KEGG ORTHOLOGY: K14959

ORTHOLOGY: K14959

Entry

K14959                      KO

Symbol

MLL4

Name

[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H00831

Primary dystonia

H01613

Follicular lymphoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   03036 Chromosome and associated proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   HMT complexes
    MLL3/MLL4 complex
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4

Other DBs

GO:

0042800

Genes

HSA:	9757(KMT2B)

PTR:	455959(KMT2B)

PPS:	100979249(KMT2B)

GGO:	101139923(KMT2B)

PON:	100442005(KMT2B)

NLE:	100594433(KMT2B)

HMH:	116478917(KMT2B)

MCC:	718835(KMT2B)

MCF:	102115861(KMT2B)

MTHB:

126941879

MNI:	105495504(KMT2B)

CSAB:

103234531(KMT2B)

CATY:

105578189(KMT2B)

PANU:

101011413(KMT2B)

TGE:	112613055(KMT2B)

MLEU:

105543104(KMT2B)

RRO:	104667085(KMT2B)

RBB:	108512323(KMT2B)

TFN:	117092369(KMT2B)

PTEH:

111529937(KMT2B)

CANG:

105516695(KMT2B)

CJC:	100407541(KMT2B)

SBQ:	101034359(KMT2B)

CIMI:

108286344(KMT2B)

CSYR:

103249681(KMT2B)

MMUR:

105876915(KMT2B)

LCAT:

123624459(KMT2B)

PCOQ:

105816259(KMT2B)

OGA:	100941061(KMT2B)

MMU:	75410(Kmt2b)

MCAL:

110297666(Kmt2b)

MPAH:

110338314(Kmt2b)

RNO:	102550344(Kmt2b)

MCOC:

116101986(Kmt2b)

ANU:	117709080(Kmt2b)

MUN:	110550986(Kmt2b)

CGE:	100750575(Kmt2b)

MAUA:

101835352(Kmt2b)

PROB:

127238764(Kmt2b)

PLEU:

114681635(Kmt2b)

MORG:

121449315(Kmt2b)

MFOT:

126486716

AAMP:

119820602(Kmt2b)

NGI:	103729965(Kmt2b)

HGL:	101699273(Kmt2b)

CPOC:

100735175(Kmt2b)

CCAN:

109689598(Kmt2b)

DORD:

105993122(Kmt2b)

DSP:	122097464(Kmt2b)

PLOP:

125368349(Kmt2b)

NCAR:

124966333

MMMA:

107151676(Kmt2b)

OCU:

100353483

OPI:	101535318(KMT2B)

TUP:	102477772(KMT2B)

GVR:	103583372 103592831(KMT2B)

CFA:	100688666(KMT2B)

CLUD:

112643518(KMT2B)

VVP:	112928324(KMT2B)

VLG:	121484255(KMT2B)

NPO:	129499888(KMT2B)

AML:	100469094(KMT2B)

UMR:	103682560(KMT2B)

UAH:	113244759(KMT2B)

UAR:	123793892(KMT2B)

ELK:

111161417

LLV:

125088364

MPUF:

101685930(KMT2B)

MNP:	132005509(KMT2B)

MLK:	131818658(KMT2B)

NVS:	122911561(KMT2B)

ORO:	101370290(KMT2B)

EJU:	114224359(KMT2B)

ZCA:	113935548(KMT2B)

MLX:	118022788(KMT2B)

NSU:	110590086(KMT2B)

LWW:	102730782(KMT2B)

FCA:	101098760(KMT2B)

PYU:	121011346(KMT2B)

PCOO:

112851004(KMT2B)

PBG:	122495065(KMT2B)

PVIV:

125153519(KMT2B)

LRUF:

124511218

PTG:	102964982(KMT2B)

PPAD:

109251503(KMT2B)

PUC:	125918291 125918297

AJU:

106974745

HHV:	120243477(KMT2B)

BTA:	785776(KMT2B)

BOM:	102269320(KMT2B)

BIU:	109572325(KMT2B)

BBIS:

104995419(KMT2B)

CHX:	102172292(KMT2B)

OAS:	101104086(KMT2B)

BTAX:

128062799(KMT2B)

ODA:	120872497(KMT2B)

CCAD:

122421375(KMT2B)

MBEZ:

129546059(KMT2B)

SSC:	100520742(KMT2B)

CFR:	102520520(KMT2B)

CBAI:

105065102(KMT2B)

CDK:

105088051

VPC:	102538562(KMT2B)

BACU:

103015601(KMT2B)

BMUS:

118884797(KMT2B)

LVE:	103073652(KMT2B)

OOR:	101276223(KMT2B)

DLE:	111181136(KMT2B)

PCAD:

102987727(KMT2B)

PSIU:

116744553(KMT2B)

NASI:

112392388(KMT2B)

ECB:	100059802(KMT2B)

EPZ:	103566091(KMT2B)

EAI:	106829152(KMT2B)

MYB:	102259087(KMT2B)

MYD:	102771251(KMT2B)

MMYO:

118674717(KMT2B)

MLF:	102433699(KMT2B)

PKL:	118720655(KMT2B)

EFUS:

103284776(KMT2B)

MNA:	107543372(KMT2B)

DRO:	112320053(KMT2B)

SHON:

118982549(KMT2B)

AJM:	119044204(KMT2B)

PDIC:

114511083(KMT2B)

PHAS:

123823661(KMT2B)

MMF:	118638673(KMT2B)

PPAM:

129083195(KMT2B)

HAI:	109372008(KMT2B)

RFQ:	117034916(KMT2B)

PALE:

102881431(KMT2B)

PGIG:

120592489(KMT2B)

PVP:	105306647(KMT2B)

RAY:	107497624(KMT2B)

MJV:	108401519(KMT2B)

TOD:	119250148(KMT2B)

SARA:

101537418(KMT2B)

SETR:

126027579(KMT2B)

LAV:	100669611(KMT2B)

TMU:

101345928

ETF:	101656752(KMT2B)

DNM:	101413650(KMT2B)

MDO:	100617561(KMT2B)

GAS:

123256611

SHR:	100927672(KMT2B)

AFZ:

127556061

PCW:	110201341(KMT2B)

OAA:	103165316(KMT2B)

ASN:	102382195(KMT2B)

CMY:	102931937(KMT2B)

CCAY:

125625630(KMT2B)

DCC:	119847681(KMT2B)

CPIC:

101950574(KMT2B)

TST:	117869515(KMT2B)

CABI:

116839067(KMT2B)

MRV:	120390254(KMT2B)

ACS:	100556600(kmt2b)

ASAO:

132780295(KMT2B)

PVT:	110089900(KMT2B)

SUND:

121915298(KMT2B)

PBI:	103058696(KMT2B)

PMUR:

107287999(KMT2B)

CTIG:

120300040(KMT2B)

TSR:	106550780(KMT2B)

PGUT:

117669309(KMT2B)

APRI:

131204277(KMT2B)

PTEX:

113437418(KMT2B)

NSS:	113419887(KMT2B)

VKO:	123025799(KMT2B)

PMUA:

114603572(KMT2B)

PRAF:

128418584(KMT2B)

ZVI:	118085945(KMT2B)

HCG:	128332572(KMT2B)

GJA:	107108169(KMT2B)

STOW:

125434769(KMT2B)

EMC:	129343103(KMT2B)

XLA:	108696880 108697287

XTR:	100144721(kmt2b)

NPR:	108799776(KMT2B)

RTEM:

120916238(KMT2B)

BBUF:

120993856(KMT2B)

BGAR:

122929120(KMT2B)

MUO:	115476211(KMT2B)

GSH:	117369214(KMT2B)

DRE:	560856(kmt2ba) 566825(kmt2bb)

SRX:	107724085 107739503 107745205 107747652

SANH:

107665484 107675870 107693264 107701550

SGH:	107571391(kmt2b) 107585719 107589473 107599517

CCAR:

109085861 109103645 109112389

CAUA:

113061939 113061940 113062164 113069211 113077794 113099189 113099201 113114935 113120015

CGIB:

127935245 127973165 127979018 128028980

PTET:

122323526(kmt2ba) 122358939(kmt2bb)

LROH:

127157412(kmt2bb) 127182023(kmt2ba)

OMC:	131520426(kmt2bb) 131525286(kmt2ba)

PPRM:

120478822(kmt2bb) 120483374(kmt2ba)

RKG:	130070691(kmt2bb) 130070833(kmt2ba)

MAMB:

125248738 125275959(kmt2ba)

CIDE:

127495955 127501701

MASI:

127421184 127422178 127425593 127429839

TROS:

130564368(kmt2bb) 130566892(kmt2ba)

TDW:	130415530(kmt2ba) 130428110(kmt2bb)

MANU:

129438380(kmt2bb) 129454902(kmt2ba)

IPU:	108272954(kmt2ba) 108277672(kmt2bb)

IFU:	128615464(kmt2ba) 128621843(kmt2bb)

PHYP:

113535181 113539221(kmt2b)

SMEO:

124381839(kmt2ba) 124394710(kmt2bb)

TFD:	113641273(kmt2ba) 113642372(kmt2bb)

TVC:	132842880(kmt2ba) 132858299(kmt2bb)

AMEX:

103022217(kmt2b) 103024771

CMAO:

118803799(kmt2bb) 118805983(kmt2ba)

EEE:	113572597 113586392(kmt2b)

CHAR:

105901266(kmt2bb) 105902047(kmt2ba)

TRU:	101064190 101073293(kmt2b) 115251849

TFS:	130518561(kmt2ba) 130532714(kmt2bb)

TNG:	GSTEN00032527G001

LCO:	104927558 104932361(kmt2b)

NCC:	104960690 104961389(kmt2b)

TBEN:

117477555(kmt2ba) 117480290(kmt2bb)

CGOB:

115016046 115021110(kmt2b)

PGEO:

117455559(kmt2ba) 117460876(kmt2bb)

GACU:

117542674(kmt2ba) 117553899(kmt2bb)

EMAC:

134861535(kmt2bb) 134874859

ELY:	117263326(kmt2ba) 117266030(kmt2bb)

EFO:	125893714(kmt2bb) 125904405(kmt2ba)

PLEP:

121946079(kmt2bb) 121957413(kmt2ba)

SLUC:

116047504(kmt2ba) 116049332(kmt2bb)

ECRA:

117946883(kmt2bb) 117956541(kmt2ba)

ESP:	116690992(kmt2b) 116701633

PFLV:

114556540(kmt2b) 114567833

GAT:	120811149(kmt2bb) 120826849(kmt2ba)

PPUG:

119197459(kmt2bb) 119218734(kmt2ba)

AFB:	129097316 129110093(kmt2bb)

CLUM:

117739150(kmt2ba) 117745348(kmt2bb)

PSWI:

130193257 130213312(kmt2bb)

MSAM:

119898296(kmt2bb) 119907919(kmt2ba)

SCHU:

122864889(kmt2ba) 122881423(kmt2bb)

CUD:	121512979(kmt2bb) 121524572(kmt2ba)

ALAT:

119005807(kmt2bb) 119016569(kmt2ba)

MZE:	101467874 101481309(kmt2b)

ONL:	100689867 100700132(kmt2b)

OAU:	116319815(kmt2bb) 116320047(kmt2ba)

OLA:	101157226 101174945(kmt2b)

OML:	112143279(kmt2bb) 112162480(kmt2ba)

CSAI:

133428222(kmt2bb) 133461414(kmt2ba)

XMA:	102222844 102229737(kmt2b)

XCO:	114142152(kmt2b) 114156616

XHE:	116713912(kmt2b) 116730674

PRET:

103472504 103478519(kmt2b)

PFOR:

103143107(kmt2b) 103146865

PLAI:

106945874(kmt2b) 106960535

PMEI:

106919951 106928418(kmt2b)

GAF:	122831339(kmt2bb) 122843072(kmt2ba)

PPRL:

129371385(kmt2bb) 129374949

CVG:	107086122(kmt2b) 107101115

CTUL:

119775533(kmt2bb) 119779627

GMU:	124864459(kmt2bb) 124879104

NFU:	107372442(kmt2b) 107394636

KMR:	108240680(kmt2ba) 108241999(kmt2bb)

ALIM:

106517704(kmt2b) 106537143

NWH:	119409464(kmt2bb) 119425834(kmt2ba)

AOCE:

111571387 111577070(kmt2b)

MCEP:

125015742(kmt2bb) 125020556

CSEM:

103388508(kmt2b) 103394161

POV:	109633105(kmt2b) 109638782

SSEN:

122774538(kmt2bb) 122786593(kmt2ba)

HHIP:

117770576 117776549(kmt2bb)

HSP:	118113601(kmt2bb) 118124314(kmt2ba)

SMAU:

118291930(kmt2ba) 118300255(kmt2bb)

LCF:	108888836 108890658(kmt2bb)

SDU:	111223127 111234049(kmt2b)

SLAL:

111657578 111664979(kmt2b)

XGL:	120783762(kmt2bb) 120786435(kmt2ba)

HCQ:	109514546 109525616(kmt2b)

SSCV:

125975503 125987183

SBIA:

133499114(kmt2ba) 133500576(kmt2bb)

PEE:	133396134 133401744(kmt2bb)

PTAO:

133471228(kmt2ba) 133479257(kmt2bb)

BPEC:

110161138 110171497(kmt2b)

MALB:

109971699(kmt2b) 109973928

BSPL:

114843364(kmt2bb) 114866253(kmt2ba)

SJO:	128366747(kmt2bb) 128374749(kmt2ba)

SASA:

106570121 106577926 106588247 106594944 106605615

STRU:

115164151 115173397 115176084 115177337

OTW:	112226731 112230014 112246968 112264909

OMY:	110487656 110496098 110510370 110538034

OGO:	123998007 124005299 124012097 124043698

ONE:	115101452 115128277 115131800 115140822

OKI:	109900891 109901820 109903796 109907621

OKE:	118367807 118373824 118398340 118399190

SALP:

111955007 111955466 111958933 111964605

SNH:	120022385 120026748 120030911 120047222

CCLU:

121556964 121571388 121585346 121586284

ELS:	105007527 105019114(kmt2b)

SFM:	108930328(kmt2b)

PKI:	111833696(kmt2b) 111839650

AANG:

118212590(kmt2bb) 118233860

LOC:	102692171(kmt2b)

PSPA:

121299031(kmt2bb) 121304193

ARUT:

117434041(kmt2bb) 117971976 117971978

HOC:

CGLO:

CSET:

AGB:

FCD:

DMK:

PJA:

PCLA:

EAF:

PPOI:

EGL:

NVE:	5501691 5502141

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

Reference

PMID:17707229

Authors

Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M

Title

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Journal

Mol Cell 27:573-84 (2007)
DOI:10.1016/j.molcel.2007.06.022

Sequence

[hsa:9757]

Reference

PMID:17500065

Authors

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K

Title

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Journal

J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200

Sequence

[hsa:9757]

ORTHOLOGY: K11419

Entry

K11419                      KO

Symbol

SUV39H, CLR4

Name

[histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.355  [histone H3]-lysine9 N-trimethyltransferase
     K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H

Other DBs

GO:

0046974

Genes

HSA:	6839(SUV39H1) 79723(SUV39H2)

PTR:	107971148(SUV39H1) 466014(SUV39H2)

PPS:	100977497(SUV39H1) 100982469(SUV39H2)

GGO:	101126338(SUV39H2) 101146540(SUV39H1)

PON:	100172621(SUV39H1) 100436926(SUV39H2)

NLE:	100591032(SUV39H2) 100598636(SUV39H1)

HMH:	116470963(SUV39H2) 116811661(SUV39H1)

MCC:	697378(SUV39H2) 711040(SUV39H1)

MCF:	102123944 102134179(SUV39H1) 102136014(SUV39H2)

MTHB:

126945594 126962370

MNI:	105490642(SUV39H2) 105493901(SUV39H1)

CSAB:

103231938(SUV39H1) 103237926(SUV39H2)

CATY:

105573130(SUV39H1) 105583853(SUV39H2) 105598847

PANU:

101002260(SUV39H2) 101003206 101007672(SUV39H1)

TGE:	112604683 112616406(SUV39H1) 112631347(SUV39H2)

MLEU:

105530542(SUV39H2) 105547724(SUV39H1)

RRO:	104660660(SUV39H1) 104664471(SUV39H2)

RBB:	108517467(SUV39H1) 108531071(SUV39H2)

TFN:	117062164 117078273(SUV39H1) 117082672(SUV39H2)

PTEH:

111528202 111535700(SUV39H1) 111550038(SUV39H2)

CANG:

105506196(SUV39H2) 105515012(SUV39H1) 105519677

CJC:	100401369(SUV39H1) 100401513(SUV39H2)

SBQ:	101040475(SUV39H2) 101052197(SUV39H1)

CIMI:

108300896(SUV39H1) 108305252(SUV39H2)

CSYR:

103254226(SUV39H1) 103267726(SUV39H2)

MMUR:

105856353(SUV39H2) 105856376(SUV39H1) 105871464

LCAT:

123625405(SUV39H2) 123628362(SUV39H1)

PCOQ:

105816777(SUV39H1) 105823671(SUV39H2)

OGA:	100954282(SUV39H2) 100956539(SUV39H1)

MMU:	20937(Suv39h1) 64707(Suv39h2)

MCAL:

110287176(Suv39h1) 110289296(Suv39h2)

MPAH:

110313347(Suv39h1) 110333642(Suv39h2)

RNO:	302553(Suv39h1) 364785(Suv39h2)

MCOC:

116068177(Suv39h1) 116082667(Suv39h2)

ANU:	117694599(Suv39h1) 117714230(Suv39h2)

MUN:	110554698(Suv39h2) 110561991(Suv39h1)

CGE:	100755145(Suv39h2) 100764568(Suv39h1)

MAUA:

101838624(Suv39h1) 101844757(Suv39h2)

PROB:

127237547(Suv39h2)

PLEU:

114686373 114701015 114701306(Suv39h1) 114710826(Suv39h2)

MORG:

121432621(Suv39h2) 121442585 121442661

MFOT:

126506760 126512880

AAMP:

119805158(Suv39h1) 119816729(Suv39h2)

NGI:	103735184(Suv39h2) 103741644(Suv39h1)

HGL:	101701917(Suv39h2) 101706867(Suv39h1)

CPOC:

100728513(Suv39h2) 100731248(Suv39h1)

CCAN:

109691500(Suv39h2) 109701207(Suv39h1)

DORD:

105984374(Suv39h2) 105997867(Suv39h1) 106000651

DSP:	122098810(Suv39h1) 122113286(Suv39h2) 122120623

PLOP:

125343311(Suv39h1) 125343986 125366781(Suv39h2)

NCAR:

124961476 124971891

MMMA:

107140435(Suv39h2) 107159818(Suv39h1)

OCU:	100354725 100358024

OPI:	101516403(SUV39H2) 101529760 101533574(SUV39H1)

TUP:	102468719(SUV39H1) 102472765

GVR:	103589452(SUV39H1) 103602806(SUV39H2)

CFA:	477995(SUV39H2) 491868(SUV39H1)

CLUD:

112658894(SUV39H2) 112673138(SUV39H1)

VVP:	112907242(SUV39H1) 112933120(SUV39H2)

VLG:	121482956(SUV39H1) 121497217(SUV39H2)

NPO:	129514028(SUV39H2) 129517744(SUV39H1)

AML:	100469547(SUV39H2) 100472595(SUV39H1)

UMR:	103664189(SUV39H2) 103669105(SUV39H1)

UAH:	113241391(SUV39H2) 113265922(SUV39H1)

UAR:	123785960(SUV39H2) 123790887(SUV39H1)

ELK:	111150521 111155595

LLV:	125091942 125107523

MPUF:

101675209(SUV39H1) 101693651(SUV39H2)

MNP:	132006848(SUV39H1) 132020152(SUV39H2)

MLK:	131820762(SUV39H1) 131838248(SUV39H2)

NVS:	122892395(SUV39H2) 122896983(SUV39H1)

ORO:	101374258(SUV39H2) 101381146(SUV39H1)

EJU:	114210177 114216775(SUV39H1) 114217278(SUV39H2)

ZCA:	113921911(SUV39H2) 113925008 113930896(SUV39H1)

MLX:	118010050(SUV39H1) 118021560(SUV39H2)

NSU:	110570881(SUV39H1) 110586530(SUV39H2)

LWW:	102732476(SUV39H2) 102734674(SUV39H1)

FCA:	101083571(SUV39H1) 101099218(SUV39H2)

PYU:	121014778(SUV39H2) 121025917(SUV39H1)

PCOO:

112867563(SUV39H2) 112870989(SUV39H1)

PBG:	122473257(SUV39H2) 122477943(SUV39H1)

PVIV:

125157596(SUV39H1) 125170198(SUV39H2)

LRUF:

124502538 124509510

PTG:	102950897(SUV39H1) 102963752(SUV39H2)

PPAD:

109248069(SUV39H1) 109273698(SUV39H2)

PUC:	125918609 125931659

AJU:	106970864 106971016

HHV:	120221011(SUV39H1) 120236934(SUV39H2)

BTA:	523047(SUV39H1) 536936(SUV39H2)

BOM:	102264756(SUV39H2) 102271191(SUV39H1)

BIU:	109567973(SUV39H2)

BBUB:

102401546(SUV39H1) 102415169(SUV39H2)

BBIS:

105003032(SUV39H2)

CHX:	102174919(SUV39H1) 102176621(SUV39H2)

OAS:	101110031(SUV39H1) 101116417(SUV39H2)

BTAX:

128058674(SUV39H2) 128069954(SUV39H1)

ODA:	120869586(SUV39H2) 120882096(SUV39H1)

CCAD:

122434492(SUV39H1) 122448086(SUV39H2) 122453800

MBEZ:

129539286 129558220(SUV39H2) 129564331(SUV39H1)

SSC:	664651(SUV39H2) 767626(SUV39H1)

CFR:	102521199(SUV39H2)

CBAI:

105072449(SUV39H2) 105079433(SUV39H1)

CDK:	105103308(SUV39H1) 105104521(SUV39H2)

VPC:	102525580(SUV39H1) 102545741(SUV39H2)

BACU:

102999710(SUV39H2) 103005831(SUV39H1)

BMUS:

118889064(SUV39H1) 118889791(SUV39H2)

LVE:	103073919(SUV39H1) 103084616(SUV39H2)

OOR:	101279239(SUV39H2) 101289196(SUV39H1)

DLE:	111169525(SUV39H1) 111178089(SUV39H2)

PCAD:

102988226(SUV39H2) 102988363(SUV39H1)

PSIU:

116747305(SUV39H1) 116748760(SUV39H2)

NASI:

112395395(SUV39H2) 112415988(SUV39H1)

ECB:	100062108(SUV39H1) 100068891(SUV39H2)

EPZ:	103544360 103544897(SUV39H1) 103556824(SUV39H2)

EAI:	106827436(SUV39H1) 106840452(SUV39H2)

MYB:	102243180(SUV39H1) 102260054(SUV39H2)

MYD:	102757145(SUV39H2) 102763954(SUV39H1)

MMYO:

118653933(SUV39H1) 118655474(SUV39H2)

MLF:	102425465(SUV39H1) 102432659(SUV39H2)

PKL:	118731722(SUV39H2) 118731771(SUV39H1)

EFUS:

103292577(SUV39H2) 103301285(SUV39H1)

MNA:	107534821(SUV39H2) 107541392(SUV39H1)

DRO:	112320455(SUV39H2) 112322458(SUV39H1)

SHON:

118997120(SUV39H2) 118998320(SUV39H1)

AJM:	119046306(SUV39H2) 119059808(SUV39H1)

PDIC:

114492683(SUV39H2) 114504865(SUV39H1)

PHAS:

123831095(SUV39H2) 123832782(SUV39H1)

MMF:	118636303(SUV39H1) 118643229(SUV39H2)

PPAM:

129065126(SUV39H1) 129086670(SUV39H2)

HAI:	109374812(SUV39H1) 109393823(SUV39H2)

RFQ:	117019247(SUV39H2) 117027799(SUV39H1)

PALE:

102894853(SUV39H1) 102898400(SUV39H2)

PGIG:

120587091(SUV39H1) 120614623(SUV39H2)

PVP:	105291688(SUV39H2) 105310010(SUV39H1)

RAY:	107504834(SUV39H2) 107515026(SUV39H1)

MJV:	108397103(SUV39H2) 108408400(SUV39H1)

TOD:	119244708(SUV39H2) 119246174(SUV39H1)

SARA:

101537099(SUV39H2) 101551845(SUV39H1)

SETR:

125999218(SUV39H1) 126014500(SUV39H2)

LAV:	100653780(SUV39H1) 100674328(SUV39H2)

TMU:	101347009 101348006

ETF:	101642805(SUV39H1) 101650388(SUV39H2)

DNM:	101410810(SUV39H2) 101431137(SUV39H1)

MDO:	100014806(SUV39H2) 100018670(SUV39H1)

GAS:	123249577(SUV39H2) 123254217(SUV39H1)

SHR:	100922258(SUV39H1) 100933751(SUV39H2)

AFZ:	127538359 127542923

PCW:	110201087(SUV39H1) 110217388(SUV39H2)

OAA:	100084051(SUV39H1) 100085175(SUV39H2)

GGA:	112529927(SUV39H1) 426314(SUV39H2)

PCOC:

116226677(SUV39H2) 116240919(SUV39H1)

MGP:	100539540(SUV39H2) 100548070 104916314

CJO:	107307203(SUV39H1) 107319605(SUV39H2)

TPAI:

128079646(SUV39H2)

LMUT:

125701293(SUV39H2)

NMEL:

110391539(SUV39H1) 110392282(SUV39H2)

APLA:

101796000(SUV39H2)

ACYG:

106046190(SUV39H2)

