KEGG   ORTHOLOGY: K06752Help
Entry
K06752                      KO                                     

Name
MHC2
Definition
MHC class II antigen
Pathway
ko04145  Phagosome
ko04514  Cell adhesion molecules (CAMs)
ko04612  Antigen processing and presentation
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04672  Intestinal immune network for IgA production
ko04940  Type I diabetes mellitus
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05164  Influenza A
ko05166  Human T-cell leukemia virus 1 infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05310  Asthma
ko05320  Autoimmune thyroid disease
ko05321  Inflammatory bowel disease (IBD)
ko05322  Systemic lupus erythematosus
ko05323  Rheumatoid arthritis
ko05330  Allograft rejection
ko05332  Graft-versus-host disease
ko05416  Viral myocarditis
Disease
H00079  Asthma
H00080  Systemic lupus erythematosus
H00081  Hashimoto thyroiditis
H00082  Graves disease
H00083  Allograft rejection
H00294  Dilated cardiomyopathy
H00295  Viral myocarditis
H00342  Tuberculosis
H00408  Type 1 diabetes mellitus
H01362  Dermatitis herpetiformis
H01468  Eosinophilic granulomatosis with polyangiitis
H01490  Multiple sclerosis
H01492  Systemic sclerosis
H01502  Sjogren syndrome
H01504  Vogt-Koyanagi-Harada syndrome
H01516  Adult onset Still disease
H01698  Giant cell arteritis
H02123  Celiac disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06752  MHC2; MHC class II antigen
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06752  MHC2; MHC class II antigen
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06752  MHC2; MHC class II antigen
   04612 Antigen processing and presentation
    K06752  MHC2; MHC class II antigen
   04658 Th1 and Th2 cell differentiation
    K06752  MHC2; MHC class II antigen
   04659 Th17 cell differentiation
    K06752  MHC2; MHC class II antigen
   04672 Intestinal immune network for IgA production
    K06752  MHC2; MHC class II antigen
 09160 Human Diseases
  09163 Immune disease
   05310 Asthma
    K06752  MHC2; MHC class II antigen
   05322 Systemic lupus erythematosus
    K06752  MHC2; MHC class II antigen
   05323 Rheumatoid arthritis
    K06752  MHC2; MHC class II antigen
   05320 Autoimmune thyroid disease
    K06752  MHC2; MHC class II antigen
   05321 Inflammatory bowel disease (IBD)
    K06752  MHC2; MHC class II antigen
   05330 Allograft rejection
    K06752  MHC2; MHC class II antigen
   05332 Graft-versus-host disease
    K06752  MHC2; MHC class II antigen
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06752  MHC2; MHC class II antigen
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K06752  MHC2; MHC class II antigen
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06752  MHC2; MHC class II antigen
   05152 Tuberculosis
    K06752  MHC2; MHC class II antigen
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06752  MHC2; MHC class II antigen
   05164 Influenza A
    K06752  MHC2; MHC class II antigen
   05168 Herpes simplex virus 1 infection
    K06752  MHC2; MHC class II antigen
   05169 Epstein-Barr virus infection
    K06752  MHC2; MHC class II antigen
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K06752  MHC2; MHC class II antigen
   05140 Leishmaniasis
    K06752  MHC2; MHC class II antigen
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06752  MHC2; MHC class II antigen
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06752  MHC2; MHC class II antigen
  Exosomal proteins of epithelial cells
   K06752  MHC2; MHC class II antigen
  Exosomal proteins of breast milk
   K06752  MHC2; MHC class II antigen
BRITE hierarchy
Genes
HSA: 3108(HLA-DMA) 3109(HLA-DMB) 3111(HLA-DOA) 3112(HLA-DOB) 3113(HLA-DPA1) 3115(HLA-DPB1) 3117(HLA-DQA1) 3118(HLA-DQA2) 3119(HLA-DQB1) 3122(HLA-DRA) 3123(HLA-DRB1) 3125(HLA-DRB3) 3126(HLA-DRB4) 3127(HLA-DRB5)
PTR: 100608816(MAMU-DMA) 100616520 104006793 449592(PATR-DMB) 462591(PATR-DRA) 462592(PATR-DRB5) 462594(PATR-DQB1) 462598(PATR-DPA1) 462599(PATR-DPB1) 471974(PATR-DQA1) 471976(PATR-DQA2) 471977(PATR-DOB) 471979
PPS: 100967376 100967723 100968410(MHC-DMB) 100968989 100970847 100972641 100972994 100973583 100979649 100986750 100987081 100987433 100993508 100993847 100995226(Papa-DPB1) 100995577
