KEGG   Myotis davidii (David's myotis): 102763670
Entry
102763670         CDS       T02992                                 
Symbol
PIK3R2
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
myd  Myotis davidii (David's myotis)
Pathway
myd01521  EGFR tyrosine kinase inhibitor resistance
myd01522  Endocrine resistance
myd01524  Platinum drug resistance
myd04012  ErbB signaling pathway
myd04014  Ras signaling pathway
myd04015  Rap1 signaling pathway
myd04024  cAMP signaling pathway
myd04062  Chemokine signaling pathway
myd04066  HIF-1 signaling pathway
myd04068  FoxO signaling pathway
myd04070  Phosphatidylinositol signaling system
myd04071  Sphingolipid signaling pathway
myd04072  Phospholipase D signaling pathway
myd04140  Autophagy - animal
myd04150  mTOR signaling pathway
myd04151  PI3K-Akt signaling pathway
myd04152  AMPK signaling pathway
myd04210  Apoptosis
myd04211  Longevity regulating pathway
myd04213  Longevity regulating pathway - multiple species
myd04218  Cellular senescence
myd04360  Axon guidance
myd04370  VEGF signaling pathway
myd04380  Osteoclast differentiation
myd04510  Focal adhesion
myd04550  Signaling pathways regulating pluripotency of stem cells
myd04611  Platelet activation
myd04613  Neutrophil extracellular trap formation
myd04620  Toll-like receptor signaling pathway
myd04625  C-type lectin receptor signaling pathway
myd04630  JAK-STAT signaling pathway
myd04650  Natural killer cell mediated cytotoxicity
myd04660  T cell receptor signaling pathway
myd04662  B cell receptor signaling pathway
myd04664  Fc epsilon RI signaling pathway
myd04666  Fc gamma R-mediated phagocytosis
myd04668  TNF signaling pathway
myd04670  Leukocyte transendothelial migration
myd04722  Neurotrophin signaling pathway
myd04725  Cholinergic synapse
myd04750  Inflammatory mediator regulation of TRP channels
myd04810  Regulation of actin cytoskeleton
myd04910  Insulin signaling pathway
myd04914  Progesterone-mediated oocyte maturation
myd04915  Estrogen signaling pathway
myd04917  Prolactin signaling pathway
myd04919  Thyroid hormone signaling pathway
myd04923  Regulation of lipolysis in adipocytes
myd04926  Relaxin signaling pathway
myd04929  GnRH secretion
myd04930  Type II diabetes mellitus
myd04931  Insulin resistance
myd04932  Non-alcoholic fatty liver disease
myd04933  AGE-RAGE signaling pathway in diabetic complications
myd04935  Growth hormone synthesis, secretion and action
myd04960  Aldosterone-regulated sodium reabsorption
myd04973  Carbohydrate digestion and absorption
myd05010  Alzheimer disease
myd05017  Spinocerebellar ataxia
myd05020  Prion disease
myd05100  Bacterial invasion of epithelial cells
myd05135  Yersinia infection
myd05142  Chagas disease
myd05146  Amoebiasis
myd05160  Hepatitis C
myd05161  Hepatitis B
myd05162  Measles
myd05163  Human cytomegalovirus infection
myd05164  Influenza A
myd05165  Human papillomavirus infection
myd05166  Human T-cell leukemia virus 1 infection
myd05167  Kaposi sarcoma-associated herpesvirus infection
myd05168  Herpes simplex virus 1 infection
myd05169  Epstein-Barr virus infection
myd05170  Human immunodeficiency virus 1 infection
myd05171  Coronavirus disease - COVID-19
myd05200  Pathways in cancer
myd05203  Viral carcinogenesis
myd05205  Proteoglycans in cancer
myd05206  MicroRNAs in cancer
myd05207  Chemical carcinogenesis - receptor activation
myd05208  Chemical carcinogenesis - reactive oxygen species
myd05210  Colorectal cancer
myd05211  Renal cell carcinoma
myd05212  Pancreatic cancer
myd05213  Endometrial cancer
myd05214  Glioma
myd05215  Prostate cancer
myd05218  Melanoma
myd05220  Chronic myeloid leukemia
myd05221  Acute myeloid leukemia
myd05222  Small cell lung cancer
myd05223  Non-small cell lung cancer
myd05224  Breast cancer
myd05225  Hepatocellular carcinoma
myd05226  Gastric cancer
myd05230  Central carbon metabolism in cancer
myd05231  Choline metabolism in cancer
myd05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
myd05415  Diabetic cardiomyopathy
myd05417  Lipid and atherosclerosis
myd05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:myd00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102763670 (PIK3R2)
   04014 Ras signaling pathway
    102763670 (PIK3R2)
   04015 Rap1 signaling pathway
    102763670 (PIK3R2)
   04370 VEGF signaling pathway
    102763670 (PIK3R2)
   04630 JAK-STAT signaling pathway
    102763670 (PIK3R2)