CATA:

118249431(SUV39H2)

AFUL:

116501666(SUV39H1) 116502296(SUV39H2)

TGU:	100225827(SUV39H2)

LSR:	110470972(SUV39H2) 110481760(SUV39H1)

SCAN:

103813741(SUV39H2)

PMOA:

120508289(SUV39H1) 120509265(SUV39H2)

OTC:	121339649(SUV39H1) 121340539(SUV39H2)

PRUF:

121351466(SUV39H1) 121362326(SUV39H2)

GFR:	102031848(SUV39H2)

FAB:	101814584 101816158(SUV39H2)

OMA:	130248391(SUV39H2)

PHI:	102110616(SUV39H1) 102114300(SUV39H2)

PMAJ:

107204624(SUV39H2)

CCAE:

111923103(SUV39H2)

CCW:	104694491(SUV39H2)

CBRC:

103619827(SUV39H2)

ETL:	114067551(SUV39H2)

ZAB:	102072951(SUV39H2)

ACHL:

103809755(SUV39H2)

SVG:	106857201(SUV39H2) 106863835(SUV39H1)

MMEA:

130573756(SUV39H2)

HRT:	120751545(SUV39H2)

FPG:	101912815(SUV39H2)

FCH:	102059458(SUV39H2)

CLV:	102098917(SUV39H2)

EGZ:	104132393(SUV39H2)

NNI:	104014630(SUV39H2)

PCRI:

104025251(SUV39H2)

PLET:

104621630(SUV39H2)

EHS:	104504052(SUV39H2)

PCAO:

104040081(SUV39H2)

ACUN:

113489768(SUV39H2)

TALA:

104358970(SUV39H2)

PADL:

103915032(SUV39H2)

AFOR:

103904163(SUV39H2)

ACHC:

115341481(SUV39H2)

HALD:

104311858(SUV39H2)

HLE:	104840187(SUV39H2)

AGEN:

126044433

GCL:	127013323 127028025

CCRI:

104165623(SUV39H2)

CSTI:

104554346(SUV39H2)

CMAC:

104474267(SUV39H2)

MUI:	104548728(SUV39H2)

BREG:

104630351(SUV39H2)

FGA:	104071424(SUV39H2)

GSTE:

104252364(SUV39H2)

LDI:	104351471(SUV39H2)

MNB:	103778373(SUV39H2)

OHA:	104337645(SUV39H2)

NNT:	104400243(SUV39H2)

SHAB:

115604906(SUV39H2) 115614601(SUV39H1)

DPUB:

104300079(SUV39H2)

PGUU:

104467057(SUV39H2)

ACAR:

104518833(SUV39H2)

CPEA:

104391931(SUV39H2)

AVIT:

104280300(SUV39H2)

CVF:	104284642(SUV39H2)

RTD:	128903193(SUV39H1) 128906894(SUV39H2)

CUCA:

104059191 104066427(SUV39H2)

TEO:	104370577(SUV39H2)

BRHI:

104494427(SUV39H2)

AAM:	106485143(SUV39H2)

AROW:

112978060(SUV39H2)

NPD:	112942367(SUV39H2)

TGT:	104569918(SUV39H2)

DNE:	112994764(SUV39H2)

SCAM:

104147717(SUV39H2)

ASN:	102375358(SUV39H2) 102378805(SUV39H1)

AMJ:	102558468(SUV39H1) 102563656(SUV39H2)

CPOO:

109315785(SUV39H2)

GGN:	109292195(SUV39H2)

PSS:	102454204(SUV39H2) 102462370(SUV39H1)

CMY:	102937045(SUV39H2) 102937831(SUV39H1)

CCAY:

125628293(SUV39H1) 125630502(SUV39H2)

DCC:	119846993(SUV39H1) 119850738(SUV39H2)

CPIC:

101945875(SUV39H2) 101951503(SUV39H1)

TST:	117874798(SUV39H2)

CABI:

116818898(SUV39H1) 116836408(SUV39H2)

MRV:	120388525(SUV39H1) 120395171(SUV39H2)

ACS:	100553897(suv39h1)

ASAO:

132767602(SUV39H1)

PVT:	110081193(SUV39H1)

SUND:

121922732(SUV39H1)

PBI:	103052540(SUV39H1)

PMUR:

107300048(SUV39H1)

CTIG:

120306632(SUV39H1)

TSR:	106546114(SUV39H1)

PGUT:

117675420(SUV39H1)

APRI:

131191629(SUV39H1)

PTEX:

113443263(SUV39H1)

NSS:	113417787(SUV39H1)

VKO:	123023976(SUV39H1)

PMUA:

114588136(SUV39H1)

PRAF:

128405041(SUV39H1)

ZVI:	118097686(SUV39H1)

HCG:	128343984(SUV39H1)

GJA:	107112843(SUV39H1)

STOW:

125429255(SUV39H1)

EMC:	129346140(SUV39H1)

XLA:	100037174(suv39h2.L) 108700299(suv39h1.S) 108713053(suv39h2.S) 431943(suv39h1.L)

XTR:	116408207 549262(suv39h2)

NPR:	108788266(SUV39H1) 108794066(SUV39H2)

RTEM:

120914074(SUV39H1) 120931719(SUV39H2)

BBUF:

120983221(SUV39H2) 121009587(SUV39H1)

BGAR:

122925399(SUV39H2) 122946834(SUV39H1)

MUO:	115462395(SUV39H1) 115478820(SUV39H2)

GSH:	117349866(SUV39H1) 117366471(SUV39H2)

DRE:	326906(suv39h1b) 445198(suv39h1a)

SRX:	107707679(suv39h1) 107711921 107731148

SANH:

107668084 107669636 107679310

SGH:	107549953 107550505 107571686 107591797

CCAR:

109050848 109068236 109082351

CAUA:

113080156 113093937 113107270 113107584 113107647

CGIB:

127963667 127963948 128018622

PTET:

122350199(suv39h1a) 122350205(suv39h1b)

LROH:

127169300(suv39h1a) 127170313(suv39h1b)

OMC:	131545270(suv39h1b) 131546077(suv39h1a)

PPRM:

120469056(suv39h1a) 120483495(suv39h1b)

RKG:	130094587(suv39h1b) 130094655(suv39h1a)

MAMB:

125279861(suv39h1b) 125280489(suv39h1a)

CIDE:

127516956 127518080

MASI:

127414501 127423831 127424355

TROS:

130568294(suv39h1b) 130568410(suv39h1a)

TDW:	130440295(suv39h1b) 130440297(suv39h1a)

MANU:

129413716(suv39h1b) 129414325(suv39h1a)

IPU:	108265282(suv39h1a) 108265881(suv39h1b)

IFU:	128607866(suv39h1a) 128607941(suv39h1b)

PHYP:

113534019 113540759

SMEO:

124399714(suv39h1a) 124399954(suv39h1b)

TFD:	113655884(suv39h1a) 113656002(suv39h1b)

TVC:	132853834(suv39h1a) 132853939(suv39h1b)

AMEX:

103040252 103041908

CMAO:

118812876(suv39h1a) 118813757(suv39h1b)

EEE:	113579097 113581117

CHAR:

105893664(suv39h1b) 105898965(suv39h1a)

TRU:	101070634 115249168

TFS:

130529445

TNG:	GSTEN00008490G001

LCO:	104932794(suv39h1)

NCC:	104953540(suv39h1)

TBEN:

117481505

CGOB:

115019085(suv39h1)

PGEO:

117448963 117449516

GACU:

117535476

EMAC:

134872286(suv39h1b)

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116693088(suv39h1)

PFLV:

114559282(suv39h1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130199704(suv39h1b)

MSAM:

119904964

SCHU:

122882470

CUD:

121518164

ALAT:

119022825(suv39h1b)

MZE:	101475727(suv39h1)

ONL:	100693758(suv39h1)

OAU:	116311434 116317088

OLA:	101155408(suv39h1)

OML:

112140032

XMA:	102218201(suv39h1)

XCO:	114142201(suv39h1)

XHE:	116721277(suv39h1)

PRET:

103466971(suv39h1)

PFOR:

103154222(suv39h1)

PLAI:

106957137(suv39h1)

PMEI:

106928341(suv39h1)

GAF:	122820970 122837012

PPRL:

129371865(suv39h1b)

CVG:	107090999(suv39h1)

CTUL:

119786878

GMU:

124875741

NFU:	107390532(suv39h1)

KMR:

108231967

ALIM:

106527380(suv39h1)

NWH:

119416867

AOCE:

111588288(suv39h1)

MCEP:

125020725

CSEM:

103384853(suv39h1)

POV:	109630999(suv39h1)

SSEN:

122777668

HHIP:

117765148(suv39h1a)

HSP:

118111057

SMAU:

118317298

LCF:

108900517

SDU:	111219081(suv39h1)

SLAL:

111670830(suv39h1)

XGL:

120804350

HCQ:	109528227(suv39h1)

SSCV:

125988769

SBIA:

133511861(suv39h1a)

PEE:	133408196(suv39h1a)

PTAO:

133486514(suv39h1a)

BPEC:

110156027(suv39h1)

MALB:

109965296(suv39h1)

BSPL:

114859242(suv39h1b)

SJO:	128356886(suv39h1b)

SASA:

106566827 106567313 106572223 106572377

STRU:

115165747 115166297 115168254

OTW:	112215887 112216612 112222060

OMY:	110492276 110532480

OGO:	124022560 124031815 124045067

ONE:	115102224 115132021 115132329

OKI:	109869445 109907876 109908559

OKE:	118359742 118360846 118361267

SALP:

111966328 111966640 111976965

SNH:	120058874 120058957 120060725

CCLU:

121538205 121538517 121545532 121545663

ELS:	105013831(suv39h1) 105022372

SFM:	108934780(suv39h1)

PKI:	111847791(suv39h1)

AANG:

118208326(suv39h1a)

LOC:	102685370(suv39h1)

PSPA:

121328396

ARUT:

117401622 117404230

PSEX:

120542706

LCM:	102351913 102360554(SUV39H2)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116942370(SUV39H2)

LRJ:	133349470(SUV39H2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG43664(Su(var)3-9)

DAN:

DPO:

DPE:

DMN:

DWI:	6647325 6649359

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

AARA:

AMER:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ019323

CPII:

120426320

CNS:

116347715

BCOO:

119066565 119075575 119078065 119080347

ACER:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NVG:

TCA:

DPA:

AGRG:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

MSEX:

DPL:	KGM_203219

BANY:

112043085 112047822

MJU:	123870125 123880531

NIQ:

VCD:

MCIX:

PRAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CCRN:

API:	100161603(Su(var)3-9) 100161910 100165299 103309898

DNX:	107165795 107173978 107174002

AGS:	114131380 114131445

RMD:	113556537 113557531

ACOO:

126838163 126838549

DVT:	126894257 126897767

BTAB:

109035926 109038184

DCI:	103505434 103507862

CLEC:

106661131

MQU:

128991507

PHU:	Phum_PHUM423590

FOC:	113204601 113206980

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:	110848867 110850699

DPX:	DAPPUDRAFT_306854

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:	111243931 111246042

VJA:	111260615 111267950

CSCU:

111614908

PTEP:

107457147

ABRU:

129960866 129971436 129972293

UDV:

129221009

SDM:	118195474 118205485

LPOL:

106457344

NAI:	NECAME_05130 NECAME_06579

LOA:	LOAG_18944

TSP:

Tsp_05330

HRO:	HELRODRAFT_131923

LGI:	LOTGIDRAFT_134869

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111107127 111110608

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_027300

SHX:	MS3_00007274

OVI:	T265_13777

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:	100640934 109585408

PVIR:

120678325

OLU:	OSTLU_25709(SDG3507)

OTA:	OT_ostta18g00210

BPG:	Bathy14g00980

MIS:	MICPUN_64853

MPP:	MICPUCDRAFT_54214(JGI:MicpuC2_54214)

NCR:	NCU04402(dim-5)

NTE:	NEUTE1DRAFT121214(NEUTE1DRAFT_121214)

SMP:	SMAC_07345

PAN:	PODANSg7447

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2114845

MTM:	MYCTH_2086155

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_02778

FPU:	FPSE_10781

FPOA:

FPOAC1_002919(DIM5)

FVN:	FVRRES_03236

FVR:	FVEG_08911

FOX:	FOXG_10263

NHE:	NECHADRAFT_94199(SDG2104)

FFC:	NCS54_00791900

FMU:	J7337_005481(DIM5)

TRE:	TRIREDRAFT_111216

TRR:	M419DRAFT_89807

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_03193

PTKZ:

JDV02_005401

VDA:	VDAG_07826

CHIG:

CH63R_00107

ELA:	UCREL1_2940

PFY:	PFICI_00682

SSL:	SS1G_01550

BFU:	BCIN_11g02360(BcDIM5)

MBE:

MBM_05751

PSCO:

LY89DRAFT_600648

GLZ:	GLAREA_08846

ANI:	ANIA_01170

AFM:	AFUA_1G11090

ACT:	ACLA_024460

NFI:	NFIA_014540

AOR:	AO090038000300

ANG:	An08g03380

AFV:	AFLA_008787

ALUC:

AKAW2_30689A

ACHE:

ACHE_30207S

APUU:

APUU_50577S

PCS:	N7525_003280

PDP:	PDIP_30370

POU:	POX_c04074

TMF:	EYB26_003001

TRG:	TRUGW13939_03059

CIM:	CIMG_06955

CPW:	CPC735_033270

URE:	UREG_05902

PBL:	PAAG_03011

PBN:	PADG_02881

ABE:

ARB_02816

TVE:

TRV_01916

AJE:	HCAG_01813

BGH:	BDBG_00259

PNO:	SNOG_14974

PTE:

PTT_11395

BZE:	COCCADRAFT_96085

BSC:	COCSADRAFT_123285

BOR:	COCMIDRAFT_92785

AALT:

CC77DRAFT_1060195

ARAB:

EKO05_0001435

ZTR:	MYCGRDRAFT_107709(SDG2411)

PFJ:	MYCFIDRAFT_149458

FFU:	CLAFUR5_00190 CLAFUR5_12582

CBET:

CB0940_00773

BCOM:

BAUCODRAFT_100172

NPA:	UCRNP2_4835

SPO:	SPBC428.08c(clr4)

SOM:	SOMG_05025(clr4)

CNE:

CNH00720

CNB:

CNBL0680

CNG:	CNAG_05404

CGI:	CGB_L0430W

CDEU:

CNBG_4448

TMS:	TREMEDRAFT_74418

TASA:

A1Q1_02905

TVS:	TRAVEDRAFT_112981 TRAVEDRAFT_55782

DSQ:	DICSQDRAFT_110205 DICSQDRAFT_51443

SHS:	STEHIDRAFT_168918

HIR:	HETIRDRAFT_319697

PSQ:	PUNSTDRAFT_54070 PUNSTDRAFT_80062

ADL:	AURDEDRAFT_114614 AURDEDRAFT_93052 AURDEDRAFT_93062

FME:	FOMMEDRAFT_167613 FOMMEDRAFT_20301

GTR:	GLOTRDRAFT_125040

LBC:	LACBIDRAFT_296206(SDG16210) LACBIDRAFT_300409(SDG16205)

CCI:	CC1G_12392

ABP:	AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)

ABV:	AGABI2DRAFT146074(AGABI2DRAFT_146074) AGABI2DRAFT180791(AGABI2DRAFT_180791)

MRR:	Moror_11412 Moror_2531

E1B28_007567

SCM:	SCHCO_01174894(SCHCODRAFT_01174894)

CPUT:

CONPUDRAFT_117641 CONPUDRAFT_56532

SLA:	SERLADRAFT_391489 SERLADRAFT_468863

DPP:	DICPUDRAFT_55529

EHX:	EMIHUDRAFT_457456

NGR:	NAEGRDRAFT_51681

» show all

Reference

PMID:14765126

Authors

Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva I, Robin P, Cabon F, Polesskaya A, Harel-Bellan A

Title

A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

Journal

EMBO J 23:605-15 (2004)
DOI:10.1038/sj.emboj.7600074

Sequence

[hsa:6839 79723]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (3136)   
   KEGG GENES (1015)   
   KEGG MGENES (478)   
   RefGene (1620)   
   OC (23)   
Literature (1)   
   PubMed (1)   
All databases (3153)   

Download RDF

ORTHOLOGY: K06101

Entry

K06101                      KO

Symbol

ASH1L

Name

[histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L

Other DBs

GO:

0042800

Genes

HSA:	55870(ASH1L)

PTR:	107971434(ASH1L)

PPS:	100979709(ASH1L)

GGO:	101134264(ASH1L)

NLE:	100580011(ASH1L)

HMH:	116469304(ASH1L)

MCC:	717778(ASH1L)

MCF:	101867084(ASH1L)

MTHB:

126932888

MNI:	105498260(ASH1L)

CSAB:

103223879(ASH1L)

CATY:

105593539(ASH1L)

PANU:

101019457(ASH1L)

TGE:	112621576(ASH1L)

MLEU:

105544859(ASH1L)

RRO:	104659604(ASH1L)

RBB:	108526806(ASH1L)

TFN:	117074556(ASH1L)

PTEH:

111543765(ASH1L)

CANG:

105502046(ASH1L)

CJC:	100393607(ASH1L)

SBQ:	101046051(ASH1L)

CIMI:

108297159(ASH1L)

CSYR:

103255836(ASH1L)

MMUR:

105873156(ASH1L)

LCAT:

123634072(ASH1L)

PCOQ:

105821867(ASH1L)

OGA:	100954638(ASH1L)

MMU:	192195(Ash1l)

MCAL:

110291461(Ash1l)

MPAH:

110320636(Ash1l)

RNO:	310638(Ash1l)

MCOC:

116093147(Ash1l)

ANU:	117707081(Ash1l)

MUN:	110548961(Ash1l)

CGE:	100754103(Ash1l)

MAUA:

101823215(Ash1l)

PROB:

127232663(Ash1l)

PLEU:

114707881(Ash1l)

MORG:

121450522(Ash1l)

MFOT:

126516121

AAMP:

119800836(Ash1l)

NGI:	103750808(Ash1l)

HGL:	101723836(Ash1l)

CPOC:

100717586(Ash1l)

CCAN:

109688014(Ash1l)

DORD:

105984904(Ash1l)

DSP:	122109545(Ash1l)

PLOP:

125359696(Ash1l)

NCAR:

124994959

MMMA:

107156714(Ash1l)

OCU:

100354541

OPI:	101535854(ASH1L)

TUP:	102469443(ASH1L)

GVR:	103603651(ASH1L)

CFA:	480128(ASH1L)

CLUD:

112648925(ASH1L)

VVP:	112918925(ASH1L)

VLG:	121485278(ASH1L)

NPO:	129508576(ASH1L)

AML:	100474237(ASH1L)

UMR:	103668369(ASH1L)

UAH:	113245266(ASH1L)

UAR:	123783381(ASH1L)

ELK:

111138933

LLV:

125085470

MPUF:

101692156(ASH1L)

MNP:	132025893(ASH1L)

MLK:	131815219(ASH1L)

NVS:	122918271(ASH1L)

ORO:	101362745(ASH1L)

EJU:	114198572(ASH1L)

ZCA:	113933287(ASH1L)

MLX:	118013887(ASH1L)

NSU:	110573557(ASH1L)

LWW:	102729035(ASH1L)

FCA:	101086114(ASH1L)

PYU:	121015632(ASH1L)

PCOO:

112851746(ASH1L)

PBG:	122476171(ASH1L)

PVIV:

125155107(ASH1L)

LRUF:

124521683

PTG:	102969379(ASH1L)

PPAD:

109256230(ASH1L)

PUC:

125925697

AJU:

106981535

HHV:	120244733(ASH1L)

BTA:	540563(ASH1L)

BOM:	102275046(ASH1L)

BIU:	109553548(ASH1L)

BBUB:

102415367(ASH1L)

BBIS:

104987397(ASH1L)

CHX:	102185413(ASH1L)

OAS:	101119775(ASH1L)

BTAX:

128044530(ASH1L)

ODA:	120855721(ASH1L)

CCAD:

122432434(ASH1L)

MBEZ:

129541286(ASH1L)

SSC:	100155920(ASH1L)

CFR:	102510601(ASH1L)

CBAI:

105068149(ASH1L)

CDK:	105088782(ASH1L)

VPC:	102541092(ASH1L)

BACU:

103015822(ASH1L)

BMUS:

118883966(ASH1L)

LVE:	103087473(ASH1L)

OOR:	101288541(ASH1L)

DLE:	111167169(ASH1L)

PCAD:

102993773(ASH1L)

PSIU:

116749029(ASH1L)

NASI:

112401717(ASH1L)

ECB:	100057386(ASH1L)

EPZ:	103548807 103552840

EAI:	106828486(ASH1L)

MYB:	102256394(ASH1L)

MYD:	102764796(ASH1L)

MMYO:

118673205(ASH1L)

MLF:	102422609(ASH1L)

PKL:	118721618(ASH1L)

EFUS:

103298888(ASH1L)

MNA:	107543779(ASH1L)

DRO:	112316914(ASH1L)

SHON:

118990223(ASH1L)

AJM:	119039727(ASH1L)

PDIC:

114489233(ASH1L)

PHAS:

123804317(ASH1L)

MMF:	118637054(ASH1L)

PPAM:

129062300(ASH1L)

HAI:	109393386(ASH1L)

RFQ:	117014381(ASH1L)

PALE:

102888124(ASH1L)

PGIG:

120592114(ASH1L)

PVP:	105296438(ASH1L)

RAY:	107521457(ASH1L)

MJV:	108407349(ASH1L)

TOD:	119235659(ASH1L)

SARA:

101536883(ASH1L)

SETR:

126020683(ASH1L)

LAV:	100668468(ASH1L)

TMU:

101348724

ETF:	101640320(ASH1L)

DNM:	101437622(ASH1L)

MDO:	100017118(ASH1L)

GAS:	123247906(ASH1L)

SHR:	100931585(ASH1L)

AFZ:

127559804

PCW:	110211945(ASH1L)

OAA:	103168045(ASH1L)

GGA:	425064(ASH1L)

PCOC:

116240863(ASH1L)

MGP:	100539732(ASH1L)

CJO:	107324503(ASH1L)

TPAI:

128092065(ASH1L)

LMUT:

125685860(ASH1L)

NMEL:

110387902(ASH1L)

APLA:

119713747(ASH1L)

ACYG:

106048498(ASH1L)

CATA:

118258443(ASH1L)

AFUL:

116499662(ASH1L)

TGU:	100229714(ASH1L)

LSR:	110471483(ASH1L)

SCAN:

103823951(ASH1L)

PMOA:

120498930(ASH1L)

OTC:	121332147(ASH1L)

PRUF:

121352178(ASH1L)

GFR:	102042927(ASH1L)

FAB:	101819907(ASH1L)

OMA:	130263172(ASH1L)

PHI:	102113028(ASH1L)

PMAJ:

107214568(ASH1L)

CCAE:

111939443(ASH1L)

CBRC:

103611269(ASH1L)

ETL:	114069574(ASH1L)

SVG:	106861120(ASH1L)

MMEA:

130586867(ASH1L)

HRT:	120764150(ASH1L)

FPG:	101913546(ASH1L)

FCH:	102056587(ASH1L)

CLV:	102090928(ASH1L)

EGZ:	104134854(ASH1L)

NNI:	104020487(ASH1L)

PCRI:

104034316

EHS:	104504530(ASH1L)

ACUN:

113488743(ASH1L)

TALA:

104365486(ASH1L)

PADL:

103913294(ASH1L)

AFOR:

103894959(ASH1L)

ACHC:

115346307(ASH1L)

HALD:

104311829(ASH1L)

HLE:	104829641(ASH1L)

AGEN:

126040631

GCL:

127027048

CCRI:

104156176

CSTI:

104554497(ASH1L)

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:	104341118(ASH1L)

MNB:	103776047(ASH1L)

OHA:	104329765(ASH1L)

NNT:	104406553(ASH1L)

SHAB:

115602803(ASH1L)

DPUB:

104310254(ASH1L)

PGUU:

104460694

CPEA:

104387244(ASH1L)

AVIT:

104280494

CVF:	104294109(ASH1L)

RTD:	128901143(ASH1L)

CUCA:

104057090(ASH1L)

BRHI:

104492230

AAM:	106494341(ASH1L)

AROW:

112978246(ASH1L)

NPD:	112952957(ASH1L)

TGT:	104565882(ASH1L)

DNE:	112992196(ASH1L)

SCAM:

104139355(ASH1L)

ASN:	102372997(ASH1L)

AMJ:	102571713(ASH1L)

CPOO:

109324810(ASH1L)

GGN:	109305142(ASH1L)

PSS:	102448117(ASH1L)

CMY:	102943662(ASH1L)

CCAY:

125626207(ASH1L)

DCC:	119848004(ASH1L)

CPIC:

101942050(ASH1L)

TST:	117888659(ASH1L)

CABI:

116817234(ASH1L)

MRV:	120390221(ASH1L)

ACS:	100563888(ash1l)

ASAO:

132764246(ASH1L)

PVT:	110081037(ASH1L)

SUND:

121916058(ASH1L)

PBI:	103060233(ASH1L)

PMUR:

107297020(ASH1L)

CTIG:

120317174(ASH1L)

TSR:

106538172

PGUT:

117658860(ASH1L)

APRI:

131186393(ASH1L)

PTEX:

113446585(ASH1L)

NSS:	113426974(ASH1L)

VKO:	123032623(ASH1L)

PMUA:

114586229(ASH1L)

PRAF:

128403918(ASH1L)

ZVI:	118076583(ASH1L)

HCG:	128336928(ASH1L)

GJA:	107119617(ASH1L)

STOW:

125441054(ASH1L)

