Entry |
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Gene name |
Nos3, 2310065A03Rik, No, Nos-3, e, eNOS, ec, ecNOS
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Definition |
(RefSeq) nitric oxide synthase 3, endothelial cell
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KO |
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Organism |
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Pathway |
mmu00330 | Arginine and proline metabolism |
mmu04933 | AGE-RAGE signaling pathway in diabetic complications |
mmu05418 | Fluid shear stress and atherosclerosis |
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Brite |
KEGG Orthology (KO) [BR:mmu00001]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
18127 (Nos3)
00330 Arginine and proline metabolism
18127 (Nos3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
18127 (Nos3)
04371 Apelin signaling pathway
18127 (Nos3)
04066 HIF-1 signaling pathway
18127 (Nos3)
04020 Calcium signaling pathway
18127 (Nos3)
04071 Sphingolipid signaling pathway
18127 (Nos3)
04022 cGMP-PKG signaling pathway
18127 (Nos3)
04151 PI3K-Akt signaling pathway
18127 (Nos3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
18127 (Nos3)
09152 Endocrine system
04915 Estrogen signaling pathway
18127 (Nos3)
04921 Oxytocin signaling pathway
18127 (Nos3)
04926 Relaxin signaling pathway
18127 (Nos3)
09160 Human Diseases
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
18127 (Nos3)
05415 Diabetic cardiomyopathy
18127 (Nos3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
18127 (Nos3)
04933 AGE-RAGE signaling pathway in diabetic complications
18127 (Nos3)
Enzymes [BR:mmu01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
18127 (Nos3)
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SSDB |
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Motif |
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Other DBs |
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Position |
5 A3; 5 11.32 cM
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AA seq |
1202 aa
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAPPSPTRPAPDHSPPLTR
PPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSLVFPRKLQSRPTQGPSPTE
QLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF
RIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILV
RLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE
EWKWFSCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLA
YRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF
RGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDP
GSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIP
GS |
NT seq |
3609 nt +upstreamnt +downstreamnt
atgggcaacttgaagagtgtgggccaggagcctgggccaccctgtggcctagggctcggg
ctgggtttagggctgtgcggcaagcagggcccagcctctccagcaccggagcctagccag
gcgccagcacccccgtccccaacccgaccagcaccagaccacagccccccgctaacccgg
cccccagacggacccaggtttcctcgagtaaagaattgggaagtgggcagcatcacctac
gacaccctcagtgcccaggctcagcaggatgggccctgtacctcaagacgctgcttggga
tccctggtgtttccaaggaagttacagagccggcccacccagggcccttcacccactgag
cagctattgggtcaagcccgggacttcatcaatcagtactataactccatcaaaaggagt
ggctcccaggctcatgagcagcggcttcaggaagtggaggctgaggtggcagccacaggc
