KEGG ORTHOLOGY: K11427

ORTHOLOGY: K11427

Entry

K11427                      KO

Symbol

DOT1L, DOT1

Name

[histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map05202

Transcriptional misregulation in cancer

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
   HMT complexes
    Dot1-containing complex
     K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase

Other DBs

GO:

0031151

Genes

HSA:	84444(DOT1L)

PTR:	455566(DOT1L)

PPS:	100969530(DOT1L)

GGO:	101134931(DOT1L)

PON:	100450564(DOT1L)

NLE:	100587281 100606063(DOT1L)

HMH:	116472185 116484129(DOT1L)

MCC:	710033(DOT1L)

MCF:	101926502(DOT1L)

MTHB:

126942460

MNI:	105485848(DOT1L)

CSAB:

103233645(DOT1L)

CATY:

105591743(DOT1L)

PANU:

101006747(DOT1L)

TGE:	112612802(DOT1L)

MLEU:

105551998(DOT1L)

RRO:	104671393(DOT1L)

RBB:	108531435(DOT1L)

TFN:	117073985(DOT1L)

PTEH:

111520730(DOT1L)

CANG:

105527695(DOT1L)

CJC:	100407532(DOT1L)

SBQ:	101038132(DOT1L)

CIMI:

108288448(DOT1L)

CSYR:

103267705(DOT1L)

MMUR:

105860741(DOT1L)

LCAT:

123633033(DOT1L)

PCOQ:

105811277(DOT1L)

OGA:	100943444(DOT1L)

MMU:	208266(Dot1l)

MCAL:

110302935(Dot1l)

MPAH:

110326191(Dot1l)

RNO:	362831(Dot1l)

MCOC:

116076571(Dot1l)

ANU:	117696542(Dot1l)

MUN:	110555618(Dot1l)

CGE:	100771005(Dot1l)

MAUA:

101827360(Dot1l)

PROB:

127216594(Dot1l)

PLEU:

114686509(Dot1l)

MORG:

121459335(Dot1l)

MFOT:

126489209

AAMP:

119804509(Dot1l)

NGI:	103737299(Dot1l)

HGL:	101712712(Dot1l)

CPOC:

100713595(Dot1l)

CCAN:

109689927 109689929(Dot1l)

DORD:

105990338(Dot1l)

DSP:	122122869(Dot1l)

PLOP:

125348469(Dot1l)

NCAR:

124968797

MMMA:

107157417(Dot1l)

OPI:	101536127(DOT1L)

TUP:	102494943(DOT1L)

GVR:	103601162(DOT1L)

CFA:	485073(DOT1L)

CLUD:

112666222(DOT1L)

VVP:	112935591(DOT1L)

VLG:	121495589(DOT1L)

NPO:	129521545(DOT1L)

AML:	100464435(DOT1L)

UMR:	103681799(DOT1L)

UAH:	113242759(DOT1L)

UAR:	123793993(DOT1L)

ELK:	111161651 111161720

LLV:

125088548

MPUF:

101684140(DOT1L)

MNP:	132009576(DOT1L)

MLK:	131823234(DOT1L)

NVS:	122909912(DOT1L)

ORO:	101366843(DOT1L)

EJU:	114226156(DOT1L)

ZCA:	113916359(DOT1L)

MLX:	118005686(DOT1L)

NSU:	110593857(DOT1L)

LWW:	102737420(DOT1L)

FCA:	101101194(DOT1L)

PYU:	121021471(DOT1L)

PBG:	122486637(DOT1L)

PVIV:

125160765(DOT1L)

LRUF:

124522929

PTG:	102966497(DOT1L)

PPAD:

109257714(DOT1L)

PUC:

125928821

AJU:

106983698

HHV:	120242313(DOT1L)

BTA:	510442(DOT1L)

BOM:	102280735(DOT1L)

BIU:	109561797(DOT1L)

BBUB:

102405560(DOT1L)

BBIS:

104979876(DOT1L)

CHX:	102180119(DOT1L)

OAS:	101121261(DOT1L)

BTAX:

128050783(DOT1L)

ODA:	120864760(DOT1L)

CCAD:

122440167(DOT1L)

MBEZ:

129559595(DOT1L)

SSC:	100738665(DOT1L)

CFR:	106729841(DOT1L)

CBAI:

105078365(DOT1L)

CDK:	105103623(DOT1L)

VPC:

102542063

BACU:

103011331(DOT1L)

BMUS:

118893214(DOT1L)

LVE:	103083056(DOT1L)

OOR:	101281886(DOT1L)

DLE:	111166180(DOT1L)

PCAD:

102996362(DOT1L)

PSIU:

116752059(DOT1L)

NASI:

112396299(DOT1L)

ECB:	100068506(DOT1L)

EPZ:

103543191

EAI:	106834163(DOT1L)

MYB:	102240787(DOT1L)

MYD:	102773641(DOT1L)

MMYO:

118658025(DOT1L)

MLF:	102433201(DOT1L)

PKL:	118711157(DOT1L)

EFUS:

103294274(DOT1L)

MNA:	107534598(DOT1L)

DRO:	112312198(DOT1L)

SHON:

118984445(DOT1L)

AJM:	119043705(DOT1L)

PDIC:

114502661(DOT1L)

PHAS:

123813761(DOT1L)

MMF:	118643514(DOT1L)

PPAM:

129081426(DOT1L)

HAI:	109390613(DOT1L)

RFQ:	117037866(DOT1L)

PALE:

102893368(DOT1L)

PGIG:

120583726(DOT1L)

PVP:	105300457(DOT1L)

RAY:	107520102(DOT1L)

MJV:	108393233(DOT1L)

TOD:	119240531(DOT1L)

SARA:

101542520(DOT1L)

SETR:

126029612(DOT1L)

LAV:	100661109(DOT1L)

TMU:

101350137

ETF:	101640736(DOT1L)

DNM:	101427615(DOT1L)

MDO:	100619840(DOT1L)

GAS:	123243886(DOT1L)

SHR:	100918350(DOT1L)

AFZ:

127545146

PCW:	110223514(DOT1L)

OAA:	100088528(DOT1L)

GGA:	420078(DOT1L)

PCOC:

116235866(DOT1L)

MGP:	100546682(DOT1L)

CJO:	107325391(DOT1L)

TPAI:

128090426(DOT1L)

LMUT:

125685104(DOT1L)

NMEL:

110388996(DOT1L)

APLA:

101804645(DOT1L)

ACYG:

106045654(DOT1L)

CATA:

118259833(DOT1L)

AFUL:

116498985(DOT1L)

TGU:	100222310(DOT1L)

LSR:	110469481(DOT1L)

SCAN:

103821998(DOT1L)

PMOA:

120496392(DOT1L)

OTC:	121345945(DOT1L)

PRUF:

121353371(DOT1L)

GFR:	102036723(DOT1L)

FAB:	101807609(DOT1L)

OMA:	130264557(DOT1L)

PHI:	102108358(DOT1L)

PMAJ:

107215544(DOT1L)

CCAE:

111940168(DOT1L)

CCW:	104696943(DOT1L)

CBRC:

103620743(DOT1L)

ETL:	114071249(DOT1L) 114071752

ZAB:	102074377(DOT1L)

ACHL:

103797684

SVG:	106857995(DOT1L)

MMEA:

130585505

HRT:	120763502(DOT1L)

FPG:	101911291(DOT1L)

FCH:	102053275(DOT1L)

CLV:	102097756(DOT1L)

EGZ:	104131107(DOT1L)

NNI:	104009661(DOT1L)

PCRI:

104035670(DOT1L)

PLET:

104620532(DOT1L)

EHS:	104508566(DOT1L)

PCAO:

104042665(DOT1L)

ACUN:

113489497(DOT1L)

TALA:

104363231(DOT1L)

PADL:

103921169(DOT1L)

AFOR:

103903641(DOT1L)

ACHC:

115349672(DOT1L)

HALD:

104324695(DOT1L)

HLE:	104831211(DOT1L)

AGEN:

126041799

GCL:

127025623

CCRI:

104162767(DOT1L)

CSTI:

104556762(DOT1L)

CMAC:

104476603(DOT1L)

MUI:	104545131(DOT1L)

BREG:

104642520(DOT1L)

FGA:	104083090(DOT1L)

GSTE:

104255223(DOT1L)

LDI:	104352503(DOT1L)

MNB:

103782145

OHA:	104329413(DOT1L)

NNT:	104404199(DOT1L)

SHAB:

115618067(DOT1L)

DPUB:

104300751(DOT1L)

PGUU:

104461583(DOT1L)

ACAR:

104524443(DOT1L)

CPEA:

104392136(DOT1L)

AVIT:

104278880(DOT1L)

CVF:	104286459(DOT1L)

RTD:	128900525(DOT1L)

CUCA:

104060963(DOT1L)

TEO:	104377974(DOT1L)

BRHI:

104499835(DOT1L)

AAM:	106489522 106489524

AROW:

112971271(DOT1L)

NPD:	112952684(DOT1L)

TGT:	104564488(DOT1L)

DNE:	112991567(DOT1L)

SCAM:

104150642(DOT1L)

ASN:	102368409(DOT1L)

AMJ:	102567829(DOT1L)

CPOO:

109324920(DOT1L)

GGN:	109294827(DOT1L)

PSS:	102455080(DOT1L)

CMY:	102943895(DOT1L)

CCAY:

125627140(DOT1L)

DCC:	119848446(DOT1L)

CPIC:

101947542(DOT1L)

TST:	117869110(DOT1L)

CABI:

116824481(DOT1L)

MRV:	120391639(DOT1L)

ACS:	103282705(dot1l)

ASAO:

132781142(DOT1L)

PVT:	110072436(DOT1L) 110072437

SUND:

121937052(DOT1L)

PBI:	103061368(DOT1L)

PMUR:

107282186(DOT1L)

CTIG:

120301364(DOT1L)

TSR:	106548138(DOT1L) 106555419

PGUT:

117677503(DOT1L)

APRI:

131188263(DOT1L)

PTEX:

113435272(DOT1L)

NSS:	113420953(DOT1L)

VKO:	123035334(DOT1L)

PMUA:

114588420(DOT1L)

PRAF:

128405642(DOT1L)

ZVI:	118085936(DOT1L)

HCG:	128343215(DOT1L)

GJA:	107122041(DOT1L)

STOW:

125432967(DOT1L)

EMC:	129330004(DOT1L)

XLA:	108706873(dot1l.S) 108712856(dot1l.L)

XTR:	100497594(dot1l)

NPR:

108801355

RTEM:

120913393(DOT1L)

BBUF:

120989505(DOT1L)

BGAR:

122919790(DOT1L)

MUO:	115480877(DOT1L)

GSH:	117364629(DOT1L)

DRE:	559945(dot1l)

SRX:	107719574 107729667

SANH:

107655195 107676944

SGH:	107586394 107593341

CCAR:

109047010(dot1l) 109047583 109071951 109099236

CAUA:

113039587 113064939 113077116

CGIB:

127942988 127987341

PTET:

122327709(dot1l)

LROH:

127153523(dot1l)

OMC:	131530447(dot1l)

PPRM:

120495223(dot1l)

RKG:	130089186(dot1l)

MAMB:

125263799(dot1l)

CIDE:

127519717

MASI:

127437915 127439273

TROS:

130548372(dot1l)

TDW:	130429614(dot1l)

MANU:

129453351(dot1l)

IPU:

108270738

IFU:	128613550(dot1l)

PHYP:

113547045(dot1l)

SMEO:

124391641(dot1l)

TFD:	113646121(dot1l)

TVC:	132850972(dot1l)

AMEX:

103023208(dot1l)

CMAO:

118818772(dot1l)

EEE:	113582386(dot1l)

CHAR:

105910723(dot1l)

TRU:	101062350(dot1l)

TFS:	130528223(dot1l)

TNG:	GSTEN00007367G001

LCO:	104918483(dot1l)

NCC:

104968234

TBEN:

117495383(dot1l)

CGOB:

115006711(dot1l)

PGEO:

117445938(dot1l)

GACU:

117546116(dot1l)

EMAC:

134869352(dot1l)

ELY:	117253533(dot1l)

EFO:	125895418(dot1l)

PLEP:

121938762(dot1l)

SLUC:

116063452(dot1l)

ECRA:

117951070(dot1l)

ESP:	116695108(dot1l)

PFLV:

114561070(dot1l)

GAT:	120823388(dot1l)

PPUG:

119216789(dot1l)

AFB:	129094331(dot1l)

CLUM:

117729163(dot1l)

PSWI:

130194420(dot1l)

MSAM:

119900868(dot1l) 119918779

SCHU:

122878097(dot1l)

CUD:	121512146(dot1l)

ALAT:

119028445(dot1l)

MZE:	101473918(dot1l)

ONL:	100700031(dot1l)

OAU:	116310046(dot1l)

OLA:	101166952(dot1l)

OML:	112137065(dot1l)

CSAI:

133458118(dot1l)

XMA:	102227320(dot1l)

XCO:	114151376(dot1l)

XHE:	116725679(dot1l)

PRET:

103463635(dot1l)

PFOR:

103155506(dot1l) 103155507

PLAI:

106950711(dot1l)

PMEI:

106908766(dot1l) 106920479

GAF:	122839040(dot1l)

PPRL:

129370748(dot1l)

CVG:	107089710(dot1l)

CTUL:

119779405(dot1l)

GMU:	124873360(dot1l)

NFU:	107397320(dot1l)

KMR:	108230786(dot1l)

ALIM:

106515034 106534283(dot1l)

NWH:	119430709(dot1l)

AOCE:

111566583(dot1l)

MCEP:

125009262(dot1l)

CSEM:

103376710(dot1l)

POV:	109625401 109645771

SSEN:

122780557(dot1l)

HHIP:

117759933(dot1l)

HSP:	124854783(dot1l)

SMAU:

118318874(dot1l)

LCF:

108877359

SDU:	111232114(dot1l)

SLAL:

111656359(dot1l)

XGL:	120790488(dot1l)

HCQ:	109532198(dot1l)

SSCV:

125974533

SBIA:

133503425(dot1l)

PEE:	133405865(dot1l)

PTAO:

133481343(dot1l)

BPEC:

110174051(dot1l)

MALB:

109973059(dot1l)

BSPL:

114853611(dot1l)

SJO:	128361319(dot1l)

SASA:

106584426 106613781(dot1l)

STRU:

115158259 115192618

OTW:	112233976 112250978

OMY:	110521445 110524305

OGO:	123997071 124037046

ONE:	115108316 115144895

OKI:	109897856 109902511

OKE:	118359228 118389810(dot1l)

SALP:

111972106 111975388

SNH:	120052441 120054782

CCLU:

121533519 121540357

ELS:	105011570(dot1l)

SFM:	108919875(dot1l)

PKI:	111860240(dot1l)

AANG:

118225430(dot1l) 118229550

LOC:	102690905(dot1l)

PSPA:

121301374 121301560

ARUT:

117401515 117428812

PSEX:

120537735(dot1l)

LCM:	102351844(DOT1L)

CMK:	103181918(dot1l)

RTP:

109926363

CPLA:

122565329(dot1l)

HOC:	132828878(dot1l)

LERI:

129711131(dot1l)

PMRN:

116943593(DOT1L)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG42803(gpp)

DER:

6553084

DSE:

6614114

DSI:	Dsimw501_GD19874(Dsim_GD19874)

DYA:	Dyak_GE10220

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23014

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108354426 108361828

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ001411

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:

DPA:	109540967 109542323

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201750

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:	110380490(gpp)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:	114125081 114125093 114125095

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM478060

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_198981 DAPPUDRAFT_47843

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

111629121 111630420 111639298

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_F54F7.7(dot-1.2) CELE_F55G7.2(dot-1.4) CELE_W06D11.4(dot-1.3) CELE_Y39G10AR.18(dot-1.1)

CBR:	CBG_03979 CBG_03980 CBG_26504

NAI:	NECAME_11271

BMY:	BM_BM9325(Bm9325)

LOA:	LOAG_17417

HRO:	HELRODRAFT_74931

LGI:	LOTGIDRAFT_220459

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

OBI:

OSN:

LAK:

SMM:	Smp_165000

SHX:	MS3_00008704(DOT1L_1)

OVI:	T265_14564

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_58052

AQU:

109584002

SCE:	YDR440W(DOT1)

SEUB:

DI49_0608

SPAO:

SPAR_D06230

AGO:	AGOS_AER326C

ERC:

Ecym_4091

KLA:	KLLA0_B01287g

KMX:	KLMA_40588(DOT1)

LTH:	KLTH0G04422g

VPO:	Kpol_1004p44

ZRO:	ZYRO0D13200g

CGR:	CAGL0J10516g

NCS:	NCAS_0F01220(NCAS0F01220)

NDI:	NDAI_0H01750(NDAI0H01750)

TPF:	TPHA_0D02550(TPHA0D02550)

TBL:	TBLA_0D01440(TBLA0D01440) TBLA_0E03030(TBLA0E03030)

TGB:	HG536_0A05750

TDL:	TDEL_0A04190(TDEL0A04190)

KAF:	KAFR_0I00880(KAFR0I00880)

KNG:	KNAG_0C03070(KNAG0C03070)

ZMK:	HG535_0D05220

PPA:	PAS_chr3_1133

DHA:	DEHA2D01694g

PIC:	PICST_41120

PGU:	PGUG_04903

SPAA:

SPAPADRAFT_140015

LEL:	PVL30_003554(DOT1)

CAL:	CAALFM_C306300WA(DOT1)

CTP:	CTRG_02231

COT:	CORT_0C04010

CDU:	CD36_86180

CTEN:

CANTEDRAFT_115043

YLI:	YALI0E22715g

CLU:	CLUG_01248

CLUS:

A9F13_06g00440

CAUR:

CJI96_0001481

SLB:	AWJ20_173(DOT1)

PKZ:	C5L36_0E04360

BBRX:

BRETT_005002

OPA:	HPODL_00709

NCR:

NCU06266

NTE:	NEUTE1DRAFT146228(NEUTE1DRAFT_146228)

SMP:	SMAC_00083(putative_dot1)

PAN:	PODANSg5036

PBEL:

QC761_0106140(DOT1)

PPSD:

QC762_706450(DOT1)

PPSP:

QC763_706450(DOT1)

PPSA:

QC764_706450(DOT1)

TTT:	THITE_2119121

MTM:	MYCTH_2304605

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_5322

SSCK:

SPSK_07317

FGR:	FGSG_02567

FPU:	FPSE_08685

FPOA:

FPOAC1_002690(DOT1)

FVN:	FVRRES_02988

FVR:	FVEG_16524

FOX:	FOXG_10481

NHE:	NECHADRAFT_70385

FFC:	NCS54_00839700

FKR:	NCS57_00882800

FMU:	J7337_005263(DOT1)

TRE:	TRIREDRAFT_48225

TRR:	M419DRAFT_99879

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_04750

PTKZ:

JDV02_002820(DOT1)

VAL:	VDBG_10194

VDA:	VDAG_10394

CFJ:	CFIO01_01877

CLUP:

CLUP02_02843

CHIG:

CH63R_02106

SAPO:

SAPIO_CDS2155

ELA:	UCREL1_8381

PFY:	PFICI_08108

SSL:	SS1G_03126

BFU:	BCIN_08g04180(Bcdot1)

MBE:

MBM_01079

PSCO:

LY89DRAFT_638470

GLZ:	GLAREA_11312

ANI:	ANIA_00091

AFM:	AFUA_5G12110

ACT:	ACLA_015130

NFI:	NFIA_075180

AOR:	AO090120000327

ANG:	An09g02720

AFV:	AFLA_009549

ALUC:

AKAW2_40325A(DOT1)

ACHE:

ACHE_41229S(DOT1)

APUU:

APUU_12067S(DOT1)

PCS:	N7525_007194

PDP:	PDIP_59550

POU:	POX_d05316

TMF:	EYB26_001600

TRG:	TRUGW13939_05683

CIM:	CIMG_09225

CPW:	CPC735_016390

URE:	UREG_05056

PBL:	PAAG_02460

PBN:	PADG_05610

ABE:

ARB_04392

TVE:

TRV_03181

AJE:	HCAG_02616

BGH:	BDBG_07779

PNO:	SNOG_16009

PTE:

PTT_12191

BZE:	COCCADRAFT_98480

BSC:	COCSADRAFT_116087

BOR:	COCMIDRAFT_97389

AALT:

CC77DRAFT_1026200

ARAB:

EKO05_0005237

ZTR:	MYCGRDRAFT_23780(DOT2401)

PFJ:	MYCFIDRAFT_202245 MYCFIDRAFT_80111

FFU:	CLAFUR5_02936 CLAFUR5_06494

CBET:

CB0940_03229

BCOM:

BAUCODRAFT_32279

NPA:	UCRNP2_8424

TML:	GSTUM_00007723001

CNE:

CNK02230

CNB:

CNBK1310

CNG:	CNAG_01882

CGI:	CGB_K1580W

CDEU:

CNBG_3059

TMS:	TREMEDRAFT_74374

TASA:

A1Q1_01745

CCAC:

CcaHIS019_0606110(DOT1)

PPL:	POSPLDRAFT_96954

TVS:	TRAVEDRAFT_140731

DSQ:	DICSQDRAFT_130599 DICSQDRAFT_90557

PCO:	PHACADRAFT_132924

SHS:	STEHIDRAFT_106597

HIR:	HETIRDRAFT_479507

PSQ:	PUNSTDRAFT_94330

ADL:	AURDEDRAFT_93731

FME:	FOMMEDRAFT_107161

GTR:	GLOTRDRAFT_69490

RSX:	RhiXN_00388

LBC:	LACBIDRAFT_321307

CCI:	CC1G_08658

ABP:	AGABI1DRAFT32345(AGABI1DRAFT_32345)

ABV:	AGABI2DRAFT190074(AGABI2DRAFT_190074)

MRR:	Moror_12676

E1B28_009755

SCM:	SCHCO_02521437(SCHCODRAFT_02521437)

CPUT:

CONPUDRAFT_46848

SLA:	SERLADRAFT_478945

WSE:	WALSEDRAFT_34014

WIC:	J056_001693

UMA:	UMAG_05545

PFP:	PFL1_05108

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_00890 PGTG_00895 PGTG_02618

PTRC:

PtA15_17A262

PSTR:

Pst134EA_030521

MLR:	MELLADRAFT_92166

MBR:	MONBRDRAFT_34214

SRE:	PTSG_04671

» show all

Reference

PMID:20230194

Authors

Barry ER, Corry GN, Rasmussen TP

Title

Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.

Journal

Expert Opin Ther Targets 14:405-18 (2010)
DOI:10.1517/14728221003623241

Reference

PMID:11029058

Authors

San-Segundo PA, Roeder GS

Title

Role for the silencing protein Dot1 in meiotic checkpoint control.