EMC:	129339539(ASH1L)

XLA:	108699167 108700623

XTR:	108645568(ash1l)

NPR:	108794233(ASH1L)

RTEM:

120920770(ASH1L)

MUO:	115456952(ASH1L)

GSH:	117350090(ASH1L)

DRE:	563799(ash1l)

SRX:	107707165 107724081 107739498 107743194

SANH:

107656475 107673015 107685579 107693346

SGH:	107589474 107596620 107598430 107599509

CCAR:

109111952

CAUA:

113059914 113116331 113120006

CGIB:

127934925 127979019

PTET:

122323584(ash1l)

LROH:

127181447(ash1l)

OMC:	131525287(ash1l)

PPRM:

120483798(ash1l) 120484714

RKG:	130070828(ash1l)

MAMB:

125244159 125275540(ash1l)

CIDE:

127500630

MASI:

127420966 127425594

TROS:

130566565(ash1l)

TDW:	130415758(ash1l)

MANU:

129455335(ash1l)

IPU:	108267029 108272684(ash1l)

IFU:	128615239(ash1l)

PHYP:

113535206 113542280(ash1l)

SMEO:

124381860(ash1l) 124385197

TFD:	113641274(ash1l) 113644404

TVC:	132842875(ash1l)

AMEX:

103022779 103036607

CMAO:

118805977(ash1l)

EEE:	113570594 113572615

CHAR:

105901435(ash1l) 105906726

TRU:	101065064 101078475

TFS:	130518819(ash1l) 130532300

TNG:	GSTEN00032567G001

LCO:	104929091 104934663

NCC:	104942643 104958848(ash1l)

TBEN:

117477916(ash1l) 117480263

CGOB:

115015423

PGEO:

117455328(ash1l) 117461084

GACU:

117540997 117542568(ash1l)

EMAC:

134861400 134874850(ash1l)

ELY:	117263128(ash1l) 117265713

EFO:	125892769 125904401(ash1l)

PLEP:

121945149 121957926(ash1l)

SLUC:

116047314(ash1l) 116049571

ECRA:

117946694 117956323(ash1l)

ESP:	116691354 116701264

PFLV:

114557800(ash1l) 114567637

GAT:	120825936(ash1l)

PPUG:

119197439 119218735(ash1l)

AFB:	129097038(ash1l) 129109105

CLUM:

117738591(ash1l) 117745551

PSWI:

130199528(ash1l) 130212726

MSAM:

119897568 119908147(ash1l)

SCHU:

122864341(ash1l) 122882158

CUD:	121513663 121524306(ash1l)

ALAT:

119005927 119014819(ash1l)

MZE:	101465538 101472002

ONL:	100706567(ash1l) 100707110

OAU:	116315704 116319419(ash1l)

OLA:	101156847(ash1l) 101161417

OML:	112143321 112162542(ash1l)

CSAI:

133432525 133461347(ash1l)

XMA:	102219717 102229525(ash1l)

XCO:	114141764(ash1l) 114156414

XHE:	116717078(ash1l) 116730665

PRET:

103472762 103478185(ash1l)

PFOR:

103140776(ash1l) 103144472

PLAI:

106938021 106954688 106964214

PMEI:

106917899(ash1l) 106918176

GAF:	122830959 122843303(ash1l)

PPRL:

129371196 129374981(ash1l)

CVG:	107084057 107088414(ash1l)

CTUL:

119779602(ash1l) 119783008

GMU:	124865811 124879004(ash1l)

NFU:	107379592(ash1l) 107394561

KMR:	108240202(ash1l) 108241069

ALIM:

106520872 106531577(ash1l)

NWH:	119409732 119425388(ash1l)

AOCE:

111570477

MCEP:

125016431 125019564(ash1l)

CSEM:

103388251(ash1l) 103394569

POV:	109633377 109639158

SSEN:

122774591 122786837(ash1l)

HHIP:

117770539(ash1l)

HSP:	118113702 118125034(ash1l)

SMAU:

118291884(ash1l) 118299741

LCF:	108885923 108888847

SDU:	111223036 111230135(ash1l)

SLAL:

111652181(ash1l) 111657636

XGL:	120783754 120786127(ash1l)

HCQ:	109513128 109521050(ash1l)

SSCV:

125986976

SBIA:

133500492 133504115(ash1l)

PEE:	133395365(ash1l) 133401323

PTAO:

133471177(ash1l) 133479435

BPEC:

110163006(ash1l) 110167402

MALB:

109951508 109964099(ash1l)

BSPL:

114843444 114865435(ash1l)

SJO:	128366440 128373753(ash1l)

SASA:

106570093 106588182 106605880(ash1l)

STRU:

115173287 115176059

OTW:	112229989 112266640

OMY:	110487650 110496012(ash1l) 110520799 110520835

OGO:	123998200 124013137 124043678

ONE:	115128210 115131772

OKI:	109882336 109882341 109903805 109907687

OKE:	118379684 118383326 118398364 118399115

SALP:

111955046 112070639

SNH:	120026898(ash1l) 120041142 120047244 120048866

CCLU:

121571414(ash1l) 121586317

ELS:	105006914 105024439

SFM:	108925420(ash1l)

PKI:	111840856(ash1l) 111858202

AANG:

118234224(ash1l) 118236528

PSPA:

121306919

ARUT:

117395225 117969039

PSEX:

120537978(ash1l)

LCM:	102367246(ASH1L)

CPLA:

122544720(ash1l)

HOC:	132805626(ash1l)

LERI:

129715786

PMRN:

116942143 116954923(ASH1L)

LRJ:	133342177(ASH1L) 133343620

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG8887(ash1)

DER:

6545341

DSI:	Dsimw501_GD12268(Dsim_GD12268)

DYA:	Dyak_GE22484

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13513

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:	101901319 131805647

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ001202 CpipJ_CPIJ001203

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208029

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119839737 119839791

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM244720

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DMK:

PVM:	113819372 113819373

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

PPOI:

DSV:

RMP:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_T12F5.4(lin-59)

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

PPA:	PAS_chr1-1_0102

YLI:	YALI0D21684g

NCR:	NCU01932(set-3)

NTE:	NEUTE1DRAFT125465(NEUTE1DRAFT_125465)

SMP:	SMAC_05383

PAN:	PODANSg050

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2111453

MTM:	MYCTH_2298281

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_7438

SSCK:

SPSK_05820

FGR:	FGSG_08916

FPU:	FPSE_08917

FPOA:

FPOAC1_005073

FVN:	FVRRES_05596

FVR:	FVEG_02520

FOX:	FOXG_03647

NHE:	NECHADRAFT_123121(SDG2103)

FFC:	NCS54_00437800

FKR:	NCS57_00444500

FMU:	J7337_008861

TRE:	TRIREDRAFT_59359

TRR:	M419DRAFT_75768

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_02950

PTKZ:

JDV02_008304

VAL:	VDBG_01967

VDA:	VDAG_10334

CFJ:	CFIO01_08009

CLUP:

CLUP02_14796

CHIG:

CH63R_09988

SAPO:

SAPIO_CDS5211

ELA:	UCREL1_654

PFY:	PFICI_02813

SSL:	SS1G_04018

BFU:	BCIN_01g02240

MBE:

MBM_00593

PSCO:

LY89DRAFT_691849

GLZ:	GLAREA_11975

ANI:	ANIA_04764

AFM:	AFUA_3G06480

ACT:	ACLA_034430

NFI:	NFIA_070790

AOR:	AO090020000101

ANG:	An11g09860

AFV:	AFLA_010555

PCS:	N7525_009200

PDP:	PDIP_00750

POU:	POX_g09054

TMF:	EYB26_008952

TRG:	TRUGW13939_11162

CIM:	CIMG_00441

CPW:	CPC735_057720

URE:	UREG_00487

PBL:	PAAG_05913

PBN:	PADG_06078

ABE:

ARB_07287

TVE:

TRV_02019

AJE:	HCAG_01200

BGH:	BDBG_06685

ARAB:

EKO05_0004468

ZTR:	MYCGRDRAFT_97419

FFU:	CLAFUR5_14562

CBET:

CB0940_05501

BCOM:

BAUCODRAFT_402857

NPA:	UCRNP2_7239

TML:	GSTUM_00002654001

TASA:

A1Q1_02180

UMA:	UMAG_00400

PFP:	PFL1_06302

PGR:	PGTG_16563

SRE:	PTSG_04178

» show all

Reference

PMID:21239497

Authors

An S, Yeo KJ, Jeon YH, Song JJ

Title

Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.

Journal

J Biol Chem 286:8369-74 (2011)
DOI:10.1074/jbc.M110.203380

Sequence

[hsa:55870]

ORTHOLOGY: K11423

Entry

K11423                      KO

Symbol

SETD2

Name

[histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H02444

Luscan-Lumish syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.359  [histone H3]-lysine36 N-trimethyltransferase
     K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase

Other DBs

GO:

0046975

Genes

HSA:	29072(SETD2)

PTR:	460331(SETD2)

PPS:	100993006(SETD2)

GGO:	101132140(SETD2)

PON:	100433116(SETD2)

NLE:	100584442(SETD2)

HMH:	116473532(SETD2)

MCC:	711825(SETD2)

MCF:	102121581(SETD2)

MTHB:

126948577

MNI:

105480624

CSAB:

103227561(SETD2)

CATY:

105573623(SETD2)

PANU:

101026986(SETD2)

TGE:	112618523(SETD2)

MLEU:

105540477(SETD2)

RRO:	104671311(SETD2)

RBB:	108517641(SETD2)

TFN:	117080326(SETD2)

PTEH:

111555466(SETD2)

CANG:

105509827(SETD2)

CJC:	100411953(SETD2)

SBQ:	101034613(SETD2)

CIMI:

108305438(SETD2)

CSYR:

103273788(SETD2)

MMUR:

105874896(SETD2)

LCAT:

123623336(SETD2)

PCOQ:

105827280(SETD2)

OGA:	100950439(SETD2)

MMU:	235626(Setd2)

MCAL:

110301050(Setd2)

MPAH:

110328077(Setd2)

RNO:	316013(Setd2)

MCOC:

116072571(Setd2)

ANU:	117693276(Setd2)

MUN:	110554986(Setd2)

CGE:	100765637(Setd2)

MAUA:

101830442(Setd2)

PROB:

127235952(Setd2)

PLEU:

114705174(Setd2)

MORG:

121464185(Setd2)

MFOT:

126499805

AAMP:

119808984(Setd2)

NGI:	103732034(Setd2)

CPOC:

100719166(Setd2)

CCAN:

109689470(Setd2)

DORD:

105996211(Setd2)

DSP:	122126928(Setd2)

PLOP:

125342285(Setd2)

NCAR:

124969403

MMMA:

107145083(Setd2)

OCU:

100351499

OPI:	101516490(SETD2)

TUP:	102477917(SETD2)

GVR:	103591229(SETD2)

CFA:	476643(SETD2)

CLUD:

112666853(SETD2)

VVP:	112912390(SETD2)

VLG:	121494650(SETD2)

NPO:	129521732(SETD2)

AML:	100466135(SETD2)

UMR:	103675118(SETD2)

UAH:	113256807(SETD2)

UAR:	123779799(SETD2)

ELK:

111144347

LLV:

125081004

MPUF:

101681942(SETD2)

MNP:	132011261(SETD2)

MLK:	131823866(SETD2)

NVS:	122909482(SETD2)

ORO:	101365495(SETD2)

EJU:	114196503(SETD2)

ZCA:	113916609(SETD2)

MLX:	118005368(SETD2)

NSU:	110577582(SETD2)

LWW:	102727823(SETD2)

FCA:	101085029(SETD2)

PYU:	121026806 121026808

PCOO:

112852684(SETD2)

PBG:	122487199(SETD2)

PVIV:

125154219(SETD2)

LRUF:

124523532

PTG:	102955436(SETD2)

PPAD:

109247730(SETD2)

PUC:

125930654

AJU:

106969033

HHV:	120229315(SETD2)

BTA:	539860(SETD2)

BOM:	102266643(SETD2)

BIU:	109575988(SETD2)

BBUB:

102393639(SETD2)

BBIS:

105004686(SETD2)

CHX:	102183113(SETD2)

OAS:	101114649(SETD2)

BTAX:

128044432(SETD2)

ODA:	120868180(SETD2)

CCAD:

122424798(SETD2)

MBEZ:

129547776(SETD2)

SSC:	100623101(SETD2)

CFR:	102512396(SETD2)

CBAI:

105072880(SETD2)

CDK:	105103636(SETD2)

VPC:	102531919(SETD2)

BACU:

102997833(SETD2)

BMUS:

118903175(SETD2)

LVE:	103086894(SETD2)

OOR:	101269476 101280364(SETD2) 101282703 125961717

DLE:	111174450(SETD2)

PCAD:

112064944(SETD2)

PSIU:

116742461 116742477 116761205 116761609(SETD2) 116764505

NASI:

112403750(SETD2)

ECB:	100064888(SETD2)

EPZ:	103551032(SETD2)

EAI:	106823246(SETD2)

MYB:	102260404(SETD2)

MYD:	102758485(SETD2)

MMYO:

118668537(SETD2)

MLF:	102435793(SETD2)

PKL:	118714790(SETD2)

EFUS:

103299125(SETD2)

MNA:	107529409(SETD2)

DRO:	112309866(SETD2)

SHON:

118976190(SETD2)

AJM:	119037871(SETD2)

PDIC:

114501512(SETD2)

PHAS:

123830508(SETD2)

MMF:	118633365(SETD2)

PPAM:

129087631(SETD2)

HAI:	109376628(SETD2)

RFQ:	117036580(SETD2)

PALE:

102884085(SETD2)

PGIG:

120582282(SETD2)

PVP:	105302344(SETD2)

RAY:	107509112(SETD2)

MJV:	108400455(SETD2) 108401248 118966919

TOD:	119259277(SETD2)

SARA:

101550871(SETD2)

SETR:

126014003(SETD2)

LAV:	100655356(SETD2)

TMU:

101343139

ETF:	101642970(SETD2)

DNM:	101433648(SETD2)

MDO:	100024848(SETD2)

GAS:	123252909(SETD2)

SHR:	100931646(SETD2)

PCW:	110217008(SETD2)

OAA:	114816148(SETD2)

GGA:	420404(SETD2)

PCOC:

116238217(SETD2)

MGP:	100539457(SETD2)

CJO:	107308808(SETD2)

TPAI:

128087412(SETD2)

LMUT:

125695638(SETD2)

NMEL:

110393293(SETD2)

APLA:

113842604(SETD2)

ACYG:

106046805(SETD2)

CATA:

118251837(SETD2)

AFUL:

116486033(SETD2)

TGU:	100224614(SETD2)

LSR:	110476945(SETD2)

SCAN:

103813035(SETD2)

PMOA:

120510532(SETD2)

OTC:	121337966(SETD2)

PRUF:

121351804(SETD2)

GFR:	102039322(SETD2)

FAB:	101814785(SETD2)

OMA:	130249334(SETD2)

PHI:	102106397(SETD2)

PMAJ:

107215411(SETD2)

CCAE:

111925482(SETD2)

CCW:	104686490(SETD2)

CBRC:

103623957(SETD2)

ETL:	114070402(SETD2)

ZAB:	102070924(SETD2)

ACHL:

103808009(SETD2)

SVG:	106862800(SETD2)

MMEA:

130574556(SETD2)

HRT:	120754330(SETD2)

FPG:	101913975(SETD2)

FCH:	102053248(SETD2)

CLV:	102098192(SETD2)

EGZ:	104123260(SETD2)

NNI:	104019238(SETD2)

PCRI:

104035741(SETD2)

PLET:

104618506(SETD2)

EHS:	104510412(SETD2)

PCAO:

104043224(SETD2)

ACUN:

113476423(SETD2)

TALA:

104358172(SETD2)

PADL:

103916778(SETD2)

AFOR:

103903408(SETD2)

ACHC:

115338781(SETD2)

HALD:

104322327

HLE:	104829204(SETD2)

AGEN:

126038089

GCL:

127012720

CCRI:

104159334(SETD2)

CMAC:

104473045(SETD2)

MUI:	104544284(SETD2)

BREG:

104641398(SETD2)

FGA:	104082936(SETD2)

GSTE:

104255118

LDI:	104353735(SETD2)

OHA:	104332883(SETD2)

NNT:

104407506

SHAB:

115611158(SETD2)

DPUB:

104306779(SETD2)

PGUU:

104457667(SETD2)

ACAR:

104529664(SETD2)

CPEA:

104387994(SETD2)

AVIT:

104275817(SETD2)

CVF:	104289689(SETD2)

RTD:	128906101(SETD2)

CUCA:

104055045(SETD2)

TEO:	104378282(SETD2)

BRHI:

104493974(SETD2)

AROW:

112977399(SETD2)

NPD:	112947562 112951575

TGT:	104570962(SETD2)

DNE:	112992776(SETD2)

SCAM:

104150107(SETD2)

ASN:	102378063(SETD2)

AMJ:	102567964(SETD2)

CPOO:

109306447(SETD2)

GGN:	109291156(SETD2)

PSS:	102460966(SETD2)

CMY:	102947543(SETD2)

CCAY:

125631124(SETD2)

DCC:	119851175(SETD2)

CPIC:

101953039(SETD2)

TST:	117871919(SETD2)

CABI:

116819138(SETD2)

MRV:	120397709(SETD2)

ACS:	100559621(setd2)

ASAO:

132779047(SETD2)

PVT:	110069987(SETD2)

SUND:

121933414(SETD2)

PBI:	103055763(SETD2)

PMUR:

107286005(SETD2)

CTIG:

120319695(SETD2)

TSR:	106542655(SETD2)

PGUT:

117656347(SETD2)

APRI:

131196724(SETD2)

PTEX:

113452005(SETD2)

NSS:	113427149(SETD2)

VKO:	123020920(SETD2)

PMUA:

114607160(SETD2)

PRAF:

128423845(SETD2)

ZVI:	118091669(SETD2)

HCG:	128329599(SETD2)

GJA:	107120098(SETD2)

STOW:

125440838(SETD2)

EMC:	129338042(SETD2)

XLA:	108718681(setd2.L) 108719797(setd2.S)

XTR:	100492810(setd2)

RTEM:

120941687(SETD2)

BBUF:

121000811(SETD2)

BGAR:

122938723(SETD2)

MUO:	115465989(SETD2)

GSH:	117354403(SETD2)

DRE:	794199(setd2)

SRX:	107743179 107752833

SANH:

107673014 107685560

SGH:	107581536 107596709

CCAR:

109063165

CAUA:

113060209 113116306

CGIB:

127969714 127975534 128030804

PTET:

122360104(setd2)

LROH:

127178249(setd2)

OMC:	131521470(setd2)

PPRM:

120484453(setd2)

RKG:	130070181(setd2)

MAMB:

125243135(setd2)

CIDE:

127497709

MASI:

127454335

TROS:

130557516(setd2)

TDW:	130432613(setd2)

MANU:

129447809(setd2)

IPU:

108267177

IFU:	128608990(setd2)

PHYP:

113542507(setd2)

SMEO:

124384161(setd2)

TFD:	113644580(setd2)

TVC:	132845981(setd2)

AMEX:

103039344(setd2)

CMAO:

118825674(setd2)

EEE:	113570706(setd2)

TRU:	101076040(setd2)

TFS:	130532370(setd2)

TNG:	GSTEN00034080G001

LCO:	104940331(setd2)

NCC:	104948745(setd2) 104957630

TBEN:

117480208(setd2)

CGOB:

115021807(setd2)

PGEO:

117460444(setd2)

GACU:

117554101(setd2)

EMAC:

134861484(setd2)

ELY:	117265736(setd2)

EFO:	125893649(setd2)

PLEP:

121945864(setd2)

SLUC:

116049433(setd2)

ECRA:

117945702(setd2)

ESP:	116690678(setd2)

PFLV:

114557737(setd2)

GAT:	120810650(setd2)

PPUG:

119197772(setd2)

AFB:	129109168(setd2)

CLUM:

117745025(setd2)

PSWI:

130212725(setd2)

MSAM:

119897705(setd2)

SCHU:

122881330(setd2)

CUD:	121513186(setd2)

ALAT:

119006696(setd2)

MZE:	101471514(setd2)

ONL:	100689872(setd2)

OAU:	116325355(setd2)

OLA:	101163764(setd2)

OML:	112143951(setd2)

CSAI:

133430454(setd2)

XMA:	102216591(setd2)

XCO:	114141991(setd2)

XHE:	116717187(setd2)

PRET:

103478611(setd2)

PFOR:

103152270(setd2)

PLAI:

106939758(setd2)

PMEI:

106906609(setd2)

GAF:	122831473(setd2)

PPRL:

129371146(setd2)

CVG:	107081814(setd2)

CTUL:

119772867(setd2)

GMU:	124865731(setd2)

NFU:	107395695(setd2)

KMR:	108241998(setd2)

ALIM:

106534862

NWH:	119409449(setd2)

AOCE:

111572050(setd2)

MCEP:

125016073(setd2)

CSEM:

103388382(setd2)

POV:	109633212(setd2)

SSEN:

122774466(setd2)

HHIP:

117777387(setd2)

HSP:	118113301(setd2)

SMAU:

118308029(setd2)

LCF:

108891907

SDU:	111236791(setd2)

SLAL:

111652786(setd2)

XGL:	120783986(setd2)

HCQ:	109518019(setd2)

SSCV:

125975337

SBIA:

133500905(setd2)

PEE:	133401664(setd2)

PTAO:

133479116(setd2)

BPEC:

110171513(setd2)

MALB:

109967312(setd2)

BSPL:

114843737(setd2)

SJO:	128366082(setd2)

SASA:

106593284 106593288 106606040

STRU:

115187660 115187661

OTW:	112243644(setd2)

OMY:	110520688(setd2)

OGO:	124019594(setd2)

ONE:

115115571

OKI:

109882680

SALP:

112076057(setd2)

SNH:	120031365(setd2)

CCLU:

121542611(setd2) 121542806

ELS:	105018749(setd2)

SFM:	108927425(setd2)

PKI:	111850417(setd2)

AANG:

118228444(setd2)

LOC:	102690042 102692025(setd2)

PSPA:

121312967 121314673

ARUT:

117394754 117400236

PSEX:

120515800(setd2)

LCM:	102359121(SETD2)

CMK:	103190896(setd2)

CPLA:

122548953(setd2)

HOC:	132815050(setd2)

LERI:

129714861(setd2)

PMRN:

116940988(SETD2)

LRJ:	133344877(SETD2)

BFO:

BBEL:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG1716(Set2)

DER:

6551019

DSE:

6618681

DSI:	Dsimw501_GD17127(Dsim_GD17127)

DYA:	Dyak_GE17076

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12297

DAZ:	108614554 108619464

DNV:	108652260 108656778

DHE:	111593003 111598712

DVI:	6623058 6631536

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ005876

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:	109855296 109859218

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM463920

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_319776

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

BGT:

GAE:

HRF:

HRJ:

CRG:

PMAX:

OBI:

OSN:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

Reference

PMID:16118227

Authors

Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z

Title

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.

