KEGG ORTHOLOGY: K07966

ORTHOLOGY: K07966

Entry

K07966                      KO

Symbol

B4GALT1

Name

beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

Pathway

map00052

Galactose metabolism

map00510

N-Glycan biosynthesis

map00513

Various types of N-glycan biosynthesis

map00514

Other types of O-glycan biosynthesis

map00515

Mannose type O-glycan biosynthesis

map00533

Glycosaminoglycan biosynthesis - keratan sulfate

map00601

Glycosphingolipid biosynthesis - lacto and neolacto series

map01100

Metabolic pathways

Module

M00071

Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer

M00075

N-glycan biosynthesis, complex type

Reaction

R00503

UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase

R05977

R05989

UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase

R06033

R06067

UDP-galactose:D-glucose 4-beta-D-galactotransferase

R07617

R09299

Disease

H00119

Congenital disorders of glycosylation type II

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00052 Galactose metabolism
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00513 Various types of N-glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00515 Mannose type O-glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00514 Other types of O-glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00533 Glycosaminoglycan biosynthesis - keratan sulfate
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.22  lactose synthase
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
    2.4.1.38  beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
    2.4.1.90  N-acetyllactosamine synthase
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Glycosyltransferases [BR:ko01003]
Glycan extension
  Type 2 chain/Poly-N-acetyllactosamine
   K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of breast milk
   K07966  B4GALT1; beta-1,4-galactosyltransferase 1

Other DBs

GO:	0004461 0003945 0003831

CAZy:

GT7

Genes

HSA:	2683(B4GALT1)

PTR:	100613700(B4GALT1)

PPS:	100974756(B4GALT1)

GGO:	101138982(B4GALT1)

PON:	100438031(B4GALT1)

NLE:	100597531(B4GALT1)

HMH:	116458785(B4GALT1)

MCC:	703541(B4GALT1)

MCF:	102131044(B4GALT1)

MTHB:

126937402

MNI:	105485655(B4GALT1)

CSAB:

103219294(B4GALT1)

CATY:

105590081(B4GALT1)

PANU:

101022281(B4GALT1)

TGE:	112607911(B4GALT1)

MLEU:

105539643(B4GALT1)

RRO:	104674271(B4GALT1)

RBB:	108518246(B4GALT1)

TFN:	117069449(B4GALT1)

PTEH:

111529202(B4GALT1)

CANG:

105526267(B4GALT1)

CJC:	100385157(B4GALT1)

SBQ:	101054125(B4GALT1)

CIMI:

108317680(B4GALT1)

CSYR:

103277047(B4GALT1)

MMUR:

105874372(B4GALT1)

LCAT:

123646221(B4GALT1)

PCOQ:

105820532(B4GALT1)

OGA:	100962109(B4GALT1)

MMU:	14595(B4galt1)

MCAL:

110292819(B4galt1)

MPAH:

110338771(B4galt1)

RNO:	24390(B4galt1)

MCOC:

116095826(B4galt1)

ANU:	117708230(B4galt1)

MUN:	110561670(B4galt1)

CGE:	100689430(B4galt1)

MAUA:

101824894(B4galt1)

PROB:

127224511(B4galt1)

PLEU:

114703257(B4galt1)

MORG:

121458383(B4galt1)

MFOT:

126509804

AAMP:

119826215(B4galt1)

NGI:	103741594(B4galt1)

HGL:	101698779 101721414(B4galt1)

CPOC:

100719604(B4galt1)

CCAN:

109681413

DORD:

105993397(B4galt1)

DSP:	122121438(B4galt1)

PLOP:

125363275(B4galt1)

NCAR:

124964217

OCU:

100345726

OPI:	101522535(B4GALT1)

TUP:	102470655(B4GALT1)

GVR:	103606522(B4GALT1)

CFA:	481579(B4GALT1)

CLUD:

112649799(B4GALT1)

VVP:	112927554(B4GALT1)

VLG:	121494980(B4GALT1)

NPO:	129494858(B4GALT1)