Journal

Mol Biol Cell 11:3601-15 (2000)
DOI:10.1091/mbc.11.10.3601

Sequence

[sce:YDR440W]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (3436)   
   KEGG GENES (829)   
   KEGG MGENES (691)   
   RefGene (1907)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (3456)   

Download RDF

ORTHOLOGY: K15588

Entry

K15588                      KO

Symbol

NSD1

Name

[histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00718

Sotos syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K15588  NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K15588  NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.357  [histone H3]-lysine36 N-dimethyltransferase
     K15588  NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K15588  NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1

Other DBs

GO:

0046975

Genes

HSA:	64324(NSD1)

PTR:	471754(NSD1)

PPS:	100991882(NSD1)

GGO:	101130126(NSD1)

PON:	100461473(NSD1)

NLE:	100583251(NSD1)

HMH:	116471895(NSD1)

MCC:	706131(NSD1)

MCF:	102120529(NSD1)

MTHB:

126956311

MNI:	105484060(NSD1)

CSAB:

103245045(NSD1)

CATY:

105581718(NSD1)

PANU:

100999694(NSD1)

TGE:	112625995(NSD1)

MLEU:

105546716(NSD1)

RRO:	104680450(NSD1)

RBB:	108544783(NSD1)

TFN:	117065338(NSD1)

PTEH:

111521582(NSD1)

CANG:

105515145(NSD1)

CJC:	100405201(NSD1)

SBQ:	101052510(NSD1)

CSYR:

103251805(NSD1)

MMUR:

105883848(NSD1)

LCAT:

123623464(NSD1)

PCOQ:

105823490(NSD1)

OGA:	100959941(NSD1)

MMU:	18193(Nsd1)

MCAL:

110308568(Nsd1)

MPAH:

110334011(Nsd1)

RNO:	306764(Nsd1)

MCOC:

116081879(Nsd1)

ANU:	117713601(Nsd1)

MUN:	110549759(Nsd1)

CGE:	100773206(Nsd1)

MAUA:

101826029(Nsd1)

PROB:

127229198(Nsd1)

PLEU:

114689293(Nsd1)

MORG:

121453335(Nsd1)

MFOT:

126502790

AAMP:

119818059(Nsd1)

NGI:	103732357(Nsd1)

HGL:	101698401(Nsd1)

CPOC:

100727598(Nsd1)

CCAN:

109685765(Nsd1)

DORD:

105985509(Nsd1)

DSP:	122096492(Nsd1)

PLOP:

125341966(Nsd1)

NCAR:

124986605

MMMA:

107144631(Nsd1)

OCU:

100355926

OPI:	101523688(NSD1)

TUP:	102476810(NSD1)

GVR:	103594900(NSD1)

CFA:	489094(NSD1)

CLUD:

112651220(NSD1)

VVP:	112925575(NSD1)

VLG:	121487862(NSD1)

NPO:	129509800(NSD1)

AML:	100477428(NSD1)

UMR:	103664453(NSD1)

UAH:	113264138(NSD1)

UAR:	123792255(NSD1)

ELK:

111140757

LLV:

125100900

MPUF:

101692273(NSD1)

MNP:	132028464(NSD1)

MLK:	131831967(NSD1)

NVS:	122892347(NSD1)

ORO:	101380596(NSD1)

EJU:	114208577(NSD1)

ZCA:	113929324(NSD1)

MLX:	118017168(NSD1)

NSU:	110590521(NSD1)

LWW:	102747175(NSD1)

FCA:	101100618(NSD1)

PYU:	121011581(NSD1)

PCOO:

112860995(NSD1)

PBG:	122490135(NSD1)

PVIV:

125165477(NSD1)

LRUF:

124520017

PTG:	102967043(NSD1)

PPAD:

109267571(NSD1)

PUC:

125934959

AJU:

106975404

HHV:	120236753(NSD1)

BTA:	540197(NSD1)

BOM:	102268569(NSD1)

BIU:	109561894(NSD1)

BBUB:

102389358(NSD1)

BBIS:

104993340(NSD1)

CHX:	102184804(NSD1)

OAS:	101120917(NSD1)

BTAX:

128051481(NSD1)

ODA:	120863859(NSD1)

CCAD:

122440040(NSD1)

MBEZ:

129558762(NSD1)

SSC:	100524976(NSD1)

CFR:	102509336(NSD1)

CBAI:

105062042(NSD1)

CDK:

105099584

VPC:	102532487(NSD1)

BACU:

103015430(NSD1)

BMUS:

118892559(NSD1)

LVE:	103079235(NSD1)

OOR:	101279526(NSD1)

DLE:	111169837(NSD1)

PCAD:

102985495(NSD1)

PSIU:

116751743(NSD1)

NASI:

112400062(NSD1)

ECB:	100058570(NSD1)

EPZ:	103565989(NSD1)

EAI:	106827129(NSD1)

MYB:	102257499(NSD1)

MYD:	102764830(NSD1)

MMYO:

118659117(NSD1)

MLF:	102419435(NSD1)

PKL:	118711073(NSD1)

EFUS:

103290251(NSD1)

MNA:	107529770(NSD1)

DRO:	112320360(NSD1)

SHON:

118999742(NSD1)

AJM:	119035139(NSD1)

PDIC:

114510041(NSD1)

PHAS:

123808357(NSD1)

MMF:	118615116(NSD1)

PPAM:

129066718(NSD1)

HAI:	109389766(NSD1)

RFQ:	117016525(NSD1)

PALE:

102879695(NSD1)

PGIG:

120616558(NSD1)

PVP:	105293515(NSD1)

RAY:	107517519(NSD1)

MJV:	108398430(NSD1)

TOD:	119235617(NSD1)

SARA:

101538270(NSD1)

SETR:

126011923(NSD1)

LAV:	100672481(NSD1)

TMU:

101343565

ETF:	101660610(NSD1)

DNM:	101436987(NSD1)

MDO:	100031881(NSD1)

GAS:	123237471(NSD1)

SHR:	100913201(NSD1)

AFZ:

127550272

PCW:	110216684(NSD1)

OAA:	100085446(NSD1)

GGA:	416214(NSD1)

PCOC:

116232071(NSD1)

MGP:	100538695(NSD1)

CJO:	107320315(NSD1)

TPAI:

128081317(NSD1)

LMUT:

125699999(NSD1)

NMEL:

110405534(NSD1)

APLA:

101789499(NSD1)

ACYG:

106049510(NSD1)

CATA:

118254416(NSD1)

AFUL:

116494972(NSD1)

TGU:	100219515(NSD1)

LSR:	110470818(NSD1)

SCAN:

103817363(NSD1)

PMOA:

120498485(NSD1)

OTC:	121332276(NSD1)

PRUF:

121361314(NSD1)

GFR:	102044678(NSD1)

FAB:	101815424(NSD1)

OMA:	130258980(NSD1)

PHI:	102101098(NSD1)

PMAJ:

107210674(NSD1)

CCAE:

111935455(NSD1)

CCW:	104689518(NSD1)

CBRC:

103611554(NSD1)

ETL:	114063848(NSD1)

ZAB:	102072409(NSD1)

SVG:	106852945(NSD1)

MMEA:

130580761(NSD1)

HRT:	120759078(NSD1)

FPG:	101914789(NSD1)

FCH:	102055251(NSD1)

CLV:	102084521(NSD1)

EGZ:	104128865(NSD1)

NNI:	104018995(NSD1)

PCRI:

104038869(NSD1)

PLET:

104619167(NSD1)

EHS:

104514387

PCAO:

104046716(NSD1)

ACUN:

113485238(NSD1)

TALA:

104364331(NSD1)

PADL:

103918809(NSD1)

AFOR:

103904332(NSD1)

ACHC:

115334250(NSD1)

HLE:	104838967(NSD1)

AGEN:

126050779

GCL:

127022004

CCRI:

104167336(NSD1)

CSTI:

104556451(NSD1)

CMAC:

104487773(NSD1)

MUI:	104540881(NSD1)

BREG:

104643598

FGA:	104074595(NSD1)

GSTE:

104254986(NSD1)

LDI:

104353837

MNB:

103768912

OHA:

104331844

NNT:	104402143(NSD1)

SHAB:

115615727(NSD1)

DPUB:

104303995(NSD1)

PGUU:

104465098(NSD1)

ACAR:

104532258(NSD1)

CPEA:

104392668(NSD1)

AVIT:

104277025

CVF:	104294123(NSD1)

RTD:	128916316(NSD1)

CUCA:

104065597(NSD1)

TEO:	104376165(NSD1)

AAM:	106489717(NSD1)

AROW:

112964900(NSD1)

NPD:	112954291(NSD1)

TGT:	104571955(NSD1)

DNE:	112996920(NSD1)

SCAM:

104138156(NSD1)

ASN:	102368735(NSD1)

CPOO:

109310242(NSD1)

GGN:	109289819(NSD1)

PSS:

102461475

CMY:	102930063(NSD1)

CCAY:

125641255(NSD1)

DCC:	119859667(NSD1)

CPIC:

101946796(NSD1)

TST:	117881216(NSD1)

MRV:	120370574(NSD1)

ACS:	100554343(nsd1)

ASAO:

132769045(NSD1)

PVT:	110077543(NSD1)

SUND:

121922396(NSD1)

PBI:	103052448(NSD1)

PMUR:

107295675(NSD1)

CTIG:

120314083(NSD1)

TSR:	106540883(NSD1)

PGUT:

117679936(NSD1)

APRI:

131192538(NSD1)

PTEX:

113455092(NSD1)

NSS:	113415820(NSD1)

VKO:	123033959(NSD1)

PMUA:

114591437(NSD1)

PRAF:

128408058(NSD1)

ZVI:	118080502(NSD1)

HCG:	128344429(NSD1)

GJA:	107111562(NSD1)

STOW:

125428144(NSD1)

EMC:	129327639(NSD1)

XLA:	108710978(nsd1.L) 108713231(nsd1.S)

XTR:	100145675(nsd1)

NPR:	108783740(NSD1)

RTEM:

120932198(NSD1)

BBUF:

120977377(NSD1)

BGAR:

122928197(NSD1)

MUO:	115476125(NSD1)

GSH:	117351507(NSD1)

DRE:	556086(nsd1a) 564592(nsd1b)

SRX:	107707133 107732327 107749737 107750369

SANH:

107668568 107680604 107692785 107697366

SGH:	107587202 107594901 107594938

CCAR:

109066222

CAUA:

113038348 113057599 113070107 113114008

CGIB:

127971584 127985754 128027578

PTET:

122326499(nsd1b) 122357593(nsd1a)

LROH:

127152475(nsd1b) 127176157(nsd1a)

OMC:	131528903(nsd1b) 131553388(nsd1a)

PPRM:

120461163(nsd1a) 120484873(nsd1b)

RKG:	130095533(nsd1b) 130095671(nsd1a)

MAMB:

125253369(nsd1b) 125258751(nsd1a)

CIDE:

127494182 127503936

MASI:

127413112 127417885 127429312 127431017

TROS:

130563597(nsd1a) 130570041(nsd1b)

TDW:	130408001(nsd1b) 130437676(nsd1a)

MANU:

129422153(nsd1a) 129424087(nsd1b)

IPU:	108274654(nsd1a) 108278839(nsd1b)

IFU:	128617777(nsd1a) 128622196(nsd1b)

PHYP:

113541409(nsd1) 113547101

SMEO:

124392022(nsd1a) 124397961(nsd1b)

TFD:	113653696(nsd1a) 113662452(nsd1b)

TVC:	132856806(nsd1a) 132860189(nsd1b)

AMEX:

103025117 103039586(nsd1)

CMAO:

118812144(nsd1a) 118819669(nsd1b)

EEE:	113571257(nsd1) 113586032

CHAR:

105892263(nsd1b) 122130258(nsd1a)

TRU:	101067941 101068764

TFS:	130531626(nsd1a) 130537069(nsd1b)

LCO:	104918973(nsd1) 104938502

NCC:	104946245 104947748

TBEN:

117475084(nsd1a) 117490330(nsd1b)

CGOB:

115014841 115018694

PGEO:

117453693(nsd1a) 117458193(nsd1b)

GACU:

117554586(nsd1b) 117556014(nsd1a)

EMAC:

134860258(nsd1a) 134871747(nsd1b)

ELY:	117261036(nsd1a) 117266280(nsd1b)

EFO:	125894495(nsd1a) 125898149(nsd1b)

PLEP:

121947918(nsd1a) 121952204(nsd1b)

SLUC:

116055965(nsd1b) 116064417(nsd1a)

ECRA:

117952096(nsd1a) 117955328(nsd1b)

ESP:	116697219 116701131

PFLV:

114562336 114566381(nsd1)

GAT:	120817770(nsd1a) 120822047(nsd1b)

PPUG:

119210320(nsd1a) 119215462(nsd1b)

AFB:	129089993(nsd1a) 129113341(nsd1b)

CLUM:

117737432(nsd1a) 117743188(nsd1b)

PSWI:

130209760(nsd1a) 130211970(nsd1b)

MSAM:

119888963(nsd1a) 119895341(nsd1b)

SCHU:

122879955(nsd1a) 122887940(nsd1b)

CUD:	121516378(nsd1a) 121518725(nsd1b)

ALAT:

119007214(nsd1a) 119030826(nsd1b)

MZE:	101464914 101485022

ONL:	100692734 100711505

OAU:	116319053(nsd1b) 116329176(nsd1a)

OLA:	101160669 101161079

OML:	112142357(nsd1b) 112153222(nsd1a)

CSAI:

133446905(nsd1a) 133459376(nsd1b)

XMA:	102216707 102218934

XCO:	114139208 114153215

XHE:	116714363 116728633

PRET:

103460020 103471190

PFOR:

103131187(nsd1) 103135607

PLAI:

106955399 106964181

PMEI:

106925649 106933171

GAF:	122837590(nsd1a) 122845326(nsd1b)

PPRL:

129362639(nsd1a) 129373462

CVG:	107098399(nsd1) 107101862

CTUL:

119786906 119792508(nsd1a)

GMU:	124860268(nsd1a) 124876432(nsd1b)

NFU:	107375248 107386691(nsd1)

KMR:	108238064(nsd1b) 108240580(nsd1a)

ALIM:

106517727 106532900

NWH:	119408262(nsd1a) 119420823

AOCE:

111575329 111583207

MCEP:

125007772(nsd1a) 125020842(nsd1b)

CSEM:

103391225 103394931

POV:

109628620

SSEN:

122778246(nsd1a) 122780080(nsd1b)

HHIP:

117769406(nsd1a) 117774297(nsd1b)

HSP:	118112241(nsd1a) 118122475(nsd1b)

SMAU:

118300350(nsd1b) 118319314(nsd1a)

LCF:	108882946(nsd1a) 108893500(nsd1b)

SDU:	111226751 111234523

SLAL:

111652699 111659982

XGL:	120785217(nsd1a) 120802452(nsd1b)

HCQ:	109515816 109517985

SSCV:

125981764 125982156

SBIA:

133492276(nsd1b) 133509200(nsd1a)

PEE:	133407737(nsd1a) 133416443(nsd1b)

PTAO:

133467744(nsd1b) 133484513

BPEC:

110156439(nsd1) 110157647

MALB:

109959233 109971164

BSPL:

114864545(nsd1a) 114869004(nsd1b)

SJO:	128363085(nsd1a) 128371810(nsd1b)

SASA:

106568016 106603477 106604211 106612244

STRU:

115148812 115154280 115167353 115205703

OTW:	112221254 112228536 112255881 112257909(nsd1b)

OMY:	110489176 110504362 110533599 110537528(nsd1b)

OGO:	123992395 124000401(nsd1b) 124011037 124011600

ONE:	115105497 115120485 115129191 115135948

OKI:	109873277 109878333 109880548 109892779

OKE:	118376376(nsd1a) 118384071 118390692 118391120

SALP:

111950608 111981370

SNH:	120043850 120047361(nsd1a)

CCLU:

121530909 121538892 121551679 121578879

ELS:	105011124 105026233

SFM:	108920103(nsd1) 108925444

PKI:	111847915 111860900(nsd1)

AANG:

118222572(nsd1a) 118235812(nsd1b)

PSPA:

121296991 121324882

ARUT:

117413340 117431641

PSEX:

120542612

LCM:	102346523(NSD1)

CMK:

103189717

HOC:	132823306(nsd1a)

LERI:

CSET:

AGB:

LDC:

PPYR:

BMOR:

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

HHAL:

CSEC:

PTRU:

EAF:

OVI:	T265_13785

» show all

Reference

PMID:12151224

Authors

Schneider R, Bannister AJ, Kouzarides T

Title

Unsafe SETs: histone lysine methyltransferases and cancer.

Journal

Trends Biochem Sci 27:396-402 (2002)
DOI:10.1016/S0968-0004(02)02141-2

Reference

PMID:21196496

Authors

Qiao Q, Li Y, Chen Z, Wang M, Reinberg D, Xu RM

Title

The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation.

Journal

J Biol Chem 286:8361-8 (2011)
DOI:10.1074/jbc.M110.204115

Sequence

[hsa:64324]

ORTHOLOGY: K11431

Entry

K11431                      KO

Symbol

SETD7

Name

[histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04068

FoxO signaling pathway

Reaction

R03875

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11431  SETD7; [histone H3]-lysine4 N-methyltransferase
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K11431  SETD7; [histone H3]-lysine4 N-methyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11431  SETD7; [histone H3]-lysine4 N-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.364  [histone H3]-lysine4 N-methyltransferase
     K11431  SETD7; [histone H3]-lysine4 N-methyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11431  SETD7; [histone H3]-lysine4 N-methyltransferase

Genes

HSA:	80854(SETD7)

PTR:	737682(SETD7)

PPS:	100981554(SETD7)

GGO:	101136477(SETD7)

PON:	100449956(SETD7)

NLE:	100602353(SETD7)

HMH:	116464191(SETD7)

MCC:	700426(SETD7)

MCF:	102140141(SETD7)

MTHB:

126954611

MNI:	105493270(SETD7)

CSAB:

103236281(SETD7)

CATY:

105580796(SETD7)

PANU:

101000127(SETD7)

TGE:	112624982(SETD7)

MLEU:

105543640(SETD7)

RRO:	104654337(SETD7)

RBB:	108522758(SETD7)

TFN:	117085930(SETD7)

PTEH:

111551894(SETD7)

CANG:

105513712(SETD7)

CJC:	100414241(SETD7)

SBQ:	101047679(SETD7)

CIMI:

108285584(SETD7)

CSYR:

103268843(SETD7)

MMUR:

105872354(SETD7)

LCAT:

123638556(SETD7)

PCOQ:

105818790(SETD7)

OGA:	100945363(SETD7)

MMU:	73251(Setd7)

MCAL:

110291535(Setd7)

MPAH:

110320364(Setd7)

RNO:	689954(Setd7)

MCOC:

116094448(Setd7)

ANU:	117707268(Setd7)

MUN:	110545142(Setd7)

CGE:	100767175(Setd7)

MAUA:

101833171(Setd7)

PROB:

127216290(Setd7)

PLEU:

114695856(Setd7)

MORG:

121452703(Setd7)

MFOT:

126499295

AAMP:

119826811(Setd7)

NGI:	103742371(Setd7)

HGL:	101715832(Setd7)

CPOC:

100717030(Setd7)

CCAN:

109691464(Setd7)

DORD:

105995681(Setd7)

DSP:	122127063(Setd7)

PLOP:

125341559(Setd7)

NCAR:

124994431

MMMA:

107136774(Setd7)

OCU:	100347837 103347079

OPI:	101525115(SETD7)

TUP:	102470517(SETD7)

GVR:	103598077(SETD7)

CFA:	476079(SETD7)

CLUD:

112669303(SETD7)

VVP:	112934919(SETD7)

VLG:	121493076(SETD7)

NPO:	129504360(SETD7)

AML:	100472168(SETD7)

UMR:	103658074(SETD7)

UAH:	113255688(SETD7)

UAR:	123793270(SETD7)

ELK:

111149217

LLV:

125093407

MPUF:

101689867(SETD7)

MNP:	132003198(SETD7)

MLK:	131827580(SETD7)

NVS:	122919177(SETD7)

ORO:	101368440(SETD7)

EJU:	114208204(SETD7)

ZCA:	113924298(SETD7)

MLX:	118022305(SETD7)

NSU:	110571226(SETD7)

LWW:	102732503(SETD7)

FCA:	101091191(SETD7)

PYU:	121029498(SETD7)

PCOO:

112858830(SETD7)

PBG:	122497157(SETD7)

PVIV:

125163461(SETD7)

LRUF:

124520384

PTG:	102953445(SETD7)

PPAD:

109249505(SETD7)

PUC:

125923703

AJU:

106976180

HHV:	120243120(SETD7)

BTA:	515928(SETD7)

BOM:	102281809(SETD7)

BIU:	109571070(SETD7)

BBUB:

102394548(SETD7)

BBIS:

104981281(SETD7)

CHX:	102191824(SETD7)

OAS:	101115990(SETD7)

BTAX:

128062407(SETD7)

ODA:	120870919(SETD7)

CCAD:

122452420(SETD7)

MBEZ:

129542908(SETD7)

SSC:	100626704(SETD7)

CFR:	102506865(SETD7)

CBAI:

105068694(SETD7)

CDK:	105087090(SETD7)

VPC:	102524998(SETD7)

BACU:

103002269(SETD7)

BMUS:

118895399(SETD7)

LVE:	103071598(SETD7)

OOR:	101282114(SETD7)

DLE:	111179118(SETD7)

PCAD:

102986025(SETD7)

PSIU:

116754191(SETD7)

NASI:

112393722(SETD7)

ECB:	100063257(SETD7)

EPZ:	103551020(SETD7)

EAI:	106838612(SETD7)

MYB:	102246482(SETD7)

MYD:	102760166(SETD7)

MMYO:

118658870(SETD7)

MLF:	102420812(SETD7)

PKL:	118711609(SETD7)

EFUS:

103287919(SETD7)

MNA:	107534917(SETD7)

DRO:	112312687(SETD7)

SHON:

118995450(SETD7)

AJM:	119035000(SETD7)

PDIC:

114502804(SETD7)

PHAS:

123813703(SETD7)

MMF:	118616067(SETD7)

PPAM:

129062210(SETD7)

HAI:	109394201(SETD7)

RFQ:	117037595(SETD7)

PALE:

102890289(SETD7)

PGIG:

120613215(SETD7)

PVP:	105301564(SETD7)

RAY:	107515339(SETD7)

MJV:	108408880(SETD7)

TOD:	119233342(SETD7)

SARA:

101549012(SETD7)

SETR:

126003756(SETD7)

LAV:	100653839(SETD7)

TMU:

101344981

ETF:	101659235(SETD7)

DNM:	101421633(SETD7)

MDO:	100027436(SETD7)

GAS:	123252357(SETD7)

SHR:	100929261(SETD7)

AFZ:

127541067

PCW:	110194897(SETD7)

OAA:	100081674(SETD7)

GGA:	422443(SETD7)

PCOC:

116226098(SETD7)

MGP:	100541967(SETD7)

CJO:	107313101(SETD7)

TPAI:

128084197(SETD7)

LMUT:

125692603(SETD7)

NMEL:

110397503(SETD7)

APLA:

101800254(SETD7)

ACYG:

106040965(SETD7)

CATA:

118249041(SETD7)

AFUL:

116488501(SETD7)

TGU:	100219994(SETD7)

LSR:	110468513(SETD7)

SCAN:

103822533(SETD7)

PMOA:

120496051(SETD7)

OTC:	121339860(SETD7)

PRUF:

121354681(SETD7)

GFR:	102040515(SETD7)

FAB:	101807375(SETD7)

OMA:	130252415(SETD7)

PHI:	102106186(SETD7)

PMAJ:

107203381(SETD7)

CCAE:

111928908(SETD7)

CCW:	104697344(SETD7)

CBRC:

103614500(SETD7)

ETL:	114058383(SETD7)

ZAB:	102060643(SETD7)

ACHL:

103811991(SETD7)

SVG:	106854850(SETD7)

MMEA:

130582140(SETD7)

HRT:	120752876(SETD7)

FPG:	101917301(SETD7)

FCH:	102053523(SETD7)

CLV:	102087865(SETD7)

EGZ:	104134673(SETD7)

NNI:	104015980(SETD7)

PCRI:

104025880(SETD7)

PLET:

104615039(SETD7)

EHS:	104506793(SETD7)

PCAO:

104043135(SETD7)

ACUN:

113479515(SETD7)

TALA:

104355912(SETD7)

PADL:

103920974(SETD7)

AFOR:

103908041(SETD7)

ACHC:

115340127(SETD7)

HALD:

104311811(SETD7)

HLE:	104841757(SETD7)

AGEN:

126044801

GCL:

127015791

CCRI:

104156546(SETD7)

CSTI:

104558150(SETD7)

CMAC:

104482055(SETD7)

MUI:	104534099(SETD7)

BREG:

104633114(SETD7)

FGA:	104071165(SETD7)

GSTE:

104261127(SETD7)

LDI:	104355035(SETD7)

MNB:

103777339

OHA:	104336712(SETD7)

NNT:	104399857(SETD7)

SHAB:

115610541(SETD7)

DPUB:

104296893(SETD7)

PGUU:

104466135(SETD7)

ACAR:

104518406(SETD7)

CPEA:

104398836(SETD7)

AVIT:

104277500(SETD7)

CVF:	104292760(SETD7)

RTD:	128909777(SETD7)

CUCA:

104066446(SETD7)

TEO:	104370121(SETD7)

BRHI:

104494161(SETD7)

AAM:	106491857(SETD7)

AROW:

112965423(SETD7)

NPD:	112950140(SETD7)

TGT:	104572216(SETD7)

DNE:	112986730(SETD7)

SCAM:

104153396(SETD7)

ASN:	102374512(SETD7)

AMJ:	102568755(SETD7)

CPOO:

109309619(SETD7)

GGN:	109300943(SETD7)

PSS:	102461649(SETD7)

CMY:	102943205(SETD7)

DCC:	119854462(SETD7)

CPIC:

101930966(SETD7)

TST:	117878085(SETD7)

CABI:

116838884(SETD7)

MRV:	120406434(SETD7)

ACS:	100551939(setd7)

ASAO:

132776841(SETD7)

PVT:	110073660(SETD7)

SUND:

121931253(SETD7)

PBI:	103056555(SETD7)

PMUR:

107293153(SETD7)

CTIG:

120308391(SETD7)

TSR:	106552387(SETD7)

PGUT:

117654595(SETD7)

APRI:

131202936(SETD7)

PTEX:

113434727(SETD7)

NSS:	113412900(SETD7)

VKO:	123023767(SETD7)

PMUA:

114604135(SETD7)

PRAF:

128421082(SETD7)

ZVI:	118083714(SETD7)

HCG:	128328141(SETD7)

GJA:	107110772(SETD7)

STOW:

125439932(SETD7)

EMC:	129336639(SETD7)

XLA:	108699643(setd7.L)

XTR:	613102(setd7)

NPR:	108787523(SETD7)

RTEM:

120919160(SETD7)

BBUF:

120989985(SETD7)

BGAR:

122943234(SETD7)

MUO:	115461695(SETD7)

GSH:	117358068(SETD7)

DRE:	436729(setd7)

SRX:	107756477(setd7)

SANH:

107676520 107680671

SGH:	107550878(setd7)

CCAR:

109102488 109102490

CAUA:

113091145 113114054

CGIB:

127971159 128027536

PTET:

122357501(setd7)

LROH:

127176589(setd7)

OMC:	131552944(setd7)

PPRM:

120461020(setd7)

RKG:	130089750(setd7)

MAMB:

125258654(setd7)

CIDE:

127525633

MASI:

127413043 127417647

TROS:

130564145(setd7)

TDW:	130437854(setd7)

MANU:

129422106(setd7)

IPU:

108268872

IFU:	128611939(setd7)

PHYP:

113542848(setd7)

SMEO:

124386009(setd7)

TFD:	113646026(setd7)

TVC:	132856283(setd7)

AMEX:

103021629(setd7)

CMAO:

118806996(setd7)

EEE:	113581529(setd7)

CHAR:

105906286(setd7)

TRU:	101062805(setd7)

TFS:	130531797(setd7)

TNG:	GSTEN00006924G001

LCO:	104921509(setd7)

EMAC:

134860066(setd7)

ELY:	117261475(setd7)

EFO:	125894079(setd7)

PLEP:

121948402(setd7)

SLUC:

116064266(setd7)

ECRA:

117951530(setd7)

ESP:	116696640(setd7)

PFLV:

114562736(setd7)

GAT:	120817395(setd7)

PPUG:

119210080(setd7)

AFB:	129090365(setd7)

CLUM:

117737829(setd7)

PSWI:

130209445(setd7)

MSAM:

119888249(setd7)

SCHU:

122880152(setd7)

CUD:	121506619(setd7)

ALAT:

119008014(setd7)

MZE:	101473334(setd7)

ONL:	100690490(setd7)

OAU:	116315791(setd7)

OLA:	101168630(setd7)

OML:	112137845(setd7)

CSAI:

133447300(setd7)

XMA:	102221628 111606868

XCO:	114138924 114138925 114138929 114139661

XHE:	116714746(setd7)

PRET:

103470998(setd7)

PFOR:

103131843(setd7)

PLAI:

106940589(setd7)

PMEI:

106911657

GAF:	122836555(setd7)

PPRL:

129353849(setd7)

CVG:	107098607(setd7)

CTUL:

119791848(setd7)

GMU:	124860286(setd7)

NFU:	107387053(setd7)

KMR:	108240006(setd7)

ALIM:

106533608(setd7)

AOCE:

111573617(setd7)

MCEP:

125008622(setd7)

CSEM:

103391447(setd7)

POV:	109627395(setd7)

SSEN:

122778922(setd7)

HHIP:

117769700(setd7)

HSP:	118111964(setd7)

SMAU:

118319969(setd7)

LCF:

108875518

SDU:	111230382(setd7)

SLAL:

111663588(setd7)

XGL:

120784942

HCQ:	109529075(setd7)

SSCV:

125988864

SBIA:

133509122(setd7)

PEE:	133407712(setd7)

PTAO:

133484935(setd7)

BPEC:

110173499(setd7)

MALB:

109966416(setd7)

SJO:	128363339(setd7)

SASA:

106604693(setd7)

STRU:

115172267(setd7)

OTW:	112220930(setd7)

OMY:	110488800(setd7)

OGO:	123993393(setd7)

ONE:	115130681(setd7)

OKI:	109864768(setd7)

OKE:	118377847(setd7)

SALP:

111965713(setd7)

SNH:	120048113(setd7)

CCLU:

121542657(setd7)

ELS:	105029145(setd7)

SFM:	108930830(setd7)

PKI:	111847325(setd7)

AANG:

118232021(setd7)

LOC:	102697545(setd7)

PSPA:

121330524(setd7)

ARUT:

117408888(setd7)

PSEX:

120527812(setd7)

LCM:	102350182(SETD7)

CMK:	103181297(setd7)

RTP:	109919566(setd7)

CPLA:

122539362(setd7)

HOC:	132833222(setd7)

PMRN:

116942974(SETD7)

LRJ:	133343014(SETD7)

BFO:

118404594

BBEL:

109465143

LSM:	121115289 121115290 121115291 121115870 121116800 121119313 121119989 121121197 121121404 121121906 121122188 121123424 121124562 121125595 121126320 121126321

TCF:	131877368 131877932 131878774 131878780 131878800 131878986 131879688 131880850 131881794 131884191 131887594 131887734 131888582 131889043 131890169 131891539

HMG:

101238060

HSY:

130655480

TAD:	TRIADDRAFT_26073

AQU:

105311972

MBR:	MONBRDRAFT_17496

DDI:	DDB_G0288227

DPP:	DICPUDRAFT_154738

DFA:

DFA_11520

ACAN:

ACA1_399220

SMIN:

v1.2.013565.t1(symbB.v1.2.013565.t1)

EHX:	EMIHUDRAFT_196287

GTT:	GUITHDRAFT_99101

» show all

Reference

PMID:12540855

Authors

Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ

Title

Structure and catalytic mechanism of the human histone methyltransferase SET7/9.