Journal

J Biol Chem 280:35261-71 (2005)
DOI:10.1074/jbc.M504012200

Sequence

[hsa:29072]

ORTHOLOGY: K11422

Entry

K11422                      KO

Symbol

SETD1, SET1

Name

[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H02463

Syndromic intellectual developmental disorder

H02535

Neurodevelopmental disorder with dysmorphic facies

H02696

Early-onset epilepsy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
   HMT complexes
    COMPASS/SET1 complex
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
    COMPASS/SET1 complex (yeast)
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1

Other DBs

GO:

0042800

Genes

HSA:	23067(SETD1B) 9739(SETD1A)

PTR:	468101(SETD1A) 473295(SETD1B)

PPS:	100972983(SETD1A) 100985657(SETD1B)

PON:	100432076(SETD1A) 100435324(SETD1B)

NLE:	100584028(SETD1B) 100602268(SETD1A)

HMH:	116471174(SETD1A) 116477776(SETD1B)

MCC:	703717(SETD1B) 712416(SETD1A)

MCF:	102123137(SETD1B) 102134166(SETD1A)

MTHB:

126930593 126944171

MNI:	105483007(SETD1A) 105494476(SETD1B)

CSAB:

103231168(SETD1A) 103239290(SETD1B)

CATY:

105590973(SETD1B) 105599378(SETD1A)

PANU:

101020341(SETD1A) 101023789(SETD1B)

TGE:	112614267(SETD1A) 112635333(SETD1B)

MLEU:

105528008(SETD1B) 105541460(SETD1A)

RRO:	104661596(SETD1A) 104666361(SETD1B)

RBB:	108523384(SETD1B) 108526582(SETD1A)

TFN:	117087676(SETD1A) 117089265(SETD1B)

PTEH:

111525679(SETD1A) 111538048(SETD1B)

CANG:

105505730(SETD1A) 105516393(SETD1B)

CJC:	100398610(SETD1B) 100415635(SETD1A)

SBQ:	101042903(SETD1A) 101045177(SETD1B)

CIMI:

108293904(SETD1A) 108315141(SETD1B)

CSYR:

103264403(SETD1A) 103266138(SETD1B)

MMUR:

105871051(SETD1A) 105880900(SETD1B)

LCAT:

123626072(SETD1B) 123632706(SETD1A)

PCOQ:

105823084(SETD1A) 105825690(SETD1B)

OGA:	100945599(SETD1A) 100958719 100961024(SETD1B)

MMU:	208043(Setd1b) 233904(Setd1a)

MCAL:

110295015(Setd1b) 110298244(Setd1a)

MPAH:

110312745(Setd1b) 110317687(Setd1a)

RNO:	100359816(Setd1b)

MCOC:

116068383(Setd1b) 116103030(Setd1a)

ANU:	117696415(Setd1a) 117697926(Setd1b)

MUN:	110545334(Setd1b) 110559774(Setd1a)

CGE:	100753294(Setd1b) 100753962(Setd1a)

MAUA:

101829014(Setd1b)

PROB:

127216087(Setd1b)

PLEU:

114704387(Setd1a) 114704545(Setd1b)

MORG:

121445946(Setd1b)

MFOT:

126504215

AAMP:

119823471(Setd1a) 119825033(Setd1b)

NGI:	103726333(Setd1a) 103739104(Setd1b)

HGL:	101702850(Setd1b) 101709197(Setd1a)

CPOC:

100714908(Setd1b) 100715930(Setd1a)

CCAN:

109682842(Setd1a) 109686401(Setd1b)

DORD:

105982177(Setd1a) 105990633(Setd1b)

DSP:	122096261(Setd1a) 122098518(Setd1b)

PLOP:

125340333(Setd1a) 125349152(Setd1b)

NCAR:

124970066 124990549

MMMA:

107146965(Setd1a) 107156350(Setd1b)

OCU:	100347618 100354139

OPI:	101518304(SETD1A) 101533528(SETD1B)

TUP:	102478405(SETD1A)

GVR:	103606160(SETD1B) 103609922(SETD1A)

CFA:	486257(SETD1B) 489916(SETD1A)

CLUD:

112640121(SETD1A) 112676504(SETD1B)

VVP:	112929256(SETD1A) 112935175(SETD1B)

VLG:	121475438(SETD1B) 121487211(SETD1A)

NPO:	129507853(SETD1B) 129520097(SETD1A)

AML:	100478541(SETD1B) 100482700(SETD1A)

UMR:	103657933(SETD1A) 103661268(SETD1B)

UAH:	113266937(SETD1B) 113267709(SETD1A)

UAR:	123779442(SETD1B) 123784667(SETD1A)

ELK:	111156373 111162294

LLV:	125081907 125091088

MPUF:

101676784(SETD1A) 101682975(SETD1B)

MNP:	132023125(SETD1B) 132026692(SETD1A)

MLK:	131811292(SETD1B) 131819356(SETD1A)

NVS:	122896122 122896125 122903042(SETD1B)

ORO:	101376995(SETD1A)

EJU:	114214467(SETD1A) 114219185(SETD1B)

ZCA:	113912965(SETD1B) 113933089(SETD1A)

MLX:	117999573(SETD1A) 118018434(SETD1B)

NSU:	110588211(SETD1B) 110589952(SETD1A)

LWW:	102746225(SETD1B) 102748564

FCA:	101091070(SETD1A) 101096419(SETD1B)

PYU:	121010353(SETD1B) 121022169(SETD1A)

PCOO:

112857241(SETD1A)

PBG:	122470187(SETD1B) 122471425(SETD1A)

PVIV:

125149038(SETD1B) 125154172(SETD1A)

LRUF:

124517826 124518311

PTG:	102969005(SETD1A) 102970685(SETD1B)

PPAD:

109258968(SETD1A) 109277797(SETD1B)

PUC:	125914205 125928103

AJU:	106967594 106979084

HHV:	120242216(SETD1A) 120243585(SETD1B)

BTA:	514102(SETD1B) 782887(SETD1A)

BOM:	102279495(SETD1A) 102280610(SETD1B)

BIU:	109570912(SETD1B) 109578511(SETD1A)

BBUB:

102393219(SETD1B) 102401677(SETD1A)

BBIS:

104986763(SETD1A) 104989678(SETD1B)

CHX:	102170478(SETD1A) 102179971(SETD1B)

OAS:	101103509(SETD1B) 101105467(SETD1A)

BTAX:

128062225(SETD1B) 128068443(SETD1A)

ODA:	120871020(SETD1B) 120877526(SETD1A)

CCAD:

122423872(SETD1B) 122432971(SETD1A)

MBEZ:

129542812(SETD1B) 129545547(SETD1A)

SSC:	100156137(SETD1B) 100511747(SETD1A)

CFR:	102509980(SETD1A) 102521372(SETD1B)

CBAI:

105080705(SETD1B) 105082875(SETD1A)

CDK:	105102557(SETD1B) 105102789(SETD1A)

VPC:	102525013(SETD1A) 102533681(SETD1B)

BACU:

103008957(SETD1A) 103010622(SETD1B)

BMUS:

118879821(SETD1B) 118881222(SETD1A)

LVE:	103077679(SETD1B) 103079757(SETD1A)

OOR:	101278914(SETD1B) 101283071(SETD1A)

DLE:	111182119(SETD1A) 111186875(SETD1B)

PCAD:

102977910(SETD1B) 102992941(SETD1A)

PSIU:

116738782(SETD1B) 116740357(SETD1A)

NASI:

112399257(SETD1A) 112408730(SETD1B)

ECB:	100063523(SETD1A) 100146430(SETD1B)

EPZ:	103541678(SETD1B) 103547270(SETD1A)

EAI:	106831838(SETD1A) 106842219(SETD1B)

MYB:	102253255(SETD1A) 102255512(SETD1B)

MYD:	102756071(SETD1A)

MMYO:

118656653(SETD1A) 118678406(SETD1B)

MLF:	102442931(SETD1A)

PKL:	118704848(SETD1A) 118725309(SETD1B)

EFUS:

103287230(SETD1B) 103296321(SETD1A)

MNA:	107540799(SETD1A) 107541833(SETD1B)

DRO:	112304818(SETD1A) 112310608(SETD1B)

SHON:

118991063(SETD1B)

AJM:	119041139(SETD1A) 119048615(SETD1B)

PDIC:

114509374(SETD1B) 114512730(SETD1A)

PHAS:

123820603(SETD1B) 123825564(SETD1A)

MMF:	118639802(SETD1B) 118642749(SETD1A)

PPAM:

129078017(SETD1A) 129087511(SETD1B)

HAI:	109374193(SETD1A) 109386061(SETD1B)

RFQ:	117017510(SETD1B) 117019889(SETD1A)

PALE:

102879153(SETD1B) 102884674(SETD1A)

PGIG:

120616066(SETD1B) 120620062(SETD1A)

PVP:	105289379(SETD1B) 105304517(SETD1A)

RAY:	107503985(SETD1A) 107515234(SETD1B)

MJV:	108385302(SETD1A) 108390371(SETD1B)

TOD:	119241716(SETD1A) 119245021(SETD1B)

SARA:

101545082(SETD1A) 101555815(SETD1B)

SETR:

126001027(SETD1B) 126030840(SETD1A)

LAV:	100662609(SETD1A) 100668488(SETD1B)

TMU:	101349124 101354370

ETF:	101660780(SETD1A) 101661209(SETD1B)

DNM:	101411688(SETD1B) 101430254(SETD1A)

MDO:	100013387(SETD1A) 100618514(SETD1B)

GAS:	123233557(SETD1A)

SHR:	100929291(SETD1A)

AFZ:	127545436 127562842

PCW:	110196787(SETD1B) 110223143(SETD1A)

OAA:	100074411(SETD1B) 100090957(SETD1A)

GGA:	416851(SETD1B)

PCOC:

116228609(SETD1B)

MGP:	100544670(SETD1B)

CJO:	107321274(SETD1B)

TPAI:

128084789(SETD1B)

LMUT:

125701628(SETD1B)

NMEL:

110406578(SETD1B)

APLA:

101803072(SETD1B)

ACYG:

106031413(SETD1B)

CATA:

118257585(SETD1B)

AFUL:

116496232(SETD1B)

TGU:	100225647(SETD1B)

LSR:	110471750(SETD1B)

SCAN:

103818319(SETD1B)

PMOA:

120509726(SETD1B)

OTC:	121338904(SETD1B)

PRUF:

121365177(SETD1B)

GFR:	102040049(SETD1B)

FAB:	101812652(SETD1B)

OMA:	130259859(SETD1B)

PHI:	102114734(SETD1B)

PMAJ:

107211664(SETD1B)

CCW:	104688830(SETD1B)

CBRC:

103616030(SETD1B)

ETL:	114055005(SETD1B)

ZAB:	102063205(SETD1B)

ACHL:

103797867(SETD1B)

SVG:	106852411(SETD1B)

MMEA:

130580359(SETD1B)

HRT:	120760602(SETD1B)

FPG:	101911864(SETD1B)

FCH:	102051296(SETD1B)

CLV:	102083945(SETD1B)

EGZ:	104122745(SETD1B)

NNI:	104020788(SETD1B)

PCRI:

104028829(SETD1B)

PLET:

104627930(SETD1B)

EHS:	104509211(SETD1B)

PCAO:

104046246(SETD1B)

ACUN:

113485968(SETD1B)

TALA:

104357553(SETD1B)

PADL:

103914561(SETD1B)

AFOR:

103902864(SETD1B)

ACHC:

115346137(SETD1B)

HALD:

104322588(SETD1B)

HLE:	104840889(SETD1B)

AGEN:

126040986

GCL:

127022697

CCRI:

104167027(SETD1B)

CSTI:

104558267

CMAC:

104484378

MUI:

104533896

BREG:

104629600(SETD1B)

FGA:	104079639(SETD1B)

GSTE:

104261514(SETD1B)

LDI:

104343025

MNB:

103770219

OHA:	104339361(SETD1B)

NNT:	104404373(SETD1B)

SHAB:

115614298(SETD1B)

DPUB:

104308403(SETD1B)

PGUU:

104468713(SETD1B)

ACAR:

104518583(SETD1B)

CPEA:

104389444(SETD1B)

AVIT:

104281140

CVF:	104282211(SETD1B)

RTD:	128917164(SETD1B)

CUCA:

104058823(SETD1B)

TEO:	104380420(SETD1B)

BRHI:

104500111(SETD1B)

AAM:	106495668(SETD1B)

AROW:

112962587(SETD1B)

NPD:	112949410(SETD1B)

TGT:	104578305(SETD1B)

DNE:	112991769(SETD1B)

SCAM:

104138886(SETD1B)

ASN:	102378568(SETD1B)

AMJ:	102574091(SETD1B) 102576444(SETD1A)

CPOO:

109312977(SETD1B)

GGN:	109290592(SETD1B)

PSS:	102448089(SETD1B)

CMY:	102934693(SETD1B) 102937004(SETD1A)

CCAY:

125623122(SETD1B) 125639094(SETD1A)

DCC:	119843486(SETD1B) 119856799(SETD1A)

CPIC:

101936901(SETD1A) 101939661(SETD1B)

TST:	117870265 117888012(SETD1B)

CABI:

116815510(SETD1A) 116836803(SETD1B)

MRV:	120386207(SETD1B) 120403295(SETD1A)

ACS:	103279564(setd1a)

ASAO:

132777736(SETD1A) 132781641(SETD1B)

PVT:	110086418(SETD1A)

SUND:

121916642(SETD1B) 121933310(SETD1A)

PBI:	103054534(SETD1A)

CTIG:

120302200(SETD1A) 120316755(SETD1B)

PGUT:

117666830(SETD1A) 117672218(SETD1B)

APRI:

131185725(SETD1B)

PTEX:

113448694(SETD1B) 113452159

NSS:	113424897(SETD1B)

VKO:	123019576(SETD1A) 123028714(SETD1B)

PMUA:

114582823(SETD1A)

PRAF:

128399355(SETD1A) 128404488(SETD1B)

ZVI:	118076323(SETD1B) 118094883(SETD1A)

HCG:	128329422(SETD1A)

GJA:	107106655(SETD1A)

STOW:

125442810(SETD1B) 125444539(SETD1A)

EMC:	129338613(SETD1A) 129341324(SETD1B)

XLA:	108703944(setd1a.L) 108705280(setd1a.S) 108716786(setd1b.L) 447454(setd1b.S)

XTR:	100487270(setd1a) 780106(setd1b)

NPR:	108787262(SETD1B) 108800988(SETD1A)

RTEM:

120933662(SETD1B) 120943008(SETD1A)

BBUF:

120988587(SETD1B) 121008361(SETD1A)

BGAR:

122924535(SETD1B) 122944789(SETD1A)

MUO:	115473844(SETD1A) 115480576(SETD1B)

GSH:	117361385(SETD1A) 117364226 117364645(SETD1B)

DRE:	556535(setd1a) 567970(setd1ba) 571274(setd1bb)

SRX:	107729457 107737760 107753154 107758578

SANH:

107658500 107658592 107659604 107669245 107689149 107689688

SGH:	107550568 107554121 107555095 107558115 107582993

CCAR:

109054791 109065597 109080175 109107633

CAUA:

113045528 113047154(setd1a) 113047180 113054558 113078041 113097050 113110255

CGIB:

127950214 127953796 127963529 127966568 128020707

PTET:

122336438(setd1a) 122350125(setd1bb) 122352610(setd1ba)

LROH:

127156198(setd1a) 127169181(setd1bb) 127172078(setd1ba)

OMC:	131538114(setd1a) 131545246(setd1bb) 131548075(setd1ba)

PPRM:

120474215(setd1ba) 120485487(setd1bb) 120489364(setd1a)

RKG:	130078096(setd1ba) 130088464(setd1a) 130102052(setd1bb)

MAMB:

125262333(setd1ba) 125277583(setd1a) 125280089(setd1bb)

CIDE:

127507469 127521933

MASI:

127415408 127432980 127433402 127450448 127452313

TROS:

130545699(setd1ba) 130561353(setd1a) 130568326(setd1bb)

TDW:	130412062(setd1ba) 130426845(setd1a) 130440017(setd1bb)

MANU:

129415041(setd1bb) 129436029(setd1a) 129446574(setd1ba)

IPU:	108265096(setd1bb) 108277000(setd1ba) 108280267

IFU:	128604168(setd1a) 128607319(setd1bb) 128620716(setd1ba)

PHYP:

113528616 113544030(setd1b) 113546023

SMEO:

124393411(setd1ba) 124396744(setd1a) 124399738(setd1bb)

TFD:	113635362(setd1a) 113639360(setd1ba) 113645820(setd1bb)

TVC:	132854228(setd1bb) 132861519(setd1a) 132863328(setd1ba)

AMEX:

103026160 103032383(setd1b) 103040137

CMAO:

118800494(setd1a) 118812860(setd1bb) 118824675(setd1ba)

EEE:	113580885 113588670 113589255

CHAR:

105889485(setd1ba) 105898764(setd1a)

TRU:

101071878

TFS:	130515280(setd1a) 130517033(setd1ba)

TNG:	GSTEN00017296G001 GSTEN00027808G001

LCO:	104930237(setd1a) 104931165

NCC:

104953386

TBEN:

117476722(setd1ba) 117492295(setd1a)

CGOB:

115012067 115016385

PGEO:

117450876(setd1a) 117456664(setd1ba)

GACU:

117548512(setd1a) 117558155(setd1ba)

EMAC:

134868298(setd1ba) 134878202(setd1a)

ELY:	117268078(setd1a) 117269643(setd1ba)

EFO:	125879848(setd1a) 125905720(setd1ba)

PLEP:

121956150(setd1a) 121959451(setd1ba)

SLUC:

116034957(setd1ba) 116063825(setd1a)

ECRA:

117958583(setd1a) 117959061(setd1ba)

ESP:	116703213(setd1a)

PFLV:

114570178 114570901(setd1b)

GAT:	120827549(setd1a) 120832108(setd1ba)

PPUG:

119220208(setd1a) 119226293(setd1ba)

AFB:	129098180(setd1a) 129102119(setd1ba)

CLUM:

117734502(setd1a) 117740988(setd1ba)

PSWI:

130188420(setd1a) 130205831(setd1ba)

MSAM:

119893620(setd1a) 119914572(setd1ba)

SCHU:

122865873(setd1ba) 122868800(setd1a)

CUD:	121524894(setd1ba) 121529292(setd1a)

ALAT:

119013716(setd1a) 119029523(setd1ba)

MZE:	101469655(setd1a) 101470643(setd1b)

ONL:	100692647 100694318(setd1a)

OAU:	116322482(setd1ba) 116328737(setd1a)

OLA:	101162384(setd1b) 101168786

OML:	112146211(setd1a) 112163127(setd1ba)

CSAI:

133422463(setd1a) 133455255(setd1ba)

XMA:	102225235(setd1b) 102234339

XCO:	114149871(setd1b) 114159965(setd1a)

XHE:	116724415(setd1b) 116735517(setd1a)

PRET:

103468931(setd1a) 103473729(setd1b)

PFOR:

103144989(setd1a) 103148866(setd1b)

PLAI:

106953546 106961097(setd1a) 106961351(setd1b)

PMEI:

106906014(setd1a) 106921080 106924260(setd1b)

GAF:	122821898(setd1a) 122847186(setd1ba)

PPRL:

129366299(setd1ba) 129373887(setd1a)

CVG:	107084799(setd1a) 107091290

CTUL:

119783331(setd1a) 119788941(setd1ba)

GMU:	124863082 124864576 124872561(setd1ba)

NFU:	107373342(setd1b) 107378515(setd1a)

KMR:	108232668(setd1ba) 108237760(setd1a)

ALIM:

106529534(setd1a) 106535557

NWH:	119421858(setd1a) 119425184(setd1ba)

AOCE:

111581839(setd1b) 111588889(setd1a)

MCEP:

124996358(setd1ba) 124997463(setd1a)

CSEM:

103390461 103392668(setd1a)

POV:	109626185 109634234(setd1a) 109644957

SSEN:

122758289(setd1ba) 122784967(setd1a)

HHIP:

117766827(setd1a) 117772255(setd1ba)

HSP:	118123874(setd1a) 118125992(setd1ba)

SMAU:

118285083(setd1ba) 118288668(setd1a)

LCF:	108879820 108880620(setd1a)

SDU:	111217531(setd1a) 111234229(setd1b)

SLAL:

111655176(setd1b) 111660529(setd1a)

XGL:	120805979(setd1ba) 120807354(setd1a)

HCQ:	109517174(setd1b) 109531597

SSCV:

125979699 125983463

SBIA:

133490972(setd1ba) 133513990(setd1a)

PEE:	133413415(setd1ba) 133414744(setd1a)

PTAO:

133465637(setd1a) 133489880(setd1ba)

BPEC:

110160594(setd1b) 110164423(setd1a)

MALB:

109951316(setd1b) 109963139

BSPL:

114860538(setd1a) 114866446(setd1ba)

SJO:	128380097(setd1ba)

SASA:

106564528(setd1b) 106585338 106585476 106601535

STRU:

115149174 115159411(setd1b) 115171516 115203755

OTW:	112219446(setd1ba) 112248372 112258963 112259260

OMY:	110485207(setd1a) 110523727 110525298 110537198 110538637

OGO:	123998987 123999068 124015385(setd1a) 124034391 124048812(setd1ba)

ONE:	115105818 115110761 115111191 115124735(setd1b)

OKI:	109868353(setd1b) 109873484 109878662 109892528 116375924

OKE:	118372568 118378068 118387666 118391389

SALP:

111961475(setd1b) 111974001 111980138

SNH:	120025981(setd1ba) 120034473 120040543 120045034

CCLU:

121568624 121573795 121582371 123491170

ELS:	105013001(setd1a) 105014918

SFM:	108921845(setd1b) 108922553

PKI:	111839212(setd1b) 111842099 111854094

AANG:

118206991 118212758 118216609(setd1a)

LOC:	102690392(setd1a) 102699109(setd1b)

PSPA:

121305207(setd1a) 121307737 121307751(setd1ba)

ARUT:

117398266(setd1a) 117428209 117973335

PSEX:

120540822

LCM:	102363172(SETD1B)

HOC:	132827128(setd1ba)

LERI:

129709397

BFO:	118411046 118425946

BBEL:

CIN:

SCLV:

SPU:

SKO:

DME:	Dmel_CG40351(Set1)

DER:

26527103

DSE:

6620474

DSI:	Dsimw501_GD11928(Dsim_GD11928)

DYA:	Dyak_GE25383

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23985

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ013516

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207038

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

API:	100159159 100573227

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

DMK:	116931940 123477137

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

PTEP:

CEL:	CELE_C26E6.9(set-2)

CBR:

CBG_18192

CRQ:	GCK72_009980

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

OBI:

OSN:

LAK:

TAD:	TRIADDRAFT_32357

SCE:	YHR119W(SET1)

SEUB:

DI49_2524

SPAO:

SPAR_H01610

AGO:	AGOS_ABR136W

ERC:

Ecym_8199

KLA:	KLLA0_F24134g

KMX:	KLMA_60252(SET1)

LTH:	KLTH0B05280g

VPO:	Kpol_1048p18

ZRO:	ZYRO0G06446g

CGR:	CAGL0L12980g

NCS:	NCAS_0B07030(NCAS0B07030)

NDI:	NDAI_0B04360(NDAI0B04360)

TPF:	TPHA_0I01480(TPHA0I01480)

TBL:	TBLA_0C05500(TBLA0C05500)

TGB:	HG536_0D03100

TDL:	TDEL_0B05100(TDEL0B05100)

KAF:	KAFR_0F00700(KAFR0F00700)

KNG:	KNAG_0H03550(KNAG0H03550)

ZMK:	HG535_0A02610

PPA:	PAS_chr2-2_0494

DHA:	DEHA2F20834g

PIC:	PICST_32740(SET1)

PGU:	PGUG_00321

SPAA:

SPAPADRAFT_133304

LEL:	PVL30_001340(SET1)

CAL:	CAALFM_C100960CA(SET1)

CTP:	CTRG_04399

COT:	CORT_0B11090

CDU:	CD36_00910

CTEN:

CANTEDRAFT_128029

YLI:	YALI0B14883g

CLU:	CLUG_03935

CLUS:

A9F13_01g01903

CAUR:

CJI96_0004142

SLB:	AWJ20_608(SET1)

PKZ:	C5L36_0E00970

BNN:	FOA43_003623

BBRX:

BRETT_004481

OPA:	HPODL_02902

NCR:	NCU01206(set-1)

NTE:	NEUTE1DRAFT144212(NEUTE1DRAFT_144212)

SMP:	SMAC_07534

PAN:	PODANSg8424

PBEL:

QC761_206140(SET1)

PPSD:

QC762_206140(SET1)

PPSP:

QC763_206140(SET1)

PPSA:

QC764_206140(SET1)

TTT:	THITE_129744

MTM:	MYCTH_79077

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_4938

SSCK:

SPSK_05816

FGR:	FGSG_07445

FPU:	FPSE_09407

FPOA:

FPOAC1_011239(SET1)

FVN:	FVRRES_12271

FVR:	FVEG_07811

FOX:	FOXG_01447

NHE:	NECHADRAFT_49470(SDG2101)

FFC:	NCS54_01123100

FKR:	NCS57_01113900

FMU:	J7337_003137(SET1)

TRE:	TRIREDRAFT_81925

TRR:	M419DRAFT_90299

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_07734

PTKZ:

JDV02_005368(SET1)

VAL:	VDBG_04198

VDA:	VDAG_01423

CFJ:	CFIO01_10439

CLUP:

CLUP02_08272

CHIG:

CH63R_04383

SAPO:

SAPIO_CDS9661

ELA:	UCREL1_3105

PFY:	PFICI_07909

SSL:	SS1G_03070

BFU:	BCIN_06g06760(Bcset1)

MBE:

MBM_05396

PSCO:

LY89DRAFT_691442

GLZ:	GLAREA_05909

ANI:	ANIA_05795

AFM:	AFUA_6G06335

ACT:	ACLA_088100

NFI:	NFIA_051950

AOR:	AO090003000002

ANG:	An18g06840

AFV:	AFLA_001694

ALUC:

AKAW2_30966A(SET1)

ACHE:

ACHE_20429A(SET1)

APUU:

APUU_41186S(SET1)

PCS:	N7525_000090

PDP:	PDIP_68080

POU:	POX_e06511

TMF:	EYB26_003357

TRG:	TRUGW13939_09770

CIM:	CIMG_07257

CPW:	CPC735_000650

URE:	UREG_07821

PBL:	PAAG_00848

PBN:	PADG_03985

ABE:

ARB_00972

TVE:

TRV_00712

AJE:	HCAG_04084

BGH:	BDBG_01703

PNO:	SNOG_03803

PTE:

PTT_01686

BZE:	COCCADRAFT_699

BSC:	COCSADRAFT_162605

BOR:	COCMIDRAFT_9083

AALT:

CC77DRAFT_846141

ARAB:

EKO05_0008232

ZTR:	MYCGRDRAFT_10108(SDG2403)

PFJ:	MYCFIDRAFT_204567

FFU:	CLAFUR5_12482

CBET:

CB0940_11106

BCOM:

BAUCODRAFT_80239

NPA:	UCRNP2_10139

TML:	GSTUM_00009579001

SPO:	SPCC306.04c(set1)

SOM:	SOMG_04222(set1)

CNE:

CND03610

CNB:

CNBD2720

CNG:	CNAG_01243

CGI:	CGB_D6310C

CDEU:

CNBG_0809

PCO:	PHACADRAFT_142398

MRR:	Moror_10709

E1B28_006614

WIC:	J056_000219

UMA:	UMAG_02677

DDI:	DDB_G0289257(set1)

PTI:	PHATRDRAFT_15937

TPS:	THAPSDRAFT_35182

TVA:	TVAG_2v0765810

» show all

Reference

PMID:12670868

Authors

Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W

Title

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

Journal

Genes Dev 17:896-911 (2003)
DOI:10.1101/gad.252103

Sequence

[hsa:9739]

Reference

PMID:12845608

Authors

Boa S, Coert C, Patterton HG

Title

Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.