GGO: 101128237 101131235 101132303 101133052 101133995 101134815 101137108 101139685 101140024(MHC-DMB) 101140641 101141025 101141395 109027175
PON: 100438181 100442586 100442956 100443317 100443682 100444477 100448112 100448477 100453254 100456477 100457574 100458290 100460187
NLE: 100579397 100584042 100601771 100602317 100602659 100602736 100602990 100603340 100603684 100606472 100606816 100607501 100607843
MCC: 100187587(MAMU-DRA) 100428228(MAMU-DRB5) 100428435 100429857(MAMU-DMB) 114669810 692100(MAMU-DRB1) 716823(MAMU-DQB1) 717702(MAMU-DOB) 717870(MAMU-DMA) 717947(MAMU-DOA) 717969(MAMU-DPB) 717992(MAMU-DPA) 720582(MAMU-DQA1)
MCF: 102132662(Mafa-DQA) 102133044(DQB1) 102136468(DPB1) 102136862(Mafa-DPA) 102137481(Mafa-DOA) 102139994(Mafa-DMA) 102140649(Mafa-DMB) 102140782(Mafa-DRB) 102141176(Mafa-DQA) 102141582(Mafa-DRB) 102141962 102144039(DRA) 102144414(Mafa-DRB) 102144782(DQB1) 102145413(Mafa-DOB)
CSAB: 103221682(MHC-DPB1) 103221683(MHC-DPA1) 103221684(MHC-DOA) 103221688(MHC-DMA) 103221689(MHC-DMB) 103221695(MHC-DOB) 103221696(MHC-DQB1) 103221698(MHC-DQA1) 103221700 103221702 103221704(MHC-DRA) 103247136 103247138 103247148
RRO: 104657985 104657986 104666619 104666621 104666623 104673840 104673850 104673860 104673868 104673877 104673884
CJC: 100385427(CAJA-DRA) 100386155(CAJA-DRB1) 100386508(HLA-DQA1) 100386865(Caja-DQB1) 100387227 100387854(HLA-DRB1) 100397732(caja-DRB) 100405222(Caja-DQB2) 100407771(CAJA-DMA) 100408132(CAJA-DOA) 100408503(CAJA-DPB1) 100410700(Caja-DRB) 100411388(Caja-DQA1) 100412691(CAJA-DMB) 100413648(CAJA-DPA1) 103792390 108591149(Caja-DQB1)
MMU: 100504404(H2-Ea) 14960(H2-Aa) 14961(H2-Ab1) 14969(H2-Eb1) 14998(H2-DMa) 14999(H2-DMb1) 15000(H2-DMb2) 15001(H2-Oa) 15002(H2-Ob)
RNO: 100911800 108348072 108348139 24984(RT1-DOa) 24986(RT1-Ha) 294269(RT1-Da) 294270(RT1-Db1) 294273(RT1-DMb) 294274(RT1-DMa) 309621(RT1-Ba) 309622(RT1-Bb) 365542(RT1-DOb) 688090(Bb)
OCU: 100328929(RLA-DR-ALPHA) 100341358 100343144(Orcu-DQA) 100348904(RLA-DRB1) 100349408 100349667 100350168(Orcu-DRB) 100350656(RLA-DRB1) 100351163(RLA-DQB) 100351416 100352415(RLA-DMA) 100352672 100352927 100355948(RLA-DMB)
CFA: 100856137 474860(HLA-DRB1) 474861(DLA-DQA1) 474862(DLA-DQB1) 474869(DLA-DOA) 481731(DLA-DRA) 481732(DLA-DMA) 607786(DLA-DOB) 607827(DLA-DMB)
AML: 100463634 100463773(Aime-DQA) 100463889 100464279(Aime-DRA) 100464393 100464636(HLA-DMA) 100464780(Aime-DRB1) 100477284(HLA-DMB) 100478290(HLA-DOB) 100478546 100484974(Aime-DQB)
BTA: 100848815 282490(BOLA-DMA) 282491(BOLA-DMB) 282493(BOLA-DOB) 282494(BOLA-DQA5) 282495(BOLA-DQB) 282497(BOLA-DYA) 282498(BOLA-DYB) 282530(BOLA-DRB3) 282535(BOLA-DQA2) 506214(BOLA-DRA) 525727(BOLA-DOA) 538700(BOLA-DRB2) 539241(BLA-DQB) 618722(DSB)
SSC: 100037921(SLA-DQB1) 100135040(SLA-DRA) 100135049(SLA-DOB) 100135050(SLA-DMB) 100153386(SLA-DRB1) 100153387(SLA-DQA1) 100157996(SLA-DOA) 106504372 445528(SLA-DMA)
GGA: 101747454(BLB2) 417050(MHCDMA) 417051(DMB2) 425256(BLB3) 430189(BLA) 693256(BLB1)
MGP: 100547088 100549648(DMA) 100550217(DMB2)
FPG: 101911209(Fape-DAB) 101911566 101920105
XTR: 100127727(hla-dqa1) 100145090 100145508 100495183 100495336(mhc2a) 100495492(hla-dra) 734125(hla-drb1)
DRE: 100038779(zgc:158870) 30762(mhc2dab) 30763(mhc2dcb) 30783(mhc2a) 368614(si:busm1-48c11.3) 368615(mhc2b) 368816(si:busm1-194e12.8) 368877(si:busm1-266f07.1) 368878(si:busm1-266f07.2) 571282 654336(zgc:123077)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC
  Title
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.
  Journal
Genes Immun 11:99-112 (2010)
DOI:10.1038/gene.2009.83
Reference
PMID:8849454
  Authors
Weber DA, Evavold BD, Jensen PE
  Title
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
  Journal
Science 274:618-20 (1996)
DOI:10.1126/science.274.5287.618
  Sequence
[hsa:3109]
Reference
PMID:1922365
  Authors
Kelly AP, Monaco JJ, Cho SG, Trowsdale J
  Title
A new human HLA class II-related locus, DM.
  Journal
Nature 353:571-3 (1991)
DOI:10.1038/353571a0
  Sequence
[hsa:3108]

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