Journal

Nature 421:652-6 (2003)
DOI:10.1038/nature01378

Sequence

[hsa:80854]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (6246)   
   KEGG GENES (461)   
   KEGG MGENES (284)   
   RefGene (5499)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (6260)   

Download RDF

ORTHOLOGY: K06101

Entry

K06101                      KO

Symbol

ASH1L

Name

[histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L

Other DBs

GO:

0042800

Genes

HSA:	55870(ASH1L)

PTR:	107971434(ASH1L)

PPS:	100979709(ASH1L)

GGO:	101134264(ASH1L)

NLE:	100580011(ASH1L)

HMH:	116469304(ASH1L)

MCC:	717778(ASH1L)

MCF:	101867084(ASH1L)

MTHB:

126932888

MNI:	105498260(ASH1L)

CSAB:

103223879(ASH1L)

CATY:

105593539(ASH1L)

PANU:

101019457(ASH1L)

TGE:	112621576(ASH1L)

MLEU:

105544859(ASH1L)

RRO:	104659604(ASH1L)

RBB:	108526806(ASH1L)

TFN:	117074556(ASH1L)

PTEH:

111543765(ASH1L)

CANG:

105502046(ASH1L)

CJC:	100393607(ASH1L)

SBQ:	101046051(ASH1L)

CIMI:

108297159(ASH1L)

CSYR:

103255836(ASH1L)

MMUR:

105873156(ASH1L)

LCAT:

123634072(ASH1L)

PCOQ:

105821867(ASH1L)

OGA:	100954638(ASH1L)

MMU:	192195(Ash1l)

MCAL:

110291461(Ash1l)

MPAH:

110320636(Ash1l)

RNO:	310638(Ash1l)

MCOC:

116093147(Ash1l)

ANU:	117707081(Ash1l)

MUN:	110548961(Ash1l)

CGE:	100754103(Ash1l)

MAUA:

101823215(Ash1l)

PROB:

127232663(Ash1l)

PLEU:

114707881(Ash1l)

MORG:

121450522(Ash1l)

MFOT:

126516121

AAMP:

119800836(Ash1l)

NGI:	103750808(Ash1l)

HGL:	101723836(Ash1l)

CPOC:

100717586(Ash1l)

CCAN:

109688014(Ash1l)

DORD:

105984904(Ash1l)

DSP:	122109545(Ash1l)

PLOP:

125359696(Ash1l)

NCAR:

124994959

MMMA:

107156714(Ash1l)

OCU:

100354541

OPI:	101535854(ASH1L)

TUP:	102469443(ASH1L)

GVR:	103603651(ASH1L)

CFA:	480128(ASH1L)

CLUD:

112648925(ASH1L)

VVP:	112918925(ASH1L)

VLG:	121485278(ASH1L)

NPO:	129508576(ASH1L)

AML:	100474237(ASH1L)

UMR:	103668369(ASH1L)

UAH:	113245266(ASH1L)

UAR:	123783381(ASH1L)

ELK:

111138933

LLV:

125085470

MPUF:

101692156(ASH1L)

MNP:	132025893(ASH1L)

MLK:	131815219(ASH1L)

NVS:	122918271(ASH1L)

ORO:	101362745(ASH1L)

EJU:	114198572(ASH1L)

ZCA:	113933287(ASH1L)

MLX:	118013887(ASH1L)

NSU:	110573557(ASH1L)

LWW:	102729035(ASH1L)

FCA:	101086114(ASH1L)

PYU:	121015632(ASH1L)

PCOO:

112851746(ASH1L)

PBG:	122476171(ASH1L)

PVIV:

125155107(ASH1L)

LRUF:

124521683

PTG:	102969379(ASH1L)

PPAD:

109256230(ASH1L)

PUC:

125925697

AJU:

106981535

HHV:	120244733(ASH1L)

BTA:	540563(ASH1L)

BOM:	102275046(ASH1L)

BIU:	109553548(ASH1L)

BBUB:

102415367(ASH1L)

BBIS:

104987397(ASH1L)

CHX:	102185413(ASH1L)

OAS:	101119775(ASH1L)

BTAX:

128044530(ASH1L)

ODA:	120855721(ASH1L)

CCAD:

122432434(ASH1L)

MBEZ:

129541286(ASH1L)

SSC:	100155920(ASH1L)

CFR:	102510601(ASH1L)

CBAI:

105068149(ASH1L)

CDK:	105088782(ASH1L)

VPC:	102541092(ASH1L)

BACU:

103015822(ASH1L)

BMUS:

118883966(ASH1L)

LVE:	103087473(ASH1L)

OOR:	101288541(ASH1L)

DLE:	111167169(ASH1L)

PCAD:

102993773(ASH1L)

PSIU:

116749029(ASH1L)

NASI:

112401717(ASH1L)

ECB:	100057386(ASH1L)

EPZ:	103548807 103552840

EAI:	106828486(ASH1L)

MYB:	102256394(ASH1L)

MYD:	102764796(ASH1L)

MMYO:

118673205(ASH1L)

MLF:	102422609(ASH1L)

PKL:	118721618(ASH1L)

EFUS:

103298888(ASH1L)

MNA:	107543779(ASH1L)

DRO:	112316914(ASH1L)

SHON:

118990223(ASH1L)

AJM:	119039727(ASH1L)

PDIC:

114489233(ASH1L)

PHAS:

123804317(ASH1L)

MMF:	118637054(ASH1L)

PPAM:

129062300(ASH1L)

HAI:	109393386(ASH1L)

RFQ:	117014381(ASH1L)

PALE:

102888124(ASH1L)

PGIG:

120592114(ASH1L)

PVP:	105296438(ASH1L)

RAY:	107521457(ASH1L)

MJV:	108407349(ASH1L)

TOD:	119235659(ASH1L)

SARA:

101536883(ASH1L)

SETR:

126020683(ASH1L)

LAV:	100668468(ASH1L)

TMU:

101348724

ETF:	101640320(ASH1L)

DNM:	101437622(ASH1L)

MDO:	100017118(ASH1L)

GAS:	123247906(ASH1L)

SHR:	100931585(ASH1L)

AFZ:

127559804

PCW:	110211945(ASH1L)

OAA:	103168045(ASH1L)

GGA:	425064(ASH1L)

PCOC:

116240863(ASH1L)

MGP:	100539732(ASH1L)

CJO:	107324503(ASH1L)

TPAI:

128092065(ASH1L)

LMUT:

125685860(ASH1L)

NMEL:

110387902(ASH1L)

APLA:

119713747(ASH1L)

ACYG:

106048498(ASH1L)

CATA:

118258443(ASH1L)

AFUL:

116499662(ASH1L)

TGU:	100229714(ASH1L)

LSR:	110471483(ASH1L)

SCAN:

103823951(ASH1L)

PMOA:

120498930(ASH1L)

OTC:	121332147(ASH1L)

PRUF:

121352178(ASH1L)

GFR:	102042927(ASH1L)

FAB:	101819907(ASH1L)

OMA:	130263172(ASH1L)

PHI:	102113028(ASH1L)

PMAJ:

107214568(ASH1L)

CCAE:

111939443(ASH1L)

CBRC:

103611269(ASH1L)

ETL:	114069574(ASH1L)

SVG:	106861120(ASH1L)

MMEA:

130586867(ASH1L)

HRT:	120764150(ASH1L)

FPG:	101913546(ASH1L)

FCH:	102056587(ASH1L)

CLV:	102090928(ASH1L)

EGZ:	104134854(ASH1L)

NNI:	104020487(ASH1L)

PCRI:

104034316

EHS:	104504530(ASH1L)

ACUN:

113488743(ASH1L)

TALA:

104365486(ASH1L)

PADL:

103913294(ASH1L)

AFOR:

103894959(ASH1L)

ACHC:

115346307(ASH1L)

HALD:

104311829(ASH1L)

HLE:	104829641(ASH1L)

AGEN:

126040631

GCL:

127027048

CCRI:

104156176

CSTI:

104554497(ASH1L)

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:	104341118(ASH1L)

MNB:	103776047(ASH1L)

OHA:	104329765(ASH1L)

NNT:	104406553(ASH1L)

SHAB:

115602803(ASH1L)

DPUB:

104310254(ASH1L)

PGUU:

104460694

CPEA:

104387244(ASH1L)

AVIT:

104280494

CVF:	104294109(ASH1L)

RTD:	128901143(ASH1L)

CUCA:

104057090(ASH1L)

BRHI:

104492230

AAM:	106494341(ASH1L)

AROW:

112978246(ASH1L)

NPD:	112952957(ASH1L)

TGT:	104565882(ASH1L)

DNE:	112992196(ASH1L)

SCAM:

104139355(ASH1L)

ASN:	102372997(ASH1L)

AMJ:	102571713(ASH1L)

CPOO:

109324810(ASH1L)

GGN:	109305142(ASH1L)

PSS:	102448117(ASH1L)

CMY:	102943662(ASH1L)

CCAY:

125626207(ASH1L)

DCC:	119848004(ASH1L)

CPIC:

101942050(ASH1L)

TST:	117888659(ASH1L)

CABI:

116817234(ASH1L)

MRV:	120390221(ASH1L)

ACS:	100563888(ash1l)

ASAO:

132764246(ASH1L)

PVT:	110081037(ASH1L)

SUND:

121916058(ASH1L)

PBI:	103060233(ASH1L)

PMUR:

107297020(ASH1L)

CTIG:

120317174(ASH1L)

TSR:

106538172

PGUT:

117658860(ASH1L)

APRI:

131186393(ASH1L)

PTEX:

113446585(ASH1L)

NSS:	113426974(ASH1L)

VKO:	123032623(ASH1L)

PMUA:

114586229(ASH1L)

PRAF:

128403918(ASH1L)

ZVI:	118076583(ASH1L)

HCG:	128336928(ASH1L)

GJA:	107119617(ASH1L)

STOW:

125441054(ASH1L)

EMC:	129339539(ASH1L)

XLA:	108699167 108700623

XTR:	108645568(ash1l)

NPR:	108794233(ASH1L)

RTEM:

120920770(ASH1L)

MUO:	115456952(ASH1L)

GSH:	117350090(ASH1L)

DRE:	563799(ash1l)

SRX:	107707165 107724081 107739498 107743194

SANH:

107656475 107673015 107685579 107693346

SGH:	107589474 107596620 107598430 107599509

CCAR:

109111952

CAUA:

113059914 113116331 113120006

CGIB:

127934925 127979019

PTET:

122323584(ash1l)

LROH:

127181447(ash1l)

OMC:	131525287(ash1l)

PPRM:

120483798(ash1l) 120484714

RKG:	130070828(ash1l)

MAMB:

125244159 125275540(ash1l)

CIDE:

127500630

MASI:

127420966 127425594

TROS:

130566565(ash1l)

TDW:	130415758(ash1l)

MANU:

129455335(ash1l)

IPU:	108267029 108272684(ash1l)

IFU:	128615239(ash1l)

PHYP:

113535206 113542280(ash1l)

SMEO:

124381860(ash1l) 124385197

TFD:	113641274(ash1l) 113644404

TVC:	132842875(ash1l)

AMEX:

103022779 103036607

CMAO:

118805977(ash1l)

EEE:	113570594 113572615

CHAR:

105901435(ash1l) 105906726

TRU:	101065064 101078475

TFS:	130518819(ash1l) 130532300

TNG:	GSTEN00032567G001

LCO:	104929091 104934663

NCC:	104942643 104958848(ash1l)

TBEN:

117477916(ash1l) 117480263

CGOB:

115015423

PGEO:

117455328(ash1l) 117461084

GACU:

117540997 117542568(ash1l)

EMAC:

134861400 134874850(ash1l)

ELY:	117263128(ash1l) 117265713

EFO:	125892769 125904401(ash1l)

PLEP:

121945149 121957926(ash1l)

SLUC:

116047314(ash1l) 116049571

ECRA:

117946694 117956323(ash1l)

ESP:	116691354 116701264

PFLV:

114557800(ash1l) 114567637

GAT:	120825936(ash1l)

PPUG:

119197439 119218735(ash1l)

AFB:	129097038(ash1l) 129109105

CLUM:

117738591(ash1l) 117745551

PSWI:

130199528(ash1l) 130212726

MSAM:

119897568 119908147(ash1l)

SCHU:

122864341(ash1l) 122882158

CUD:	121513663 121524306(ash1l)

ALAT:

119005927 119014819(ash1l)

MZE:	101465538 101472002

ONL:	100706567(ash1l) 100707110

OAU:	116315704 116319419(ash1l)

OLA:	101156847(ash1l) 101161417

OML:	112143321 112162542(ash1l)

CSAI:

133432525 133461347(ash1l)

XMA:	102219717 102229525(ash1l)

XCO:	114141764(ash1l) 114156414

XHE:	116717078(ash1l) 116730665

PRET:

103472762 103478185(ash1l)

PFOR:

103140776(ash1l) 103144472

PLAI:

106938021 106954688 106964214

PMEI:

106917899(ash1l) 106918176

GAF:	122830959 122843303(ash1l)

PPRL:

129371196 129374981(ash1l)

CVG:	107084057 107088414(ash1l)

CTUL:

119779602(ash1l) 119783008

GMU:	124865811 124879004(ash1l)

NFU:	107379592(ash1l) 107394561

KMR:	108240202(ash1l) 108241069

ALIM:

106520872 106531577(ash1l)

NWH:	119409732 119425388(ash1l)

AOCE:

111570477

MCEP:

125016431 125019564(ash1l)

CSEM:

103388251(ash1l) 103394569

POV:	109633377 109639158

SSEN:

122774591 122786837(ash1l)

HHIP:

117770539(ash1l)

HSP:	118113702 118125034(ash1l)

SMAU:

118291884(ash1l) 118299741

LCF:	108885923 108888847

SDU:	111223036 111230135(ash1l)

SLAL:

111652181(ash1l) 111657636

XGL:	120783754 120786127(ash1l)

HCQ:	109513128 109521050(ash1l)

SSCV:

125986976

SBIA:

133500492 133504115(ash1l)

PEE:	133395365(ash1l) 133401323

PTAO:

133471177(ash1l) 133479435

BPEC:

110163006(ash1l) 110167402

MALB:

109951508 109964099(ash1l)

BSPL:

114843444 114865435(ash1l)

SJO:	128366440 128373753(ash1l)

SASA:

106570093 106588182 106605880(ash1l)

STRU:

115173287 115176059

OTW:	112229989 112266640

OMY:	110487650 110496012(ash1l) 110520799 110520835

OGO:	123998200 124013137 124043678

ONE:	115128210 115131772

OKI:	109882336 109882341 109903805 109907687

OKE:	118379684 118383326 118398364 118399115

SALP:

111955046 112070639

SNH:	120026898(ash1l) 120041142 120047244 120048866

CCLU:

121571414(ash1l) 121586317

ELS:	105006914 105024439

SFM:	108925420(ash1l)

PKI:	111840856(ash1l) 111858202

AANG:

118234224(ash1l) 118236528

PSPA:

121306919

ARUT:

117395225 117969039

PSEX:

120537978(ash1l)

LCM:	102367246(ASH1L)

CPLA:

122544720(ash1l)

HOC:	132805626(ash1l)

LERI:

129715786

PMRN:

116942143 116954923(ASH1L)

LRJ:	133342177(ASH1L) 133343620

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG8887(ash1)

DER:

6545341

DSI:	Dsimw501_GD12268(Dsim_GD12268)

DYA:	Dyak_GE22484

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13513

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:	101901319 131805647

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ001202 CpipJ_CPIJ001203

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208029

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119839737 119839791

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM244720

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DMK:

PVM:	113819372 113819373

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

PPOI:

DSV:

RMP:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_T12F5.4(lin-59)

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

PPA:	PAS_chr1-1_0102

YLI:	YALI0D21684g

NCR:	NCU01932(set-3)

NTE:	NEUTE1DRAFT125465(NEUTE1DRAFT_125465)

SMP:	SMAC_05383

PAN:	PODANSg050

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2111453

MTM:	MYCTH_2298281

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_7438

SSCK:

SPSK_05820

FGR:	FGSG_08916

FPU:	FPSE_08917

FPOA:

FPOAC1_005073

FVN:	FVRRES_05596

FVR:	FVEG_02520

FOX:	FOXG_03647

NHE:	NECHADRAFT_123121(SDG2103)

FFC:	NCS54_00437800

FKR:	NCS57_00444500

FMU:	J7337_008861

TRE:	TRIREDRAFT_59359

TRR:	M419DRAFT_75768

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_02950

PTKZ:

JDV02_008304

VAL:	VDBG_01967

VDA:	VDAG_10334

CFJ:	CFIO01_08009

CLUP:

CLUP02_14796

CHIG:

CH63R_09988

SAPO:

SAPIO_CDS5211

ELA:	UCREL1_654

PFY:	PFICI_02813

SSL:	SS1G_04018

BFU:	BCIN_01g02240

MBE:

MBM_00593

PSCO:

LY89DRAFT_691849

GLZ:	GLAREA_11975

ANI:	ANIA_04764

AFM:	AFUA_3G06480

ACT:	ACLA_034430

NFI:	NFIA_070790

AOR:	AO090020000101

ANG:	An11g09860

AFV:	AFLA_010555

PCS:	N7525_009200

PDP:	PDIP_00750

POU:	POX_g09054

TMF:	EYB26_008952

TRG:	TRUGW13939_11162

CIM:	CIMG_00441

CPW:	CPC735_057720

URE:	UREG_00487

PBL:	PAAG_05913

PBN:	PADG_06078

ABE:

ARB_07287

TVE:

TRV_02019

AJE:	HCAG_01200

BGH:	BDBG_06685

ARAB:

EKO05_0004468

ZTR:	MYCGRDRAFT_97419

FFU:	CLAFUR5_14562

CBET:

CB0940_05501

BCOM:

BAUCODRAFT_402857

NPA:	UCRNP2_7239

TML:	GSTUM_00002654001

TASA:

A1Q1_02180

UMA:	UMAG_00400

PFP:	PFL1_06302

PGR:	PGTG_16563

SRE:	PTSG_04178

» show all

Reference

PMID:21239497

Authors

An S, Yeo KJ, Jeon YH, Song JJ

Title

Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.