Journal

Yeast 20:827-35 (2003)
DOI:10.1002/yea.995

Sequence

[sce:YHR119W]

ORTHOLOGY: K11421

Entry

K11421                      KO

Symbol

SETDB1

Name

[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04550

Signaling pathways regulating pluripotency of stem cells

Reaction

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.366  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
     K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase

Other DBs

GO:

0046974

Genes

HSA:	9869(SETDB1)

PTR:	469481(SETDB1)

PPS:	100972839(SETDB1)

GGO:	101146215(SETDB1)

PON:	100431310(SETDB1)

NLE:	100581330(SETDB1)

HMH:	116469470(SETDB1)

MCC:	716141(SETDB1)

MCF:	102117410(SETDB1)

MTHB:

126931370

MNI:	105497821(SETDB1)

CSAB:

103247223(SETDB1)

CATY:

105590302(SETDB1)

PANU:

101002056(SETDB1)

TGE:	112620272(SETDB1)

MLEU:

105534755(SETDB1)

RRO:	104681064(SETDB1)

RBB:	108533259(SETDB1)

TFN:	117075079(SETDB1)

PTEH:

111543630(SETDB1)

CANG:

105508932(SETDB1)

CJC:	100411734(SETDB1)

SBQ:	101042658(SETDB1)

CIMI:

108316459(SETDB1)

MMUR:

105872992(SETDB1)

LCAT:

123633944(SETDB1)

PCOQ:

105821953(SETDB1)

OGA:	100940994(SETDB1)

MMU:	84505(Setdb1)

MCAL:

110291522(Setdb1)

MPAH:

110320737(Setdb1)

RNO:	689883(Setdb1)

MCOC:

116093409(Setdb1)

ANU:	117706616(Setdb1)

MUN:	110560774(Setdb1)

CGE:	100765697(Setdb1)

MAUA:

101843804(Setdb1)

PROB:

127232822(Setdb1)

PLEU:

114682368(Setdb1)

MORG:

121437839 121450501

MFOT:

126489995

AAMP:

119800749(Setdb1)

NGI:	103730089(Setdb1)

HGL:	101715248(Setdb1)

CPOC:

100721293(Setdb1)

CCAN:

109681205(Setdb1)

DORD:

105984728(Setdb1)

DSP:	122109123(Setdb1)

PLOP:

125360015(Setdb1)

NCAR:

124959679

MMMA:

107156826(Setdb1)

OCU:

100355877

OPI:	101525521(SETDB1)

TUP:	102502264(SETDB1)

GVR:	103600244(SETDB1)

CFA:	483186(SETDB1)

CLUD:

112663993(SETDB1)

VVP:	112907769(SETDB1)

VLG:	121490848(SETDB1)

NPO:	129501338(SETDB1)

AML:	100482250(SETDB1)

UMR:	103667532(SETDB1)

UAH:	113246155(SETDB1)

UAR:	123787733(SETDB1)

ELK:

111162065

LLV:

125097118

MPUF:

101677094(SETDB1)

MNP:	132001451(SETDB1)

MLK:	131808783(SETDB1)

NVS:	122900483(SETDB1)

ORO:	101372094(SETDB1)

EJU:	114197337(SETDB1)

ZCA:	113925244(SETDB1)

MLX:	118000316(SETDB1)

NSU:	110578595(SETDB1)

LWW:	102732334(SETDB1)

FCA:	101094118(SETDB1)

PCOO:

112871086(SETDB1)

PBG:	122481136(SETDB1)

PVIV:

125159475(SETDB1)

LRUF:

124514448

PTG:	102970727(SETDB1)

PPAD:

109257028(SETDB1)

PUC:

125912118

AJU:

106979835

HHV:	120241290(SETDB1)

BTA:	100138100(SETDB1)

BOM:	102288279(SETDB1)

BIU:	109555305(SETDB1)

BBUB:

102408652(SETDB1)

BBIS:

104987649(SETDB1)

CHX:	102180982(SETDB1)

OAS:	101109230(SETDB1)

BTAX:

128044362(SETDB1)

ODA:	120855906(SETDB1)

CCAD:

122434373(SETDB1)

MBEZ:

129540648(SETDB1)

SSC:	100157920(SETDB1)

CFR:	102512057(SETDB1)

CBAI:

105071738(SETDB1)

CDK:	105103196(SETDB1)

VPC:	102545931(SETDB1)

BACU:

103009894(SETDB1)

BMUS:

118897508(SETDB1)

LVE:	103076461(SETDB1)

OOR:	101270688(SETDB1)

DLE:	111169744(SETDB1)

PSIU:

116751422(SETDB1)

NASI:

112411620(SETDB1)

ECB:	100059254(SETDB1)

EPZ:	103547642(SETDB1)

EAI:	106846522(SETDB1)

MYB:	102257713(SETDB1)

MYD:	102773684(SETDB1)

MMYO:

118672742(SETDB1)

MLF:	102441225(SETDB1)

PKL:	118727467(SETDB1)

EFUS:

103298980(SETDB1)

MNA:	107539129(SETDB1)

DRO:	112313537(SETDB1)

AJM:	119034734(SETDB1)

PDIC:

114488934(SETDB1)

PHAS:

123804304(SETDB1)

MMF:	118637044(SETDB1)

PPAM:

129062305(SETDB1)

HAI:	109372277(SETDB1)

RFQ:	117014537(SETDB1)

PGIG:

120585218(SETDB1)

PVP:	105303858(SETDB1)

RAY:	107499036(SETDB1)

MJV:	108409453(SETDB1)

TOD:	119237184(SETDB1)

SARA:

101554078(SETDB1)

SETR:

125997533(SETDB1)

LAV:	100673374(SETDB1)

TMU:

101349341

ETF:	101658224(SETDB1)

DNM:	101437951(SETDB1)

MDO:	100618580(SETDB1)

GAS:	123244280(SETDB1)

SHR:	100928904(SETDB1)

AFZ:

127559091

PCW:	110220597(SETDB1)

OAA:	100091318(SETDB1)

GGA:	100859816(SETDB1)

PCOC:

116238423(SETDB1)

MGP:	100542346(SETDB1)

CJO:	107324577(SETDB1)

TPAI:

128071922(SETDB1)

LMUT:

125685794(SETDB1)

NMEL:

110387900(SETDB1)

APLA:

101794756(SETDB1)

ACYG:

106049268(SETDB1)

CATA:

118260462(SETDB1)

AFUL:

116499648(SETDB1)

TGU:	100231651(SETDB1)

LSR:	110476821(SETDB1)

SCAN:

103824025

PMOA:

120502592(SETDB1)

OTC:	121335607(SETDB1)

PRUF:

121353495(SETDB1)

GFR:	102034546(SETDB1)

OMA:	130263386(SETDB1)

PHI:	102101563(SETDB1)

PMAJ:

107214655(SETDB1)

CCAE:

111939473(SETDB1)

CBRC:

103619600(SETDB1)

ETL:	114071955(SETDB1)

ZAB:	102061470(SETDB1)

SVG:	106862356(SETDB1)

MMEA:

130587054(SETDB1)

HRT:	120764209(SETDB1)

FPG:	101912073(SETDB1)

FCH:	102055212(SETDB1)

CLV:	102094505(SETDB1)

EGZ:	104129700(SETDB1)

NNI:	104014430(SETDB1)

PCRI:

104037271(SETDB1)

PLET:

104619247(SETDB1)

EHS:	104509218(SETDB1)

PCAO:

104051886(SETDB1)

ACUN:

113488725(SETDB1)

TALA:

116964156 122152589

PADL:

103919479(SETDB1)

AFOR:

103900501(SETDB1)

ACHC:

115345534(SETDB1)

HALD:

104312868(SETDB1)

HLE:	104830529(SETDB1)

AGEN:

126040314

GCL:

127027051

CCRI:

104157123(SETDB1)

CMAC:

104487401

MUI:

104548107

BREG:

104638314(SETDB1)

FGA:	104082850(SETDB1)

GSTE:

104254890(SETDB1)

OHA:	104330237(SETDB1)

NNT:

104409719

SHAB:

115602619(SETDB1)

PGUU:

104471117(SETDB1)

ACAR:

104527661(SETDB1)

CPEA:

104390376(SETDB1)

CVF:	104285442(SETDB1)

RTD:	128900884(SETDB1)

CUCA:

104066027(SETDB1)

TEO:	104372742(SETDB1)

AAM:	106495416(SETDB1)

AROW:

112972521(SETDB1)

NPD:	112952968(SETDB1)

TGT:	104573259(SETDB1)

DNE:	112990032(SETDB1)

SCAM:

104139540(SETDB1)

ASN:	102382539(SETDB1)

AMJ:	102575637(SETDB1)

CPOO:

109324826(SETDB1)

CMY:	102937828(SETDB1)

CCAY:

125625560(SETDB1)

DCC:	119848135(SETDB1)

CPIC:

101931963(SETDB1)

TST:	117869706(SETDB1)

CABI:

116817630(SETDB1)

MRV:	120390026(SETDB1)

ACS:	100565799(setdb1)

ASAO:

132764180(SETDB1)

PVT:	110081479(SETDB1)

SUND:

121916245(SETDB1)

PBI:	103053131(SETDB1)

PMUR:

107292899(SETDB1)

CTIG:

120317077(SETDB1)

TSR:	106546292(SETDB1)

PGUT:

117670132(SETDB1)

APRI:

131186537(SETDB1)

PTEX:

113452534 113452537

VKO:	123032928(SETDB1)

PMUA:

114586177(SETDB1)

PRAF:

128403733(SETDB1)

ZVI:	118075630(SETDB1)

HCG:	128337288(SETDB1)

GJA:	107121584(SETDB1)

STOW:

125436664(SETDB1)

EMC:	129342370(SETDB1)

XLA:	108700333(setdb1.S) 432147(setdb1.L)

XTR:	100490309(setdb1)

NPR:	108789810(SETDB1)

RTEM:

120920703(SETDB1)

BBUF:

120981785(SETDB1)

BGAR:

122923222(SETDB1)

MUO:	115458064(SETDB1)

GSH:	117349981(SETDB1)

DRE:	553292(setdb1a) 768131(setdb1b)

SRX:	107717459 107723461 107724106 107739578

SANH:

107656477 107671207 107693347 107700161

SGH:	107573682 107582057 107589406 107599511

CCAR:

109105279 109111939 109111941

CAUA:

113060012 113062169 113077897 113116442 113120007

CGIB:

127935667 127974706 127979020 128030992

PTET:

122360609(setdb1b)

LROH:

127178914(setdb1b) 127182106(setdb1a)

OMC:	131522361(setdb1b) 131525288(setdb1a)

PPRM:

120483677(setdb1a) 120484392(setdb1b)

RKG:	130070813(setdb1a) 130101819(setdb1b)

MAMB:

125243644(setdb1b) 125275542(setdb1a)

CIDE:

127497987 127500631

MASI:

127420967 127425596 127452895 127453831

TROS:

130557672(setdb1b) 130567279(setdb1a)

TDW:	130415319(setdb1a) 130433287(setdb1b)

MANU:

129447933(setdb1b) 129454460(setdb1a)

IPU:	108266106(setdb1b) 108272679(setdb1a)

IFU:	128607541(setdb1b) 128615241(setdb1a)

PHYP:

113535137 113542451(setdb1)

SMEO:

124382145(setdb1a) 124384982(setdb1b)

TFD:	113641276(setdb1a) 113643512(setdb1b)

TVC:	132842876(setdb1a) 132846150(setdb1b)

AMEX:

103027968(setdb1) 103028156

CMAO:

118805978(setdb1a) 118824354(setdb1b)

EEE:	113570608(setdb1) 113572599

CHAR:

105912991(setdb1b)

TRU:	101075200(setdb1)

TFS:

130532902

TNG:	GSTEN00015370G001

LCO:	104920543(setdb1)

NCC:	104944919(setdb1)

TBEN:

117471276 117480563(setdb1b)

CGOB:

115021722

PGEO:

117461095(setdb1b)

GACU:

117541016(setdb1b)

EMAC:

134861592(setdb1b)

ELY:	117266438(setdb1b)

EFO:

125893368

PLEP:

121946021

SLUC:

116049589(setdb1b)

ECRA:

117946699(setdb1b)

ESP:	116691442(setdb1)

PFLV:

114557339

GAT:	120810231(setdb1b)

PPUG:

119198096(setdb1b)

AFB:

129109882

CLUM:

117745225(setdb1b)

PSWI:

130213014(setdb1b)

MSAM:

119897547(setdb1b)

SCHU:

122881587(setdb1b)

CUD:	121514026(setdb1b)

ALAT:

119006504(setdb1b)

MZE:	101465322(setdb1)

ONL:	100710331(setdb1)

OAU:	116321097(setdb1b)

OLA:	101158302(setdb1)

OML:

112143498

CSAI:

133432938(setdb1b)

XMA:	102235762(setdb1)

XCO:	114141956(setdb1)

XHE:	116717442(setdb1)

PRET:

103478723(setdb1)

PFOR:

103136616 103136620

PLAI:

106938375 106943293

PMEI:

106922006(setdb1)

GAF:	122830571(setdb1b)

PPRL:

129371135(setdb1b)

CVG:	107088829(setdb1)

CTUL:

119783009(setdb1b)

GMU:	124866219(setdb1b)

NFU:	107379696(setdb1)

KMR:	108241152(setdb1b)

ALIM:

106515090

NWH:	119410006(setdb1b)

AOCE:

111586482(setdb1)

MCEP:

125016823(setdb1b)

CSEM:

103388279(setdb1)

POV:

109633224

SSEN:

122774888

HHIP:

117777184(setdb1b)

HSP:	118113532(setdb1b)

SMAU:

118299766(setdb1b)

LCF:

108885905

SDU:	111230127(setdb1)

SLAL:

111652197(setdb1)

XGL:	120784269(setdb1b)

HCQ:	109522778(setdb1)

SSCV:

125975637

SBIA:

133501043(setdb1b)

PEE:	133401340(setdb1b)

PTAO:

133479743(setdb1b)

BPEC:

110163046(setdb1)

MALB:

109970226

BSPL:

114842555(setdb1b)

SJO:	128366464(setdb1b)

SASA:

106574954 106588190

STRU:

115173296 115176358 115189463

OTW:	112236082 112247848 112266649

OMY:	110496022 110520820 110536431

OGO:	123998183 124005934 124012669

ONE:	115113782 115123820 115128219

OKI:	109883759 109886460 109907679

OKE:	118374768 118383196 118399124

SALP:

111955709 111964582(setdb1)

SNH:	120022441 120031206 120037512

CCLU:

121543877 121586324 123484099

ELS:	105018987(setdb1) 105030119

SFM:	108923796(setdb1)

PKI:	111853328(setdb1)

AANG:

118225516(setdb1b)

PSPA:

121306955

ARUT:

117395637 117962652

PSEX:

120538027(setdb1a)

LCM:	102356699(SETDB1)

HOC:	132805644(setdb1b)

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG12196(egg)

DER:

6548401

DSE:

6618876

DSI:	Dsimw501_GD24920(Dsim_GD24920)

DYA:	Dyak_GE11418

DAN:

DSR:

DPO:

DPE:

DMN:	108159156 117192580

DWI:

6640308

DGR:

6560486

DMO:	Dmoj_GI19513

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119680913 119682533

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AALB:

CQU:	CpipJ_CPIJ016652

CPII:

120413132

CNS:	116338143 116352420

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:	110383113(egg)

HZE:

TNL:

SLIU:

OFU:

PXY:	105384716 105392435

CCRN:

123299289

API:	100165352 100574903

DNX:	107166873 107167319

AGS:	114120564 114123773

RMD:	113553560 113553623

ACOO:

126843160

DVT:	126893853 126893854 126902782

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM415050

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:	110847722 110850679

DPX:	DAPPUDRAFT_303556 DAPPUDRAFT_304216

DMK:	116929683 116932783

DPZ:	124312290 124351093

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135200471 135200933 135204636

HAZT:

108673081

EAF:	111695332 111709742

LSM:

121123621

TCF:

131879963

PPOI:

119104173 119107951 119107955

DSV:	119440663 119450321

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_R05D3.11(met-2)

CBR:	CBG_18157(Cbr-met-2)

CRQ:	GCK72_010167

BMY:	BM_BM5216(Bma-met-2)

LOA:	LOAG_17898

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:

SMM:	Smp_150850.1

SHX:	MS3_00010918(SETDB1B)

OVI:	T265_08195

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

DGT:

XEN:

HMG:

Reference

PMID:17952062

Authors

Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S

Title

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.

Journal

Nat Cell Biol 9:1273-85 (2007)
DOI:10.1038/ncb1647

Sequence

[hsa:9869]

Reference

PMID:11791185

Authors

Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y

Title

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.

Journal

Oncogene 21:148-52 (2002)
DOI:10.1038/sj.onc.1204998

Sequence

[mmu:84505]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (3428)   
   KEGG GENES (684)   
   KEGG MGENES (364)   
   RefGene (2374)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (3444)   

Download RDF

ORTHOLOGY: K11420

Entry

K11420                      KO

Symbol

EHMT

Name

[histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04211

Longevity regulating pathway

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00907

Kleefstra syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.355  [histone H3]-lysine9 N-trimethyltransferase
     K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDAC complexes
    REST complex
     K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11420  EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT

Other DBs

GO:

0046974

Genes

HSA:	10919(EHMT2) 79813(EHMT1)

PTR:	462572(EHMT2) 464891(EHMT1)

PPS:	100968253(EHMT1) 100991724(EHMT2)

GGO:	101139808(EHMT2) 101151843(EHMT1)

PON:	100449422(EHMT1) 100460372(EHMT2)

NLE:	100584465(EHMT1) 100606578(EHMT2)

HMH:	116460291(EHMT2) 116475942(EHMT1)

MCC:	715824(EHMT2) 721470(EHMT1)

MCF:	102125769(EHMT1) 102139754(EHMT2)

MTHB:

126936884 126953213

MNI:	105472004(EHMT1) 105497604(EHMT2)

CSAB:

103221737(EHMT2) 103239544(EHMT1)

CATY:

105573427(EHMT2) 105580648(EHMT1)

TGE:	112608061(EHMT1) 112622121(EHMT2)

MLEU:

105543337(EHMT1) 105554192(EHMT2)

RRO:	104669606(EHMT1) 104678126(EHMT2)

RBB:	108520267(EHMT2) 108542880(EHMT1)

TFN:	117086972(EHMT2) 117099071(EHMT1)

PTEH:

111523903(EHMT2) 111553022(EHMT1)

CANG:

105513763(EHMT2) 105522658(EHMT1)

CJC:	100408867(EHMT2)

SBQ:	101046305(EHMT2) 101054241(EHMT1)

CIMI:

108287299(EHMT1) 108299809(EHMT2)

CSYR:

103271295(EHMT2) 103276313(EHMT1)

MMUR:

105858186(EHMT2) 105882234(EHMT1)

LCAT:

123631758(EHMT2) 123646348(EHMT1)

PCOQ:

105817873(EHMT2) 105818718(EHMT1)

OGA:	100948087(EHMT2) 100957636(EHMT1)

MMU:	110147(Ehmt2) 77683(Ehmt1)

MCAL:

110284133(Ehmt2) 110312405(Ehmt1)

MPAH:

110317691(Ehmt1) 110335935(Ehmt2)

RNO:	361798(Ehmt2) 362078(Ehmt1)

MCOC:

116075347(Ehmt2) 116089787(Ehmt1)

ANU:	117710555(Ehmt1) 117724322(Ehmt2)

MUN:	110560108(Ehmt2) 110565639(Ehmt1)

CGE:	100754544(Ehmt1) 100769417(Ehmt2)

MAUA:

101823944(Ehmt1) 101829402(Ehmt2)

PROB:

127222558(Ehmt1) 127224318(Ehmt2)

PLEU:

114692754(Ehmt1) 114705861(Ehmt2)

MORG:

121435226(Ehmt2) 121462735(Ehmt1)

MFOT:

126495376 126500209

AAMP:

119818898(Ehmt1) 119822462(Ehmt2)

NGI:	103724422(Ehmt2) 103732609(Ehmt1)

HGL:	101697232(Ehmt2) 101699104(Ehmt1)

CPOC:

100728628(Ehmt2) 100735478(Ehmt1)

CCAN:

109688969(Ehmt1) 109689573(Ehmt2)

DORD:

105995652(Ehmt1) 105999864(Ehmt2)

DSP:	122102130(Ehmt1) 122111369(Ehmt2)

PLOP:

125351955(Ehmt1) 125352752(Ehmt2)

NCAR:

124963991 124989524

MMMA:

107143740(Ehmt2) 107159187(Ehmt1)

OCU:	100348361 100355131 127488907

OPI:	101519409(EHMT2) 101522414(EHMT1)

TUP:	102479735(EHMT2) 102498729(EHMT1)

GVR:	103592352(EHMT2) 103593591(EHMT1)

CFA:	474851(EHMT2) 491224(EHMT1)

CLUD:

112641330(EHMT2) 112677512(EHMT1)

VVP:	112911417(EHMT1) 112913622(EHMT2)

VLG:	121472597(EHMT1) 121500746(EHMT2)

NPO:	129508857(EHMT1) 129512457(EHMT2)

AML:	100466861(EHMT1) 100468794(EHMT2)

UMR:	103675323(EHMT1) 103682289(EHMT2)

UAH:	113243735(EHMT2) 113248390 113248430

UAR:	123790982(EHMT2) 123796293(EHMT1)

ELK:	111146323 111152229

LLV:	125083739 125102708

MPUF:

101672446(EHMT1) 101693123(EHMT2)

MNP:	132017818(EHMT2) 132024178(EHMT1)

MLK:	131812451(EHMT1) 131834322(EHMT2)

NVS:	122911459(EHMT2) 122917049(EHMT1)

ORO:	101375740(EHMT1) 101376988(EHMT2)

EJU:	114201776(EHMT1) 114222217(EHMT2)

ZCA:	113927718(EHMT2) 113934575(EHMT1)

MLX:	118017468(EHMT1) 118027316(EHMT2)

NSU:	110581313(EHMT1) 110586856(EHMT2)

LWW:	102732190(EHMT2) 102740990(EHMT1)

FCA:	101087111(EHMT1) 101091940(EHMT2)

PYU:	121020251(EHMT1) 121022333(EHMT2)

PCOO:

112853522(EHMT2) 112860854(EHMT1)

PBG:	122474697(EHMT1) 122478262(EHMT2)

PVIV:

125150998(EHMT1) 125166100(EHMT2)

LRUF:

124522319 124528601

PTG:	102954489(EHMT1) 102968259(EHMT2)

PPAD:

109260239(EHMT1) 109260503(EHMT2)

PUC:	125923980 125938426

AJU:	106983481 106989056

HHV:	120221909(EHMT2) 120222801(EHMT1)

BTA:	514062(EHMT2) 528606(EHMT1)

BOM:	102271111(EHMT1) 102279999(EHMT2)

BIU:	109565691(EHMT1) 109576929(EHMT2)

BBUB:

102395323(EHMT1) 102405188(EHMT2)

BBIS:

104981276(EHMT1) 104983802(EHMT2)

CHX:	102178316(EHMT2) 102189411(EHMT1)

OAS:	101115739(EHMT2) 101123545(EHMT1)

BTAX:

128056619(EHMT2) 128056896(EHMT1)

ODA:	120851867(EHMT1) 120870570(EHMT2)

CCAD:

122429704(EHMT2) 122442444(EHMT1)

MBEZ:

129539846(EHMT1) 129543544(EHMT2)

SSC:	100124382(EHMT2) 110258080(EHMT1)

CFR:	102518579(EHMT2) 102521526(EHMT1)

CBAI:

105073403(EHMT1) 105074044(EHMT2)

CDK:	105087443(EHMT2) 105102102(EHMT1)

VPC:	102527884(EHMT2) 102539319(EHMT1)

BACU:

103017744(EHMT1) 103018553(EHMT2)

BMUS:

118896565(EHMT1) 118903147(EHMT2)

LVE:	103072310(EHMT2) 103079038(EHMT1)

OOR:	101272833(EHMT1) 101282385(EHMT2)

DLE:	111170699(EHMT2) 111176964(EHMT1)

PCAD:

102978732(EHMT1) 102993056(EHMT2)

PSIU:

116755232(EHMT1) 116762596(EHMT2)

NASI:

112395441(EHMT2) 112411202(EHMT1)

ECB:	100058869(EHMT1) 100059118(EHMT2)

EPZ:	103554163(EHMT1) 103563300(EHMT2)

EAI:	106822324(EHMT2) 106822761(EHMT1)

MYB:	102245485(EHMT1) 102263672(EHMT2)

MYD:	102756540(EHMT1) 102773857(EHMT2)

MMYO:

118655270(EHMT1) 118679573(EHMT2)

MLF:	102416827(EHMT2) 102417065(EHMT1)

PKL:	118705352(EHMT2) 118707004(EHMT1)

EFUS:

103296120(EHMT1) 103300523(EHMT2)

MNA:	107536199(EHMT1) 107538997(EHMT2)

DRO:	112302258(EHMT2) 112306260(EHMT1)

SHON:

118980361(EHMT1) 118987556(EHMT2)

AJM:	119036154(EHMT1) 119053719(EHMT2)

PDIC:

114493954(EHMT2) 114503245(EHMT1)

PHAS:

123810361(EHMT2) 123823426(EHMT1)

MMF:	118621070(EHMT2) 118629406(EHMT1)

PPAM:

129067327(EHMT2) 129079139(EHMT1)

HAI:	109373117(EHMT2) 109382055(EHMT1)

RFQ:	117020464(EHMT2) 117031680(EHMT1)

PALE:

102879374(EHMT2) 102893102(EHMT1)

PGIG:

120599828(EHMT1) 120618905(EHMT2)

PVP:	105298547(EHMT1) 105305296(EHMT2)

RAY:	107498490(EHMT2) 107503067(EHMT1)

