KEGG   ORTHOLOGY: K20152
Entry
K20152            Tight     KO                                     

Name
kanK, kacC
Definition
2'-dehydrokanamycin reductase [EC:1.1.1.355]
Pathway
ko00524  Neomycin, kanamycin and gentamicin biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20152  kanK, kacC; 2'-dehydrokanamycin reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.355  2'-dehydrokanamycin reductase
     K20152  kanK, kacC; 2'-dehydrokanamycin reductase
Other DBs
RN: R10417
COG: COG0451
Genes
AG: BAD20766(kanK)
Reference
  Authors
Yanai K, Murakami T
  Title
The kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus.
  Journal
J Antibiot (Tokyo) 57:351-4 (2004)
DOI:10.7164/antibiotics.57.351
  Sequence
Reference
  Authors
Sucipto H, Kudo F, Eguchi T
  Title
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.
  Journal
Angew Chem Int Ed Engl 51:3428-31 (2012)
DOI:10.1002/anie.201108122

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