Journal

J Biol Chem 286:8369-74 (2011)
DOI:10.1074/jbc.M110.203380

Sequence

[hsa:55870]

ORTHOLOGY: K11419

Entry

K11419                      KO

Symbol

SUV39H, CLR4

Name

[histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.355  [histone H3]-lysine9 N-trimethyltransferase
     K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H

Other DBs

GO:

0046974

Genes

HSA:	6839(SUV39H1) 79723(SUV39H2)

PTR:	107971148(SUV39H1) 466014(SUV39H2)

PPS:	100977497(SUV39H1) 100982469(SUV39H2)

GGO:	101126338(SUV39H2) 101146540(SUV39H1)

PON:	100172621(SUV39H1) 100436926(SUV39H2)

NLE:	100591032(SUV39H2) 100598636(SUV39H1)

HMH:	116470963(SUV39H2) 116811661(SUV39H1)

MCC:	697378(SUV39H2) 711040(SUV39H1)

MCF:	102123944 102134179(SUV39H1) 102136014(SUV39H2)

MTHB:

126945594 126962370

MNI:	105490642(SUV39H2) 105493901(SUV39H1)

CSAB:

103231938(SUV39H1) 103237926(SUV39H2)

CATY:

105573130(SUV39H1) 105583853(SUV39H2) 105598847

PANU:

101002260(SUV39H2) 101003206 101007672(SUV39H1)

TGE:	112604683 112616406(SUV39H1) 112631347(SUV39H2)

MLEU:

105530542(SUV39H2) 105547724(SUV39H1)

RRO:	104660660(SUV39H1) 104664471(SUV39H2)

RBB:	108517467(SUV39H1) 108531071(SUV39H2)

TFN:	117062164 117078273(SUV39H1) 117082672(SUV39H2)

PTEH:

111528202 111535700(SUV39H1) 111550038(SUV39H2)

CANG:

105506196(SUV39H2) 105515012(SUV39H1) 105519677

CJC:	100401369(SUV39H1) 100401513(SUV39H2)

SBQ:	101040475(SUV39H2) 101052197(SUV39H1)

CIMI:

108300896(SUV39H1) 108305252(SUV39H2)

CSYR:

103254226(SUV39H1) 103267726(SUV39H2)

MMUR:

105856353(SUV39H2) 105856376(SUV39H1) 105871464

LCAT:

123625405(SUV39H2) 123628362(SUV39H1)

PCOQ:

105816777(SUV39H1) 105823671(SUV39H2)

OGA:	100954282(SUV39H2) 100956539(SUV39H1)

MMU:	20937(Suv39h1) 64707(Suv39h2)

MCAL:

110287176(Suv39h1) 110289296(Suv39h2)

MPAH:

110313347(Suv39h1) 110333642(Suv39h2)

RNO:	302553(Suv39h1) 364785(Suv39h2)

MCOC:

116068177(Suv39h1) 116082667(Suv39h2)

ANU:	117694599(Suv39h1) 117714230(Suv39h2)

MUN:	110554698(Suv39h2) 110561991(Suv39h1)

CGE:	100755145(Suv39h2) 100764568(Suv39h1)

MAUA:

101838624(Suv39h1) 101844757(Suv39h2)

PROB:

127237547(Suv39h2)

PLEU:

114686373 114701015 114701306(Suv39h1) 114710826(Suv39h2)

MORG:

121432621(Suv39h2) 121442585 121442661

MFOT:

126506760 126512880

AAMP:

119805158(Suv39h1) 119816729(Suv39h2)

NGI:	103735184(Suv39h2) 103741644(Suv39h1)

HGL:	101701917(Suv39h2) 101706867(Suv39h1)

CPOC:

100728513(Suv39h2) 100731248(Suv39h1)

CCAN:

109691500(Suv39h2) 109701207(Suv39h1)

DORD:

105984374(Suv39h2) 105997867(Suv39h1) 106000651

DSP:	122098810(Suv39h1) 122113286(Suv39h2) 122120623

PLOP:

125343311(Suv39h1) 125343986 125366781(Suv39h2)

NCAR:

124961476 124971891

MMMA:

107140435(Suv39h2) 107159818(Suv39h1)

OCU:	100354725 100358024

OPI:	101516403(SUV39H2) 101529760 101533574(SUV39H1)

TUP:	102468719(SUV39H1) 102472765

GVR:	103589452(SUV39H1) 103602806(SUV39H2)

CFA:	477995(SUV39H2) 491868(SUV39H1)

CLUD:

112658894(SUV39H2) 112673138(SUV39H1)

VVP:	112907242(SUV39H1) 112933120(SUV39H2)

VLG:	121482956(SUV39H1) 121497217(SUV39H2)

NPO:	129514028(SUV39H2) 129517744(SUV39H1)

AML:	100469547(SUV39H2) 100472595(SUV39H1)

UMR:	103664189(SUV39H2) 103669105(SUV39H1)

UAH:	113241391(SUV39H2) 113265922(SUV39H1)

UAR:	123785960(SUV39H2) 123790887(SUV39H1)

ELK:	111150521 111155595

LLV:	125091942 125107523

MPUF:

101675209(SUV39H1) 101693651(SUV39H2)

MNP:	132006848(SUV39H1) 132020152(SUV39H2)

MLK:	131820762(SUV39H1) 131838248(SUV39H2)

NVS:	122892395(SUV39H2) 122896983(SUV39H1)

ORO:	101374258(SUV39H2) 101381146(SUV39H1)

EJU:	114210177 114216775(SUV39H1) 114217278(SUV39H2)

ZCA:	113921911(SUV39H2) 113925008 113930896(SUV39H1)

MLX:	118010050(SUV39H1) 118021560(SUV39H2)

NSU:	110570881(SUV39H1) 110586530(SUV39H2)

LWW:	102732476(SUV39H2) 102734674(SUV39H1)

FCA:	101083571(SUV39H1) 101099218(SUV39H2)

PYU:	121014778(SUV39H2) 121025917(SUV39H1)

PCOO:

112867563(SUV39H2) 112870989(SUV39H1)

PBG:	122473257(SUV39H2) 122477943(SUV39H1)

PVIV:

125157596(SUV39H1) 125170198(SUV39H2)

LRUF:

124502538 124509510

PTG:	102950897(SUV39H1) 102963752(SUV39H2)

PPAD:

109248069(SUV39H1) 109273698(SUV39H2)

PUC:	125918609 125931659

AJU:	106970864 106971016

HHV:	120221011(SUV39H1) 120236934(SUV39H2)

BTA:	523047(SUV39H1) 536936(SUV39H2)

BOM:	102264756(SUV39H2) 102271191(SUV39H1)

BIU:	109567973(SUV39H2)

BBUB:

102401546(SUV39H1) 102415169(SUV39H2)

BBIS:

105003032(SUV39H2)

CHX:	102174919(SUV39H1) 102176621(SUV39H2)

OAS:	101110031(SUV39H1) 101116417(SUV39H2)

BTAX:

128058674(SUV39H2) 128069954(SUV39H1)

ODA:	120869586(SUV39H2) 120882096(SUV39H1)

CCAD:

122434492(SUV39H1) 122448086(SUV39H2) 122453800

MBEZ:

129539286 129558220(SUV39H2) 129564331(SUV39H1)

SSC:	664651(SUV39H2) 767626(SUV39H1)

CFR:	102521199(SUV39H2)

CBAI:

105072449(SUV39H2) 105079433(SUV39H1)

CDK:	105103308(SUV39H1) 105104521(SUV39H2)

VPC:	102525580(SUV39H1) 102545741(SUV39H2)

BACU:

102999710(SUV39H2) 103005831(SUV39H1)

BMUS:

118889064(SUV39H1) 118889791(SUV39H2)

LVE:	103073919(SUV39H1) 103084616(SUV39H2)

OOR:	101279239(SUV39H2) 101289196(SUV39H1)

DLE:	111169525(SUV39H1) 111178089(SUV39H2)

PCAD:

102988226(SUV39H2) 102988363(SUV39H1)

PSIU:

116747305(SUV39H1) 116748760(SUV39H2)

NASI:

112395395(SUV39H2) 112415988(SUV39H1)

ECB:	100062108(SUV39H1) 100068891(SUV39H2)

EPZ:	103544360 103544897(SUV39H1) 103556824(SUV39H2)

EAI:	106827436(SUV39H1) 106840452(SUV39H2)

MYB:	102243180(SUV39H1) 102260054(SUV39H2)

MYD:	102757145(SUV39H2) 102763954(SUV39H1)

MMYO:

118653933(SUV39H1) 118655474(SUV39H2)

MLF:	102425465(SUV39H1) 102432659(SUV39H2)

PKL:	118731722(SUV39H2) 118731771(SUV39H1)

EFUS:

103292577(SUV39H2) 103301285(SUV39H1)

MNA:	107534821(SUV39H2) 107541392(SUV39H1)

DRO:	112320455(SUV39H2) 112322458(SUV39H1)

SHON:

118997120(SUV39H2) 118998320(SUV39H1)

AJM:	119046306(SUV39H2) 119059808(SUV39H1)

PDIC:

114492683(SUV39H2) 114504865(SUV39H1)

PHAS:

123831095(SUV39H2) 123832782(SUV39H1)

MMF:	118636303(SUV39H1) 118643229(SUV39H2)

PPAM:

129065126(SUV39H1) 129086670(SUV39H2)

HAI:	109374812(SUV39H1) 109393823(SUV39H2)

RFQ:	117019247(SUV39H2) 117027799(SUV39H1)

PALE:

102894853(SUV39H1) 102898400(SUV39H2)

PGIG:

120587091(SUV39H1) 120614623(SUV39H2)

PVP:	105291688(SUV39H2) 105310010(SUV39H1)

RAY:	107504834(SUV39H2) 107515026(SUV39H1)

MJV:	108397103(SUV39H2) 108408400(SUV39H1)

TOD:	119244708(SUV39H2) 119246174(SUV39H1)

SARA:

101537099(SUV39H2) 101551845(SUV39H1)

SETR:

125999218(SUV39H1) 126014500(SUV39H2)

LAV:	100653780(SUV39H1) 100674328(SUV39H2)

TMU:	101347009 101348006

ETF:	101642805(SUV39H1) 101650388(SUV39H2)

DNM:	101410810(SUV39H2) 101431137(SUV39H1)

MDO:	100014806(SUV39H2) 100018670(SUV39H1)

GAS:	123249577(SUV39H2) 123254217(SUV39H1)

SHR:	100922258(SUV39H1) 100933751(SUV39H2)

AFZ:	127538359 127542923

PCW:	110201087(SUV39H1) 110217388(SUV39H2)

OAA:	100084051(SUV39H1) 100085175(SUV39H2)

GGA:	112529927(SUV39H1) 426314(SUV39H2)

PCOC:

116226677(SUV39H2) 116240919(SUV39H1)

MGP:	100539540(SUV39H2) 100548070 104916314

CJO:	107307203(SUV39H1) 107319605(SUV39H2)

TPAI:

128079646(SUV39H2)

LMUT:

125701293(SUV39H2)

NMEL:

110391539(SUV39H1) 110392282(SUV39H2)

APLA:

101796000(SUV39H2)

ACYG:

106046190(SUV39H2)

CATA:

118249431(SUV39H2)

AFUL:

116501666(SUV39H1) 116502296(SUV39H2)

TGU:	100225827(SUV39H2)

LSR:	110470972(SUV39H2) 110481760(SUV39H1)

SCAN:

103813741(SUV39H2)

PMOA:

120508289(SUV39H1) 120509265(SUV39H2)

OTC:	121339649(SUV39H1) 121340539(SUV39H2)

PRUF:

121351466(SUV39H1) 121362326(SUV39H2)

GFR:	102031848(SUV39H2)

FAB:	101814584 101816158(SUV39H2)

OMA:	130248391(SUV39H2)

PHI:	102110616(SUV39H1) 102114300(SUV39H2)

PMAJ:

107204624(SUV39H2)

CCAE:

111923103(SUV39H2)

CCW:	104694491(SUV39H2)

CBRC:

103619827(SUV39H2)

ETL:	114067551(SUV39H2)

ZAB:	102072951(SUV39H2)

ACHL:

103809755(SUV39H2)

SVG:	106857201(SUV39H2) 106863835(SUV39H1)

MMEA:

130573756(SUV39H2)

HRT:	120751545(SUV39H2)

FPG:	101912815(SUV39H2)

FCH:	102059458(SUV39H2)

CLV:	102098917(SUV39H2)

EGZ:	104132393(SUV39H2)

NNI:	104014630(SUV39H2)

PCRI:

104025251(SUV39H2)

PLET:

104621630(SUV39H2)

EHS:	104504052(SUV39H2)

PCAO:

104040081(SUV39H2)

ACUN:

113489768(SUV39H2)

TALA:

104358970(SUV39H2)

PADL:

103915032(SUV39H2)

AFOR:

103904163(SUV39H2)

ACHC:

115341481(SUV39H2)

HALD:

104311858(SUV39H2)

HLE:	104840187(SUV39H2)

AGEN:

126044433

GCL:	127013323 127028025

CCRI:

104165623(SUV39H2)

CSTI:

104554346(SUV39H2)

CMAC:

104474267(SUV39H2)

MUI:	104548728(SUV39H2)

BREG:

104630351(SUV39H2)

FGA:	104071424(SUV39H2)

GSTE:

104252364(SUV39H2)

LDI:	104351471(SUV39H2)

MNB:	103778373(SUV39H2)

OHA:	104337645(SUV39H2)

NNT:	104400243(SUV39H2)

SHAB:

115604906(SUV39H2) 115614601(SUV39H1)

DPUB:

104300079(SUV39H2)

PGUU:

104467057(SUV39H2)

ACAR:

104518833(SUV39H2)

CPEA:

104391931(SUV39H2)

AVIT:

104280300(SUV39H2)

CVF:	104284642(SUV39H2)

RTD:	128903193(SUV39H1) 128906894(SUV39H2)

CUCA:

104059191 104066427(SUV39H2)

TEO:	104370577(SUV39H2)

BRHI:

104494427(SUV39H2)

AAM:	106485143(SUV39H2)

AROW:

112978060(SUV39H2)

NPD:	112942367(SUV39H2)

TGT:	104569918(SUV39H2)

DNE:	112994764(SUV39H2)

SCAM:

104147717(SUV39H2)

ASN:	102375358(SUV39H2) 102378805(SUV39H1)

AMJ:	102558468(SUV39H1) 102563656(SUV39H2)

CPOO:

109315785(SUV39H2)

GGN:	109292195(SUV39H2)

PSS:	102454204(SUV39H2) 102462370(SUV39H1)

CMY:	102937045(SUV39H2) 102937831(SUV39H1)

CCAY:

125628293(SUV39H1) 125630502(SUV39H2)

DCC:	119846993(SUV39H1) 119850738(SUV39H2)

CPIC:

101945875(SUV39H2) 101951503(SUV39H1)

TST:	117874798(SUV39H2)

CABI:

116818898(SUV39H1) 116836408(SUV39H2)

MRV:	120388525(SUV39H1) 120395171(SUV39H2)

ACS:	100553897(suv39h1)

ASAO:

132767602(SUV39H1)

PVT:	110081193(SUV39H1)

SUND:

121922732(SUV39H1)

PBI:	103052540(SUV39H1)

PMUR:

107300048(SUV39H1)

CTIG:

120306632(SUV39H1)

TSR:	106546114(SUV39H1)

PGUT:

117675420(SUV39H1)

APRI:

131191629(SUV39H1)

PTEX:

113443263(SUV39H1)

NSS:	113417787(SUV39H1)

VKO:	123023976(SUV39H1)

PMUA:

114588136(SUV39H1)

PRAF:

128405041(SUV39H1)

ZVI:	118097686(SUV39H1)

HCG:	128343984(SUV39H1)

GJA:	107112843(SUV39H1)

STOW:

125429255(SUV39H1)

EMC:	129346140(SUV39H1)

XLA:	100037174(suv39h2.L) 108700299(suv39h1.S) 108713053(suv39h2.S) 431943(suv39h1.L)

XTR:	116408207 549262(suv39h2)

NPR:	108788266(SUV39H1) 108794066(SUV39H2)

RTEM:

120914074(SUV39H1) 120931719(SUV39H2)

BBUF:

120983221(SUV39H2) 121009587(SUV39H1)

BGAR:

122925399(SUV39H2) 122946834(SUV39H1)

MUO:	115462395(SUV39H1) 115478820(SUV39H2)

GSH:	117349866(SUV39H1) 117366471(SUV39H2)

DRE:	326906(suv39h1b) 445198(suv39h1a)

SRX:	107707679(suv39h1) 107711921 107731148

SANH:

107668084 107669636 107679310

SGH:	107549953 107550505 107571686 107591797

CCAR:

109050848 109068236 109082351

CAUA:

113080156 113093937 113107270 113107584 113107647

CGIB:

127963667 127963948 128018622

PTET:

122350199(suv39h1a) 122350205(suv39h1b)

LROH:

127169300(suv39h1a) 127170313(suv39h1b)

OMC:	131545270(suv39h1b) 131546077(suv39h1a)

PPRM:

120469056(suv39h1a) 120483495(suv39h1b)

RKG:	130094587(suv39h1b) 130094655(suv39h1a)

MAMB:

125279861(suv39h1b) 125280489(suv39h1a)

CIDE:

127516956 127518080

MASI:

127414501 127423831 127424355

TROS:

130568294(suv39h1b) 130568410(suv39h1a)

TDW:	130440295(suv39h1b) 130440297(suv39h1a)

MANU:

129413716(suv39h1b) 129414325(suv39h1a)

IPU:	108265282(suv39h1a) 108265881(suv39h1b)

IFU:	128607866(suv39h1a) 128607941(suv39h1b)

PHYP:

113534019 113540759

SMEO:

124399714(suv39h1a) 124399954(suv39h1b)

TFD:	113655884(suv39h1a) 113656002(suv39h1b)

TVC:	132853834(suv39h1a) 132853939(suv39h1b)

AMEX:

103040252 103041908

CMAO:

118812876(suv39h1a) 118813757(suv39h1b)

EEE:	113579097 113581117

CHAR:

105893664(suv39h1b) 105898965(suv39h1a)

TRU:	101070634 115249168

TFS:

130529445

TNG:	GSTEN00008490G001

LCO:	104932794(suv39h1)

NCC:	104953540(suv39h1)

TBEN:

117481505

CGOB:

115019085(suv39h1)

PGEO:

117448963 117449516

GACU:

117535476

EMAC:

134872286(suv39h1b)

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116693088(suv39h1)

PFLV:

114559282(suv39h1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130199704(suv39h1b)

MSAM:

119904964

SCHU:

122882470

CUD:

121518164

ALAT:

119022825(suv39h1b)

MZE:	101475727(suv39h1)

ONL:	100693758(suv39h1)

OAU:	116311434 116317088

OLA:	101155408(suv39h1)

OML:

112140032

XMA:	102218201(suv39h1)

XCO:	114142201(suv39h1)

XHE:	116721277(suv39h1)

PRET:

103466971(suv39h1)

PFOR:

103154222(suv39h1)

PLAI:

106957137(suv39h1)

PMEI:

106928341(suv39h1)

GAF:	122820970 122837012

PPRL:

129371865(suv39h1b)

CVG:	107090999(suv39h1)

CTUL:

119786878

GMU:

124875741

NFU:	107390532(suv39h1)

KMR:

108231967

ALIM:

106527380(suv39h1)

NWH:

119416867

AOCE:

111588288(suv39h1)

MCEP:

125020725

CSEM:

103384853(suv39h1)

POV:	109630999(suv39h1)

SSEN:

122777668

HHIP:

117765148(suv39h1a)

HSP:

118111057

SMAU:

118317298

LCF:

108900517

SDU:	111219081(suv39h1)

SLAL:

111670830(suv39h1)

XGL:

120804350

HCQ:	109528227(suv39h1)

SSCV:

125988769

SBIA:

133511861(suv39h1a)

PEE:	133408196(suv39h1a)

PTAO:

133486514(suv39h1a)

BPEC:

110156027(suv39h1)

MALB:

109965296(suv39h1)

BSPL:

114859242(suv39h1b)

SJO:	128356886(suv39h1b)

SASA:

106566827 106567313 106572223 106572377

STRU:

115165747 115166297 115168254

OTW:	112215887 112216612 112222060

OMY:	110492276 110532480

OGO:	124022560 124031815 124045067

ONE:	115102224 115132021 115132329

OKI:	109869445 109907876 109908559

OKE:	118359742 118360846 118361267

SALP:

111966328 111966640 111976965

SNH:	120058874 120058957 120060725

CCLU:

121538205 121538517 121545532 121545663

ELS:	105013831(suv39h1) 105022372

SFM:	108934780(suv39h1)

PKI:	111847791(suv39h1)

AANG:

118208326(suv39h1a)

LOC:	102685370(suv39h1)

PSPA:

121328396

ARUT:

117401622 117404230

PSEX:

120542706

LCM:	102351913 102360554(SUV39H2)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116942370(SUV39H2)

LRJ:	133349470(SUV39H2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG43664(Su(var)3-9)

DAN:

DPO:

DPE:

DMN:

DWI:	6647325 6649359

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

AARA:

AMER:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ019323

CPII:

120426320

CNS:

116347715

BCOO:

119066565 119075575 119078065 119080347

ACER:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NVG:

TCA:

DPA:

AGRG:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

MSEX:

DPL:	KGM_203219

BANY:

112043085 112047822

MJU:	123870125 123880531

NIQ:

VCD:

MCIX:

PRAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CCRN:

API:	100161603(Su(var)3-9) 100161910 100165299 103309898

DNX:	107165795 107173978 107174002

AGS:	114131380 114131445

RMD:	113556537 113557531

ACOO:

126838163 126838549

DVT:	126894257 126897767

BTAB:

109035926 109038184

DCI:	103505434 103507862

CLEC:

106661131

MQU:

128991507

PHU:	Phum_PHUM423590

FOC:	113204601 113206980

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:	110848867 110850699

DPX:	DAPPUDRAFT_306854

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:	111243931 111246042

VJA:	111260615 111267950

CSCU:

111614908

PTEP:

107457147

ABRU:

129960866 129971436 129972293

UDV:

129221009

SDM:	118195474 118205485

LPOL:

106457344

NAI:	NECAME_05130 NECAME_06579

LOA:	LOAG_18944

TSP:

Tsp_05330

HRO:	HELRODRAFT_131923

LGI:	LOTGIDRAFT_134869

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111107127 111110608

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_027300

SHX:	MS3_00007274

OVI:	T265_13777

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:	100640934 109585408

PVIR:

120678325

OLU:	OSTLU_25709(SDG3507)

OTA:	OT_ostta18g00210

BPG:	Bathy14g00980

MIS:	MICPUN_64853

MPP:	MICPUCDRAFT_54214(JGI:MicpuC2_54214)

NCR:	NCU04402(dim-5)

NTE:	NEUTE1DRAFT121214(NEUTE1DRAFT_121214)

SMP:	SMAC_07345

PAN:	PODANSg7447

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2114845

MTM:	MYCTH_2086155

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_02778

FPU:	FPSE_10781

FPOA:

FPOAC1_002919(DIM5)

FVN:	FVRRES_03236

FVR:	FVEG_08911

FOX:	FOXG_10263

NHE:	NECHADRAFT_94199(SDG2104)

FFC:	NCS54_00791900

FMU:	J7337_005481(DIM5)

TRE:	TRIREDRAFT_111216

TRR:	M419DRAFT_89807

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_03193

PTKZ:

JDV02_005401

VDA:	VDAG_07826

CHIG:

CH63R_00107

ELA:	UCREL1_2940

PFY:	PFICI_00682

SSL:	SS1G_01550

BFU:	BCIN_11g02360(BcDIM5)

MBE:

MBM_05751

PSCO:

LY89DRAFT_600648

GLZ:	GLAREA_08846

ANI:	ANIA_01170

AFM:	AFUA_1G11090

ACT:	ACLA_024460

NFI:	NFIA_014540

AOR:	AO090038000300

ANG:	An08g03380

AFV:	AFLA_008787

ALUC:

AKAW2_30689A

ACHE:

ACHE_30207S

APUU:

APUU_50577S

PCS:	N7525_003280

PDP:	PDIP_30370

POU:	POX_c04074

TMF:	EYB26_003001

TRG:	TRUGW13939_03059

CIM:	CIMG_06955

CPW:	CPC735_033270

URE:	UREG_05902

PBL:	PAAG_03011

PBN:	PADG_02881

ABE:

ARB_02816

TVE:

TRV_01916

AJE:	HCAG_01813

BGH:	BDBG_00259

PNO:	SNOG_14974

PTE:

PTT_11395

BZE:	COCCADRAFT_96085

BSC:	COCSADRAFT_123285

BOR:	COCMIDRAFT_92785

AALT:

CC77DRAFT_1060195

ARAB:

EKO05_0001435

ZTR:	MYCGRDRAFT_107709(SDG2411)

PFJ:	MYCFIDRAFT_149458

FFU:	CLAFUR5_00190 CLAFUR5_12582

CBET:

CB0940_00773

BCOM:

BAUCODRAFT_100172

NPA:	UCRNP2_4835

SPO:	SPBC428.08c(clr4)

SOM:	SOMG_05025(clr4)

CNE:

CNH00720

CNB:

CNBL0680

CNG:	CNAG_05404

CGI:	CGB_L0430W

CDEU:

CNBG_4448

TMS:	TREMEDRAFT_74418

TASA:

A1Q1_02905

TVS:	TRAVEDRAFT_112981 TRAVEDRAFT_55782

DSQ:	DICSQDRAFT_110205 DICSQDRAFT_51443

SHS:	STEHIDRAFT_168918

HIR:	HETIRDRAFT_319697

PSQ:	PUNSTDRAFT_54070 PUNSTDRAFT_80062

ADL:	AURDEDRAFT_114614 AURDEDRAFT_93052 AURDEDRAFT_93062

FME:	FOMMEDRAFT_167613 FOMMEDRAFT_20301

GTR:	GLOTRDRAFT_125040

LBC:	LACBIDRAFT_296206(SDG16210) LACBIDRAFT_300409(SDG16205)

CCI:	CC1G_12392

ABP:	AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)

ABV:	AGABI2DRAFT146074(AGABI2DRAFT_146074) AGABI2DRAFT180791(AGABI2DRAFT_180791)

MRR:	Moror_11412 Moror_2531

E1B28_007567

SCM:	SCHCO_01174894(SCHCODRAFT_01174894)

CPUT:

CONPUDRAFT_117641 CONPUDRAFT_56532

SLA:	SERLADRAFT_391489 SERLADRAFT_468863

DPP:	DICPUDRAFT_55529

EHX:	EMIHUDRAFT_457456

NGR:	NAEGRDRAFT_51681

» show all

Reference

PMID:14765126

Authors

Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva I, Robin P, Cabon F, Polesskaya A, Harel-Bellan A

Title

A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

Journal

EMBO J 23:605-15 (2004)
DOI:10.1038/sj.emboj.7600074

Sequence

[hsa:6839 79723]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (3136)   
   KEGG GENES (1015)   
   KEGG MGENES (478)   
   RefGene (1620)   
   OC (23)   
Literature (1)   
   PubMed (1)   
All databases (3153)   

Download RDF

ORTHOLOGY: K11428

Entry

K11428                      KO

Symbol

SETD8

Name

[histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11428  SETD8; [histone H4]-lysine20 N-methyltransferase SETD8
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11428  SETD8; [histone H4]-lysine20 N-methyltransferase SETD8
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.361  [histone H4]-lysine20 N-methyltransferase
     K11428  SETD8; [histone H4]-lysine20 N-methyltransferase SETD8
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11428  SETD8; [histone H4]-lysine20 N-methyltransferase SETD8

Other DBs

GO:

0042799

Genes

HSA:	387893(KMT5A)

PTR:	452343(KMT5A)

PPS:	100978154 100986737(KMT5A) 117978852

GGO:	101145513(KMT5A)

PON:	100451760(KMT5A)

NLE:	100580339(KMT5A)

HMH:	116477743(KMT5A)

MCC:	709345(KMT5A)

MCF:	102128021(KMT5A)

MTHB:

126930652

MNI:	105494001(KMT5A)

CSAB:

103239328(KMT5A)

CATY:

105591004(SETD8)

PANU:

101010043(KMT5A)

TGE:	112635259(KMT5A)

MLEU:

105528012(SETD8)

RRO:	104666320(KMT5A)

RBB:	108540752(KMT5A)

TFN:	117080344 117089217(KMT5A)

PTEH:

111538508 111539563

CANG:

105516385(SETD8) 105526098

CJC:	100414548(KMT5A)

SBQ:	101040690(SETD8)

CIMI:

108294847 108315116(KMT5A)

CSYR:

103271959(KMT5A)

MMUR:

105880868(KMT5A)

LCAT:

123626118(KMT5A)

PCOQ:

105825686(SETD8)

OGA:	100940536(KMT5A)

MMU:	67956(Kmt5a)

MCAL:

110295130(Kmt5a)

MPAH:

110312821(Kmt5a)

RNO:	100361623(Kmt5al2) 100909949(Kmt5al1) 288346(Kmt5al3) 689820(Kmt5a)