MJV:	108400840(EHMT2) 108404637(EHMT1)

TOD:	119230503(EHMT1) 119252227(EHMT2)

SARA:

101541664(EHMT2) 101546737(EHMT1)

SETR:

125996181(EHMT2) 126020493(EHMT1)

LAV:	100659207(EHMT2)

TMU:	101344600 101349603

ETF:	101644172(EHMT2) 101647797(EHMT1)

DNM:	101435395(EHMT2) 101444858(EHMT1)

MDO:	100023838(EHMT1) 100025360(EHMT2)

GAS:	123237182(EHMT1) 123246359(EHMT2)

SHR:	100931147(EHMT2) 100932927(EHMT1)

AFZ:	127549061 127561084

PCW:	110199440(EHMT2) 110205249(EHMT1)

OAA:	100078328(EHMT1) 100082943(EHMT2)

GGA:	417250(EHMT1)

PCOC:

116234163(EHMT1)

MGP:	100538392(EHMT1)

CJO:	107321652(EHMT1)

TPAI:

128073144(EHMT1)

LMUT:

125702744(EHMT1)

NMEL:

110406734(EHMT1)

APLA:

101805087(EHMT1)

ACYG:

106037080(EHMT1)

CATA:

118257121(EHMT1)

AFUL:

116496806(EHMT1)

TGU:	100217666(EHMT1)

LSR:	110476956(EHMT1)

SCAN:

103819172(EHMT1)

PMOA:

120504860(EHMT2) 120507404(EHMT1)

OTC:	121336951(EHMT1)

PRUF:

121357548(EHMT1)

GFR:	102036198(EHMT1)

FAB:	101806838(EHMT1)

OMA:	130260086(EHMT1) 130265426

PHI:	102099526(EHMT1)

PMAJ:

107212039(EHMT1)

CCAE:

111936927(EHMT1)

CCW:	104688230(EHMT1)

CBRC:

103619754(EHMT1)

ETL:	114067139(EHMT1)

ZAB:	102068401(EHMT1)

ACHL:

103807342

SVG:	106855969(EHMT1) 106864180(EHMT2)

MMEA:

130580701

HRT:

120761667

FPG:	101916063(EHMT1)

FCH:	102057247(EHMT1)

CLV:	102085960(EHMT1)

EGZ:	104124045(EHMT1)

NNI:	104022219(EHMT1)

PCRI:

104033859(EHMT1)

PLET:

104628592(EHMT1)

EHS:	104509851(EHMT1)

PCAO:

104052160

ACUN:

113486655(EHMT1)

TALA:

104366265(EHMT1)

PADL:

103918930(EHMT1)

AFOR:

103901384(EHMT1)

ACHC:

115335008(EHMT1) 115338419(EHMT2)

HALD:

104319093

HLE:	104833972(EHMT1)

AGEN:

126034829 126052094

GCL:

127023620

CCRI:

104167916(EHMT1)

CMAC:

104480753

MUI:	104537159(EHMT1)

BREG:

104640884(EHMT1)

FGA:

104079014

GSTE:

104255054(EHMT1)

LDI:

104352080

MNB:

103768552

OHA:	104335641(EHMT1)

NNT:	104413053(EHMT1)

SHAB:

115616993(EHMT1)

DPUB:

104296984(EHMT1)

PGUU:

104463876(EHMT1)

CPEA:

104385814(EHMT1)

CVF:	104289057(EHMT1)

RTD:	128917393(EHMT1)

CUCA:

104055878(EHMT1)

TEO:

104379339

BRHI:

104502195

AAM:	106493032(EHMT1)

AROW:

112963025(EHMT1)

NPD:	112955805(EHMT1)

TGT:	104568739(EHMT1)

DNE:	112991335(EHMT1)

SCAM:

104139829(EHMT1)

ASN:	102374916(EHMT1) 102381770(EHMT2)

AMJ:	102564850(EHMT1) 102574756(EHMT2)

CPOO:

109313837(EHMT1)

GGN:	109292861(EHMT1)

PSS:	102450225(EHMT1)

CMY:	102933671(EHMT1)

CCAY:

125621301(EHMT2) 125623355(EHMT1)

DCC:	119844083(EHMT1)

CPIC:

101942163(EHMT1) 101947321(EHMT2)

TST:	117889342(EHMT1)

CABI:

116815182 116816188(EHMT1)

MRV:	120386712(EHMT1) 120392432(EHMT2)

ACS:	100556375(ehmt2) 100565730(ehmt1)

ASAO:

132763865(EHMT1) 132765238(EHMT2)

PVT:	110088696(EHMT2) 110089799(EHMT1)

SUND:

121921274(EHMT2) 121936454(EHMT1)

PBI:	103049261(EHMT2) 103057390(EHMT1)

PMUR:

107295037(EHMT2)

CTIG:

120300707(EHMT1) 120305187(EHMT2)

PGUT:

117667837(EHMT2) 117670273(EHMT1)

APRI:

131186002(EHMT1) 131192517(EHMT2)

PTEX:

113443967(EHMT1) 113449073(EHMT2)

NSS:	113424782(EHMT1) 113425448(EHMT2)

VKO:	123017991(EHMT2) 123028253(EHMT1)

PMUA:

114589035(EHMT1) 114592073(EHMT2)

PRAF:

128406823(EHMT1) 128408977(EHMT2)

ZVI:	118081033(EHMT2) 118083831(EHMT1)

HCG:	128338982(EHMT1) 128344745(EHMT2)

GJA:	107105480(EHMT2) 107118801(EHMT1)

STOW:

125441535(EHMT1)

EMC:	129328200(EHMT2) 129342045(EHMT1)

XLA:	108698163(ehmt1.L) 108698559(ehmt2.L) 108699889(ehmt1.S)

XTR:	100124713(ehmt1) 100484992(ehmt2)

NPR:	108786543(EHMT2) 108794390(EHMT1)

RTEM:

120913250(EHMT2) 120913883(EHMT1)

BBUF:

120977486(EHMT2) 121009155(EHMT1)

BGAR:

122945955(EHMT2) 122946313(EHMT1)

MUO:	115466206(EHMT2) 115472720(EHMT1)

GSH:	117346551(EHMT2) 117368109(EHMT1)

DRE:	100005761(ehmt1a) 402830(ehmt1b) 569250(ehmt2)

SRX:	107706570 107709696 107736883 107739706 107751678 107757960

SANH:

107661424 107681217 107692285 107694038 107694747

SGH:	107548795 107566127 107566632 107595675

CCAR:

109045145 109053896

CAUA:

113038793 113049308 113064116 113074244 113119902 113119918

CGIB:

127941610 127958362 127978942 127985727 128008940

PTET:

122326935(ehmt1b) 122326950 122335280(ehmt2) 122345917(ehmt1a)

LROH:

127152712(ehmt1b) 127164862(ehmt1a) 127182167(ehmt2)

OMC:	131526023(ehmt2) 131529439(ehmt1b) 131540924(ehmt1a)

PPRM:

120469900(ehmt1a) 120475084(ehmt2) 120490807(ehmt1b)

RKG:	130075535(ehmt2) 130089817(ehmt1a)

MAMB:

125252857(ehmt1b) 125266726(ehmt1a) 125275908(ehmt2)

CIDE:

127500885 127503303 127512554

MASI:

127421499 127425224 127428598 127430577 127439577

TROS:

130556561(ehmt2) 130569755(ehmt1b) 130571028

TDW:	130407939(ehmt1b) 130415460(ehmt2) 130418961(ehmt1a)

MANU:

129424382(ehmt1b) 129440155(ehmt1a) 129455022(ehmt2)

IPU:	108255843(ehmt1a) 108274790 108278950(ehmt1b)

IFU:	128598976(ehmt1a) 128618202(ehmt2) 128622493(ehmt1b)

PHYP:

113535464 113536884

SMEO:

124380827(ehmt1a) 124392524(ehmt2) 124397803(ehmt1b)

TFD:	113640067(ehmt1b) 113653372(ehmt1a) 113656482(ehmt2)

TVC:	132854743(ehmt1a) 132856917(ehmt2) 132859532(ehmt1b)

AMEX:

103023021 103023298 103025689(ehmt1)

CMAO:

118800154 118803028 118819695(ehmt1b) 118827356(ehmt1a)

EEE:	113573424(ehmt1) 113577937 113590720

CHAR:

105890033(ehmt1a) 105902570(ehmt1b) 105907713(ehmt2)

TRU:	101072913(ehmt1) 101076450(ehmt2)

TFS:	130516772(ehmt1b) 130518332(ehmt2)

TNG:	GSTEN00009265G001

LCO:	104922530(ehmt2) 104922882 104923797

NCC:	104944159(ehmt1) 104964983(ehmt2)

TBEN:

117477880(ehmt2) 117479040(ehmt1b) 117484616(ehmt1a)

CGOB:

115012933 115015448(ehmt2) 115016519

PGEO:

117452544(ehmt1a) 117455282(ehmt2) 117456526

GACU:

117535740(ehmt1a) 117542604(ehmt2) 117558802(ehmt1b)

EMAC:

134868804(ehmt1b) 134874039(ehmt1a) 134875405(ehmt2)

ELY:	117252502(ehmt1a) 117264216(ehmt2) 117269706(ehmt1b)

EFO:	125890234(ehmt1a) 125904241(ehmt2) 125906001(ehmt1b)

PLEP:

121944074(ehmt1a) 121957927(ehmt2)

SLUC:

116034715(ehmt1b) 116047257(ehmt2) 116050659(ehmt1a)

ECRA:

117944728(ehmt1a) 117956281(ehmt2) 117959394(ehmt1b)

ESP:	116689668 116701771(ehmt2) 116704343

PFLV:

114555209 114568445(ehmt2) 114570753

GAT:	120826184(ehmt2) 120830284(ehmt1a) 120831490(ehmt1b)

PPUG:

119219094(ehmt2) 119225062(ehmt1a) 119226286(ehmt1b)

AFB:	129097232(ehmt2) 129101033(ehmt1a) 129102281(ehmt1b)

CLUM:

117736407(ehmt1a) 117738722(ehmt2) 117740479(ehmt1b)

PSWI:

130198714(ehmt2) 130204992(ehmt1b)

MSAM:

119884592 119891667 119892967 119907368(ehmt2) 119914403(ehmt1b)

SCHU:

122863847(ehmt2) 122865183(ehmt1b) 122875721(ehmt1a)

CUD:	121510414(ehmt1a) 121523685(ehmt2) 121525182(ehmt1b)

ALAT:

119015027(ehmt2) 119019050(ehmt1a) 119029779(ehmt1b)

MZE:	101468177(ehmt2) 101469152 101481293

ONL:	100691163 100697605(ehmt2) 100700166(ehmt1)

OAU:	116318920(ehmt2) 116319606(ehmt1b) 116336331(ehmt1a)

OLA:	101167635 101167716(ehmt2) 101171173

OML:	112141389 112162481(ehmt2) 112163195(ehmt1b)

CSAI:

133450779 133455436(ehmt1b) 133461330(ehmt2)

XMA:	102219854(ehmt1) 102232589(ehmt2)

XCO:	114149754 114156436(ehmt2)

XHE:	116724435(ehmt1) 116730493 116731476(ehmt2)

PRET:

103472894(ehmt2) 103473948

PFOR:

103141958 103154514 103154564(ehmt2)

PLAI:

106951540 106957654 106958856(ehmt2)

PMEI:

106905943 106920575 106931605(ehmt2)

GAF:	122819180(ehmt1b) 122827704(ehmt1a) 122843390(ehmt2)

PPRL:

129351567(ehmt1a) 129354180(ehmt2) 129366627(ehmt1b)

CVG:	107083748(ehmt1) 107086188(ehmt2)

CTUL:

119771641(ehmt1a) 119778038(ehmt2) 119785162(ehmt1b)

GMU:	124872570(ehmt1b) 124877314(ehmt1a) 124879536(ehmt2)

NFU:	107375115 107394506(ehmt2)

KMR:	108243867(ehmt2) 108249279(ehmt1b) 108251110(ehmt1a)

ALIM:

106520823 106527649 106528745

NWH:	119414144 119424964(ehmt1b) 119425759(ehmt2)

AOCE:

111569232 111580771 111581451

MCEP:

124996757(ehmt1b) 125012730(ehmt1a) 125020372(ehmt2)

CSEM:

103394057(ehmt2) 103397363

POV:	109639092 109639137(ehmt2) 109641231 109642561

SSEN:

122758215 122769887 122786699(ehmt2)

HHIP:

117767818(ehmt1a) 117770075(ehmt2) 117771793(ehmt1b)

HSP:	118115404(ehmt1a) 118124531(ehmt2) 118125578(ehmt1b)

SMAU:

118285009(ehmt1b) 118292441(ehmt2) 118314162(ehmt1a)

LCF:	108878664(ehmt1a) 108889015(ehmt1b) 108901185

SDU:	111221113 111223051(ehmt2) 111227770

SLAL:

111648028 111650148 111657826

XGL:	120786732(ehmt2) 120805368(ehmt1a) 120806320(ehmt1b)

HCQ:	109510555 109516321(ehmt2) 109527076

SSCV:

125979190 125987520 125994738

SBIA:

133499359(ehmt2) 133499564(ehmt1a) 133515238(ehmt1b)

PEE:	133395807(ehmt2) 133400457(ehmt1a) 133413308(ehmt1b)

PTAO:

133470624(ehmt2) 133473428 133489952(ehmt1b)

BPEC:

110154648(ehmt1) 110173288(ehmt2)

MALB:

109958623(ehmt2) 109968663

BSPL:

114862136 114865958(ehmt2) 114867111(ehmt1b)

SJO:	128364278(ehmt1a) 128373861(ehmt2) 128380247(ehmt1b)

SASA:

100380769(ehmt2) 106563135 106585429

STRU:

115159671 115164720 115173409 115176004 115203981

OTW:	112229939 112232794(ehmt1a) 112234384(ehmt1b)

OMY:	110487637 110496106 110509707(ehmt1b) 110523494 110525474(ehmt1a)

OGO:	124006763 124012652 124034453 124044385 124047693

ONE:	115111441 115121652 115128285 115131723 115147148

OKI:	109868032 109873685 109877723 109903715 109907615(ehmt2)

OKE:	118375639(ehmt1a) 118385502(ehmt1b) 118387461 118398293 118399193

SALP:

111955128 111963944 111974241

SNH:	120021281 120022460 120025850 120027420 120048332

CCLU:

121541595 121571467 121582604 121584696 121586361

ELS:	105014136 105014923(ehmt1) 105027858(ehmt2)

SFM:	108922673(ehmt1) 108935584(ehmt2)

PKI:	111842789(ehmt2) 111853979

AANG:

118206310(ehmt1a) 118212814(ehmt1b) 118234483(ehmt2)

LOC:

102691045

PSPA:

121299246 121304178 121306708

ARUT:

117396889 117434270 117964709 117964869

PSEX:

120539042(ehmt2) 120543003

LCM:	102361297(EHMT1)

CMK:

103180404

RTP:	109926709(ehmt1b)

CPLA:

122541532 122564772

HOC:	132825820 132832838

LERI:

129711920 129716250(ehmt2)

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

SPU:

DME:	Dmel_CG2995(G9a)

DER:

6555648

DSE:

6615843

DSI:	Dsimw501_GD16494(Dsim_GD16494)

DYA:	Dyak_GE16600

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21426

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101896182 131802332

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

AGRG:

AGB:

LDC:

NVL:

PPYR:

OTU:

BMOR:

MSEX:

BANY:

NIQ:

VCD:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

SLIU:

OFU:

CCRN:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128991607 128992279

PHU:	Phum_PHUM447810

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

DMK:	116929946 123468131

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

PTEP:

ABRU:

UDV:

SDM:

PCAN:

BGT:

GAE:

HRF:

HRJ:	124269370 124291244

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:

NVE:

ATEN:

HMG:

HSY:

ATH:	AT2G22740(SUVH6) AT2G33290(SUVH2) AT2G35160(SUVH5) AT4G13460(SUVH9) AT5G13960(SUVH4)

ALY:	9299204 9309710 9314698 9317341 9317447

CRB:	17877879 17884260 17887759 17888990 17889023

CSAT:

104700122 104702810 104705663 104719111 104723852 104732370 104735412 104749545 104751910 104769624 104781916 104786246

EUS:	EUTSA_v10000700mg EUTSA_v10012985mg EUTSA_v10016339mg

BRP:	103841329 103856044 103864378 103865258 103867384

BNA:	106375862 106392112 106414948 106415578 106431229 106436574 106441185 106446445 106447143 111204287 125609321

BOE:	106312229 106328177 106336729 106336973 106341787

RSZ:	108806095 108835120 108843436 108847015 108854469 108855936

THJ:	104807934 104822423 104826099

CPAP:

110825045 110825586

CIT:	102624087 102628829

CIC:	CICLE_v10004481mg CICLE_v100233292m

PVY:	116108901 116113879 116128387

MINC:

123196253 123211198 123211900 123220962 123222725

TCC:	18601132 18603340 18606171

GRA:	105780142 105792011 105800654

GHI:	107920357 107929106 107929390 107943109 107948509 107948568

GAB:	108456814 108460800 108470114

HSYR:

120114300 120118646 120147726 120173597 120175787 120178236 120178237

DZI:	111292266 111292932 111305110 111306770

EGR:	104414410 104443628 104455565 104456069 120287219

GMX:	100795514 100795584 100796701 100803378 100804592

GSJ:	114390873 114398360 114402488 114419133 114423328

PVU:	PHAVU_002G001600g PHAVU_002G094200g PHAVU_003G007700g

VRA:	106753639 106753665 106777887

VAR:	108329575 108335748 108335858

VUN:	114173754 114174166 114193765

VUM:	124835679 124837331

CCAJ:

109800043 109801539 109818923

APRC:

113863063 113868662 113868919

MTR:	11438560 11438908

TPRA:

123888181 123908222 123915987 123922357

CAM:	101489576 101498068 101508428

PSAT:

127091778 127120572 127126749

VVO:	131595694 131595696 131595697 131595699 131609845 131652341

LJA:	Lj1g3v3904410.1(Lj1g3v3904410.1) Lj2g3v1989010.1(Lj2g3v1989010.1)

ADU:	107471969 107487512 107494601

AIP:	107604874 107623560 107642602

AHF:	112697097 112717100 112720750 112747816 112754988 112782471 112800377 112801997

LANG:

109333113 109338148 109361049

PCIN:

129284405 129306820 129308465 129312630 129320772

QSA:	O6P43_006101 O6P43_009761 O6P43_034032

FVE:	101291792 101300058 101303829

RCN:	112180971 112187610 112196395

PPER:

18776331 18782141 18790095

PMUM:

103323790 103330434 103337130

PAVI:

110756442 110764407 110765817

PDUL:

117628538 117636714

MDM:	103442704 108174661 114820745

MSYL:

126590050 126595167 126596170 126608132 126634541

PXB:	103933655 103937005 103957194

ZJU:	107404291 107422747 107427999

MNT:	21392039 21393025 21396328 21406794 21406798

CSAV:

115700602 115705091 115716228

CSV:	101204477 101212973 101222210

CMO:	103483537 103490844 103491710

BHJ:	120073339 120078619 120090088

MCHA:

111016869 111022642 111024563

CMAX:

111473189 111479670 111481473 111486639 111500227

CMOS:

111431109 111432002 111435244 111441673 111444784

CPEP:

111790527 111790983 111793253 111800298 111809848

RCU:	8265757 8269020 8273097

JCU:	105630213 105632345 105638439

HBR:	110632155 110638606 110648349 110657515

MESC:

110601977 110611292 110612972 110629614

POP:	18096889 7458012 7462391 7475430 7480897

PEU:	105125822 105129392 105130938 105132136 105137430

PALZ:

118041800 118043573 118048781 118057858 118062942

JRE:	108981017 108991569 109001855

CILL:

122289566 122300624 122307316

CAVE:

132175260 132179808 132180876

QSU:	111989703 111996522 112035570

QLO:	115971226 115976353 115981080 115994278

TWL:	119986507 120000506 120015248 120016842 120017272

VVI:	100242100 100244174 100261297 100265173

VRI:	117908502 117914612 117924590 117930160 117933494

SLY:	101247436 101260505 101268173

SPEN:

107005164 107008776 107023216

SOT:	102587095 102596505 102599225

SSTN:

125848905 125862067 125872692

SDUL:

129873821 129882809 129898614

CANN:

107853169 107860805 107872914

LBB:	132604338 132625061 132640842

NTA:	107771580 107776831 107785273 107810602 107825141 107832023

NSY:	104226196 104233835 104244020 104246210

NTO:	104084631 104090127 104095270 104117537

NAU:	109211485 109218116 109227163 109236863

INI:	109174871 109175855 109176461 109185125

ITR:	116021943 116028390

SIND:

105158616 105164786 105171817 105177488

OEU:	111383328 111388414 111407536

EGT:	105975288 105976710

SSPL:

121751931 121779411 121779669 121782525 121782891 121785100 121804683 121808442

SMIL:

131008676 131015206

SHIS:

125197178 125211006 125211808 125214922

APAN:

127255706 127258864

HAN:	110911300 110927345 110930748

ECAD:

122578864 122582213 122600720

LSV:	111881729 111897557 111908241 111911399

CCAV:

112501907 112504010 112521078

DCR:	108203736 108205268 108219203

CSIN:

114261527 114289847 114312670 114316558 114321116 114322219

RVL:	131298444 131303880 131309987 131315992 131332101

AEW:	130755311 130775202 130795296

BVG:	104889398 104897664 104906822

SOE:	110781780 110803243 110805240

CQI:	110692535 110702627 110727202 110727304 110730304

ATRI:

130800284 130809199 130817576 130820923 130821361 130825857

MOF:	131144881 131167720

NNU:	104589448 104591863 104600986 104602742

MING:

122076744 122079906 122081686 122086029 122086299

TSS:	122648479 122653680 122663762 122664641

PSOM:

113304357 113318144 113329937 113333672

OSA:	4326952 4343074 4346352 4346857

DOSA:

Os01t0927000-01(Os01g0927000) Os07t0435900-01(Os07g0435900) Os08t0565700-01(Os08g0565700) Os09t0362900-01(Os09g0362900)

OBR:	102712565 102713421 102720354 102722786

OGL:	127779615 127781812 127784374 127784769

BDI:	100824574 100825032 100833051 104582943

ATS:	109741537 109741621 109749619 109750455 109766085 109769961 109770115 109774279

TDC:	119270185 119270279 119272931 119278253 119279960 119279961 119285308 119293736 119301344 119301379 119308903 119309055 119318206 119341542 119354419 119357594 119360691 119363575

TUA:	125509135 125509165 125516074 125530707 125531244 125537226 125545821 125549117

LPER:

127300771 127300814 127316100 127323768 127331563 127333443 127345470 127345567

LRD:	124648808 124650974 124651390 124652315 124656704 124656746 124661676 124661863 124662476 124670298 124670634 124682128

SBI:	8054815 8055575 8059729 8081297

ZMA:	100382441 100383674 103647380 542089

SITA:

101756377 101768597 101771696 101783431

SVS:	117843653 117847100 117858146 117859500 117864810

PVIR:

120641474 120659885 120660470 120669983 120675206 120677551 120683361 120698859 120709139 120713147

PHAI:

112880488 112884119 112893853 112896686 112899159

PDA:	103707804 103721289 103723084 103723719

EGU:	105034894 105043130 105049737 105057553

MUS:	103985050 103993760 103994178

ZOF:	121971026 121976638 121979952 121985426 122020107 122020642 122022562 122023903

DCT:	110101480 110103468 110111597

PEQ:	110022007 110038667 110039425

AOF:	109822591 109824931 109838123

MSIN:

131246622 131248061

NCOL:

116257570 116265645

ATR:	18429167 18447704

SMO:	SELMODRAFT_104841 SELMODRAFT_232379(SDG33-1)

PPP:	112273076 112281546

» show all

Reference

PMID:20118233

Authors

Huang J, Dorsey J, Chuikov S, Perez-Burgos L, Zhang X, Jenuwein T, Reinberg D, Berger SL

Title

G9a and Glp methylate lysine 373 in the tumor suppressor p53.