acctaccagctccgggagagcgagctggtgtttggggccaagcaggcctggcgcaatgct
ccccgctgtgtgggccggatccagtggggaaagctgcaggtatttgatgctcgggactgc
aggactgcacaggaaatgttcacctacatctgtaaccacattaaatacgcaacaaataga
ggcaatcttcgttcagccatcacagtgttcccccagcgctgccctggccggggagacttc
cggatctggaacagccagctgatacgctatgcgggctataggcagcaggatggctccgtg
cgaggggaccccgccaacgtggagatcactgagctctgtatccaacatggctggacccca
ggaaatggccgctttgatgtgctgcccctgttactccaggctcctgatgagcccccagaa
ctcttcactctgcccccagagatggtcctcgaggtgcctctggagcaccccacgctcgag
tggtttgctgcccttggcctgcgctggtatgccctcccagctgtgtccaacatgctgcta
gaaatcgggggcctggagtttcctgctgcccctttcagcggctggtacatgagttcagag
attggcatgagggacctgtgtgaccctcaccgctacaacatacttgaggatgtggctgtg
tgcatggatctggacaccaggacaacctcatccctgtggaaagacaaggcagcggtggaa
attaatgtggccgtgttgcacagttaccagctggccaaagtgaccatagtggaccaccac
gccgccacagcctccttcatgaagcacctggaaaatgagcagaaggccagagggggctgc
cctgccgattgggcctggattgtgccccccatctcaggcagcctaactcctgtcttccat
caagagatggtcaactatttcctgtcccctgccttccgctaccagccagacccctggaag
ggaagtgcagcaaagggggcaggcatcaccaggaagaagacctttaaggaagtagccaat
gcagtgaagatctctgcctcactcatgggcacggtgatggcgaagcgtgtgaaggcaacc
attctgtatggctctgagactggccgggcccagagctacgcacagcagctgggaagactc
ttccggaaggcgtttgatccccgggtcctgtgcatggatgagtatgatgtggtgtcccta
gagcacgaggcactggtgttggtggtgaccagcacatttggcaatggggatcctccggag
aatggagagagctttgcagcagcgctcatggaaatgtcaggcccgtacaacagctcccct
aggcctgagcagcacaagagctacaaaatccgattcaacagtgtctcctgctcagaccca
ctggtatcctcttggcggcgcaagaggaaggagtctagcaacacagacagtgcaggagcc
ctgggcaccctcaggttctgtgtgtttgggctgggctcccgagcatacccccacttctgt
gcctttgctcgagcggtggacacaaggctggaggagctgggcggggagcgactactgcag
ctgggccaaggtgatgagctctgtggccaggaggaggctttccgaggctgggcccaggcc
gccttccaggctgcctgtgaaaccttctgtgtgggagaagatgccaaagctgctgcccga
gatatcttcagccccaaacgcagctggaagcgccagaggtaccggctgagtacccaggct
gagagcctgcaattactaccagggctgactcacgtgcacaggcggaagatgttccaggct
acaatcctctctgtggaaaacctacagagcagcaaatccacccgagccacgatcctggtg
cgtctggacaccggaggccaggagggactgcagtaccagccaggggaccacataggtgtg
tgcccacccaaccgtcctggcctagtggaggcactgctgagccgagtggaggaccctccg
ccatccacagaacctgtggctgtggaacaactggagaaaggcagccctggtggccctccc
cccggctgggtacgggacccccggctacccccatgtacgctgcggcaggctctcacctac
ttcctggacatcacttccccgcctagtcctcgcctccttcgactgctcagcaccctggca
gaagagtccagcgaacagcaggagctagaggctctcagccaggacccccggcgctacgaa
gaatggaagtggttcagctgccccacactgctagaggtgctggagcaatttccttcagtg
gcactgcctgccccgctgatcctcacccagctgcccttgctccagccccggtactactct
gtcagttcagcacccagcgcccacccaggagagatccacctcaccatagctgtgctggct
tacagaacccaggatgggctgggccctctgcactacggtgtctgctccacgtggatgagc
cagctcaaggcgggagatccagtgccctgcttcatcaggggggctccctccttccggctg
ccacctgatcctaacttgccctgcatcctggtgggcccagggactggcattgcacccttc
cggggattctggcaagacagactacacgacattgagatcaaagggctacaacctgccccc
atgactttggtgtttggctgccgatgctcccaactggaccatctctaccgggacgaggta
ctggacgcccagcagcgtggggtgtttggacaagtcctcaccgccttttccagggatcct
ggcagccccaagacctacgtgcaagacctcctgaggacagagctagccgcggaggttcac
cgtgtgctgtgccttgagcaaggacatatgtttgtctgcggcgatgtcactatggcaacc
agcgtcctgcaaaccgtgcagagaattctggcaacagagggcggcatggagctggatgaa
gccggtgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacattttcgga
ctcacattgcgcacccaggaggtgacaagccgcatacgcacccagagcttttctttgcag
gagcgacagctgaggggcgcagtgccctggtcctttgacccgcctggcccagaaatacct
ggttcctga |