AML:	100477164(B4GALT1)

UMR:	103667105(B4GALT1)

UAH:	113260528(B4GALT1)

UAR:	123781319(B4GALT1)

ELK:

111146253

LLV:

125083661

MPUF:

101693610(B4GALT1)

MNP:	132024670(B4GALT1)

NVS:	122917530(B4GALT1)

ORO:	101362571(B4GALT1)

EJU:	114218153(B4GALT1)

ZCA:	113934251(B4GALT1)

MLX:	118018025(B4GALT1)

NSU:	110581489(B4GALT1)

LWW:	102726585(B4GALT1) 102727946

FCA:	101100927(B4GALT1)

PYU:	121034567(B4GALT1)

PCOO:

112850430(B4GALT1)

PBG:	122475074(B4GALT1)

LRUF:

124501308

PTG:	102959538(B4GALT1)

PPAD:

109252046(B4GALT1)

PUC:

125918726

AJU:

106976144

HHV:	120241747(B4GALT1)

BTA:	281781(B4GALT1)

BOM:	102269762(B4GALT1)

BIU:	109563168(B4GALT1)

BBUB:

102389487(B4GALT1)

BBIS:

104988709(B4GALT1)

CHX:	100860927(B4GALT1)

OAS:	100620048(B4GALT1)

BTAX:

128052146(B4GALT1)

ODA:	120860345 120866179

CCAD:

122431686(B4GALT1)

MBEZ:

129556931(B4GALT1)

SSC:	100511655(B4GALT1)

CFR:	102517623(B4GALT1)

CBAI:

105078745(B4GALT1)

CDK:	105085573(B4GALT1)

VPC:	102530069(B4GALT1)

BACU:

102999260(B4GALT1)

LVE:	103086401(B4GALT1)

OOR:	101285364(B4GALT1)

DLE:	111163203(B4GALT1)

PCAD:

102981888(B4GALT1)

PSIU:

116755411(B4GALT1)

NASI:

112405411(B4GALT1)

ECB:	100068209(B4GALT1)

EPZ:	103555031(B4GALT1)

EAI:	106841463(B4GALT1)

MYB:	102240062(B4GALT1)

MYD:	102751484(B4GALT1)

MMYO:

118667396(B4GALT1)

MLF:	102435984(B4GALT1)

MNA:	107544980(B4GALT1)

PKL:	118716413(B4GALT1)

EFUS:

103286482(B4GALT1)

HAI:	109371790(B4GALT1)

DRO:	112304428(B4GALT1)

SHON:

118979827(B4GALT1)

AJM:	119060005(B4GALT1)

PDIC:

114507957(B4GALT1)

PHAS:

123819973(B4GALT1)

MMF:	118629472(B4GALT1)

RFQ:	117032000(B4GALT1)

PALE:

102878748(B4GALT1)

PGIG:

120612917(B4GALT1)

PVP:	105306412(B4GALT1)

RAY:	107502798(B4GALT1)

MJV:	108404111(B4GALT1)

TOD:	119232854(B4GALT1)

SARA:

101543700(B4GALT1)

LAV:	100659897(B4GALT1)

TMU:

101341812

ETF:	101642283(B4GALT1)

DNM:	101415414(B4GALT1)

MDO:	100010600(B4GALT1)

GAS:	123250673(B4GALT1) 123253937

SHR:	100929465(B4GALT1)

AFZ:

127561996

PCW:	110194785(B4GALT1)

OAA:	100075703(B4GALT1)

GGA:	396121(B4GALT1)

PCOC:

116239467(B4GALT1)

MGP:	100543545(B4GALT1)

CJO:	107306674(B4GALT1)

TPAI:

128089755(B4GALT1)

LMUT:

125686500(B4GALT1)

NMEL:

110389893(B4GALT1)

APLA:

101792817(B4GALT1)

ACYG:

106040136(B4GALT1)

CATA:

118256243(B4GALT1)

AFUL:

116500363(B4GALT1)

TGU:	100223650(B4GALT1)

LSR:	110474049(B4GALT1)