MCOC:

116068429(Kmt5a)

ANU:	117698248(Kmt5a)

MUN:	110552670(Kmt5a)

CGE:	100774411(Kmt5a)

MAUA:

101824166 101824988(Kmt5a)

PROB:

127237018(Kmt5a)

PLEU:

114686055 114704516(Kmt5a)

MORG:

121437304 121446283(Kmt5a)

MFOT:

126504306

AAMP:

119825159(Kmt5a)

NGI:	103739033(Kmt5a)

HGL:	101726359(Kmt5a)

CPOC:

100734404(Kmt5a)

CCAN:

109683525(Kmt5a)

DORD:

105990613(Setd8)

DSP:	122098573(Kmt5a)

PLOP:

125349195(Kmt5a)

NCAR:

124990908

MMMA:

107156385(Kmt5a)

OCU:	100347868 100354805

OPI:	101521103(KMT5A)

TUP:	102471250(KMT5A)

GVR:	103606858(SETD8)

CFA:	610615(KMT5A)

CLUD:

112676464

NPO:	129507931(KMT5A)

AML:	100482312(KMT5A)

UMR:	103661256(KMT5A)

UAH:	113266900(KMT5A)

UAR:	123779868(KMT5A)

ELK:

111156510

LLV:

125082151

MPUF:

101688179(SETD8)

MNP:	132023093(KMT5A)

MLK:	131811166(KMT5A)

NVS:	122903070(KMT5A)

ORO:	101380066(SETD8)

EJU:	114200359(KMT5A)

ZCA:	113912844(KMT5A)

MLX:	118018398(KMT5A)

NSU:	110588347(KMT5A)

LWW:	102739906(KMT5A)

FCA:	101086008(KMT5A)

PYU:	121010394(KMT5A)

PCOO:

112870284(KMT5A)

PBG:	122470153(KMT5A)

PVIV:

125149201(KMT5A)

LRUF:

124518212

PTG:	102962714(KMT5A)

PPAD:

109277736(KMT5A)

PUC:

125914249

AJU:

106967577

HHV:	120236767(KMT5A)

BTA:	532622(KMT5A)

BOM:	102264795(KMT5A)

BIU:	109571313(KMT5A)

BBUB:

102392447(KMT5A)

BBIS:

104989668(SETD8)

CHX:	102183718(KMT5A)

OAS:	101122308(KMT5A)

BTAX:

128062161(KMT5A)

ODA:	120871058(KMT5A)

CCAD:

122424360(KMT5A)

MBEZ:

129542239(KMT5A)

SSC:	100626555(KMT5A)

CFR:	102521782(KMT5A)

CBAI:

105080660(SETD8)

CDK:	105102547(KMT5A)

VPC:	102527939(KMT5A)

BACU:

103012927(KMT5A)

BMUS:

118879863(KMT5A)

LVE:	103079356(SETD8)

OOR:	101270549(KMT5A)

DLE:	111186967(KMT5A)

PCAD:

102996167(KMT5A)

PSIU:

116739152(KMT5A)

NASI:

112408791(KMT5A)

ECB:	100060853(KMT5A)

EPZ:	103549882(KMT5A)

EAI:	106842331(KMT5A)

MYB:	102240957 102242179

MYD:	102770785(KMT5A)

MMYO:

118678140(KMT5A)

MLF:	102429936(KMT5A)

PKL:	118725421(KMT5A)

EFUS:

103287217(KMT5A)

MNA:	107529655(KMT5A)

DRO:	112310724(KMT5A)

SHON:

118974854 118991026(KMT5A)

AJM:	119060733(KMT5A)

PDIC:

114509389(KMT5A)

PHAS:

123821187(KMT5A)

MMF:	118639841(KMT5A)

PPAM:

129087254(KMT5A)

HAI:	109386114(KMT5A)

RFQ:	117017602(KMT5A)

PALE:

102897510(KMT5A)

PGIG:

120616022(KMT5A)

PVP:	105289367(KMT5A)

RAY:	107515249(KMT5A)

MJV:	108408425(KMT5A)

TOD:	119245049(KMT5A)

SARA:

101540129(SETD8)

SETR:

126002027(KMT5A)

LAV:	100673523(KMT5A)

TMU:

101353514

ETF:	101641327(KMT5A)

DNM:	101414380(KMT5A)

MDO:	100023739(KMT5A)

GAS:	123244631(KMT5A)

SHR:	100933547(KMT5A)

AFZ:	127542111 127542390 127545404

PCW:	110196792(KMT5A)

OAA:	100075898(KMT5A)

GGA:	416825(KMT5A)

PCOC:

116228636(KMT5A)

MGP:	100540244(KMT5A)

CJO:	107321176(KMT5A)

TPAI:

128084807(KMT5A)

LMUT:

125701678(KMT5A)

NMEL:

110406291(KMT5A)

APLA:

101791981(KMT5A)

ACYG:

106031170(KMT5A)

CATA:

118257207(KMT5A)

AFUL:

116495994(KMT5A)

TGU:	100225643(KMT5A)

LSR:	110471779(KMT5A)

SCAN:

103818327(KMT5A)

PMOA:

120509636(KMT5A)

OTC:	121338931(KMT5A)

PRUF:

121365047(KMT5A)

GFR:	102037830(KMT5A)

FAB:	101821143(KMT5A)

OMA:	130259825(KMT5A)

PHI:	102109183(SETD8)

PMAJ:

107211636(KMT5A)

CCAE:

111936365(KMT5A)

CCW:	104688723(KMT5A)

CBRC:

103616016(KMT5A)

ETL:	114054956(KMT5A)

ZAB:	102060759(KMT5A)

ACHL:

103806489(SETD8)

SVG:	106852390(KMT5A)

MMEA:

130581001(KMT5A)

HRT:	120760454(KMT5A)

FPG:	101914736(KMT5A)

FCH:	102053153(KMT5A)

CLV:	102089973(KMT5A)

EGZ:	104130151(SETD8)

NNI:	104020902(SETD8)

PCRI:

104023788(SETD8)

PLET:

104620595(SETD8)

EHS:	104502556(SETD8)

PCAO:

104039362(SETD8)

ACUN:

113485973(KMT5A)

TALA:

104355475(KMT5A)

PADL:

103914547(SETD8)

AFOR:

103902872(KMT5A)

ACHC:

115345824(KMT5A)

HALD:

104310615(SETD8)

HLE:	104840920(SETD8)

AGEN:

126040879

GCL:

127023006

CCRI:

104165021(SETD8)

CSTI:

104549246(SETD8)

CMAC:

104473009(SETD8)

MUI:	104545868(SETD8)

BREG:

104635738(SETD8)

FGA:	104069168(SETD8)

GSTE:

104250299(SETD8)

LDI:	104339768(SETD8)

MNB:	103776967(SETD8)

OHA:	104327609(SETD8)

NNT:	104399055(SETD8)

SHAB:

115614939(KMT5A)

DPUB:

104308378(SETD8)

PGUU:

104457692(SETD8)

ACAR:

104517510(KMT5A)

CPEA:

104388755(SETD8)

AVIT:

104273219(SETD8)

CVF:	104282255(SETD8)

RTD:	128916957(KMT5A)

CUCA:

104068460(SETD8)

TEO:	104369654(SETD8)

BRHI:

104492471(SETD8)

AAM:	106497676(KMT5A)

AROW:

112962511(KMT5A)

NPD:	112945813(KMT5A)

TGT:	104574851(SETD8)

DNE:	112991842(KMT5A)

SCAM:

104138814(SETD8)

ASN:	102382842(KMT5A)

AMJ:	102571182(KMT5A)

CPOO:

109312708(KMT5A)

GGN:	109290516(KMT5A)

PSS:	102463287(KMT5A)

CMY:	102929316(KMT5A)

CCAY:

125623204(KMT5A)

DCC:	119843904(KMT5A)

CPIC:

101932163(KMT5A)

TST:	117888053(KMT5A)

CABI:

116836714(KMT5A)

MRV:	120386460(KMT5A)

ACS:	100559474(kmt5a)

ASAO:

132781355(KMT5A)

PVT:	110083872(KMT5A)

SUND:

121916628(KMT5A)

PBI:	103053204(KMT5A)

PMUR:

107285441(KMT5A)

CTIG:

120316702(KMT5A)

TSR:	106540545(SETD8)

PGUT:

117672147(KMT5A)

APRI:

131185573(KMT5A)

PTEX:

113448664(KMT5A)

NSS:	113425036(KMT5A)

VKO:	123028707(KMT5A)

PMUA:

114586282(KMT5A)

PRAF:

128403602(KMT5A)

ZVI:	118075547(KMT5A)

HCG:	128337839(KMT5A)

GJA:	107117211(KMT5A)

STOW:

125442912(KMT5A)

EMC:	129341573(KMT5A)

XLA:	100158384(kmt5a.S) 398318(kmt5a.L)

XTR:	780276(kmt5a)

NPR:	108787307(KMT5A)

RTEM:

120934096(KMT5A)

BBUF:

120988620(KMT5A)

BGAR:

122934655(KMT5A)

MUO:	115480711(KMT5A)

GSH:	117352297 117365706(KMT5A)

DRE:	100004770(kmt5ab) 751629(kmt5aa)

SRX:	107706747 107722327 107728092 107740028

SANH:

107655184 107657332 107693405(kmt5a) 107702926 107704173

SGH:	107548535(kmt5a) 107554512 107556037 107578348 107588935

CCAR:

109059003 109067610 109074173 109080144 109088593

CAUA:

113054712 113085032 113094229(kmt5a) 113110209

CGIB:

127958296 127966870 127990317 128020806

PTET:

122333772(kmt5aa) 122346190(kmt5ab)

LROH:

127164824(kmt5ab) 127172239(kmt5aa)

OMC:	131540749(kmt5ab) 131547944(kmt5aa)

PPRM:

120472105(kmt5ab) 120483070(kmt5aa)

RKG:	130069118(kmt5ab) 130094948(kmt5aa)

MAMB:

125262448(kmt5aa) 125267634(kmt5ab)

CIDE:

127513635 127521439

MASI:

127432609 127433711 127436002

TROS:

130546290(kmt5aa) 130566440(kmt5ab)

TDW:	130411644(kmt5aa) 130420150(kmt5ab)

MANU:

129441120(kmt5ab) 129446503(kmt5aa)

IPU:	108256031(kmt5ab) 108276718(kmt5aa)

IFU:	128599066(kmt5ab) 128620161(kmt5aa)

PHYP:

113542401 113544710(kmt5a)

SMEO:

124393992(kmt5aa)

TFD:	113638387(kmt5aa)

TVC:	132863456(kmt5aa)

AMEX:

103024833 103046457 111197404

CMAO:

118824954(kmt5aa) 118827214(kmt5ab)

EEE:	113581614 113584033(kmt5a)

CHAR:

105889376(kmt5aa) 105905089(kmt5ab)

TRU:	101062904(kmt5a) 101068946

TFS:	130517062(kmt5aa) 130525629(kmt5ab)

TNG:	GSTEN00025268G001 GSTEN00029438G001

LCO:	104920299(kmt5a) 104940038

NCC:	104947636 104962306(setd8)

TBEN:

117476384(kmt5aa) 117496893(kmt5ab)

CGOB:

115013499 115016800(kmt5a)

PGEO:

117453176(kmt5ab) 117456051(kmt5aa)

GACU:

117561043(kmt5ab) 117561434(kmt5aa)

EMAC:

134868523(kmt5aa) 134874034(kmt5ab)

ELY:	117253040(kmt5ab) 117269340(kmt5aa)

EFO:	125890454(kmt5ab) 125906085(kmt5aa)

PLEP:

121944809(kmt5ab) 121959919

SLUC:

116051045(kmt5aa) 116056808(kmt5ab)

ECRA:

117944747(kmt5ab) 117959177(kmt5aa)

ESP:	116690287 116704008

PFLV:

114556014 114571152(kmt5a)

GAT:	120831092(kmt5ab) 120831743(kmt5aa)

PPUG:

119224952(kmt5ab) 119226398(kmt5aa)

AFB:	129101029(kmt5ab) 129102900(kmt5aa)

CLUM:

117736716(kmt5ab) 117740929(kmt5aa)

PSWI:

130196295(kmt5ab) 130205142(kmt5aa)

MSAM:

119891381(kmt5ab) 119914618(kmt5aa) 119917840

SCHU:

122865281(kmt5aa) 122875973(kmt5ab)

CUD:	121510055(kmt5ab) 121524944(kmt5aa)

ALAT:

119019846(kmt5ab) 119029806(kmt5aa)

MZE:	101470368(kmt5a) 101485410 112434147 112436186 112436306

ONL:	100702115 109194214(kmt5a) 109195113 109202029

OAU:	116313178(kmt5aa) 116332401(kmt5ab) 120440039 120442224

OLA:	101169793(kmt5a) 101172663

OML:	112148771(kmt5ab) 112163317(kmt5aa)

CSAI:

133450524(kmt5ab) 133455038(kmt5aa)

XMA:	102219947(kmt5a) 102233201

XCO:	114149247(kmt5a) 114154537

XHE:	116725040(kmt5a) 116729855

PRET:

103461350 103470267 103473254(kmt5a)

PFOR:

103151021(kmt5a) 103151865 103151868 103151873

PLAI:

106942166 106942497 106943016 106954785(kmt5a)

PMEI:

106909822 106925250(kmt5a) 106928543 106929479

GAF:	122819727(kmt5aa) 122828794(kmt5ab)

PPRL:

129372146(kmt5ab) 129374296(kmt5aa)

CVG:	107086058 107087301

CTUL:

119784767(kmt5aa) 119790158(kmt5ab)

GMU:	124872904(kmt5aa) 124878265(kmt5ab)

NFU:	107375146 107394219(kmt5a)

KMR:	108234482(kmt5ab) 108248169(kmt5aa)

ALIM:

106523808(setd8) 106527566

NWH:	119413069(kmt5ab) 119425123(kmt5aa)

AOCE:

111565810 111576642

MCEP:

124996558(kmt5aa) 125012176(kmt5ab)

CSEM:

103389958 103397505

POV:	109626470(kmt5a) 109638204

SSEN:

122758422(kmt5aa) 122769022(kmt5ab)

HHIP:

117767484(kmt5ab) 117771531(kmt5aa)

HSP:	118098042(kmt5aa) 118115071(kmt5ab)

SMAU:

118310057(kmt5aa) 118314035

LCF:	108878140(kmt5ab) 108897302(kmt5aa)

SDU:	111217857(kmt5a) 111230938

SLAL:

111649965 111658242

XGL:	120805543(kmt5ab) 120806784(kmt5aa)

HCQ:	109525154 109529122

SSCV:

125979925 125994152

SBIA:

133490551(kmt5aa) 133499651(kmt5ab)

PEE:	133400124(kmt5ab) 133413732(kmt5aa)

PTAO:

133474871(kmt5ab) 133489815(kmt5aa)

BPEC:

110172486(kmt5a)

MALB:

109953053 109961594(kmt5a)

BSPL:

114862890(kmt5ab) 114866997(kmt5aa)

SJO:	128365016(kmt5ab) 128380747(kmt5aa)

SASA:

106562505 106568287 106568308 106585273(kmt5a)

STRU:

115149301(kmt5a) 115159250 115164478

OTW:	112219631(kmt5aa) 112233539(kmt5ab) 112257473

OMY:	110523849 110525699(kmt5ab) 110537078

OGO:	123999640(kmt5aa) 124034294 124048656

ONE:	115105910(kmt5a) 115111631 115127850

OKI:	109868488 109880068 109892437

OKE:	118387821 118391486 118393236

SALP:

111958152 111961353 111974204 111981803(kmt5a)

SNH:	120023165(kmt5ab) 120026139 120044218

CCLU:

121530937 121574138 121582766

ELS:	105014800(kmt5a) 105026110

SFM:	108934749(kmt5a)

PKI:	111860044(kmt5a)

AANG:

118206487(kmt5ab) 118213194(kmt5aa)

LOC:	102686646(kmt5a)

PSPA:

121296780 121299694

ARUT:

117426360 117962465

PSEX:

120540871(kmt5aa)

LCM:	102355801(KMT5A)

CMK:

103188010

RTP:	109918332(kmt5ab)

CPLA:

122551012

HOC:

132827003

LERI:

129709245

PMRN:

116944662(KMT5A)

LRJ:	133340495(KMT5A)

BFO:

BBEL:

CIN:

SCLV:

SPU:	100892850 105440265 105442287 115917928 115918102 115921211 115921240 115923119 115926391 592467

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG3307(Set8)

DER:

6552524

DSE:

6606408

DSI:	Dsimw501_GD18956(Dsim_GD18956)

DYA:	Dyak_GE24231

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22805

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101900242 131803727

LCQ:

LSQ:

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

CQU:	CpipJ_CPIJ000732

CPII:

120419555

CNS:	116344844 116344849

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100123008 100123020 100677939

CSOL:

105359046 105368743

TPRE:

106658250 106658254 111693283

LHT:

LBD:

MDL:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109543766 109543771

SOY:

AGRG:

ATD:

CSET:

AGB:	108909439 108909442

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

MSEX:

DPL:	KGM_206896

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105384001 105394816

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111047050 120352923

HVI:

124369030

MQU:

128997949

PHU:	Phum_PHUM315980

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_311914

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111697097 111709992

LSM:

121127499

TCF:	131884070 131886047

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107366892 107367013

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129218562 129226092

SDM:

118195453

LPOL:

106472304

PMEO:

129589222

CEL:	CELE_T26A5.7(set-1)

CBR:	CBG_16281 CBG_16282 CBG_19678(Cbr-set-1)

CRQ:	GCK72_010704 GCK72_023057

NAI:	NECAME_10199

BMY:	BM_BM12185(Bma-set-1)

LOA:	LOAG_02341

TSP:	Tsp_09846 Tsp_09848

LGI:	LOTGIDRAFT_117025

PVUL:

126823902

PCAN:

112562936

BGT:	106067552 106070335

GAE:

121368110

HRF:

124133359

HRJ:	124272407 124276593

CRG:	105318653 117684757

CVN:

111134306

CANU:

128186593

OED:

125650397

MYI:	110442348 110445834

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:	115216802 115228427

LAK:

106173811

SMM:	Smp_055310

SHX:	MS3_00005891(KMT5A)

OVI:	T265_05161

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

HSY:

TAD:	TRIADDRAFT_59058

AQU:

100639445

SRE:	PTSG_09393

DFA:

DFA_00963

PFA:	PF3D7_0403900

PFD:	PFDG_02606

PFH:	PFHG_00728

PREI:

PRSY57_0401500

PGAB:

PGSY75_0403900

PYO:	PY17X_1003000

PCB:	PCHAS_1002500

PBE:	PBANKA_1001600

PVV:	PVVCY_0800190

PKN:	PKNH_0301900

PVX:	PVX_001050

PCY:	PCYB_031160

PREL:

PRELSG_0301100(SET8)

TAN:

TA21435

TPV:

TP01_0281

TOT:	TOT_010000260

BEQ:	BEWA_031890

BBO:	BBOV_IV004680

BMIC:

BMR1_02g00765

CPV:

cgd4_370

CHO:	Chro.40051

» show all

Reference

PMID:15933070

Authors

Couture JF, Collazo E, Brunzelle JS, Trievel RC

Title

Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase.

Journal

Genes Dev 19:1455-65 (2005)
DOI:10.1101/gad.1318405

Sequence

[hsa:387893]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2759)   
   KEGG GENES (860)   
   KEGG MGENES (155)   
   RefGene (1732)   
   OC (12)   
Literature (1)   
   PubMed (1)   
All databases (2772)   

Download RDF

ORTHOLOGY: K11430

Entry

K11430                      KO

Symbol

EZH2

Name

[histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map03083

Polycomb repressive complex

map05206

MicroRNAs in cancer

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H01613

Follicular lymphoma

H01751

Weaver syndrome

H02410

Myelodysplastic/myeloproliferative neoplasms

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2
    PRC2.2
     K11430  EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2

Other DBs

GO:

0046976

Genes

HSA:	2146(EZH2)

PTR:	745437(EZH2)

PPS:	100971244(EZH2)

GGO:	101147968(EZH2)

PON:	100447447(EZH2)

NLE:	100580962(EZH2)

HMH:	116814486(EZH2)

MCC:	709075(EZH2)

MCF:	102146280(EZH2)

MTHB:

126951580

MNI:	105474849(EZH2)

CSAB:

103227182(EZH2)

CATY:

105584692(EZH2)

PANU:

101001043(EZH2)

TGE:	112620861(EZH2)

MLEU:

105546371(EZH2)

RRO:	104667012(EZH2)

RBB:	108522307(EZH2)

TFN:	117072340(EZH2)

PTEH:

111551469(EZH2)

CANG:

105511283(EZH2)

CJC:	100394758(EZH2)

SBQ:	101051611(EZH2)

CIMI:

108285619(EZH2)

CSYR:

103259718(EZH2)

MMUR:

105873325(EZH2)

LCAT:

123647560(EZH2)

PCOQ:

105824626(EZH2)

OGA:	100961114(EZH2)

MMU:	14056(Ezh2)

MCAL:

110295592(Ezh2)

MPAH:

110315211(Ezh2)

RNO:	312299(Ezh2)

MCOC:

116098837(Ezh2)

ANU:	117720944(Ezh2)

MUN:	110547503(Ezh2)

CGE:	100758055(Ezh2)

MAUA:

101824592(Ezh2)

PROB:

127214236(Ezh2) 127216130

PLEU:

114698004(Ezh2)

MORG:

121433641(Ezh2)

MFOT:

126515091

AAMP:

119807752(Ezh2)

NGI:	103731383(Ezh2)

HGL:	101702710(Ezh2)

CPOC:

100713765(Ezh2)

CCAN:

109695508(Ezh2)

DORD:

105989599(Ezh2)

DSP:	122105935(Ezh2)

PLOP:

125347276(Ezh2)

NCAR:

124991619

MMMA:

107148970(Ezh2)

OCU:

100345157

OPI:	101528017(EZH2)

TUP:	102495627(EZH2)

GVR:	103592394(EZH2)

CFA:	475511(EZH2)

CLUD:

112650879(EZH2)

VVP:	112934818(EZH2)

VLG:	121489952(EZH2)

NPO:	129515846(EZH2)

AML:	100466177(EZH2)

UMR:	103668955(EZH2)

UAH:	113241452(EZH2)

UAR:	123788819(EZH2)

ELK:

111154333

LLV:

125080977

MPUF:

101684407(EZH2)

MNP:	132015600(EZH2)

MLK:	131829906(EZH2)

NVS:	122905177(EZH2)

ORO:	101369941(EZH2)

EJU:	114211667(EZH2)

ZCA:	113911424(EZH2)

MLX:	118021219(EZH2)

NSU:	110582991(EZH2)

LWW:

102745380

FCA:	101087309(EZH2)

PYU:	121028154(EZH2)

PCOO:

112866486(EZH2)

PBG:	122488472(EZH2)

PVIV:

125157254(EZH2)

LRUF:

124524657

PTG:	102956220(EZH2)

PPAD:

109269218(EZH2)

PUC:

125930933

AJU:

106981407

HHV:	120246406(EZH2)

BTA:	509106(EZH2)

BOM:	102287858(EZH2)

BIU:	109557756(EZH2)

BBUB:

102405899(EZH2)

BBIS:

104991414(EZH2)

CHX:	102190101(EZH2)

OAS:	101120745(EZH2)

BTAX:

128046386(EZH2)

ODA:	120877871(EZH2)

CCAD:

122438829(EZH2)

MBEZ:

129552745(EZH2)

SSC:	100625497(EZH2)

CFR:	102515793(EZH2)

CBAI:

105068876(EZH2)

CDK:	105085196(EZH2)

VPC:	102524655(EZH2)

BACU:

103011369(EZH2)

BMUS:

118900748(EZH2)

LVE:	103069623(EZH2)

OOR:	101280796(EZH2)

DLE:	111177205(EZH2)

PCAD:

102994010(EZH2)

PSIU:

116759057(EZH2)

NASI:

112398358(EZH2)

ECB:	100051290(EZH2)

EPZ:	103553703(EZH2)

EAI:	106842131(EZH2)

MYB:	102246299(EZH2)

MYD:	102768989(EZH2)

MMYO:

118666288(EZH2)

MLF:	102418971(EZH2)

PKL:	118714189(EZH2)

EFUS:

103297250(EZH2)

MNA:	107523768(EZH2)

DRO:	112308348(EZH2)

SHON:

118979486(EZH2)

AJM:	119051022(EZH2)

PDIC:

114507788(EZH2)

PHAS:

123815339(EZH2)

MMF:	118619754(EZH2)

PPAM:

129063401(EZH2)

HAI:	109395452(EZH2)

RFQ:	117018256(EZH2)

PALE:

102886689(EZH2)

PGIG:

120601486(EZH2)

PVP:	105295713(EZH2)

RAY:	107500533(EZH2)

MJV:	108386657(EZH2)

TOD:	119248372(EZH2)

SARA:

101550762(EZH2)

SETR:

126003266(EZH2) 126003373

LAV:	100664312(EZH2)

TMU:

101359039

ETF:	101647365(EZH2)

DNM:	101416064(EZH2)

MDO:	100013390(EZH2)

GAS:	123249372(EZH2)

SHR:	100926678(EZH2)

AFZ:

127564894

PCW:	110201666(EZH2)

OAA:	100073485(EZH2)

GGA:	420784(EZH2)

PCOC:

116228276(EZH2)

MGP:	100540374(EZH2)

