 101932922(IL6ST) 101952357
TST: 117869078 117878776(IL6ST)
CABI: 116818241(IL6ST) 116838490
MRV: 120407778(IL6ST)
ACS: 100562134(il6st) 103277600
ASAO: 132766997(IL6ST) 132781481
PVT: 110079290 110085393(IL6ST)
SUND: 121920678(IL6ST) 121936948
PMUR: 107294972(IL6ST) 107300506
CTIG: 120313516(IL6ST)
TSR: 106546253(IL6ST) 106546711
PGUT: 117679200(IL6ST)
PTEX: 113446884(IL6ST)
NSS: 113413897(IL6ST)
VKO: 123031593(IL6ST)
ZVI: 118077334(IL6ST) 118086030
HCG: 128344904(IL6ST)
GJA: 107113291
STOW: 125436715(IL6ST)
EMC: 129334317(IL6ST)
XLA: 100158347(il6st.L) 100174791(il6st.S)
XTR: 100489642(il6st)
NPR: 108792012(IL6ST)
RTEM: 120928395(IL6ST)
BBUF: 120992142(IL6ST)
BGAR: 122925178(IL6ST)
MUO: 115462994(IL6ST)
GSH: 117354145(IL6ST)
DRE: 100006778(il6st)
PTET: 122352748(il6st)
LROH: 127171999(il6st)
OMC: 131548471(il6st)
PPRM: 120482034(il6st)
MAMB: 125255827(il6st)
CIDE: 127520522
TROS: 130545905(il6st)
TDW: 130411742(il6st)
MANU: 129445799(il6st)
IPU: 108265121 108276998(il6st)
IFU: 128620196
PHYP: 113543547
SMEO: 124393424
TFD: 113639253
TVC: 132863742
AMEX: 103042008 103042209(il6st)
CMAO: 118819526 118825112(il6st)
CHAR: 105894607(il6st) 116222992
TFS: 130514650(il12rb2l) 130517079(il6st) 130525702
PGEO: 117451041(il12rb2l) 117452481 117456270(il6st) 117467437
GACU: 117534883(il6st) 117540516 117554452(il12rb2l) 117555372
EMAC: 134868374(il6st) 134873385 134877886(il12rb2l) 134881953
ELY: 117252812 117266832 117267794(il12rb2l) 117269354(il6st)
EFO: 125880081(il12rb2l) 125890780 125901061 125905796(il6st)
PLEP: 121954127 121956460(il12rb2l) 121959563(il6st)
SLUC: 116041458(il6st) 116054394 116057714 116059531(il12rb2l)
ECRA: 117936155 117944399 117957407(il12rb2l) 117959350(il6st)
GAT: 120827524(il12rb2l) 120830148 120831482(il6st)
PPUG: 119221050(il12rb2l) 119224839 119226627(il6st)
AFB: 129098483(il12rb2l) 129100878 129102152(il6st) 129103642
CLUM: 117735037(il12rb2l) 117740125(il6st)
PSWI: 130189258(il12rb2l) 130205360(il6st)
MSAM: 119888331(il12rb2l) 119891872 119910425 119915140(il6st)
SCHU: 122862102 122865144(il6st) 122868436(il12rb2l) 122876052
ALAT: 119004967 119013413(il12rb2l) 119019911 119030470(il6st)
OAU: 116313567 116315646(il12rb2l) 116318031 116319152(il6st)
OML: 112137718 112140342(il6st) 112142567 112146293(il12rb2l)
XMA: 102219847(il6st) 102226847
XCO: 114134540 114149108(il6st)
PRET: 103458450 103473124(il6st)
GAF: 122822432(il12rb2l) 122828531 122846249 122847131(il6st)
PPRL: 129363456(il12rb2l) 129365232 129366093 129379791(il6st)
CVG: 107084616 107102482(il6st)
CTUL: 119775733 119777669(il12rb2l) 119784846 119788485(il6st)
KMR: 108239198(il12rb2l) 108242572(il6st) 108242804
NWH: 119413005 119420953(il12rb2l) 119424484(il6st) 119427679
MCEP: 124996241(il6st) 124998022(il12rb2l) 125012211
CSEM: 103381225 103389161(il6st)
POV: 109636341 109643155(il6st)
HHIP: 117755955 117766318(il12rb2l) 117771410(il6st)
HSP: 118116784 118122769(il12rb2l) 118125991(il6st)
SMAU: 118285077(il6st) 118286499 118288964(il12rb2l)
SDU: 111221084(il6st) 111238541
XGL: 120788231(il12rb2l) 120805689 120806330(il6st)
HCQ: 109530464(il6st)
SSCV: 125979804
SBIA: 133491024(il6st) 133514864(il12rb2l)
PEE: 133414047(il6st) 133415278(il12rb2l)
PTAO: 133465263(il6st) 133466184(il12rb2l)
MALB: 109957337 109960748(il6st)
BSPL: 114848958 114861040(il12rb2l) 114862293 114867260(il6st)
SJO: 128364328 128374910 128379461(il12rb2l) 128380242(il6st)
ELS: 105013144 105021723(il6st)
SFM: 108921565 108929965(il6st)
PKI: 111834479(il6st) 111836578
LOC: 102695320(il6st) 107079649
PSEX: 120532608(il6st)
LCM: 102356131 102357816(IL6ST)
RTP: 109916916
PMRN: 116943329
CIN: 100135649(gp130-like)
PJA: 122251553
PCHN: 125036317
PCLA: 123757665
RSAN: 119385126
VJA: 111267384
GAE: 121375836
CRG: 105322392
OSN: 115218400
 » show all
Reference
PMID:2261637
  Authors
Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T
  Title
Molecular cloning and expression of an IL-6 signal transducer, gp130.
  Journal
Cell 63:1149-57 (1990)
DOI:10.1016/0092-8674(90)90411-7
  Sequence
[hsa:3572]

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