SCAN:

103821842(B4GALT1)

PMOA:

120513595(B4GALT1)

OTC:	121332678(B4GALT1)

PRUF:

121363773(B4GALT1)

GFR:	102041517(B4GALT1)

FAB:	101807052(B4GALT1)

OMA:	130265161(B4GALT1)

PHI:	102109081(B4GALT1)

PMAJ:

107198186(B4GALT1)

CCAE:

111941228(B4GALT1)

CCW:	104689823(B4GALT1)

ETL:	114057877(B4GALT1)

ZAB:	102064480(B4GALT1)

ACHL:

103801382(B4GALT1)

SVG:	106860347(B4GALT1)

MMEA:

130577574(B4GALT1)

HRT:	120765371(B4GALT1)

FPG:	101918852(B4GALT1)

FCH:	102046112(B4GALT1)

CLV:	102088289(B4GALT1)

NNI:	104022647(B4GALT1)

PCRI:

104025828(B4GALT1)

PLET:

104625205(B4GALT1)

PCAO:

104052520(B4GALT1)

ACUN:

113490200(B4GALT1)

TALA:

116963851(B4GALT1)

PADL:

103921076(B4GALT1)

AFOR:

103903797(B4GALT1)

ACHC:

115337075(B4GALT1)

HALD:

104314820

HLE:	104838429(B4GALT1)

AGEN:

126036022

GCL:

127027500

CCRI:

104155887(B4GALT1)

CSTI:

104558467(B4GALT1)

CMAC:

104477194(B4GALT1)

MUI:

104538516

BREG:

104635241(B4GALT1)

FGA:	104075898(B4GALT1)

GSTE:

104255114(B4GALT1)

LDI:	104343891(B4GALT1)

OHA:	104338458(B4GALT1)

NNT:	104406822(B4GALT1)

SHAB:

115600665(B4GALT1)

DPUB:

104300430(B4GALT1)

PGUU:

104462621(B4GALT1)

CPEA:

104391690(B4GALT1)

AVIT:

104277655

CVF:	104282639(B4GALT1)

RTD:	128902483(B4GALT1)

CUCA:

104059508(B4GALT1)

TEO:	104383756(B4GALT1)

BRHI:

104498469(B4GALT1)

AAM:	106486901(B4GALT1)

AROW:

112975301(B4GALT1)

NPD:	112948927(B4GALT1)

TGT:	104578635(B4GALT1)

DNE:	112989803(B4GALT1)

SCAM:

104144374(B4GALT1)

ASN:	102372956(B4GALT1)

AMJ:	102559129(B4GALT1)

CPOO:

109323453(B4GALT1)

GGN:	109298077(B4GALT1)

PSS:	102459690(B4GALT1)

CMY:	102942662(B4GALT1)

CCAY:

125636525(B4GALT1)

DCC:	119855468(B4GALT1)

CPIC:

101932379(B4GALT1)

TST:	117878876(B4GALT1)

CABI:

116829702(B4GALT1)

MRV:	120393939 120407933

ACS:	100561064(b4galt1)

PVT:	110087350(B4GALT1)

SUND:

121921206(B4GALT1)

PBI:	103065477(B4GALT1)

PMUR:

107285615(B4GALT1)

CTIG:

120303843(B4GALT1)

TSR:	106557055(B4GALT1)

PGUT:

117661724(B4GALT1)

APRI:

131189543

PTEX:

113444148(B4GALT1)

NSS:	113415476(B4GALT1)

VKO:	123017487(B4GALT1)

PMUA:

114587454(B4GALT1)

PRAF:

128404702(B4GALT1)

ZVI:	118097645(B4GALT1)

HCG:	128345618(B4GALT1)

GJA:	107110573(B4GALT1)

STOW:

125436666(B4GALT1)

EMC:	129334204(B4GALT1)

XLA:	108704693(b4galt1l.S) 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957(b4galt1l.L)

XTR:	100145518(b4galt1.1) 100485024(b4galt1l) 549418(b4galt1.2)

NPR:	108788802 108792261

RTEM:

120915210(B4GALT1) 120932030

BBUF:

120989596 120989622(B4GALT1)

BGAR:

122927900(B4GALT1) 122928504

MUO:	115463633(B4GALT1)

GSH:	117347383(B4GALT1)

DRE:	550425(b4galt1) 768123(b4galt1l)

SRX:	107723150 107723151 107750327 107751321 107758898

SANH:

107665944 107677371 107692709 107697619

SGH:	107557953 107562374 107565367 107587100

CCAR:

109046469 109047435 109090593 109108968

CAUA:

113044328 113057637 113057644 113105615 113113860

CGIB:

127949703 127971459 127976547 128027614 128027620

PTET:

122346701(b4galt1) 122357674(b4galt1l)

LROH:

127176044(b4galt1l) 127181503(b4galt1)

OMC:	131548760(b4galt1) 131553294(b4galt1l)

PPRM:

120460852(b4galt1l) 120478308(b4galt1)

MAMB:

125258644(b4galt1l) 125272471(b4galt1)

CIDE:

127494089 127519275

MASI:

127412632 127417611 127443998 127445014

TROS:

130553360(b4galt1) 130563630(b4galt1l)

MANU:

129422271(b4galt1l) 129444864(b4galt1)

IPU:	108260689 108277608(b4galt1l)

IFU:	128604347(b4galt1) 128623370(b4galt1l)

PHYP:

113540104(b4galt1)

SMEO:

124381523 124396963(b4galt1l)

TFD:	113635342 113645897 113645903

AMEX:

103028729 103039461

CMAO:

118816979(b4galt1) 118821644(b4galt1l)

EEE:	113583532 113583542 113587936

CHAR:

105888623(b4galt1l) 105903513 105913335 105913336 105913337

TRU:	101061762 101061991 101063106 101065400 101066088 101077184 115248431

TFS:	130513906 130514036 130514258 130520087 130520594 130520965 130521101 130521367 130531473(b4galt1l)

TNG:	GSTEN00007296G001 GSTEN00010496G001 GSTEN00012074G001

LCO:	104938299(b4galt1) 109137286 109138027

NCC:

104951664

CGOB:

115025593

ELY:	117250533 117250550 117250570 117256405(b4galt1l) 117264448 117264493 117264494 117265022 117265080

EFO:	125881893 125881895 125881896 125881897 125881898 125882295 125894959(b4galt1l)

PLEP:

121948152(b4galt1l) 121960985 121960986

SLUC:

116051105 116060258(b4galt1l)

ECRA:

117938145 117941477

ESP:

116672118

PFLV:

114549363 114562966(b4galt1)

GAT:	120811611 120817303(b4galt1l)

PPUG:

119199018 119199020 119211455(b4galt1l)

AFB:	129090102(b4galt1l) 129111123

CLUM:

117737607(b4galt1l) 117749567

MSAM:

119884175 119908413

SCHU:

122866691 122880508(b4galt1l)

CUD:	121516558(b4galt1l) 121527509 121527692 121527693

ALAT:

119007174(b4galt1l) 119008242

MZE:	101472320(b4galt1) 101486761

ONL:	100691259 100692426 100692970

OAU:	116328309 116332053(b4galt1l) 116332060

OLA:	101171148(b4galt1)

OML:	112153596(b4galt1l)

XMA:	102216445(b4galt1) 102219706 102223611 102224977 102235410 106700428 111606172 111606205 111606296

XCO:	114136451 114136452 114136454 114136457 114136458 114137012 114139607(b4galt1)

XHE:	116712151 116712154 116712173 116712176 116712231 116712342 116714600(b4galt1)

PRET:

103456521 103457015 103457016 103457033 103457329 103471786(b4galt1)

PFOR:

103130223 103131055 103131056 103135266 103155973(b4galt1)

PLAI:

106940656 106940657 106944964 106958577(b4galt1)

PMEI:

106910870 106910871 106914697 106922898(b4galt1) 106933219

GAF:	122824275 122824447 122836758(b4galt1l)