CJO:	107309835(EZH2)

TPAI:

128087776(EZH2)

LMUT:

125690558(EZH2)

NMEL:

110390789(EZH2)

APLA:

101793453(EZH2)

ACYG:

106048735(EZH2)

CATA:

118250933(EZH2)

AFUL:

116486423(EZH2)

TGU:	100226728(EZH2)

LSR:	110479186(EZH2)

SCAN:

103819367(EZH2)

PMOA:

120504998(EZH2)

OTC:	121346974(EZH2)

PRUF:

121352851(EZH2)

GFR:	102038673(EZH2)

FAB:	101809240(EZH2)

OMA:	130248948(EZH2)

PHI:	102099930(EZH2)

PMAJ:

107200653(EZH2)

CCAE:

111923642(EZH2)

CCW:	104688925(EZH2)

CBRC:

103615761(EZH2)

ETL:	114063865(EZH2)

ZAB:	102064406(EZH2)

ACHL:

103805215(EZH2)

SVG:	106860688(EZH2)

MMEA:

130584536(EZH2)

HRT:	120752327(EZH2)

FPG:	101911332(EZH2)

FCH:	102055584(EZH2)

CLV:	102093761(EZH2)

EGZ:	104125781(EZH2)

NNI:	104015388(EZH2)

PCRI:

104035749(EZH2)

PLET:

104625737(EZH2)

EHS:	104508378(EZH2)

PCAO:

104052172(EZH2)

ACUN:

113477549(EZH2)

TALA:

104356937(EZH2)

PADL:

103916088(EZH2)

AFOR:

103895384(EZH2)

ACHC:

115339606(EZH2)

HALD:

104315060

HLE:	104828376(EZH2)

AGEN:

126045481

GCL:

127013221

CCRI:

104166555(EZH2)

CMAC:

104483036(EZH2)

MUI:	104537004(EZH2)

BREG:

104633949(EZH2)

FGA:	104083691(EZH2)

GSTE:

104254098(EZH2)

LDI:	104343715(EZH2)

MNB:	103776905(EZH2)

OHA:	104334077(EZH2)

NNT:	104402768(EZH2)

SHAB:

115617674(EZH2)

DPUB:

104298305(EZH2)

PGUU:

104467158(EZH2)

ACAR:

104525061

CPEA:

104392172(EZH2)

AVIT:

104278791(EZH2)

CVF:	104295308(EZH2)

RTD:	128906343(EZH2)

CUCA:

104065929(EZH2)

TEO:	104380061(EZH2)

BRHI:

104495767(EZH2)

AAM:	106495267(EZH2)

AROW:

112970378(EZH2)

NPD:	112942708(EZH2)

TGT:	104567375(EZH2)

DNE:	112997513(EZH2)

SCAM:

104150320(EZH2)

ASN:	102372569(EZH2)

AMJ:	102562122(EZH2)

CPOO:

109313034(EZH2)

GGN:	109291897(EZH2)

PSS:	102453330(EZH2)

CMY:	102932650(EZH2)

DCC:	119851691(EZH2)

CPIC:

101937752(EZH2)

TST:	117872630(EZH2)

CABI:

116825808(EZH2)

MRV:	120397786(EZH2)

ACS:	100564989(ezh2)

ASAO:

132778518(EZH2)

PVT:	110088673(EZH2)

SUND:

121932530(EZH2)

PBI:	103051581(EZH2)

PMUR:

107288847(EZH2) 107290401

CTIG:

120316554(EZH2)

TSR:	106547020(EZH2)

PGUT:

117664971(EZH2)

APRI:

131197792(EZH2)

PTEX:

113437363(EZH2)

NSS:	113421522(EZH2)

VKO:	123035557(EZH2)

PMUA:

114607413(EZH2)

PRAF:

128398552(EZH2)

ZVI:	118077677(EZH2)

HCG:	128331826(EZH2)

GJA:	107119624(EZH2)

STOW:

125441240(EZH2)

EMC:	129337484(EZH2)

XLA:	100381148(ezh2.S) 399174(ezh2.L)

XTR:	550047(ezh2)

NPR:	108794364(EZH2)

RTEM:

120940356(EZH2)

BBUF:

121001574(EZH2)

BGAR:

122938454(EZH2)

MUO:	115470435(EZH2)

GSH:	117353865(EZH2)

DRE:	768133(ezh2)

SRX:	107727220 107741938

SANH:

107686697(ezh2) 107695380

SGH:	107549206 107595131

CCAR:

109074719(ezh2)

CAUA:

113042268 113066022

CGIB:

127946210 128013173

PTET:

122329728(ezh2)

LROH:

127155628(ezh2)

OMC:	131532968(ezh2)

PPRM:

120475953(ezh2)

RKG:	130087642(ezh2)

MAMB:

125258300(ezh2)

CIDE:

127505796

MASI:

127431759 127434185

TROS:

130547163(ezh2)

TDW:	130413153(ezh2)

MANU:

129425704(ezh2)

IPU:

108256455

IFU:	128599471(ezh2)

PHYP:

113541351(ezh2)

SMEO:

124375475(ezh2)

TFD:	113660270(ezh2)

TVC:	132840289(ezh2)

AMEX:

103027230(ezh2)

CMAO:

118798962(ezh2)

EEE:	113589064(ezh2)

CHAR:

105905243(ezh2)

TRU:	101068728(ezh2)

TFS:	130513649(ezh2)

LCO:	104933871(ezh2)

NCC:	104940789(ezh2)

TBEN:

117495748(ezh2)

PGEO:

117465631(ezh2)

GACU:

117539161(ezh2)

EMAC:

134884098(ezh2)

ELY:	117264665(ezh2)

EFO:	125881496(ezh2)

PLEP:

121960957(ezh2)

SLUC:

116053723(ezh2)

PFLV:

114548931(ezh2)

GAT:	120811509 120811957

PPUG:

119198295(ezh2)

AFB:	129110715(ezh2)

CLUM:

117749840(ezh2)

PSWI:

130205958(ezh2)

MSAM:

119896631(ezh2)

SCHU:

122866432(ezh2)

CUD:	121527226(ezh2)

ALAT:

119009068(ezh2)

MZE:	101464777 112429845(ezh2)

ONL:	100702594(ezh2)

OAU:	116329347(ezh2)

OLA:	100125823(ezh2)

OML:	112152487(ezh2)

CSAI:

133423128(ezh2)

XMA:	102218572(ezh2)

XCO:	114136427(ezh2)

XHE:	116712102(ezh2)

PRET:

103457011(ezh2)

PFOR:

103131053(ezh2)

PLAI:

106961042(ezh2)

PMEI:

106927381(ezh2)

GAF:	122824393(ezh2)

PPRL:

129354400 129378965

CVG:	107097879(ezh2)

CTUL:

119791669(ezh2)

GMU:	124858145(ezh2)

NFU:	107383138(ezh2)

KMR:	108249555(ezh2)

ALIM:

106531656(ezh2)

NWH:	119426627(ezh2)

AOCE:

111570645(ezh2)

MCEP:

125024464(ezh2)

CSEM:

103377188(ezh2)

SSEN:

122776786(ezh2)

HHIP:

117753555(ezh2)

HSP:	118098326(ezh2)

SMAU:

118291307(ezh2)

LCF:

108884998

SDU:	111238320(ezh2)

SLAL:

111647273(ezh2)

XGL:	120789563(ezh2)

HCQ:	109521815(ezh2)

SSCV:

125986045

SBIA:

133492409(ezh2)

PEE:	133396535(ezh2)

PTAO:

133470168(ezh2)

BPEC:

110158320(ezh2)

MALB:

109951056(ezh2)

BSPL:

114852915(ezh2)

SJO:	128382102(ezh2)

SASA:

106578387(ezh2) 106590561

STRU:

115152097(ezh2) 115195415

OTW:	112215484(ezh2)

OMY:	110535410(ezh2)

OGO:	123991259(ezh2)

ONE:	115105003(ezh2) 115116302

OKI:	109909923(ezh2)

OKE:	118361674(ezh2) 118369743

SALP:

111972867(ezh2)

SNH:	120027757(ezh2) 120050935

CCLU:

121549776(ezh2) 121569320

ELS:	105022040(ezh2)

SFM:	108919665 108935505

PKI:	111834007 111854999

AANG:

118225181 118233043

LOC:	102691488(ezh2)

PSPA:

121312792(ezh2) 121314254

ARUT:

117400656 117435499(ezh2)

PSEX:

120529475(ezh2)

CMK:	103187005(ezh2)

RTP:	109916301(ezh2)

CPLA:

122550253(ezh2)

HOC:	132815737(ezh2)

LERI:

129710221(ezh2)

PMRN:

116941022(EZH2)

LRJ:	133344794(EZH2)

BFO:

BBEL:

SCLV:

SPU:

LPIC:

AJC:

DME:	Dmel_CG6502(E(z))

DER:

6546346

DSE:

6605167

DSI:	Dsimw501_GD12857(Dsim_GD12857)

DYA:	Dyak_GE20265

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13833

DAZ:

108614083

DNV:

108652219

DHE:	111599772 115483471

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119666991 119687883 119688054 119688144 119688147

MDE:	101887292 131800424

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ006484

CPII:

120416716 128092797

CNS:	116340857 116344071

BCOO:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:	108913249 108915184

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212341

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CFEL:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:	103523265 103523266

HHAL:

106683851

NLU:

111049820

HVI:

124354234

MQU:	128993213 128993334

PHU:	Phum_PHUM294210

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

PCHN:

CQD:

ESN:

MNZ:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_R06A4.7(mes-2)

CBR:	CBG_00165 CBG_02150 CBG_05455 CBG_11099(Cbr-mes-2)

CRQ:	GCK72_004674 GCK72_025986

BMY:	BM_BM5240(Bma-mes-2)

LOA:	LOAG_00180

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

NVE:

ATEN:

SPIS:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_54464

ATH:	AT2G23380(CLF) AT4G02020(SWN)

CRB:	17882618 17889727

CSAT:

104704984 104707901 104713584 104713782 104737584 104751976

EUS:	EUTSA_v10000037mg EUTSA_v10028423mg

BRP:	103836786 103864466

BNA:	106391060 106426666 106435598

BOE:	106319095 106342758

RSZ:	108825666 108851366

GMX:

GSJ:

VRA:

VUM:

APRC:

MTR:

TPRA:

PSAT:

VVO:

LJA:	Lj2g3v1890940.1(Lj2g3v1890940.1) Lj2g3v1890940.2(Lj2g3v1890940.2)

AHF:	112748576 112800564

LANG:

109332774 109348636

PCIN:

129311635 129322268

QSA:	O6P43_024618 O6P43_033836

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103401443 103403246

MSYL:

126589324 126604457

PXB:	103935244 103956959

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

CILL:

CAVE:

QLO:

SLY:	100134891(EZ1)

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107769800 107801572

NSY:

NTO:

NAU:

INI:

ITR:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

ECAD:

RVL:

AEW:

MOF:

OSA:	4332612 4340748

DOSA:

Os03t0307800-01(Os03g0307800) Os06t0275500-01(Os06g0275500)

OBR:	102702548 102706390

OGL:	127767491 127776745

ATS:

109742834

TDC:	119285509 119296293 119328378 119332633 119335528 119340717

TAES:

123085669 123092326 123097675

TUA:	125551908 125551964

LPER:

127295609

LRD:

124702220

SBI:

8083989

ZMA:	541955 542659

SITA:

101784446

SVS:

117837308

PVIR:

120652612 120670018 120690547 120702724

PHAI:

112875021

ZOF:	122012549 122015196

MSIN:

131228724

MIS:	MICPUN_63548

MPP:	MICPUCDRAFT_59369(JGI:MicpuC2_59369)

SSL:	SS1G_02779

PNO:	SNOG_00928

MBR:	MONBRDRAFT_30718

TPS:	THAPSDRAFT_268872

PIF:	PITG_10068

» show all

Reference

PMID:19026781

Authors

Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D

Title

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

Journal

Mol Cell 32:503-18 (2008)
DOI:10.1016/j.molcel.2008.11.004

Sequence

[hsa:2146]

ORTHOLOGY: K11420

Entry

K11420                      KO

Symbol

EHMT

Name

[histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04211

Longevity regulating pathway

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00907

Kleefstra syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.355  [histone H3]-lysine9 N-trimethyltransferase
     K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDAC complexes
    REST complex
     K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT

Other DBs

GO:

0046974

Genes

HSA:	10919(EHMT2) 79813(EHMT1)

PTR:	462572(EHMT2) 464891(EHMT1)

PPS:	100968253(EHMT1) 100991724(EHMT2)

GGO:	101139808(EHMT2) 101151843(EHMT1)

PON:	100449422(EHMT1) 100460372(EHMT2)

NLE:	100584465(EHMT1) 100606578(EHMT2)

HMH:	116460291(EHMT2) 116475942(EHMT1)

MCC:	715824(EHMT2) 721470(EHMT1)

MCF:	102125769(EHMT1) 102139754(EHMT2)

MTHB:

126936884 126953213

MNI:	105472004(EHMT1) 105497604(EHMT2)

CSAB:

103221737(EHMT2) 103239544(EHMT1)

CATY:

105573427(EHMT2) 105580648(EHMT1)

TGE:	112608061(EHMT1) 112622121(EHMT2)

MLEU:

105543337(EHMT1) 105554192(EHMT2)

RRO:	104669606(EHMT1) 104678126(EHMT2)

RBB:	108520267(EHMT2) 108542880(EHMT1)

TFN:	117086972(EHMT2) 117099071(EHMT1)

PTEH:

111523903(EHMT2) 111553022(EHMT1)

CANG:

105513763(EHMT2) 105522658(EHMT1)

CJC:	100408867(EHMT2)

SBQ:	101046305(EHMT2) 101054241(EHMT1)

CIMI:

108287299(EHMT1) 108299809(EHMT2)

CSYR:

103271295(EHMT2) 103276313(EHMT1)

MMUR:

105858186(EHMT2) 105882234(EHMT1)

LCAT:

123631758(EHMT2) 123646348(EHMT1)

PCOQ:

105817873(EHMT2) 105818718(EHMT1)

OGA:	100948087(EHMT2) 100957636(EHMT1)

MMU:	110147(Ehmt2) 77683(Ehmt1)

MCAL:

110284133(Ehmt2) 110312405(Ehmt1)

MPAH:

110317691(Ehmt1) 110335935(Ehmt2)

RNO:	361798(Ehmt2) 362078(Ehmt1)

MCOC:

116075347(Ehmt2) 116089787(Ehmt1)

ANU:	117710555(Ehmt1) 117724322(Ehmt2)

MUN:	110560108(Ehmt2) 110565639(Ehmt1)

CGE:	100754544(Ehmt1) 100769417(Ehmt2)

MAUA:

101823944(Ehmt1) 101829402(Ehmt2)

PROB:

127222558(Ehmt1) 127224318(Ehmt2)

PLEU:

114692754(Ehmt1) 114705861(Ehmt2)

MORG:

121435226(Ehmt2) 121462735(Ehmt1)

MFOT:

126495376 126500209

AAMP:

119818898(Ehmt1) 119822462(Ehmt2)

NGI:	103724422(Ehmt2) 103732609(Ehmt1)

HGL:	101697232(Ehmt2) 101699104(Ehmt1)

CPOC:

100728628(Ehmt2) 100735478(Ehmt1)

CCAN:

109688969(Ehmt1) 109689573(Ehmt2)

DORD:

105995652(Ehmt1) 105999864(Ehmt2)

DSP:	122102130(Ehmt1) 122111369(Ehmt2)

PLOP:

125351955(Ehmt1) 125352752(Ehmt2)

NCAR:

124963991 124989524

MMMA:

107143740(Ehmt2) 107159187(Ehmt1)

OCU:	100348361 100355131 127488907

OPI:	101519409(EHMT2) 101522414(EHMT1)

TUP:	102479735(EHMT2) 102498729(EHMT1)

GVR:	103592352(EHMT2) 103593591(EHMT1)

CFA:	474851(EHMT2) 491224(EHMT1)

CLUD:

112641330(EHMT2) 112677512(EHMT1)

VVP:	112911417(EHMT1) 112913622(EHMT2)

VLG:	121472597(EHMT1) 121500746(EHMT2)

NPO:	129508857(EHMT1) 129512457(EHMT2)

AML:	100466861(EHMT1) 100468794(EHMT2)

UMR:	103675323(EHMT1) 103682289(EHMT2)

UAH:	113243735(EHMT2) 113248390 113248430

UAR:	123790982(EHMT2) 123796293(EHMT1)

ELK:	111146323 111152229

LLV:	125083739 125102708

MPUF:

101672446(EHMT1) 101693123(EHMT2)

MNP:	132017818(EHMT2) 132024178(EHMT1)

MLK:	131812451(EHMT1) 131834322(EHMT2)

NVS:	122911459(EHMT2) 122917049(EHMT1)

ORO:	101375740(EHMT1) 101376988(EHMT2)

EJU:	114201776(EHMT1) 114222217(EHMT2)

ZCA:	113927718(EHMT2) 113934575(EHMT1)

MLX:	118017468(EHMT1) 118027316(EHMT2)

NSU:	110581313(EHMT1) 110586856(EHMT2)

LWW:	102732190(EHMT2) 102740990(EHMT1)

FCA:	101087111(EHMT1) 101091940(EHMT2)

PYU:	121020251(EHMT1) 121022333(EHMT2)

PCOO:

112853522(EHMT2) 112860854(EHMT1)

PBG:	122474697(EHMT1) 122478262(EHMT2)

PVIV:

125150998(EHMT1) 125166100(EHMT2)

LRUF:

124522319 124528601

PTG:	102954489(EHMT1) 102968259(EHMT2)

PPAD:

109260239(EHMT1) 109260503(EHMT2)

PUC:	125923980 125938426

AJU:	106983481 106989056

HHV:	120221909(EHMT2) 120222801(EHMT1)

BTA:	514062(EHMT2) 528606(EHMT1)

BOM:	102271111(EHMT1) 102279999(EHMT2)

BIU:	109565691(EHMT1) 109576929(EHMT2)

BBUB:

102395323(EHMT1) 102405188(EHMT2)

BBIS:

104981276(EHMT1) 104983802(EHMT2)

CHX:	102178316(EHMT2) 102189411(EHMT1)

OAS:	101115739(EHMT2) 101123545(EHMT1)

BTAX:

128056619(EHMT2) 128056896(EHMT1)

ODA:	120851867(EHMT1) 120870570(EHMT2)

CCAD:

122429704(EHMT2) 122442444(EHMT1)

MBEZ:

129539846(EHMT1) 129543544(EHMT2)

SSC:	100124382(EHMT2) 110258080(EHMT1)

CFR:	102518579(EHMT2) 102521526(EHMT1)

CBAI:

105073403(EHMT1) 105074044(EHMT2)

CDK:	105087443(EHMT2) 105102102(EHMT1)

VPC:	102527884(EHMT2) 102539319(EHMT1)

BACU:

103017744(EHMT1) 103018553(EHMT2)

BMUS:

118896565(EHMT1) 118903147(EHMT2)

LVE:	103072310(EHMT2) 103079038(EHMT1)

OOR:	101272833(EHMT1) 101282385(EHMT2)

DLE:	111170699(EHMT2) 111176964(EHMT1)

PCAD:

102978732(EHMT1) 102993056(EHMT2)

PSIU:

116755232(EHMT1) 116762596(EHMT2)

NASI:

112395441(EHMT2) 112411202(EHMT1)

ECB:	100058869(EHMT1) 100059118(EHMT2)

EPZ:	103554163(EHMT1) 103563300(EHMT2)

EAI:	106822324(EHMT2) 106822761(EHMT1)

MYB:	102245485(EHMT1) 102263672(EHMT2)

MYD:	102756540(EHMT1) 102773857(EHMT2)

MMYO:

118655270(EHMT1) 118679573(EHMT2)

MLF:	102416827(EHMT2) 102417065(EHMT1)

PKL:	118705352(EHMT2) 118707004(EHMT1)

EFUS:

103296120(EHMT1) 103300523(EHMT2)

MNA:	107536199(EHMT1) 107538997(EHMT2)

DRO:	112302258(EHMT2) 112306260(EHMT1)

SHON:

118980361(EHMT1) 118987556(EHMT2)

AJM:	119036154(EHMT1) 119053719(EHMT2)

PDIC:

114493954(EHMT2) 114503245(EHMT1)

PHAS:

123810361(EHMT2) 123823426(EHMT1)

MMF:	118621070(EHMT2) 118629406(EHMT1)

PPAM:

129067327(EHMT2) 129079139(EHMT1)

HAI:	109373117(EHMT2) 109382055(EHMT1)

RFQ:	117020464(EHMT2) 117031680(EHMT1)

PALE:

102879374(EHMT2) 102893102(EHMT1)

PGIG:

120599828(EHMT1) 120618905(EHMT2)

PVP:	105298547(EHMT1) 105305296(EHMT2)

RAY:	107498490(EHMT2) 107503067(EHMT1)

MJV:	108400840(EHMT2) 108404637(EHMT1)

TOD:	119230503(EHMT1) 119252227(EHMT2)

SARA:

101541664(EHMT2) 101546737(EHMT1)

SETR:

125996181(EHMT2) 126020493(EHMT1)

LAV:	100659207(EHMT2)

TMU:	101344600 101349603

ETF:	101644172(EHMT2) 101647797(EHMT1)

DNM:	101435395(EHMT2) 101444858(EHMT1)

MDO:	100023838(EHMT1) 100025360(EHMT2)

GAS:	123237182(EHMT1) 123246359(EHMT2)

SHR:	100931147(EHMT2) 100932927(EHMT1)

AFZ:	127549061 127561084

PCW:	110199440(EHMT2) 110205249(EHMT1)

OAA:	100078328(EHMT1) 100082943(EHMT2)

GGA:	417250(EHMT1)

PCOC:

116234163(EHMT1)

MGP:	100538392(EHMT1)

CJO:	107321652(EHMT1)

TPAI:

128073144(EHMT1)

LMUT:

125702744(EHMT1)

NMEL:

110406734(EHMT1)

APLA:

101805087(EHMT1)

ACYG:

106037080(EHMT1)

CATA:

118257121(EHMT1)

AFUL:

116496806(EHMT1)

TGU:	100217666(EHMT1)

LSR:	110476956(EHMT1)

SCAN:

103819172(EHMT1)

PMOA:

120504860(EHMT2) 120507404(EHMT1)

OTC:	121336951(EHMT1)

PRUF:

121357548(EHMT1)

GFR:	102036198(EHMT1)

FAB:	101806838(EHMT1)

OMA:	130260086(EHMT1) 130265426

PHI:	102099526(EHMT1)

PMAJ:

107212039(EHMT1)

CCAE:

111936927(EHMT1)

CCW:	104688230(EHMT1)

CBRC:

103619754(EHMT1)

ETL:	114067139(EHMT1)

ZAB:	102068401(EHMT1)

ACHL:

103807342

SVG:	106855969(EHMT1) 106864180(EHMT2)

MMEA:

130580701

HRT:

120761667

FPG:	101916063(EHMT1)

FCH:	102057247(EHMT1)

CLV:	102085960(EHMT1)

EGZ:	104124045(EHMT1)

NNI:	104022219(EHMT1)

PCRI:

104033859(EHMT1)

PLET:

104628592(EHMT1)

EHS:	104509851(EHMT1)

PCAO:

104052160

ACUN:

113486655(EHMT1)

TALA:

104366265(EHMT1)

PADL:

103918930(EHMT1)

AFOR:

103901384(EHMT1)

ACHC:

115335008(EHMT1) 115338419(EHMT2)

HALD:

104319093

HLE:	104833972(EHMT1)

AGEN:

126034829 126052094

GCL:

127023620

CCRI:

104167916(EHMT1)

CMAC:

104480753

MUI:	104537159(EHMT1)

BREG:

104640884(EHMT1)

FGA:

104079014

GSTE:

104255054(EHMT1)

LDI:

104352080

MNB:

103768552

OHA:	104335641(EHMT1)

NNT:	104413053(EHMT1)

SHAB:

115616993(EHMT1)

DPUB:

104296984(EHMT1)

PGUU:

104463876(EHMT1)

CPEA:

104385814(EHMT1)

CVF:	104289057(EHMT1)

RTD:	128917393(EHMT1)

CUCA:

104055878(EHMT1)

TEO:

104379339

BRHI:

104502195

AAM:	106493032(EHMT1)

AROW:

112963025(EHMT1)

NPD:	112955805(EHMT1)

TGT:	104568739(EHMT1)

DNE:	112991335(EHMT1)

SCAM:

104139829(EHMT1)

ASN:	102374916(EHMT1) 102381770(EHMT2)

AMJ:	102564850(EHMT1) 102574756(EHMT2)

CPOO:

109313837(EHMT1)

GGN:	109292861(EHMT1)

PSS:	102450225(EHMT1)

CMY:	102933671(EHMT1)

CCAY:

125621301(EHMT2) 125623355(EHMT1)

DCC:	119844083(EHMT1)

CPIC:

101942163(EHMT1) 101947321(EHMT2)

TST:	117889342(EHMT1)

CABI:

116815182 116816188(EHMT1)

MRV:	120386712(EHMT1) 120392432(EHMT2)

ACS:	100556375(ehmt2) 100565730(ehmt1)

ASAO:

132763865(EHMT1) 132765238(EHMT2)

PVT:	110088696(EHMT2) 110089799(EHMT1)

SUND:

121921274(EHMT2) 121936454(EHMT1)

PBI:	103049261(EHMT2) 103057390(EHMT1)

PMUR:

107295037(EHMT2)