Journal

J Biol Chem 285:9636-41 (2010)
DOI:10.1074/jbc.M109.062588

Sequence

[hsa:10919 79813]

ORTHOLOGY: K11427

Entry

K11427                      KO

Symbol

DOT1L, DOT1

Name

[histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map05202

Transcriptional misregulation in cancer

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
   HMT complexes
    Dot1-containing complex
     K11427  DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase

Other DBs

GO:

0031151

Genes

HSA:	84444(DOT1L)

PTR:	455566(DOT1L)

PPS:	100969530(DOT1L)

GGO:	101134931(DOT1L)

PON:	100450564(DOT1L)

NLE:	100587281 100606063(DOT1L)

HMH:	116472185 116484129(DOT1L)

MCC:	710033(DOT1L)

MCF:	101926502(DOT1L)

MTHB:

126942460

MNI:	105485848(DOT1L)

CSAB:

103233645(DOT1L)

CATY:

105591743(DOT1L)

PANU:

101006747(DOT1L)

TGE:	112612802(DOT1L)

MLEU:

105551998(DOT1L)

RRO:	104671393(DOT1L)

RBB:	108531435(DOT1L)

TFN:	117073985(DOT1L)

PTEH:

111520730(DOT1L)

CANG:

105527695(DOT1L)

CJC:	100407532(DOT1L)

SBQ:	101038132(DOT1L)

CIMI:

108288448(DOT1L)

CSYR:

103267705(DOT1L)

MMUR:

105860741(DOT1L)

LCAT:

123633033(DOT1L)

PCOQ:

105811277(DOT1L)

OGA:	100943444(DOT1L)

MMU:	208266(Dot1l)

MCAL:

110302935(Dot1l)

MPAH:

110326191(Dot1l)

RNO:	362831(Dot1l)

MCOC:

116076571(Dot1l)

ANU:	117696542(Dot1l)

MUN:	110555618(Dot1l)

CGE:	100771005(Dot1l)

MAUA:

101827360(Dot1l)

PROB:

127216594(Dot1l)

PLEU:

114686509(Dot1l)

MORG:

121459335(Dot1l)

MFOT:

126489209

AAMP:

119804509(Dot1l)

NGI:	103737299(Dot1l)

HGL:	101712712(Dot1l)

CPOC:

100713595(Dot1l)

CCAN:

109689927 109689929(Dot1l)

DORD:

105990338(Dot1l)

DSP:	122122869(Dot1l)

PLOP:

125348469(Dot1l)

NCAR:

124968797

MMMA:

107157417(Dot1l)

OPI:	101536127(DOT1L)

TUP:	102494943(DOT1L)

GVR:	103601162(DOT1L)

CFA:	485073(DOT1L)

CLUD:

112666222(DOT1L)

VVP:	112935591(DOT1L)

VLG:	121495589(DOT1L)

NPO:	129521545(DOT1L)

AML:	100464435(DOT1L)

UMR:	103681799(DOT1L)

UAH:	113242759(DOT1L)

UAR:	123793993(DOT1L)

ELK:	111161651 111161720

LLV:

125088548

MPUF:

101684140(DOT1L)

MNP:	132009576(DOT1L)

MLK:	131823234(DOT1L)

NVS:	122909912(DOT1L)

ORO:	101366843(DOT1L)

EJU:	114226156(DOT1L)

ZCA:	113916359(DOT1L)

MLX:	118005686(DOT1L)

NSU:	110593857(DOT1L)

LWW:	102737420(DOT1L)

FCA:	101101194(DOT1L)

PYU:	121021471(DOT1L)

PBG:	122486637(DOT1L)

PVIV:

125160765(DOT1L)

LRUF:

124522929

PTG:	102966497(DOT1L)

PPAD:

109257714(DOT1L)

PUC:

125928821

AJU:

106983698

HHV:	120242313(DOT1L)

BTA:	510442(DOT1L)

BOM:	102280735(DOT1L)

BIU:	109561797(DOT1L)

BBUB:

102405560(DOT1L)

BBIS:

104979876(DOT1L)

CHX:	102180119(DOT1L)

OAS:	101121261(DOT1L)

BTAX:

128050783(DOT1L)

ODA:	120864760(DOT1L)

CCAD:

122440167(DOT1L)

MBEZ:

129559595(DOT1L)

SSC:	100738665(DOT1L)

CFR:	106729841(DOT1L)

CBAI:

105078365(DOT1L)

CDK:	105103623(DOT1L)

VPC:

102542063

BACU:

103011331(DOT1L)

BMUS:

118893214(DOT1L)

LVE:	103083056(DOT1L)

OOR:	101281886(DOT1L)

DLE:	111166180(DOT1L)

PCAD:

102996362(DOT1L)

PSIU:

116752059(DOT1L)

NASI:

112396299(DOT1L)

ECB:	100068506(DOT1L)

EPZ:

103543191

EAI:	106834163(DOT1L)

MYB:	102240787(DOT1L)

MYD:	102773641(DOT1L)

MMYO:

118658025(DOT1L)

MLF:	102433201(DOT1L)

PKL:	118711157(DOT1L)

EFUS:

103294274(DOT1L)

MNA:	107534598(DOT1L)

DRO:	112312198(DOT1L)

SHON:

118984445(DOT1L)

AJM:	119043705(DOT1L)

PDIC:

114502661(DOT1L)

PHAS:

123813761(DOT1L)

MMF:	118643514(DOT1L)

PPAM:

129081426(DOT1L)

HAI:	109390613(DOT1L)

RFQ:	117037866(DOT1L)

PALE:

102893368(DOT1L)

PGIG:

120583726(DOT1L)

PVP:	105300457(DOT1L)

RAY:	107520102(DOT1L)

MJV:	108393233(DOT1L)

TOD:	119240531(DOT1L)

SARA:

101542520(DOT1L)

SETR:

126029612(DOT1L)

LAV:	100661109(DOT1L)

TMU:

101350137

ETF:	101640736(DOT1L)

DNM:	101427615(DOT1L)

MDO:	100619840(DOT1L)

GAS:	123243886(DOT1L)

SHR:	100918350(DOT1L)

AFZ:

127545146

PCW:	110223514(DOT1L)

OAA:	100088528(DOT1L)

GGA:	420078(DOT1L)

PCOC:

116235866(DOT1L)

MGP:	100546682(DOT1L)

CJO:	107325391(DOT1L)

TPAI:

128090426(DOT1L)

LMUT:

125685104(DOT1L)

NMEL:

110388996(DOT1L)

APLA:

101804645(DOT1L)

ACYG:

106045654(DOT1L)

CATA:

118259833(DOT1L)

AFUL:

116498985(DOT1L)

TGU:	100222310(DOT1L)

LSR:	110469481(DOT1L)

SCAN:

103821998(DOT1L)

PMOA:

120496392(DOT1L)

OTC:	121345945(DOT1L)

PRUF:

121353371(DOT1L)

GFR:	102036723(DOT1L)

FAB:	101807609(DOT1L)

OMA:	130264557(DOT1L)

PHI:	102108358(DOT1L)

PMAJ:

107215544(DOT1L)

CCAE:

111940168(DOT1L)

CCW:	104696943(DOT1L)

CBRC:

103620743(DOT1L)

ETL:	114071249(DOT1L) 114071752

ZAB:	102074377(DOT1L)

ACHL:

103797684

SVG:	106857995(DOT1L)

MMEA:

130585505

HRT:	120763502(DOT1L)

FPG:	101911291(DOT1L)

FCH:	102053275(DOT1L)

CLV:	102097756(DOT1L)

EGZ:	104131107(DOT1L)

NNI:	104009661(DOT1L)

PCRI:

104035670(DOT1L)

PLET:

104620532(DOT1L)

EHS:	104508566(DOT1L)

PCAO:

104042665(DOT1L)

ACUN:

113489497(DOT1L)

TALA:

104363231(DOT1L)

PADL:

103921169(DOT1L)

AFOR:

103903641(DOT1L)

ACHC:

115349672(DOT1L)

HALD:

104324695(DOT1L)

HLE:	104831211(DOT1L)

AGEN:

126041799

GCL:

127025623

CCRI:

104162767(DOT1L)

CSTI:

104556762(DOT1L)

CMAC:

104476603(DOT1L)

MUI:	104545131(DOT1L)

BREG:

104642520(DOT1L)

FGA:	104083090(DOT1L)

GSTE:

104255223(DOT1L)

LDI:	104352503(DOT1L)

MNB:

103782145

OHA:	104329413(DOT1L)

NNT:	104404199(DOT1L)

SHAB:

115618067(DOT1L)

DPUB:

104300751(DOT1L)

PGUU:

104461583(DOT1L)

ACAR:

104524443(DOT1L)

CPEA:

104392136(DOT1L)

AVIT:

104278880(DOT1L)

CVF:	104286459(DOT1L)

RTD:	128900525(DOT1L)

CUCA:

104060963(DOT1L)

TEO:	104377974(DOT1L)

BRHI:

104499835(DOT1L)

AAM:	106489522 106489524

AROW:

112971271(DOT1L)

NPD:	112952684(DOT1L)

TGT:	104564488(DOT1L)

DNE:	112991567(DOT1L)

SCAM:

104150642(DOT1L)

ASN:	102368409(DOT1L)

AMJ:	102567829(DOT1L)

CPOO:

109324920(DOT1L)

GGN:	109294827(DOT1L)

PSS:	102455080(DOT1L)

CMY:	102943895(DOT1L)

CCAY:

125627140(DOT1L)

DCC:	119848446(DOT1L)

CPIC:

101947542(DOT1L)

TST:	117869110(DOT1L)

CABI:

116824481(DOT1L)

MRV:	120391639(DOT1L)

ACS:	103282705(dot1l)

ASAO:

132781142(DOT1L)

PVT:	110072436(DOT1L) 110072437

SUND:

121937052(DOT1L)

PBI:	103061368(DOT1L)

PMUR:

107282186(DOT1L)

CTIG:

120301364(DOT1L)

TSR:	106548138(DOT1L) 106555419

PGUT:

117677503(DOT1L)

APRI:

131188263(DOT1L)

PTEX:

113435272(DOT1L)

NSS:	113420953(DOT1L)

VKO:	123035334(DOT1L)

PMUA:

114588420(DOT1L)

PRAF:

128405642(DOT1L)

ZVI:	118085936(DOT1L)

HCG:	128343215(DOT1L)

GJA:	107122041(DOT1L)

STOW:

125432967(DOT1L)

EMC:	129330004(DOT1L)

XLA:	108706873(dot1l.S) 108712856(dot1l.L)

XTR:	100497594(dot1l)

NPR:

108801355

RTEM:

120913393(DOT1L)

BBUF:

120989505(DOT1L)

BGAR:

122919790(DOT1L)

MUO:	115480877(DOT1L)

GSH:	117364629(DOT1L)

DRE:	559945(dot1l)

SRX:	107719574 107729667

SANH:

107655195 107676944

SGH:	107586394 107593341

CCAR:

109047010(dot1l) 109047583 109071951 109099236

CAUA:

113039587 113064939 113077116

CGIB:

127942988 127987341

PTET:

122327709(dot1l)

LROH:

127153523(dot1l)

OMC:	131530447(dot1l)

PPRM:

120495223(dot1l)

RKG:	130089186(dot1l)

MAMB:

125263799(dot1l)

CIDE:

127519717

MASI:

127437915 127439273

TROS:

130548372(dot1l)

TDW:	130429614(dot1l)

MANU:

129453351(dot1l)

IPU:

108270738

IFU:	128613550(dot1l)

PHYP:

113547045(dot1l)

SMEO:

124391641(dot1l)

TFD:	113646121(dot1l)

TVC:	132850972(dot1l)

AMEX:

103023208(dot1l)

CMAO:

118818772(dot1l)

EEE:	113582386(dot1l)

CHAR:

105910723(dot1l)

TRU:	101062350(dot1l)

TFS:	130528223(dot1l)

TNG:	GSTEN00007367G001

LCO:	104918483(dot1l)

NCC:

104968234

TBEN:

117495383(dot1l)

CGOB:

115006711(dot1l)

PGEO:

117445938(dot1l)

GACU:

117546116(dot1l)

EMAC:

134869352(dot1l)

ELY:	117253533(dot1l)

EFO:	125895418(dot1l)

PLEP:

121938762(dot1l)

SLUC:

116063452(dot1l)

ECRA:

117951070(dot1l)

ESP:	116695108(dot1l)

PFLV:

114561070(dot1l)

GAT:	120823388(dot1l)

PPUG:

119216789(dot1l)

AFB:	129094331(dot1l)

CLUM:

117729163(dot1l)

PSWI:

130194420(dot1l)

MSAM:

119900868(dot1l) 119918779

SCHU:

122878097(dot1l)

CUD:	121512146(dot1l)

ALAT:

119028445(dot1l)

MZE:	101473918(dot1l)

ONL:	100700031(dot1l)

OAU:	116310046(dot1l)

OLA:	101166952(dot1l)

OML:	112137065(dot1l)

CSAI:

133458118(dot1l)

XMA:	102227320(dot1l)

XCO:	114151376(dot1l)

XHE:	116725679(dot1l)

PRET:

103463635(dot1l)

PFOR:

103155506(dot1l) 103155507

PLAI:

106950711(dot1l)

PMEI:

106908766(dot1l) 106920479

GAF:	122839040(dot1l)

PPRL:

129370748(dot1l)

CVG:	107089710(dot1l)

CTUL:

119779405(dot1l)

GMU:	124873360(dot1l)

NFU:	107397320(dot1l)

KMR:	108230786(dot1l)

ALIM:

106515034 106534283(dot1l)

NWH:	119430709(dot1l)

AOCE:

111566583(dot1l)

MCEP:

125009262(dot1l)

CSEM:

103376710(dot1l)

POV:	109625401 109645771

SSEN:

122780557(dot1l)

HHIP:

117759933(dot1l)

HSP:	124854783(dot1l)

SMAU:

118318874(dot1l)

LCF:

108877359

SDU:	111232114(dot1l)

SLAL:

111656359(dot1l)

XGL:	120790488(dot1l)

HCQ:	109532198(dot1l)

SSCV:

125974533

SBIA:

133503425(dot1l)

PEE:	133405865(dot1l)

PTAO:

133481343(dot1l)

BPEC:

110174051(dot1l)

MALB:

109973059(dot1l)

BSPL:

114853611(dot1l)

SJO:	128361319(dot1l)

SASA:

106584426 106613781(dot1l)

STRU:

115158259 115192618

OTW:	112233976 112250978

OMY:	110521445 110524305

OGO:	123997071 124037046

ONE:	115108316 115144895

OKI:	109897856 109902511

OKE:	118359228 118389810(dot1l)

SALP:

111972106 111975388

SNH:	120052441 120054782

CCLU:

121533519 121540357

ELS:	105011570(dot1l)

SFM:	108919875(dot1l)

PKI:	111860240(dot1l)

AANG:

118225430(dot1l) 118229550

LOC:	102690905(dot1l)

PSPA:

121301374 121301560

ARUT:

117401515 117428812

PSEX:

120537735(dot1l)

LCM:	102351844(DOT1L)

CMK:	103181918(dot1l)

RTP:

109926363

CPLA:

122565329(dot1l)

HOC:	132828878(dot1l)

LERI:

129711131(dot1l)

PMRN:

116943593(DOT1L)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG42803(gpp)

DER:

6553084

DSE:

6614114

DSI:	Dsimw501_GD19874(Dsim_GD19874)

DYA:	Dyak_GE10220

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23014

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108354426 108361828

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ001411

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:

DPA:	109540967 109542323

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201750

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:	110380490(gpp)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:	114125081 114125093 114125095

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM478060

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_198981 DAPPUDRAFT_47843

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

111629121 111630420 111639298

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_F54F7.7(dot-1.2) CELE_F55G7.2(dot-1.4) CELE_W06D11.4(dot-1.3) CELE_Y39G10AR.18(dot-1.1)

CBR:	CBG_03979 CBG_03980 CBG_26504

NAI:	NECAME_11271

BMY:	BM_BM9325(Bm9325)

LOA:	LOAG_17417

HRO:	HELRODRAFT_74931

LGI:	LOTGIDRAFT_220459

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

OBI:

OSN:

LAK:

SMM:	Smp_165000

SHX:	MS3_00008704(DOT1L_1)

OVI:	T265_14564

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_58052

AQU:

109584002

SCE:	YDR440W(DOT1)

SEUB:

DI49_0608

SPAO:

SPAR_D06230

AGO:	AGOS_AER326C

ERC:

Ecym_4091

KLA:	KLLA0_B01287g

KMX:	KLMA_40588(DOT1)

LTH:	KLTH0G04422g

VPO:	Kpol_1004p44

ZRO:	ZYRO0D13200g

CGR:	CAGL0J10516g

NCS:	NCAS_0F01220(NCAS0F01220)

NDI:	NDAI_0H01750(NDAI0H01750)

TPF:	TPHA_0D02550(TPHA0D02550)

TBL:	TBLA_0D01440(TBLA0D01440) TBLA_0E03030(TBLA0E03030)

TGB:	HG536_0A05750

TDL:	TDEL_0A04190(TDEL0A04190)

KAF:	KAFR_0I00880(KAFR0I00880)

KNG:	KNAG_0C03070(KNAG0C03070)

ZMK:	HG535_0D05220

PPA:	PAS_chr3_1133

DHA:	DEHA2D01694g

PIC:	PICST_41120

PGU:	PGUG_04903

SPAA:

SPAPADRAFT_140015

LEL:	PVL30_003554(DOT1)

CAL:	CAALFM_C306300WA(DOT1)

CTP:	CTRG_02231

COT:	CORT_0C04010

CDU:	CD36_86180

CTEN:

CANTEDRAFT_115043

YLI:	YALI0E22715g

CLU:	CLUG_01248

CLUS:

A9F13_06g00440

CAUR:

CJI96_0001481

SLB:	AWJ20_173(DOT1)

PKZ:	C5L36_0E04360

BBRX:

BRETT_005002

OPA:	HPODL_00709

NCR:

NCU06266

NTE:	NEUTE1DRAFT146228(NEUTE1DRAFT_146228)

SMP:	SMAC_00083(putative_dot1)

PAN:	PODANSg5036

PBEL:

QC761_0106140(DOT1)

PPSD:

QC762_706450(DOT1)

PPSP:

QC763_706450(DOT1)

PPSA:

QC764_706450(DOT1)

TTT:	THITE_2119121

MTM:	MYCTH_2304605

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_5322

SSCK:

SPSK_07317

FGR:	FGSG_02567

FPU:	FPSE_08685

FPOA:

FPOAC1_002690(DOT1)

FVN:	FVRRES_02988

FVR:	FVEG_16524

FOX:	FOXG_10481

NHE:	NECHADRAFT_70385

FFC:	NCS54_00839700

FKR:	NCS57_00882800

FMU:	J7337_005263(DOT1)

TRE:	TRIREDRAFT_48225

TRR:	M419DRAFT_99879

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_04750

PTKZ:

JDV02_002820(DOT1)

VAL:	VDBG_10194

VDA:	VDAG_10394

CFJ:	CFIO01_01877

CLUP:

CLUP02_02843

CHIG:

CH63R_02106

SAPO:

SAPIO_CDS2155

ELA:	UCREL1_8381

PFY:	PFICI_08108

SSL:	SS1G_03126

BFU:	BCIN_08g04180(Bcdot1)

MBE:

MBM_01079

PSCO:

LY89DRAFT_638470

GLZ:	GLAREA_11312

ANI:	ANIA_00091

AFM:	AFUA_5G12110

ACT:	ACLA_015130

NFI:	NFIA_075180

AOR:	AO090120000327

ANG:	An09g02720

AFV:	AFLA_009549

ALUC:

AKAW2_40325A(DOT1)

ACHE:

ACHE_41229S(DOT1)

APUU:

APUU_12067S(DOT1)

PCS:	N7525_007194

PDP:	PDIP_59550

POU:	POX_d05316

TMF:	EYB26_001600

TRG:	TRUGW13939_05683

CIM:	CIMG_09225

CPW:	CPC735_016390

URE:	UREG_05056

PBL:	PAAG_02460

PBN:	PADG_05610

ABE:

ARB_04392

TVE:

TRV_03181

AJE:	HCAG_02616

BGH:	BDBG_07779

PNO:	SNOG_16009

PTE:

PTT_12191

BZE:	COCCADRAFT_98480

BSC:	COCSADRAFT_116087

BOR:	COCMIDRAFT_97389

AALT:

CC77DRAFT_1026200

ARAB:

EKO05_0005237

ZTR:	MYCGRDRAFT_23780(DOT2401)

PFJ:	MYCFIDRAFT_202245 MYCFIDRAFT_80111

FFU:	CLAFUR5_02936 CLAFUR5_06494

CBET:

CB0940_03229

BCOM:

BAUCODRAFT_32279

NPA:	UCRNP2_8424

TML:	GSTUM_00007723001

CNE:

CNK02230

CNB:

CNBK1310

CNG:	CNAG_01882

CGI:	CGB_K1580W

CDEU:

CNBG_3059

TMS:	TREMEDRAFT_74374

TASA:

A1Q1_01745

CCAC:

CcaHIS019_0606110(DOT1)

PPL:	POSPLDRAFT_96954

TVS:	TRAVEDRAFT_140731

DSQ:	DICSQDRAFT_130599 DICSQDRAFT_90557

PCO:	PHACADRAFT_132924

SHS:	STEHIDRAFT_106597

HIR:	HETIRDRAFT_479507

PSQ:	PUNSTDRAFT_94330

ADL:	AURDEDRAFT_93731

FME:	FOMMEDRAFT_107161

GTR:	GLOTRDRAFT_69490

RSX:	RhiXN_00388

LBC:	LACBIDRAFT_321307

CCI:	CC1G_08658

ABP:	AGABI1DRAFT32345(AGABI1DRAFT_32345)

ABV:	AGABI2DRAFT190074(AGABI2DRAFT_190074)

MRR:	Moror_12676

E1B28_009755

SCM:	SCHCO_02521437(SCHCODRAFT_02521437)

CPUT:

CONPUDRAFT_46848

SLA:	SERLADRAFT_478945

WSE:	WALSEDRAFT_34014

WIC:	J056_001693

UMA:	UMAG_05545

PFP:	PFL1_05108

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_00890 PGTG_00895 PGTG_02618

PTRC:

PtA15_17A262

PSTR:

Pst134EA_030521

MLR:	MELLADRAFT_92166

MBR:	MONBRDRAFT_34214

SRE:	PTSG_04671

» show all

Reference

PMID:20230194

Authors

Barry ER, Corry GN, Rasmussen TP

Title

Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.

Journal

Expert Opin Ther Targets 14:405-18 (2010)
DOI:10.1517/14728221003623241

Reference

PMID:11029058

Authors

San-Segundo PA, Roeder GS

Title

Role for the silencing protein Dot1 in meiotic checkpoint control.

Journal

Mol Biol Cell 11:3601-15 (2000)
DOI:10.1091/mbc.11.10.3601

Sequence

[sce:YDR440W]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (3436)   
   KEGG GENES (829)   
   KEGG MGENES (691)   
   RefGene (1907)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (3456)   

Download RDF

ORTHOLOGY: K17451

Entry

K17451                      KO

Symbol

EZH1

Name

[histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map03083

Polycomb repressive complex

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
    PRC2.2
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1

Other DBs

GO:

0046976

Genes

HSA:	2145(EZH1)

PTR:	454697(EZH1)

PPS:	100967877(EZH1)

GGO:	101126515(EZH1)

PON:	100171872(EZH1)

NLE:	100604860(EZH1)

HMH:	116474881(EZH1)

MCC:	711173(EZH1)

MCF:	102130547(EZH1)

MTHB:

126938434

MNI:	105472105(EZH1)

CSAB:

103243395(EZH1)

CATY:

105579681(EZH1)

PANU:

101009052(EZH1)

TGE:	112609092(EZH1)

MLEU:

105552946(EZH1)

RRO:	104680126(EZH1)

RBB:	108526767(EZH1)

TFN:	117066944(EZH1)

PTEH:

111537351(EZH1)

CANG:

105502991(EZH1)

CJC:	100411881(EZH1)

SBQ:	101038203(EZH1)

CIMI:

108289813(EZH1)

CSYR:

103270693(EZH1)

MMUR:

105859397(EZH1)

LCAT:

123620971(EZH1)

PCOQ:

105820263(EZH1)

OGA:	100953538(EZH1)

MMU:	14055(Ezh1)

MCAL:

110304611(Ezh1)

MPAH:

110331872(Ezh1)

RNO:	303547(Ezh1)

MCOC:

116078739(Ezh1)

ANU:	117710591(Ezh1)

MUN:	110550881(Ezh1)

CGE:	100760595(Ezh1)

MAUA:

101829787(Ezh1)

PROB:

127216586(Ezh1)

PLEU:

114682787(Ezh1)

MORG:

121442390(Ezh1)

MFOT:

126510201

AAMP:

119811825(Ezh1)

NGI:	103735912(Ezh1)

HGL:	101723063(Ezh1)

CPOC:

100720693(Ezh1)

CCAN:

109687337(Ezh1)

DORD:

106003218(Ezh1)

DSP:	122103240(Ezh1)

PLOP:

125365186(Ezh1)

NCAR:

124979151

MMMA:

107150556(Ezh1)

OCU:

100351852

OPI:	101532815(EZH1)

TUP:	102485788(EZH1)

GVR:	103589846(EZH1)

CFA:	480516(EZH1)

CLUD:

112655496(EZH1)

VVP:	112910738(EZH1)

VLG:	121473241(EZH1)

NPO:	129508144(EZH1)

AML:	100472619(EZH1)

UMR:	103672584(EZH1)

UAH:	113265406(EZH1)

UAR:	123781811(EZH1)

ELK:

111151338

LLV:

125087359

MPUF:

101683241(EZH1)

MNP:	132004387(EZH1)

MLK:	131816628(EZH1)

NVS:	122906181(EZH1)

ORO:	101379551(EZH1)

EJU:	114201361(EZH1)

ZCA:	113939411(EZH1)

MLX:	118024929(EZH1)

NSU:	110573309(EZH1)

LWW:

102750824

FCA:	101099602(EZH1)

PYU:	121045039(EZH1)

PCOO:

112854058(EZH1)

PBG:	122485620(EZH1)

PVIV:

125158457(EZH1)

LRUF:

124522075

PTG:	102961028(EZH1)

PPAD:

109258535(EZH1)

PUC:

125927686

AJU:

106972615

HHV:	120248460(EZH1)

BTA:	533087(EZH1)

BOM:	102276653(EZH1)

BIU:	109573994(EZH1)

BBUB:

102407322(EZH1)

BBIS:

104990428(EZH1)

CHX:	102189343(EZH1)

OAS:	101104765(EZH1)

BTAX:

128064455(EZH1)

ODA:	120867077(EZH1)

CCAD:

122441439(EZH1)

MBEZ:

129544439(EZH1)

SSC:	100518394(EZH1)

CFR:	102516907(EZH1)

CBAI:

105080100(EZH1)

CDK:	105090473(EZH1)

VPC:	102537185(EZH1)

BACU:

103015379 103020966

BMUS:

118886863(EZH1)

LVE:	103073364(EZH1)