CVG:	107082712(b4galt1) 107085956 107094320 107097868

CTUL:

119784548(b4galt1l) 119784620 119787615

GMU:	124857899 124857910 124858162 124858164 124858166 124858167 124858187 124860126(b4galt1l) 124861147

NFU:	107373064 107381099(b4galt1) 107382441 107382995 107395677 107396800

KMR:	108243995 108248973(b4galt1l) 108249546 108250944

ALIM:

106517566 106531648 106533299(b4galt1)

NWH:	119408817(b4galt1l) 119426702

AOCE:

111565921 111569747 111569748 111585098 111585099 111586043(b4galt1)

MCEP:

124995861 125007953(b4galt1l)

CSEM:

103376904 103390794(b4galt1)

POV:

109629466

SSEN:

122774288 122778195(b4galt1l)

HHIP:

117753741 117769188

HSP:	118098933 118112533(b4galt1l)

LCF:	108879172 108885296(b4galt1l) 108900792

SDU:	111233512(b4galt1) 111237265

SLAL:

111662869 111665610(b4galt1)

XGL:	120785455(b4galt1l) 120790010

HCQ:

109508336

SSCV:

125977506

BPEC:

110161009 110168019(b4galt1)

MALB:

109963721

BSPL:

114854399 114864146 114864147 114869532

SASA:

106597479 106602598 106602599 106604638 106611645

STRU:

115171563 115191838 115191839 115202190 115205174

OTW:	112220987 112231601 112231848 112245005 112256274

OMY:	110488860 110497417 110505061 110533181 110534462

OGO:	124010901 124012113 124012114 124019097

ONE:	115116662 115116883 115129493 115130741 115137371 115137545

OKI:	109864789 109887934 109894124 109900444 109901162 109905223

OKE:	118363000 118363533 118378580 118395470 118395540

SALP:

111965773 111967527 111971603 111971604 112068292

SNH:	120034976 120048073 120052222 120052908 120062281

CCLU:

121533988 121535749 121535754 121541962

ELS:	105007535(b4galt1) 105008881 105009278 105021088 105022911 105022912 106024204

SFM:	108925913 108925916 108927818 108938816

PKI:	111848718(b4galt1)

AANG:

118227568 118231327(b4galt1l)

LOC:	102691443 107077118(b4galt1)

PSPA:

121294868 121323269

ARUT:

117409235(b4galt1l) 117420622

PSEX:

120532261(b4galt1l) 120532267

LCM:

102357329

CMK:	103177647(b4galt1l)

RTP:

109917086

CPLA:

122558311

LERI:

129695578

CIN:	100175041 100176804 100185960

SCLV:

120330046 120330214 120340941 120341050 120343172

API:	100302475(NV135)

DNX:

AGS:

RMD:

NLU:

PJA:	122252242 122263470

PCHN:

125039083

PTRU:

123520613

EAF:

111706179

LSM:	121120659 121121588 121121770

RSAN:

DPTE:

UDV:

PMEO:

BGT:

HRF:

HRJ:	124256641 124269486

CRG:	105325103 105333755 105341851

CVN:	111101197 111101820 111104545 111118783 111119763 111119792 111119793

CANU:

128158707 128164749 128167671 128167711 128183445

OED:	125647206 125669850 125671426 125675745 125675797

PMAX:

MCAF:

MMER:

DPOL:

XEN:

HSY:

Reference

PMID:3091013

Authors

Appert HE, Rutherford TJ, Tarr GE, Thomford NR, McCorquodale DJ

Title

Isolation of galactosyltransferase from human milk and the determination of its N-terminal amino acid sequence.

Journal

Biochem Biophys Res Commun 138:224-9 (1986)
DOI:10.1016/0006-291X(86)90269-X

Reference

PMID:3144273

Authors

Masri KA, Appert HE, Fukuda MN

Title

Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase).

Journal

Biochem Biophys Res Commun 157:657-63 (1988)
DOI:10.1016/s0006-291x(88)80300-0

Sequence

[hsa:2683]

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