CTIG:

120300707(EHMT1) 120305187(EHMT2)

PGUT:

117667837(EHMT2) 117670273(EHMT1)

APRI:

131186002(EHMT1) 131192517(EHMT2)

PTEX:

113443967(EHMT1) 113449073(EHMT2)

NSS:	113424782(EHMT1) 113425448(EHMT2)

VKO:	123017991(EHMT2) 123028253(EHMT1)

PMUA:

114589035(EHMT1) 114592073(EHMT2)

PRAF:

128406823(EHMT1) 128408977(EHMT2)

ZVI:	118081033(EHMT2) 118083831(EHMT1)

HCG:	128338982(EHMT1) 128344745(EHMT2)

GJA:	107105480(EHMT2) 107118801(EHMT1)

STOW:

125441535(EHMT1)

EMC:	129328200(EHMT2) 129342045(EHMT1)

XLA:	108698163(ehmt1.L) 108698559(ehmt2.L) 108699889(ehmt1.S)

XTR:	100124713(ehmt1) 100484992(ehmt2)

NPR:	108786543(EHMT2) 108794390(EHMT1)

RTEM:

120913250(EHMT2) 120913883(EHMT1)

BBUF:

120977486(EHMT2) 121009155(EHMT1)

BGAR:

122945955(EHMT2) 122946313(EHMT1)

MUO:	115466206(EHMT2) 115472720(EHMT1)

GSH:	117346551(EHMT2) 117368109(EHMT1)

DRE:	100005761(ehmt1a) 402830(ehmt1b) 569250(ehmt2)

SRX:	107706570 107709696 107736883 107739706 107751678 107757960

SANH:

107661424 107681217 107692285 107694038 107694747

SGH:	107548795 107566127 107566632 107595675

CCAR:

109045145 109053896

CAUA:

113038793 113049308 113064116 113074244 113119902 113119918

CGIB:

127941610 127958362 127978942 127985727 128008940

PTET:

122326935(ehmt1b) 122326950 122335280(ehmt2) 122345917(ehmt1a)

LROH:

127152712(ehmt1b) 127164862(ehmt1a) 127182167(ehmt2)

OMC:	131526023(ehmt2) 131529439(ehmt1b) 131540924(ehmt1a)

PPRM:

120469900(ehmt1a) 120475084(ehmt2) 120490807(ehmt1b)

RKG:	130075535(ehmt2) 130089817(ehmt1a)

MAMB:

125252857(ehmt1b) 125266726(ehmt1a) 125275908(ehmt2)

CIDE:

127500885 127503303 127512554

MASI:

127421499 127425224 127428598 127430577 127439577

TROS:

130556561(ehmt2) 130569755(ehmt1b) 130571028

TDW:	130407939(ehmt1b) 130415460(ehmt2) 130418961(ehmt1a)

MANU:

129424382(ehmt1b) 129440155(ehmt1a) 129455022(ehmt2)

IPU:	108255843(ehmt1a) 108274790 108278950(ehmt1b)

IFU:	128598976(ehmt1a) 128618202(ehmt2) 128622493(ehmt1b)

PHYP:

113535464 113536884

SMEO:

124380827(ehmt1a) 124392524(ehmt2) 124397803(ehmt1b)

TFD:	113640067(ehmt1b) 113653372(ehmt1a) 113656482(ehmt2)

TVC:	132854743(ehmt1a) 132856917(ehmt2) 132859532(ehmt1b)

AMEX:

103023021 103023298 103025689(ehmt1)

CMAO:

118800154 118803028 118819695(ehmt1b) 118827356(ehmt1a)

EEE:	113573424(ehmt1) 113577937 113590720

CHAR:

105890033(ehmt1a) 105902570(ehmt1b) 105907713(ehmt2)

TRU:	101072913(ehmt1) 101076450(ehmt2)

TFS:	130516772(ehmt1b) 130518332(ehmt2)

TNG:	GSTEN00009265G001

LCO:	104922530(ehmt2) 104922882 104923797

NCC:	104944159(ehmt1) 104964983(ehmt2)

TBEN:

117477880(ehmt2) 117479040(ehmt1b) 117484616(ehmt1a)

CGOB:

115012933 115015448(ehmt2) 115016519

PGEO:

117452544(ehmt1a) 117455282(ehmt2) 117456526

GACU:

117535740(ehmt1a) 117542604(ehmt2) 117558802(ehmt1b)

EMAC:

134868804(ehmt1b) 134874039(ehmt1a) 134875405(ehmt2)

ELY:	117252502(ehmt1a) 117264216(ehmt2) 117269706(ehmt1b)

EFO:	125890234(ehmt1a) 125904241(ehmt2) 125906001(ehmt1b)

PLEP:

121944074(ehmt1a) 121957927(ehmt2)

SLUC:

116034715(ehmt1b) 116047257(ehmt2) 116050659(ehmt1a)

ECRA:

117944728(ehmt1a) 117956281(ehmt2) 117959394(ehmt1b)

ESP:	116689668 116701771(ehmt2) 116704343

PFLV:

114555209 114568445(ehmt2) 114570753

GAT:	120826184(ehmt2) 120830284(ehmt1a) 120831490(ehmt1b)

PPUG:

119219094(ehmt2) 119225062(ehmt1a) 119226286(ehmt1b)

AFB:	129097232(ehmt2) 129101033(ehmt1a) 129102281(ehmt1b)

CLUM:

117736407(ehmt1a) 117738722(ehmt2) 117740479(ehmt1b)

PSWI:

130198714(ehmt2) 130204992(ehmt1b)

MSAM:

119884592 119891667 119892967 119907368(ehmt2) 119914403(ehmt1b)

SCHU:

122863847(ehmt2) 122865183(ehmt1b) 122875721(ehmt1a)

CUD:	121510414(ehmt1a) 121523685(ehmt2) 121525182(ehmt1b)

ALAT:

119015027(ehmt2) 119019050(ehmt1a) 119029779(ehmt1b)

MZE:	101468177(ehmt2) 101469152 101481293

ONL:	100691163 100697605(ehmt2) 100700166(ehmt1)

OAU:	116318920(ehmt2) 116319606(ehmt1b) 116336331(ehmt1a)

OLA:	101167635 101167716(ehmt2) 101171173

OML:	112141389 112162481(ehmt2) 112163195(ehmt1b)

CSAI:

133450779 133455436(ehmt1b) 133461330(ehmt2)

XMA:	102219854(ehmt1) 102232589(ehmt2)

XCO:	114149754 114156436(ehmt2)

XHE:	116724435(ehmt1) 116730493 116731476(ehmt2)

PRET:

103472894(ehmt2) 103473948

PFOR:

103141958 103154514 103154564(ehmt2)

PLAI:

106951540 106957654 106958856(ehmt2)

PMEI:

106905943 106920575 106931605(ehmt2)

GAF:	122819180(ehmt1b) 122827704(ehmt1a) 122843390(ehmt2)

PPRL:

129351567(ehmt1a) 129354180(ehmt2) 129366627(ehmt1b)

CVG:	107083748(ehmt1) 107086188(ehmt2)

CTUL:

119771641(ehmt1a) 119778038(ehmt2) 119785162(ehmt1b)

GMU:	124872570(ehmt1b) 124877314(ehmt1a) 124879536(ehmt2)

NFU:	107375115 107394506(ehmt2)

KMR:	108243867(ehmt2) 108249279(ehmt1b) 108251110(ehmt1a)

ALIM:

106520823 106527649 106528745

NWH:	119414144 119424964(ehmt1b) 119425759(ehmt2)

AOCE:

111569232 111580771 111581451

MCEP:

124996757(ehmt1b) 125012730(ehmt1a) 125020372(ehmt2)

CSEM:

103394057(ehmt2) 103397363

POV:	109639092 109639137(ehmt2) 109641231 109642561

SSEN:

122758215 122769887 122786699(ehmt2)

HHIP:

117767818(ehmt1a) 117770075(ehmt2) 117771793(ehmt1b)

HSP:	118115404(ehmt1a) 118124531(ehmt2) 118125578(ehmt1b)

SMAU:

118285009(ehmt1b) 118292441(ehmt2) 118314162(ehmt1a)

LCF:	108878664(ehmt1a) 108889015(ehmt1b) 108901185

SDU:	111221113 111223051(ehmt2) 111227770

SLAL:

111648028 111650148 111657826

XGL:	120786732(ehmt2) 120805368(ehmt1a) 120806320(ehmt1b)

HCQ:	109510555 109516321(ehmt2) 109527076

SSCV:

125979190 125987520 125994738

SBIA:

133499359(ehmt2) 133499564(ehmt1a) 133515238(ehmt1b)

PEE:	133395807(ehmt2) 133400457(ehmt1a) 133413308(ehmt1b)

PTAO:

133470624(ehmt2) 133473428 133489952(ehmt1b)

BPEC:

110154648(ehmt1) 110173288(ehmt2)

MALB:

109958623(ehmt2) 109968663

BSPL:

114862136 114865958(ehmt2) 114867111(ehmt1b)

SJO:	128364278(ehmt1a) 128373861(ehmt2) 128380247(ehmt1b)

SASA:

100380769(ehmt2) 106563135 106585429

STRU:

115159671 115164720 115173409 115176004 115203981

OTW:	112229939 112232794(ehmt1a) 112234384(ehmt1b)

OMY:	110487637 110496106 110509707(ehmt1b) 110523494 110525474(ehmt1a)

OGO:	124006763 124012652 124034453 124044385 124047693

ONE:	115111441 115121652 115128285 115131723 115147148

OKI:	109868032 109873685 109877723 109903715 109907615(ehmt2)

OKE:	118375639(ehmt1a) 118385502(ehmt1b) 118387461 118398293 118399193

SALP:

111955128 111963944 111974241

SNH:	120021281 120022460 120025850 120027420 120048332

CCLU:

121541595 121571467 121582604 121584696 121586361

ELS:	105014136 105014923(ehmt1) 105027858(ehmt2)

SFM:	108922673(ehmt1) 108935584(ehmt2)

PKI:	111842789(ehmt2) 111853979

AANG:

118206310(ehmt1a) 118212814(ehmt1b) 118234483(ehmt2)

LOC:

102691045

PSPA:

121299246 121304178 121306708

ARUT:

117396889 117434270 117964709 117964869

PSEX:

120539042(ehmt2) 120543003

LCM:	102361297(EHMT1)

CMK:

103180404

RTP:	109926709(ehmt1b)

CPLA:

122541532 122564772

HOC:	132825820 132832838

LERI:

129711920 129716250(ehmt2)

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

SPU:

DME:	Dmel_CG2995(G9a)

DER:

6555648

DSE:

6615843

DSI:	Dsimw501_GD16494(Dsim_GD16494)

DYA:	Dyak_GE16600

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21426

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101896182 131802332

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

AGRG:

AGB:

LDC:

NVL:

PPYR:

OTU:

BMOR:

MSEX:

BANY:

NIQ:

VCD:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

SLIU:

OFU:

CCRN:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128991607 128992279

PHU:	Phum_PHUM447810

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

DMK:	116929946 123468131

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

PTEP:

ABRU:

UDV:

SDM:

PCAN:

BGT:

GAE:

HRF:

HRJ:	124269370 124291244

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:

NVE:

ATEN:

HMG:

HSY:

ATH:	AT2G22740(SUVH6) AT2G33290(SUVH2) AT2G35160(SUVH5) AT4G13460(SUVH9) AT5G13960(SUVH4)

ALY:	9299204 9309710 9314698 9317341 9317447

CRB:	17877879 17884260 17887759 17888990 17889023

CSAT:

104700122 104702810 104705663 104719111 104723852 104732370 104735412 104749545 104751910 104769624 104781916 104786246

EUS:	EUTSA_v10000700mg EUTSA_v10012985mg EUTSA_v10016339mg

BRP:	103841329 103856044 103864378 103865258 103867384

BNA:	106375862 106392112 106414948 106415578 106431229 106436574 106441185 106446445 106447143 111204287 125609321

BOE:	106312229 106328177 106336729 106336973 106341787

RSZ:	108806095 108835120 108843436 108847015 108854469 108855936

THJ:	104807934 104822423 104826099

CPAP:

110825045 110825586

CIT:	102624087 102628829

CIC:	CICLE_v10004481mg CICLE_v100233292m

PVY:	116108901 116113879 116128387

MINC:

123196253 123211198 123211900 123220962 123222725

TCC:	18601132 18603340 18606171

GRA:	105780142 105792011 105800654

GHI:	107920357 107929106 107929390 107943109 107948509 107948568

GAB:	108456814 108460800 108470114

HSYR:

120114300 120118646 120147726 120173597 120175787 120178236 120178237

DZI:	111292266 111292932 111305110 111306770

EGR:	104414410 104443628 104455565 104456069 120287219

GMX:	100795514 100795584 100796701 100803378 100804592

GSJ:	114390873 114398360 114402488 114419133 114423328

PVU:	PHAVU_002G001600g PHAVU_002G094200g PHAVU_003G007700g

VRA:	106753639 106753665 106777887

VAR:	108329575 108335748 108335858

VUN:	114173754 114174166 114193765

VUM:	124835679 124837331

CCAJ:

109800043 109801539 109818923

APRC:

113863063 113868662 113868919

MTR:	11438560 11438908

TPRA:

123888181 123908222 123915987 123922357

CAM:	101489576 101498068 101508428

PSAT:

127091778 127120572 127126749

VVO:	131595694 131595696 131595697 131595699 131609845 131652341

LJA:	Lj1g3v3904410.1(Lj1g3v3904410.1) Lj2g3v1989010.1(Lj2g3v1989010.1)

ADU:	107471969 107487512 107494601

AIP:	107604874 107623560 107642602

AHF:	112697097 112717100 112720750 112747816 112754988 112782471 112800377 112801997

LANG:

109333113 109338148 109361049

PCIN:

129284405 129306820 129308465 129312630 129320772

QSA:	O6P43_006101 O6P43_009761 O6P43_034032

FVE:	101291792 101300058 101303829

RCN:	112180971 112187610 112196395

PPER:

18776331 18782141 18790095

PMUM:

103323790 103330434 103337130

PAVI:

110756442 110764407 110765817

PDUL:

117628538 117636714

MDM:	103442704 108174661 114820745

MSYL:

126590050 126595167 126596170 126608132 126634541

PXB:	103933655 103937005 103957194

ZJU:	107404291 107422747 107427999

MNT:	21392039 21393025 21396328 21406794 21406798

CSAV:

115700602 115705091 115716228

CSV:	101204477 101212973 101222210

CMO:	103483537 103490844 103491710

BHJ:	120073339 120078619 120090088

MCHA:

111016869 111022642 111024563

CMAX:

111473189 111479670 111481473 111486639 111500227

CMOS:

111431109 111432002 111435244 111441673 111444784

CPEP:

111790527 111790983 111793253 111800298 111809848

RCU:	8265757 8269020 8273097

JCU:	105630213 105632345 105638439

HBR:	110632155 110638606 110648349 110657515

MESC:

110601977 110611292 110612972 110629614

POP:	18096889 7458012 7462391 7475430 7480897

PEU:	105125822 105129392 105130938 105132136 105137430

PALZ:

118041800 118043573 118048781 118057858 118062942

JRE:	108981017 108991569 109001855

CILL:

122289566 122300624 122307316

CAVE:

132175260 132179808 132180876

QSU:	111989703 111996522 112035570

QLO:	115971226 115976353 115981080 115994278

TWL:	119986507 120000506 120015248 120016842 120017272

VVI:	100242100 100244174 100261297 100265173

VRI:	117908502 117914612 117924590 117930160 117933494

SLY:	101247436 101260505 101268173

SPEN:

107005164 107008776 107023216

SOT:	102587095 102596505 102599225

SSTN:

125848905 125862067 125872692

SDUL:

129873821 129882809 129898614

CANN:

107853169 107860805 107872914

LBB:	132604338 132625061 132640842

NTA:	107771580 107776831 107785273 107810602 107825141 107832023

NSY:	104226196 104233835 104244020 104246210

NTO:	104084631 104090127 104095270 104117537

NAU:	109211485 109218116 109227163 109236863

INI:	109174871 109175855 109176461 109185125

ITR:	116021943 116028390

SIND:

105158616 105164786 105171817 105177488

OEU:	111383328 111388414 111407536

EGT:	105975288 105976710

SSPL:

121751931 121779411 121779669 121782525 121782891 121785100 121804683 121808442

SMIL:

131008676 131015206

SHIS:

125197178 125211006 125211808 125214922

APAN:

127255706 127258864

HAN:	110911300 110927345 110930748

ECAD:

122578864 122582213 122600720

LSV:	111881729 111897557 111908241 111911399

CCAV:

112501907 112504010 112521078

DCR:	108203736 108205268 108219203

CSIN:

114261527 114289847 114312670 114316558 114321116 114322219

RVL:	131298444 131303880 131309987 131315992 131332101

AEW:	130755311 130775202 130795296

BVG:	104889398 104897664 104906822

SOE:	110781780 110803243 110805240

CQI:	110692535 110702627 110727202 110727304 110730304

ATRI:

130800284 130809199 130817576 130820923 130821361 130825857

MOF:	131144881 131167720

NNU:	104589448 104591863 104600986 104602742

MING:

122076744 122079906 122081686 122086029 122086299

TSS:	122648479 122653680 122663762 122664641

PSOM:

113304357 113318144 113329937 113333672

OSA:	4326952 4343074 4346352 4346857

DOSA:

Os01t0927000-01(Os01g0927000) Os07t0435900-01(Os07g0435900) Os08t0565700-01(Os08g0565700) Os09t0362900-01(Os09g0362900)

OBR:	102712565 102713421 102720354 102722786

OGL:	127779615 127781812 127784374 127784769

BDI:	100824574 100825032 100833051 104582943

ATS:	109741537 109741621 109749619 109750455 109766085 109769961 109770115 109774279

TDC:	119270185 119270279 119272931 119278253 119279960 119279961 119285308 119293736 119301344 119301379 119308903 119309055 119318206 119341542 119354419 119357594 119360691 119363575

TUA:	125509135 125509165 125516074 125530707 125531244 125537226 125545821 125549117

LPER:

127300771 127300814 127316100 127323768 127331563 127333443 127345470 127345567

LRD:	124648808 124650974 124651390 124652315 124656704 124656746 124661676 124661863 124662476 124670298 124670634 124682128

SBI:	8054815 8055575 8059729 8081297

ZMA:	100382441 100383674 103647380 542089

SITA:

101756377 101768597 101771696 101783431

SVS:	117843653 117847100 117858146 117859500 117864810

PVIR:

120641474 120659885 120660470 120669983 120675206 120677551 120683361 120698859 120709139 120713147

PHAI:

112880488 112884119 112893853 112896686 112899159

PDA:	103707804 103721289 103723084 103723719

EGU:	105034894 105043130 105049737 105057553

MUS:	103985050 103993760 103994178

ZOF:	121971026 121976638 121979952 121985426 122020107 122020642 122022562 122023903

DCT:	110101480 110103468 110111597

PEQ:	110022007 110038667 110039425

AOF:	109822591 109824931 109838123

MSIN:

131246622 131248061

NCOL:

116257570 116265645

ATR:	18429167 18447704

SMO:	SELMODRAFT_104841 SELMODRAFT_232379(SDG33-1)

PPP:	112273076 112281546

» show all

Reference

PMID:20118233

Authors

Huang J, Dorsey J, Chuikov S, Perez-Burgos L, Zhang X, Jenuwein T, Reinberg D, Berger SL

Title

G9a and Glp methylate lysine 373 in the tumor suppressor p53.

Journal

J Biol Chem 285:9636-41 (2010)
DOI:10.1074/jbc.M109.062588

Sequence

[hsa:10919 79813]

ORTHOLOGY: K11423

Entry

K11423                      KO

Symbol

SETD2

Name

[histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H02444

Luscan-Lumish syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.359  [histone H3]-lysine36 N-trimethyltransferase
     K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase

Other DBs

GO:

0046975

Genes

HSA:	29072(SETD2)

PTR:	460331(SETD2)

PPS:	100993006(SETD2)

GGO:	101132140(SETD2)

PON:	100433116(SETD2)

NLE:	100584442(SETD2)

HMH:	116473532(SETD2)

MCC:	711825(SETD2)

MCF:	102121581(SETD2)

MTHB:

126948577

MNI:

105480624

CSAB:

103227561(SETD2)

CATY:

105573623(SETD2)

PANU:

101026986(SETD2)

TGE:	112618523(SETD2)

MLEU:

105540477(SETD2)

RRO:	104671311(SETD2)

RBB:	108517641(SETD2)

TFN:	117080326(SETD2)

PTEH:

111555466(SETD2)

CANG:

105509827(SETD2)

CJC:	100411953(SETD2)

SBQ:	101034613(SETD2)

CIMI:

108305438(SETD2)

CSYR:

103273788(SETD2)

MMUR:

105874896(SETD2)

LCAT:

123623336(SETD2)

PCOQ:

105827280(SETD2)

OGA:	100950439(SETD2)

MMU:	235626(Setd2)

MCAL:

110301050(Setd2)

MPAH:

110328077(Setd2)

RNO:	316013(Setd2)

MCOC:

116072571(Setd2)

ANU:	117693276(Setd2)

MUN:	110554986(Setd2)

CGE:	100765637(Setd2)

MAUA:

101830442(Setd2)

PROB:

127235952(Setd2)

PLEU:

114705174(Setd2)

MORG:

121464185(Setd2)

MFOT:

126499805

AAMP:

119808984(Setd2)

NGI:	103732034(Setd2)

CPOC:

100719166(Setd2)

CCAN:

109689470(Setd2)

DORD:

105996211(Setd2)

DSP:	122126928(Setd2)

PLOP:

125342285(Setd2)

NCAR:

124969403

MMMA:

107145083(Setd2)

OCU:

100351499

OPI:	101516490(SETD2)

TUP:	102477917(SETD2)

GVR:	103591229(SETD2)

CFA:	476643(SETD2)

CLUD:

112666853(SETD2)

VVP:	112912390(SETD2)

VLG:	121494650(SETD2)

NPO:	129521732(SETD2)

AML:	100466135(SETD2)

UMR:	103675118(SETD2)

UAH:	113256807(SETD2)

UAR:	123779799(SETD2)

ELK:

111144347

LLV:

125081004

MPUF:

101681942(SETD2)

MNP:	132011261(SETD2)

MLK:	131823866(SETD2)

NVS:	122909482(SETD2)

ORO:	101365495(SETD2)

EJU:	114196503(SETD2)

ZCA:	113916609(SETD2)

MLX:	118005368(SETD2)

NSU:	110577582(SETD2)

LWW:	102727823(SETD2)

FCA:	101085029(SETD2)

PYU:	121026806 121026808

PCOO:

112852684(SETD2)

PBG:	122487199(SETD2)

PVIV:

125154219(SETD2)

LRUF:

124523532

PTG:	102955436(SETD2)

PPAD:

109247730(SETD2)

PUC:

125930654

AJU:

106969033

HHV:	120229315(SETD2)

BTA:	539860(SETD2)

BOM:	102266643(SETD2)

BIU:	109575988(SETD2)

BBUB:

102393639(SETD2)

BBIS:

105004686(SETD2)

CHX:	102183113(SETD2)

OAS:	101114649(SETD2)

BTAX:

128044432(SETD2)

ODA:	120868180(SETD2)

CCAD:

122424798(SETD2)

MBEZ:

129547776(SETD2)

SSC:	100623101(SETD2)

CFR:	102512396(SETD2)

CBAI:

105072880(SETD2)

CDK:	105103636(SETD2)

VPC:	102531919(SETD2)

BACU:

102997833(SETD2)

BMUS:

118903175(SETD2)

LVE:	103086894(SETD2)

OOR:	101269476 101280364(SETD2) 101282703 125961717

DLE:	111174450(SETD2)

PCAD:

112064944(SETD2)

PSIU:

116742461 116742477 116761205 116761609(SETD2) 116764505

NASI:

112403750(SETD2)

ECB:	100064888(SETD2)

EPZ:	103551032(SETD2)

EAI:	106823246(SETD2)

MYB:	102260404(SETD2)

MYD:	102758485(SETD2)

MMYO:

118668537(SETD2)

MLF:	102435793(SETD2)

PKL:	118714790(SETD2)

EFUS:

103299125(SETD2)

MNA:	107529409(SETD2)

DRO:	112309866(SETD2)

SHON:

118976190(SETD2)

AJM:	119037871(SETD2)

PDIC:

114501512(SETD2)

PHAS:

123830508(SETD2)

MMF:	118633365(SETD2)

PPAM:

129087631(SETD2)

HAI:	109376628(SETD2)

RFQ:	117036580(SETD2)

PALE:

102884085(SETD2)

PGIG:

120582282(SETD2)

PVP:	105302344(SETD2)

RAY:	107509112(SETD2)

MJV:	108400455(SETD2) 108401248 118966919

TOD:	119259277(SETD2)

SARA:

101550871(SETD2)

SETR:

126014003(SETD2)

LAV:	100655356(SETD2)

TMU:

101343139

ETF:	101642970(SETD2)

DNM:	101433648(SETD2)

MDO:	100024848(SETD2)

GAS:	123252909(SETD2)

SHR:	100931646(SETD2)

PCW:	110217008(SETD2)

OAA:	114816148(SETD2)

GGA:	420404(SETD2)

PCOC:

116238217(SETD2)

MGP:	100539457(SETD2)

CJO:	107308808(SETD2)

TPAI:

128087412(SETD2)

LMUT:

125695638(SETD2)

NMEL:

110393293(SETD2)

APLA:

113842604(SETD2)

ACYG:

106046805(SETD2)

CATA:

118251837(SETD2)

AFUL:

116486033(SETD2)

TGU:	100224614(SETD2)

LSR:	110476945(SETD2)

SCAN:

103813035(SETD2)

PMOA:

120510532(SETD2)

OTC:	121337966(SETD2)

PRUF:

121351804(SETD2)

GFR:	102039322(SETD2)

FAB:	101814785(SETD2)

OMA:	130249334(SETD2)

PHI:	102106397(SETD2)

PMAJ:

107215411(SETD2)

CCAE:

111925482(SETD2)

CCW:	104686490(SETD2)

CBRC:

103623957(SETD2)

ETL:	114070402(SETD2)

ZAB:	102070924(SETD2)

ACHL:

103808009(SETD2)

SVG:	106862800(SETD2)

MMEA:

130574556(SETD2)

HRT:	120754330(SETD2)

FPG:	101913975(SETD2)

FCH:	102053248(SETD2)

CLV:	102098192(SETD2)

EGZ:	104123260(SETD2)

NNI:	104019238(SETD2)

PCRI:

104035741(SETD2)

PLET:

104618506(SETD2)

EHS:	104510412(SETD2)

PCAO:

104043224(SETD2)

ACUN:

113476423(SETD2)

TALA:

104358172(SETD2)

PADL:

103916778(SETD2)

AFOR:

103903408(SETD2)

ACHC:

115338781(SETD2)

HALD:

104322327

HLE:	104829204(SETD2)

AGEN:

126038089

GCL:

127012720

CCRI:

104159334(SETD2)

CMAC:

104473045(SETD2)

MUI:	104544284(SETD2)

BREG:

104641398(SETD2)

FGA:	104082936(SETD2)

GSTE:

104255118

LDI:	104353735(SETD2)

OHA:	104332883(SETD2)

NNT:

104407506

SHAB:

115611158(SETD2)

DPUB:

104306779(SETD2)

PGUU:

104457667(SETD2)

ACAR:

104529664(SETD2)

CPEA:

104387994(SETD2)

AVIT:

104275817(SETD2)

CVF:	104289689(SETD2)

RTD:	128906101(SETD2)

CUCA:

104055045(SETD2)

TEO:	104378282(SETD2)

BRHI:

104493974(SETD2)

AROW:

112977399(SETD2)

NPD:	112947562 112951575

TGT:	104570962(SETD2)

DNE:	112992776(SETD2)

SCAM:

104150107(SETD2)

ASN:	102378063(SETD2)

AMJ:	102567964(SETD2)

CPOO:

109306447(SETD2)

GGN:	109291156(SETD2)

PSS:	102460966(SETD2)

CMY:	102947543(SETD2)

CCAY:

125631124(SETD2)

DCC:	119851175(SETD2)

CPIC:

101953039(SETD2)

TST:	117871919(SETD2)

CABI:

116819138(SETD2)

MRV:	120397709(SETD2)

ACS:	100559621(setd2)

ASAO:

132779047(SETD2)

PVT:	110069987(SETD2)

SUND:

121933414(SETD2)

PBI:	103055763(SETD2)

PMUR:

107286005(SETD2)

CTIG:

120319695(SETD2)

TSR:	106542655(SETD2)

PGUT:

117656347(SETD2)

APRI:

131196724(SETD2)

PTEX:

113452005(SETD2)

NSS:	113427149(SETD2)

VKO:	123020920(SETD2)

PMUA:

114607160(SETD2)

PRAF:

128423845(SETD2)

ZVI:	118091669(SETD2)

HCG:	128329599(SETD2)

GJA:	107120098(SETD2)

STOW:

125440838(SETD2)

EMC:	129338042(SETD2)

XLA:	108718681(setd2.L) 108719797(setd2.S)

XTR:	100492810(setd2)

RTEM:

120941687(SETD2)

BBUF:

121000811(SETD2)

BGAR:

122938723(SETD2)

MUO:	115465989(SETD2)

GSH:	117354403(SETD2)

DRE:	794199(setd2)

SRX:	107743179 107752833

SANH:

107673014 107685560

SGH:	107581536 107596709

CCAR:

109063165

CAUA:

113060209 113116306

CGIB:

127969714 127975534 128030804

PTET:

122360104(setd2)

LROH:

127178249(setd2)

OMC:	131521470(setd2)

PPRM:

120484453(setd2)

RKG:	130070181(setd2)

MAMB:

125243135(setd2)

CIDE:

127497709

MASI:

127454335

TROS:

130557516(setd2)

TDW:	130432613(setd2)

MANU:

129447809(setd2)

IPU:

108267177

IFU:	128608990(setd2)

PHYP:

113542507(setd2)

SMEO:

124384161(setd2)

TFD:	113644580(setd2)

TVC:	132845981(setd2)

AMEX:

103039344(setd2)

CMAO:

118825674(setd2)

EEE:	113570706(setd2)

TRU:	101076040(setd2)

TFS:	130532370(setd2)

TNG:	GSTEN00034080G001

LCO:	104940331(setd2)

NCC:	104948745(setd2) 104957630

TBEN:

117480208(setd2)

CGOB:

115021807(setd2)

PGEO:

117460444(setd2)

GACU:

117554101(setd2)

EMAC:

134861484(setd2)

ELY:	117265736(setd2)

EFO:	125893649(setd2)

PLEP:

121945864(setd2)

SLUC:

116049433(setd2)

ECRA:

117945702(setd2)

ESP:	116690678(setd2)

PFLV:

114557737(setd2)

GAT:	120810650(setd2)

PPUG:

119197772(setd2)

AFB:	129109168(setd2)

CLUM:

117745025(setd2)

PSWI:

130212725(setd2)

MSAM:

119897705(setd2)

SCHU:

122881330(setd2)

CUD:	121513186(setd2)

ALAT:

119006696(setd2)

MZE:	101471514(setd2)

ONL:	100689872(setd2)

OAU:	116325355(setd2)

OLA:	101163764(setd2)

OML:	112143951(setd2)

CSAI:

133430454(setd2)

XMA:	102216591(setd2)

XCO:	114141991(setd2)

XHE:	116717187(setd2)

PRET:

103478611(setd2)

PFOR:

103152270(setd2)

PLAI:

106939758(setd2)

PMEI:

106906609(setd2)

GAF:	122831473(setd2)

PPRL:

129371146(setd2)

CVG:	107081814(setd2)

CTUL:

119772867(setd2)

GMU:	124865731(setd2)

NFU:	107395695(setd2)

KMR:	108241998(setd2)

ALIM:

106534862

NWH:	119409449(setd2)

AOCE:

111572050(setd2)

MCEP:

125016073(setd2)

CSEM:

103388382(setd2)

POV:	109633212(setd2)

SSEN:

122774466(setd2)

HHIP:

117777387(setd2)

HSP:	118113301(setd2)

SMAU:

118308029(setd2)

LCF:

108891907

SDU:	111236791(setd2)

SLAL:

111652786(setd2)

XGL:	120783986(setd2)

HCQ:	109518019(setd2)

SSCV:

125975337

SBIA:

133500905(setd2)

PEE:	133401664(setd2)

PTAO:

133479116(setd2)

BPEC:

110171513(setd2)

MALB:

109967312(setd2)

BSPL:

114843737(setd2)

SJO:	128366082(setd2)

SASA:

106593284 106593288 106606040

STRU:

115187660 115187661

OTW:	112243644(setd2)

OMY:	110520688(setd2)

OGO:	124019594(setd2)

ONE:

115115571

OKI:

109882680

SALP:

112076057(setd2)

SNH:	120031365(setd2)

CCLU:

121542611(setd2) 121542806

ELS:	105018749(setd2)

SFM:	108927425(setd2)

PKI:	111850417(setd2)

AANG:

118228444(setd2)

LOC:	102690042 102692025(setd2)

PSPA:

121312967 121314673

ARUT:

117394754 117400236

PSEX:

120515800(setd2)

LCM:	102359121(SETD2)

CMK:	103190896(setd2)

CPLA:

122548953(setd2)

HOC:	132815050(setd2)

LERI:

129714861(setd2)

PMRN:

116940988(SETD2)

LRJ:	133344877(SETD2)

BFO:

BBEL:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG1716(Set2)

DER:

6551019

DSE:

6618681

DSI:	Dsimw501_GD17127(Dsim_GD17127)

DYA:	Dyak_GE17076

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12297

DAZ:	108614554 108619464

DNV:	108652260 108656778

DHE:	111593003 111598712

DVI:	6623058 6631536

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ005876

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:	109855296 109859218

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM463920

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_319776

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

BGT:

GAE:

HRF:

HRJ:

CRG:

PMAX:

OBI:

OSN:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

Reference

PMID:16118227

Authors

Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z

Title

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.

Journal

J Biol Chem 280:35261-71 (2005)
DOI:10.1074/jbc.M504012200

Sequence

[hsa:29072]

ORTHOLOGY: K11421

Entry

K11421                      KO

Symbol

SETDB1

Name

[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04550

Signaling pathways regulating pluripotency of stem cells

Reaction

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.366  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
     K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase

Other DBs

GO:

0046974

Genes

HSA:	9869(SETDB1)

PTR:	469481(SETDB1)

PPS:	100972839(SETDB1)

GGO:	101146215(SETDB1)

PON:	100431310(SETDB1)

NLE:	100581330(SETDB1)

HMH:	116469470(SETDB1)

MCC:	716141(SETDB1)

MCF:	102117410(SETDB1)

MTHB:

126931370

MNI:	105497821(SETDB1)

CSAB:

103247223(SETDB1)

CATY:

105590302(SETDB1)

PANU:

101002056(SETDB1)

TGE:	112620272(SETDB1)

MLEU:

105534755(SETDB1)

RRO:	104681064(SETDB1)

RBB:	108533259(SETDB1)

TFN:	117075079(SETDB1)

PTEH:

111543630(SETDB1)

CANG:

105508932(SETDB1)

CJC:	100411734(SETDB1)

SBQ:	101042658(SETDB1)

CIMI:

108316459(SETDB1)

MMUR:

105872992(SETDB1)

LCAT:

123633944(SETDB1)

PCOQ:

105821953(SETDB1)

OGA:	100940994(SETDB1)

MMU:	84505(Setdb1)

MCAL:

110291522(Setdb1)

MPAH:

110320737(Setdb1)

RNO:	689883(Setdb1)

MCOC:

116093409(Setdb1)

ANU:	117706616(Setdb1)

MUN:	110560774(Setdb1)

CGE:	100765697(Setdb1)

MAUA:

101843804(Setdb1)

PROB:

127232822(Setdb1)

PLEU:

114682368(Setdb1)

MORG:

121437839 121450501

MFOT:

126489995

AAMP:

119800749(Setdb1)

NGI:	103730089(Setdb1)

HGL:	101715248(Setdb1)

CPOC:

100721293(Setdb1)

CCAN:

109681205(Setdb1)

DORD:

105984728(Setdb1)

DSP:	122109123(Setdb1)

PLOP:

125360015(Setdb1)

NCAR:

124959679

MMMA:

107156826(Setdb1)

OCU:

100355877

OPI:	101525521(SETDB1)

TUP:	102502264(SETDB1)

GVR:	103600244(SETDB1)

CFA:	483186(SETDB1)

CLUD:

112663993(SETDB1)

VVP:	112907769(SETDB1)

VLG:	121490848(SETDB1)

NPO:	129501338(SETDB1)

AML:	100482250(SETDB1)

UMR:	103667532(SETDB1)

UAH:	113246155(SETDB1)

UAR:	123787733(SETDB1)

ELK:

111162065

LLV:

125097118

MPUF:

101677094(SETDB1)

MNP:	132001451(SETDB1)

MLK:	131808783(SETDB1)

NVS:	122900483(SETDB1)

ORO:	101372094(SETDB1)

EJU:	114197337(SETDB1)

ZCA:	113925244(SETDB1)

MLX:	118000316(SETDB1)

NSU:	110578595(SETDB1)

LWW:	102732334(SETDB1)

FCA:	101094118(SETDB1)

PCOO:

112871086(SETDB1)

PBG:	122481136(SETDB1)

PVIV:

125159475(SETDB1)

LRUF:

124514448

PTG:	102970727(SETDB1)

PPAD:

109257028(SETDB1)

PUC:

125912118

AJU:

106979835

HHV:	120241290(SETDB1)

BTA:	100138100(SETDB1)

BOM:	102288279(SETDB1)

BIU:	109555305(SETDB1)

BBUB:

102408652(SETDB1)

BBIS:

104987649(SETDB1)

CHX:	102180982(SETDB1)

OAS:	101109230(SETDB1)

BTAX:

128044362(SETDB1)

ODA:	120855906(SETDB1)

CCAD:

122434373(SETDB1)

MBEZ:

129540648(SETDB1)

SSC:	100157920(SETDB1)

CFR:	102512057(SETDB1)

CBAI:

105071738(SETDB1)

CDK:	105103196(SETDB1)

VPC:	102545931(SETDB1)

BACU:

103009894(SETDB1)

BMUS:

118897508(SETDB1)

LVE:	103076461(SETDB1)

OOR:	101270688(SETDB1)

DLE:	111169744(SETDB1)

PSIU:

116751422(SETDB1)

NASI:

112411620(SETDB1)

ECB:	100059254(SETDB1)

EPZ:	103547642(SETDB1)

EAI:	106846522(SETDB1)

MYB:	102257713(SETDB1)

MYD:	102773684(SETDB1)

MMYO:

118672742(SETDB1)

MLF:	102441225(SETDB1)

PKL:	118727467(SETDB1)

EFUS:

103298980(SETDB1)

MNA:	107539129(SETDB1)

DRO:	112313537(SETDB1)

AJM:	119034734(SETDB1)

PDIC:

114488934(SETDB1)

PHAS:

123804304(SETDB1)

MMF:	118637044(SETDB1)

PPAM:

129062305(SETDB1)

HAI:	109372277(SETDB1)

RFQ:	117014537(SETDB1)

PGIG:

120585218(SETDB1)

PVP:	105303858(SETDB1)

RAY:	107499036(SETDB1)

MJV:	108409453(SETDB1)

TOD:	119237184(SETDB1)

SARA:

101554078(SETDB1)

SETR:

125997533(SETDB1)

LAV:	100673374(SETDB1)

TMU:

101349341

ETF:	101658224(SETDB1)

DNM:	101437951(SETDB1)

MDO:	100618580(SETDB1)

GAS:	123244280(SETDB1)

SHR:	100928904(SETDB1)

AFZ:

127559091

PCW:	110220597(SETDB1)

OAA:	100091318(SETDB1)

GGA:	100859816(SETDB1)

PCOC:

116238423(SETDB1)

MGP:	100542346(SETDB1)

CJO:	107324577(SETDB1)

TPAI:

128071922(SETDB1)

LMUT:

125685794(SETDB1)

NMEL:

110387900(SETDB1)

APLA:

101794756(SETDB1)

ACYG:

106049268(SETDB1)

CATA:

118260462(SETDB1)

AFUL:

116499648(SETDB1)

TGU:	100231651(SETDB1)

LSR:	110476821(SETDB1)

SCAN:

103824025

PMOA:

120502592(SETDB1)

OTC:	121335607(SETDB1)

PRUF:

121353495(SETDB1)

GFR:	102034546(SETDB1)

OMA:	130263386(SETDB1)

PHI:	102101563(SETDB1)

PMAJ:

107214655(SETDB1)

CCAE:

111939473(SETDB1)

CBRC:

103619600(SETDB1)

ETL:	114071955(SETDB1)

ZAB:	102061470(SETDB1)

SVG:	106862356(SETDB1)

MMEA:

130587054(SETDB1)

HRT:	120764209(SETDB1)

FPG:	101912073(SETDB1)

FCH:	102055212(SETDB1)

CLV:	102094505(SETDB1)

EGZ:	104129700(SETDB1)

NNI:	104014430(SETDB1)

PCRI:

104037271(SETDB1)

PLET:

104619247(SETDB1)

EHS:	104509218(SETDB1)

PCAO:

104051886(SETDB1)

ACUN:

113488725(SETDB1)

TALA:

116964156 122152589

PADL:

103919479(SETDB1)

AFOR:

103900501(SETDB1)

ACHC:

115345534(SETDB1)

HALD:

104312868(SETDB1)

HLE:	104830529(SETDB1)

AGEN:

126040314

GCL:

127027051

CCRI:

104157123(SETDB1)

CMAC:

104487401

MUI:

104548107

BREG:

104638314(SETDB1)

FGA:	104082850(SETDB1)

GSTE:

104254890(SETDB1)

OHA:	104330237(SETDB1)

NNT:

104409719

SHAB:

115602619(SETDB1)

PGUU:

104471117(SETDB1)

ACAR:

104527661(SETDB1)

CPEA:

104390376(SETDB1)

CVF:	104285442(SETDB1)

RTD:	128900884(SETDB1)

CUCA:

104066027(SETDB1)

TEO:	104372742(SETDB1)

AAM:	106495416(SETDB1)

AROW:

112972521(SETDB1)

NPD:	112952968(SETDB1)

TGT:	104573259(SETDB1)

DNE:	112990032(SETDB1)

SCAM:

104139540(SETDB1)

ASN:	102382539(SETDB1)

AMJ:	102575637(SETDB1)

CPOO:

109324826(SETDB1)

CMY:	102937828(SETDB1)

CCAY:

125625560(SETDB1)

DCC:	119848135(SETDB1)

CPIC:

101931963(SETDB1)

TST:	117869706(SETDB1)

CABI:

116817630(SETDB1)

MRV:	120390026(SETDB1)

ACS:	100565799(setdb1)

ASAO:

132764180(SETDB1)

PVT:	110081479(SETDB1)

SUND:

121916245(SETDB1)

PBI:	103053131(SETDB1)

PMUR:

107292899(SETDB1)

CTIG:

120317077(SETDB1)

TSR:	106546292(SETDB1)

PGUT:

117670132(SETDB1)

APRI:

131186537(SETDB1)

PTEX:

113452534 113452537

VKO:	123032928(SETDB1)

PMUA:

114586177(SETDB1)

PRAF:

128403733(SETDB1)

ZVI:	118075630(SETDB1)

HCG:	128337288(SETDB1)

GJA:	107121584(SETDB1)

STOW:

125436664(SETDB1)

EMC:	129342370(SETDB1)

XLA:	108700333(setdb1.S) 432147(setdb1.L)

XTR:	100490309(setdb1)

NPR:	108789810(SETDB1)

RTEM:

120920703(SETDB1)

BBUF:

120981785(SETDB1)

BGAR:

122923222(SETDB1)

MUO:	115458064(SETDB1)

GSH:	117349981(SETDB1)

DRE:	553292(setdb1a) 768131(setdb1b)

SRX:	107717459 107723461 107724106 107739578

SANH:

107656477 107671207 107693347 107700161

SGH:	107573682 107582057 107589406 107599511

CCAR:

109105279 109111939 109111941

CAUA:

113060012 113062169 113077897 113116442 113120007

CGIB:

127935667 127974706 127979020 128030992

PTET:

122360609(setdb1b)

LROH:

127178914(setdb1b) 127182106(setdb1a)

OMC:	131522361(setdb1b) 131525288(setdb1a)

PPRM:

120483677(setdb1a) 120484392(setdb1b)

RKG:	130070813(setdb1a) 130101819(setdb1b)

MAMB:

125243644(setdb1b) 125275542(setdb1a)

CIDE:

127497987 127500631

MASI:

127420967 127425596 127452895 127453831

TROS:

130557672(setdb1b) 130567279(setdb1a)

TDW:	130415319(setdb1a) 130433287(setdb1b)

MANU:

129447933(setdb1b) 129454460(setdb1a)

IPU:	108266106(setdb1b) 108272679(setdb1a)

IFU:	128607541(setdb1b) 128615241(setdb1a)

PHYP:

113535137 113542451(setdb1)

SMEO:

124382145(setdb1a) 124384982(setdb1b)

TFD:	113641276(setdb1a) 113643512(setdb1b)

TVC:	132842876(setdb1a) 132846150(setdb1b)

AMEX:

103027968(setdb1) 103028156

CMAO:

118805978(setdb1a) 118824354(setdb1b)

EEE:	113570608(setdb1) 113572599

CHAR:

105912991(setdb1b)

TRU:	101075200(setdb1)

TFS:

130532902

TNG:	GSTEN00015370G001

LCO:	104920543(setdb1)

NCC:	104944919(setdb1)

TBEN:

117471276 117480563(setdb1b)

CGOB:

115021722

PGEO:

117461095(setdb1b)

GACU:

117541016(setdb1b)

EMAC:

134861592(setdb1b)

ELY:	117266438(setdb1b)

EFO:

125893368

PLEP:

121946021

SLUC:

116049589(setdb1b)

ECRA:

117946699(setdb1b)

ESP:	116691442(setdb1)

PFLV:

114557339

GAT:	120810231(setdb1b)

PPUG:

119198096(setdb1b)

AFB:

129109882

CLUM:

117745225(setdb1b)

PSWI:

130213014(setdb1b)

MSAM:

119897547(setdb1b)

SCHU:

122881587(setdb1b)

CUD:	121514026(setdb1b)

ALAT:

119006504(setdb1b)

MZE:	101465322(setdb1)

ONL:	100710331(setdb1)

OAU:	116321097(setdb1b)

OLA:	101158302(setdb1)

OML:

112143498

CSAI:

133432938(setdb1b)

XMA:	102235762(setdb1)

XCO:	114141956(setdb1)

XHE:	116717442(setdb1)

PRET:

103478723(setdb1)

PFOR:

103136616 103136620

PLAI:

106938375 106943293

PMEI:

106922006(setdb1)

GAF:	122830571(setdb1b)

PPRL:

129371135(setdb1b)

CVG:	107088829(setdb1)

CTUL:

119783009(setdb1b)

GMU:	124866219(setdb1b)

NFU:	107379696(setdb1)

KMR:	108241152(setdb1b)

ALIM:

106515090

NWH:	119410006(setdb1b)

AOCE:

111586482(setdb1)

MCEP:

125016823(setdb1b)

CSEM:

103388279(setdb1)

POV:

109633224

SSEN:

122774888

HHIP:

117777184(setdb1b)

HSP:	118113532(setdb1b)

SMAU:

118299766(setdb1b)

LCF:

108885905

SDU:	111230127(setdb1)

SLAL:

111652197(setdb1)

XGL:	120784269(setdb1b)

HCQ:	109522778(setdb1)

SSCV:

125975637

SBIA:

133501043(setdb1b)

PEE:	133401340(setdb1b)

PTAO:

133479743(setdb1b)

BPEC:

110163046(setdb1)

MALB:

109970226

BSPL:

114842555(setdb1b)

SJO:	128366464(setdb1b)

SASA:

106574954 106588190

STRU:

115173296 115176358 115189463

OTW:	112236082 112247848 112266649

OMY:	110496022 110520820 110536431

OGO:	123998183 124005934 124012669

ONE:	115113782 115123820 115128219

OKI:	109883759 109886460 109907679

OKE:	118374768 118383196 118399124

SALP:

111955709 111964582(setdb1)

SNH:	120022441 120031206 120037512

CCLU:

121543877 121586324 123484099

ELS:	105018987(setdb1) 105030119

SFM:	108923796(setdb1)

PKI:	111853328(setdb1)

AANG:

118225516(setdb1b)

PSPA:

121306955

ARUT:

117395637 117962652

PSEX:

120538027(setdb1a)

LCM:	102356699(SETDB1)

HOC:	132805644(setdb1b)

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG12196(egg)

DER:

6548401

DSE:

6618876

DSI:	Dsimw501_GD24920(Dsim_GD24920)

DYA:	Dyak_GE11418

DAN:

DSR:

DPO:

DPE:

DMN:	108159156 117192580

DWI:

6640308

DGR:

6560486

DMO:	Dmoj_GI19513

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119680913 119682533

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AALB:

CQU:	CpipJ_CPIJ016652

CPII:

120413132

CNS:	116338143 116352420

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:	110383113(egg)

HZE:

TNL:

SLIU:

OFU:

PXY:	105384716 105392435

CCRN:

123299289

API:	100165352 100574903

DNX:	107166873 107167319

AGS:	114120564 114123773

RMD:	113553560 113553623

ACOO:

126843160

DVT:	126893853 126893854 126902782

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM415050

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:	110847722 110850679

DPX:	DAPPUDRAFT_303556 DAPPUDRAFT_304216

DMK:	116929683 116932783

DPZ:	124312290 124351093

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135200471 135200933 135204636

HAZT:

108673081

EAF:	111695332 111709742

LSM:

121123621

TCF:

131879963

PPOI:

119104173 119107951 119107955

DSV:	119440663 119450321

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_R05D3.11(met-2)

CBR:	CBG_18157(Cbr-met-2)

CRQ:	GCK72_010167

BMY:	BM_BM5216(Bma-met-2)

LOA:	LOAG_17898

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:

SMM:	Smp_150850.1

SHX:	MS3_00010918(SETDB1B)

OVI:	T265_08195

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

DGT:

XEN:

HMG:

Reference

PMID:17952062

Authors

Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S

Title

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.

Journal

Nat Cell Biol 9:1273-85 (2007)
DOI:10.1038/ncb1647

Sequence

[hsa:9869]

Reference

PMID:11791185

Authors

Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y

Title

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.

Journal

Oncogene 21:148-52 (2002)
DOI:10.1038/sj.onc.1204998

Sequence

[mmu:84505]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (3428)   
   KEGG GENES (684)   
   KEGG MGENES (364)   
   RefGene (2374)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (3444)   

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