OOR:	101285746(EZH1)

DLE:	111166246(EZH1)

PCAD:

102994197(EZH1)

PSIU:

116745673(EZH1)

NASI:

112398349(EZH1)

ECB:	100052411(EZH1)

EPZ:	103550351(EZH1)

EAI:	106826432(EZH1)

MYB:	102259730(EZH1)

MYD:	102755313(EZH1)

MMYO:

118671482(EZH1)

MLF:	102417096(EZH1)

PKL:	118726309(EZH1)

EFUS:

103293078(EZH1)

MNA:	107528927(EZH1)

DRO:	112298572(EZH1)

SHON:

118978195(EZH1)

AJM:	119051949(EZH1)

PDIC:

114502985(EZH1)

PHAS:

123817024(EZH1)

MMF:	118633783(EZH1)

PPAM:

129086995(EZH1)

HAI:	109395755(EZH1)

RFQ:	117012939(EZH1)

PALE:

102879627(EZH1)

PGIG:

120611077(EZH1)

PVP:	105306277(EZH1)

RAY:	107513838(EZH1)

MJV:	108386069(EZH1)

TOD:	119230360(EZH1)

SARA:

101556796(EZH1)

SETR:

126017177(EZH1)

LAV:	100673691(EZH1)

TMU:

101360468

ETF:	101658357(EZH1)

DNM:	101440065(EZH1)

MDO:	100010738(EZH1)

GAS:	123247838(EZH1)

SHR:	100932535(EZH1)

AFZ:

127560106

PCW:	110198374(EZH1)

OAA:	100082851(EZH1)

GGA:	420023(EZH1)

PCOC:

116233592(EZH1)

MGP:	100547448(EZH1)

CJO:	107325326(EZH1)

TPAI:

128089108(EZH1)

LMUT:

125684708(EZH1)

NMEL:

110388515(EZH1)

APLA:

101791765(EZH1)

ACYG:

106048025(EZH1)

CATA:

118259168(EZH1)

AFUL:

116498539(EZH1)

TGU:	100227472(EZH1)

LSR:	110471820(EZH1)

SCAN:

103821570(EZH1)

PMOA:

120496610(EZH1)

OTC:	121347663(EZH1)

PRUF:

121351146(EZH1)

GFR:	102035477(EZH1)

FAB:	101811414(EZH1)

OMA:	130263963(EZH1)

PHI:	102103576(EZH1)

PMAJ:

107215126(EZH1)

CCAE:

111940096(EZH1)

CCW:	104697765(EZH1)

CBRC:

103621230(EZH1)

ETL:	114063607(EZH1)

ZAB:	102071551(EZH1)

ACHL:

103801322(EZH1)

SVG:	106858696(EZH1)

MMEA:

130581428(EZH1)

HRT:	120763768(EZH1)

FPG:	101915579(EZH1)

FCH:	102052374(EZH1)

CLV:	102097006(EZH1)

EGZ:	104134781(EZH1)

NNI:	104009878(EZH1)

PCRI:

104034436(EZH1)

PLET:

104614357(EZH1)

ACUN:

113489070

TALA:

104365743 122152827

PADL:

103919098(EZH1)

AFOR:

103901881(EZH1)

ACHC:

115344618(EZH1)

HALD:

104322961(EZH1)

HLE:	104842949(EZH1)

AGEN:

126038535

GCL:

127026423

CCRI:

104160341

CSTI:

104557499(EZH1)

CMAC:

104487486(EZH1)

MUI:	104545865(EZH1)

BREG:

104641591

FGA:	104077897(EZH1)

GSTE:

104261338(EZH1)

LDI:	104342534(EZH1)

OHA:	104338691(EZH1)

SHAB:

115617636(EZH1)

DPUB:

104309571(EZH1)

CPEA:

104385652(EZH1)

CVF:	104295343(EZH1)

RTD:	128919318(EZH1)

CUCA:

104054392(EZH1)

TEO:	104375779(EZH1)

AAM:	106491114(EZH1)

AROW:

112968758(EZH1)

NPD:	112951845(EZH1)

TGT:	104578212(EZH1)

DNE:	112995826(EZH1)

SCAM:

104153616(EZH1)

ASN:	102383438(EZH1)

AMJ:	102566481(EZH1)

CPOO:

109320378(EZH1)

GGN:	109289608(EZH1)

PSS:	102463087(EZH1)

CMY:	102934538(EZH1)

CCAY:

125626681(EZH1)

DCC:	119848921(EZH1)

CPIC:

101934118(EZH1)

TST:	117869136(EZH1)

CABI:

116820359(EZH1)

MRV:	120392159(EZH1)

ACS:	100559669(ezh1)

ASAO:

132778389(EZH1)

PVT:	110080273(EZH1)

SUND:

121934119(EZH1)

PBI:	103052924(EZH1)

PMUR:

107302416(EZH1)

CTIG:

120301016(EZH1)

TSR:	106554239(EZH1)

PGUT:

117664836(EZH1)

APRI:

131197311(EZH1)

PTEX:

113447275(EZH1)

NSS:	113420059(EZH1)

VKO:	123031879(EZH1)

PMUA:

114581626(EZH1)

PRAF:

128400001(EZH1)

ZVI:	118094881(EZH1)

HCG:	128330017(EZH1)

GJA:	107123351(EZH1)

EMC:	129338808(EZH1)

XLA:	108701022(ezh1.L) 108702719(ezh1.S)

XTR:	100493532(ezh1)

NPR:	108796324(EZH1)

RTEM:

120918306(EZH1)

BBUF:

121004042(EZH1)

BGAR:

122941062(EZH1)

MUO:	115481816(EZH1)

GSH:	117347407(EZH1)

DRE:	664754(ezh1)

SRX:	107720007 107721487

SANH:

107654511 107688127

SGH:	107590376 107601290

CCAR:

109057529 109102790

CAUA:

113046841 113097179

CGIB:

127951387 127952888

PTET:

122342087(ezh1)

LROH:

127163486(ezh1)

OMC:	131536328(ezh1)

PPRM:

120489865(ezh1)

RKG:	130076064(ezh1)

MAMB:

125271852(ezh1)

CIDE:

127509033

MASI:

127449771 127451124

TROS:

130561746(ezh1)

TDW:	130426412(ezh1)

MANU:

129433583(ezh1) 129433788

IPU:

108279279

IFU:	128603001(ezh1)

PHYP:

113528051(ezh1)

SMEO:

124396605(ezh1)

TFD:	113652122(ezh1)

TVC:	132861544(ezh1)

AMEX:

103044086(ezh1)

CMAO:

118820890(ezh1)

EEE:

113590056

CHAR:

105898624(ezh1)

TRU:	101070195(ezh1)

TFS:	130514975(ezh1)

TNG:	GSTEN00022022G001

LCO:	104923910(ezh1)

NCC:

104944052

TBEN:

117493372(ezh1)

CGOB:

115012089(ezh1)

PGEO:

117451145(ezh1)

GACU:

117548328(ezh1)

EMAC:

134878111(ezh1)

ELY:	117268570(ezh1)

EFO:	125880116(ezh1)

PLEP:

121956843(ezh1)

SLUC:

116059672(ezh1)

ECRA:

117957411(ezh1)

ESP:	116702481(ezh1)

PFLV:

114569339(ezh1)

GAT:	120828335(ezh1)

PPUG:

119220821(ezh1)

AFB:	129097979(ezh1)

CLUM:

117734833(ezh1)

PSWI:

130188705(ezh1)

MSAM:

119892146(ezh1)

SCHU:

122868348(ezh1)

CUD:	121529431(ezh1)

ALAT:

119014259(ezh1)

MZE:	101474304(ezh1)

ONL:	100695015(ezh1)

OAU:	116312482(ezh1)

OLA:	101166385(ezh1)

OML:	112146093(ezh1)

CSAI:

133421960(ezh1)

XMA:	102228014(ezh1)

XCO:	114160264(ezh1)

XHE:	116735642(ezh1)

PRET:

103468644(ezh1) 103469387

PFOR:

103142220

PLAI:

106952635

PMEI:

106917493(ezh1)

GAF:	122821237(ezh1)

PPRL:

129352499(ezh1)

CVG:	107091776(ezh1)

CTUL:

119778867(ezh1)

GMU:	124863422 124864203

NFU:	107378461(ezh1)

KMR:	108243802(ezh1)

ALIM:

106528219(ezh1)

NWH:	119421914(ezh1)

AOCE:

111564547(ezh1)

MCEP:

124998234(ezh1)

CSEM:

103393149(ezh1)

POV:	109634330(ezh1)

SSEN:

122785080(ezh1)

HHIP:

117765699(ezh1)

HSP:	118123196(ezh1)

SMAU:

118288457(ezh1)

LCF:

108900993

SDU:	111217595(ezh1)

SLAL:

111660565(ezh1)

XGL:	120785995(ezh1)

HCQ:

109508596

SSCV:

125983811

SBIA:

133514174(ezh1)

PEE:	133414903(ezh1)

PTAO:

133465488(ezh1)

BPEC:

110166859(ezh1)

MALB:

109964204(ezh1)

BSPL:

114859794(ezh1)

SJO:	128378277(ezh1)

SASA:

106601045 106607313

STRU:

115171134 115198163

OTW:	112226003 112258676(ezh1)

OMY:	110486277 110538212

OGO:	123999293 124015525

ONE:	115104148 115110290

OKI:	109891924 109898438

OKE:	118365283 118370832

SALP:

111980227

SNH:	120034253 120036107

CCLU:

121550571 121569566

ELS:	105013194(ezh1)

SFM:	108928200 108941744

PKI:	111842507 111855907

AANG:

118221790(ezh1)

LOC:	102693111(ezh1)

PSPA:

121301885(ezh1) 121324064

ARUT:

117433259(ezh1) 117434945

PSEX:

120518228(ezh1)

LCM:	102364190(EZH1)

HOC:	132830997(ezh1)

BCOO:

DFR:

CBR:

MCAF:

GSL:	Gasu_06840

» show all

Reference

PMID:19026781

Authors

Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D

Title

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

Journal

Mol Cell 32:503-18 (2008)
DOI:10.1016/j.molcel.2008.11.004

Sequence

[hsa:2145]

ORTHOLOGY: K11425

Entry

K11425                      KO

Symbol

WHSC1L1, NSD3

Name

[histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11425  WHSC1L1, NSD3; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11425  WHSC1L1, NSD3; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.370  [histone H3]-lysine4 N-dimethyltransferase
     K11425  WHSC1L1, NSD3; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase
    2.1.1.371  [histone H3]-lysine27 N-dimethyltransferase
     K11425  WHSC1L1, NSD3; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11425  WHSC1L1, NSD3; [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase

Other DBs

GO:	0042800 0046976

Genes

HSA:	54904(NSD3)

PTR:	464119(NSD3)

PPS:	100989573(NSD3)

GGO:	101127408(NSD3)

PON:	100459660(NSD3)

NLE:	100599595(NSD3)

HMH:	116461947(NSD3)

MCC:	700254(NSD3)

MCF:	102138188(NSD3)

MTHB:

126961185

MNI:	105476625(NSD3)

CSAB:

103215646(NSD3)

CATY:

105590798(WHSC1L1)

PANU:

101000513(NSD3)

TGE:	112630794(NSD3)

MLEU:

105548959(WHSC1L1)

RRO:	104679642(NSD3)

RBB:	108512402(WHSC1L1)

TFN:	117094840(NSD3)

PTEH:

111544119(NSD3)

CANG:

105525159(WHSC1L1)

CJC:	100389349(NSD3)

SBQ:	101031525(WHSC1L1)

CIMI:

108309922(NSD3)

CSYR:

103274946(NSD3)

MMUR:

105870392(NSD3)

LCAT:

123626674(NSD3)

PCOQ:

105815829(WHSC1L1)

OGA:	100961764(NSD3)

MMU:	234135(Nsd3)

MCAL:

110299577(Nsd3)

MPAH:

110337154(Nsd3)

RNO:	290831(Nsd3)

MCOC:

116069055(Nsd3)

ANU:	117721890(Nsd3)

MUN:	110563304(Nsd3)

CGE:	100773097(Nsd3)

MAUA:

101843019(Nsd3)

PROB:

127220341(Nsd3)

PLEU:

114681351(Nsd3)

MORG:

121462361(Nsd3)

MFOT:

126504433

AAMP:

119811017(Nsd3)

NGI:	103745768(Nsd3)

HGL:	101703406(Nsd3)

CPOC:

100731623(Nsd3)

CCAN:

109688938(Nsd3)

DORD:

105992508(Whsc1l1)

DSP:	122107675(Nsd3)

PLOP:

125339238(Nsd3)

NCAR:

124983289

MMMA:

107155390(Nsd3)

OCU:	100352710(NSD3)

OPI:	101534677(NSD3)

TUP:	102487161(NSD3)

GVR:	103598752(WHSC1L1)

CFA:	475584(NSD3)

CLUD:

112649385(NSD3)

VVP:	112916135(NSD3)

VLG:	121489603(NSD3)

NPO:	129515681(NSD3)

AML:	100473259(NSD3)

UMR:	103659130(NSD3)

UAH:	113262089(NSD3)

UAR:	123780424(NSD3)

ELK:

111144613

LLV:

125092754

MPUF:

101692729(WHSC1L1)

MNP:	132006554(NSD3)

MLK:	131820407(NSD3)

NVS:	122889879(NSD3)

ORO:	101364354(WHSC1L1)

EJU:

114224800

ZCA:	113925754(NSD3)

MLX:	118009959(NSD3)

NSU:	110573151(NSD3)

LWW:	102731696(NSD3)

FCA:	101086901(NSD3)

PYU:	121017975(NSD3)

PCOO:

112859068(NSD3)

PBG:	122473400(NSD3)

PVIV:

125163477(NSD3)

LRUF:

124520314

PTG:	102949086(NSD3)

PPAD:

109262146(NSD3)

PUC:

125923275

AJU:	106978378(NSD3)

HHV:	120238666(NSD3)

BTA:	513054(NSD3)

BOM:	102268973(NSD3)

BIU:	109553299(NSD3)

BBUB:

102408813(NSD3)

BBIS:

104987721(WHSC1L1)

CHX:	102188284(WHSC1L1)

OAS:	101112880(NSD3)

BTAX:

128068200(NSD3)

ODA:	120865662(NSD3)

CCAD:

122432227(NSD3)

MBEZ:

129549406(NSD3)

SSC:	100520868(NSD3)

CFR:	102515779(NSD3)

CBAI:

105062081(WHSC1L1)

CDK:	105089934(NSD3)

VPC:	102531762(NSD3)

BACU:

103016894(NSD3)

BMUS:

118887838(NSD3)

LVE:	103072101(WHSC1L1)

OOR:	101278951(NSD3)

DLE:

111173519

PCAD:

102990993(NSD3) 129391328

PSIU:

116746681(NSD3)

NASI:

112413240(NSD3)

ECB:	100057692(NSD3)

EPZ:	103560265(NSD3)

EAI:	106824653(NSD3)

MYB:	102252817(NSD3)

MYD:	102759770(NSD3)

MMYO:

118650348(NSD3)

MLF:	102422851(NSD3)

PKL:	118728578(NSD3)

EFUS:

103290253(NSD3)

MNA:	107535114(WHSC1L1)

DRO:	112306746(NSD3)

SHON:

118993176(NSD3)

AJM:	119065038(NSD3)

PDIC:

114508778(NSD3)

PHAS:

123807640(NSD3)

MMF:	118622289(NSD3)

PPAM:

129064810(NSD3)

HAI:	109373158(NSD3)

RFQ:	117021281(NSD3)

PALE:

102879344(NSD3)

PGIG:

120595611(NSD3)

PVP:	105300277(NSD3)

RAY:	107515960(WHSC1L1)

MJV:	108396577(NSD3)

TOD:	119257819(NSD3)

SARA:

101545402(WHSC1L1)

SETR:

126006400(NSD3)

LAV:	100663420(NSD3)

TMU:

101341096

ETF:	101648902(NSD3)

DNM:	101428090(NSD3)

MDO:	100029834(NSD3)

GAS:	123236990(NSD3)

SHR:	100913907(NSD3)

AFZ:

127548238

PCW:	110207576(NSD3)

OAA:	100074284(NSD3)

GGA:	426778(WHSC1L1)

PCOC:

116234530(NSD3)

MGP:	100550821(NSD3)

CJO:	107323733(NSD3)

TPAI:

128090006(NSD3)

LMUT:

125685149(NSD3)

NMEL:

110387045(NSD3)

APLA:

101796335(NSD3)

ACYG:

106044410(NSD3)

CATA:

118256046(NSD3)

AFUL:

116499346(NSD3)

TGU:	100224170(NSD3)

LSR:	110473395(NSD3)

SCAN:

103822694(NSD3)

PMOA:

120505099(NSD3)

OTC:	121346793(NSD3)

PRUF:

121360068(NSD3)

GFR:	102033572(NSD3)

FAB:	101807043(NSD3)

OMA:	130261944(NSD3) 130266556

PHI:	102104727(WHSC1L1)

PMAJ:

107213840(NSD3)

CCAE:

111938845(NSD3)

CCW:	104694849(NSD3)

CBRC:

103614646(WHSC1L1)

ETL:	114066496(NSD3)

ZAB:	102073618(NSD3)

ACHL:

103805547(WHSC1L1)

SVG:	106862050(WHSC1L1)

MMEA:

130586094(NSD3)

HRT:	120764054(NSD3)

FPG:	101913589(NSD3)

FCH:	102055544(NSD3)

CLV:	102090497(NSD3)

EGZ:	104125799(WHSC1L1)

NNI:	104016016(WHSC1L1)

PCRI:

104036695(WHSC1L1)

PLET:

104623200(WHSC1L1)

EHS:	104510940(WHSC1L1)

PCAO:

104045432(WHSC1L1)

ACUN:

113488073(NSD3)

TALA:

104369158(NSD3)

PADL:

103912352(WHSC1L1)

AFOR:

103896951(NSD3)

ACHC:

115350174(NSD3)

HALD:

104312472(WHSC1L1)

HLE:	104828806(WHSC1L1)

AGEN:

126051779

GCL:

127025407

CCRI:

104163353(WHSC1L1)

CSTI:

104551979(WHSC1L1)

CMAC:

104477594(WHSC1L1)

MUI:

104547244

BREG:

104638549(WHSC1L1)

FGA:	104075714(WHSC1L1)

GSTE:

104254043(WHSC1L1)

LDI:	104347707(WHSC1L1)

OHA:	104335043(WHSC1L1)

NNT:

104410494

SHAB:

115618401(NSD3)

DPUB:

104301280(WHSC1L1)

PGUU:

104460409(WHSC1L1)

CPEA:

104384842(WHSC1L1)

CVF:	104283350(WHSC1L1)

RTD:	128919661(NSD3)

CUCA:

104068523(WHSC1L1)

TEO:	104382674(WHSC1L1)

BRHI:

104489149(WHSC1L1)

AAM:	106493055(NSD3)

AROW:

112965458(NSD3)

NPD:	112952905(NSD3)

TGT:	104576679(WHSC1L1)

DNE:	112991599(NSD3)

SCAM:

104148737(WHSC1L1)

ASN:	102385195(NSD3)

AMJ:	106736778(NSD3)

CPOO:

109317418(NSD3)

GGN:	109295543(NSD3)

PSS:	102457400(NSD3)

CMY:	102943320(NSD3)

CCAY:

125626483(NSD3)

DCC:	119848710(NSD3)

CPIC:

101938886(NSD3)

TST:	117873023(NSD3)

CABI:

116821414(NSD3)

MRV:	120399010(NSD3)

ACS:	100558428(nsd3)

ASAO:

132782615(NSD3)

PVT:	110072168(NSD3)

SUND:

121933496(NSD3)

PBI:	103067854(NSD3)

PMUR:

107289990(NSD3)

CTIG:

120312916(NSD3)

TSR:	106550392(WHSC1L1)

PGUT:

117674754(NSD3)

APRI:

131203638(NSD3)

PTEX:

113445632 113445684

NSS:	113420986(NSD3)

VKO:	123027006(NSD3)

PMUA:

114585486(NSD3)

PRAF:

128403113(NSD3)

ZVI:	118096806(NSD3)

HCG:	128333703(NSD3)

GJA:	107112988(NSD3)

STOW:

125441690(NSD3)

EMC:	129342492(NSD3)

XLA:	108711640(nsd3.L) 108712682

XTR:	100216035(nsd3)

NPR:	108800629(WHSC1L1)

RTEM:

120933173(NSD3)

BBUF:

120986278(NSD3)

BGAR:

122927314(NSD3)

MUO:	115469364(NSD3)

GSH:	117362351(NSD3)

DRE:	100006350(whsc1l1)

SRX:	107705078 107720716

SANH:

107678004 107687514

SGH:	107553696(whsc1l1)

CCAR:

109099915 109100150

CAUA:

113054245 113109774

CGIB:

127966832 128021289

PTET:

122352849(nsd3)

LROH:

127171920(nsd3)

OMC:	131547750(nsd3)

PPRM:

120482303(nsd3)

RKG:	130082943(nsd3)

MAMB:

125259226(nsd3)

CIDE:

127521782

MASI:

127432704 127433635

TROS:

130545973(nsd3)

TDW:	130411726(nsd3)

MANU:

129447107(nsd3)

IPU:	108277349(nsd3)

IFU:	128620402(nsd3)

PHYP:

113544017(nsd3)

SMEO:

124393235(nsd3)

TFD:	113639282(nsd3)

TVC:	132862874(nsd3)

AMEX:

103025001(nsd3)

CMAO:

118824311(nsd3)

EEE:	113582471(nsd3)

CHAR:

105904648(nsd3)

TRU:	101063468(nsd3)

TFS:	130525354(nsd3)

TNG:	GSTEN00029589G001

LCO:	109137146(nsd3)

NCC:	104951617(whsc1l1)

TBEN:

117472667(nsd3)

CGOB:

115013158(nsd3)

PGEO:

117452322(nsd3)

GACU:

117560782(nsd3)

EMAC:

134873551(nsd3)

ELY:	117252663(nsd3)

EFO:	125890393(nsd3)

PLEP:

121943929(nsd3) 121964519

SLUC:

116053944(nsd3)

ECRA:

117945475(nsd3)

ESP:	116689438(nsd3)

PFLV:

114555335(nsd3)

GAT:	120831193(nsd3)

PPUG:

119225419(nsd3)

AFB:	129100970(nsd3)

CLUM:

117736005(nsd3)

PSWI:

130196984(nsd3)

MSAM:

119891651(nsd3)

SCHU:

122875676(nsd3)

CUD:	121509831(nsd3)

ALAT:

119019798(nsd3)

MZE:	101481339(nsd3)

ONL:	100692732(nsd3)

OAU:	116310986(nsd3)

OLA:	101156018(nsd3)

OML:	112148284(nsd3)

CSAI:

133450669(nsd3)

XMA:	102222057(nsd3)

XCO:	114154602(nsd3)

XHE:	116729765(nsd3)

PRET:

103470645(whsc1l1)

PFOR:

103145846(whsc1l1)

PLAI:

106956792(whsc1l1)

PMEI:

106921735(whsc1l1)

GAF:	122826599(nsd3)

PPRL:

129365841(nsd3)

CVG:	107089672(whsc1l1)

CTUL:

119778126(nsd3)

GMU:	124877665(nsd3)

NFU:	107394238(whsc1l1)

KMR:	108233751(nsd3)

ALIM:

106513637(whsc1l1)

NWH:	119413897(nsd3)

AOCE:

111573350(nsd3)

MCEP:

125011832(nsd3)

CSEM:

103397008 103397827

POV:	109637173(nsd3)

SSEN:

122769284(nsd3)

HHIP:

117767669(nsd3)

HSP:	118115062(nsd3)

SMAU:

118313498(nsd3)

LCF:	108881778(nsd3)

SDU:	111237743(nsd3)

SLAL:

111661024(nsd3)

XGL:	120805367(nsd3)

HCQ:	109525952(nsd3)

SSCV:

125993778

SBIA:

133499069(nsd3)

PEE:	133399959(nsd3)

PTAO:

133475154(nsd3)

BPEC:

110156434(nsd3)

MALB:

109956650(nsd3)

BSPL:

114861815(nsd3)

SJO:	128364823(nsd3)

SASA:

106580439 106585046

STRU:

115164370 115200307

OTW:	112248594(nsd3) 112262742

OMY:	110525799 110536201

OGO:	124034222(nsd3) 124034924

ONE:	115111712 115140198

OKI:	109881240 109894919

OKE:	118371621 118393330

SALP:

111958177 111974608

SNH:	120031939 120063245

CCLU:

121562471 121584965(nsd3)

ELS:	105014331(nsd3)

SFM:	108934463 108940378(nsd3)

PKI:	111851463 111857590(nsd3)

AANG:

118206256 118213470

LOC:	102694526(whsc1l1)

PSPA:

121302457 121303193

ARUT:

117397959 117962539

PSEX:

120539300(nsd3)

LCM:	102359965(NSD3)

CMK:	103190419(nsd3)

RTP:	109912039(nsd3)

CPLA:

122543120(nsd3)

HOC:	132837021(nsd3)

LERI:

129713203(nsd3)

DCI:

103504837

» show all

Reference

PMID:16682010

Authors

Kim SM, Kee HJ, Eom GH, Choe NW, Kim JY, Kim YS, Kim SK, Kook H, Kook H, Seo SB

Title

Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity.

Journal

Biochem Biophys Res Commun 345:318-23 (2006)
DOI:10.1016/j.bbrc.2006.04.095

Sequence

[hsa:54904]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (9)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (1960)   
   KEGG GENES (414)   
   KEGG MGENES (548)   
   RefGene (994)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (1979)   

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