   04668 TNF signaling pathway
    102763670 (PIK3R2)
   04066 HIF-1 signaling pathway
    102763670 (PIK3R2)
   04068 FoxO signaling pathway
    102763670 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    102763670 (PIK3R2)
   04072 Phospholipase D signaling pathway
    102763670 (PIK3R2)
   04071 Sphingolipid signaling pathway
    102763670 (PIK3R2)
   04024 cAMP signaling pathway
    102763670 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    102763670 (PIK3R2)
   04152 AMPK signaling pathway
    102763670 (PIK3R2)
   04150 mTOR signaling pathway
    102763670 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102763670 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    102763670 (PIK3R2)
   04218 Cellular senescence
    102763670 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102763670 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102763670 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102763670 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102763670 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    102763670 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    102763670 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    102763670 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    102763670 (PIK3R2)
   04660 T cell receptor signaling pathway
    102763670 (PIK3R2)
   04662 B cell receptor signaling pathway
    102763670 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    102763670 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    102763670 (PIK3R2)
   04670 Leukocyte transendothelial migration
    102763670 (PIK3R2)
   04062 Chemokine signaling pathway
    102763670 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102763670 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    102763670 (PIK3R2)
   04929 GnRH secretion
    102763670 (PIK3R2)
   04915 Estrogen signaling pathway
    102763670 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    102763670 (PIK3R2)
   04917 Prolactin signaling pathway
    102763670 (PIK3R2)
   04926 Relaxin signaling pathway
    102763670 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    102763670 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    102763670 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102763670 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102763670 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    102763670 (PIK3R2)
   04722 Neurotrophin signaling pathway
    102763670 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102763670 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    102763670 (PIK3R2)
   04380 Osteoclast differentiation
    102763670 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    102763670 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    102763670 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102763670 (PIK3R2)
   05206 MicroRNAs in cancer
    102763670 (PIK3R2)
   05205 Proteoglycans in cancer
    102763670 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    102763670 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102763670 (PIK3R2)
   05203 Viral carcinogenesis
    102763670 (PIK3R2)
   05230 Central carbon metabolism in cancer
    102763670 (PIK3R2)
   05231 Choline metabolism in cancer
    102763670 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102763670 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102763670 (PIK3R2)
   05212 Pancreatic cancer
    102763670 (PIK3R2)
   05225 Hepatocellular carcinoma
    102763670 (PIK3R2)
   05226 Gastric cancer
    102763670 (PIK3R2)
   05214 Glioma
    102763670 (PIK3R2)
   05221 Acute myeloid leukemia
    102763670 (PIK3R2)
   05220 Chronic myeloid leukemia
    102763670 (PIK3R2)
   05218 Melanoma
    102763670 (PIK3R2)
   05211 Renal cell carcinoma
    102763670 (PIK3R2)
   05215 Prostate cancer
    102763670 (PIK3R2)
   05213 Endometrial cancer
    102763670 (PIK3R2)
   05224 Breast cancer
    102763670 (PIK3R2)
   05222 Small cell lung cancer
    102763670 (PIK3R2)
   05223 Non-small cell lung cancer
    102763670 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102763670 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    102763670 (PIK3R2)
   05161 Hepatitis B
    102763670 (PIK3R2)
   05160 Hepatitis C
    102763670 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    102763670 (PIK3R2)
   05164 Influenza A
    102763670 (PIK3R2)
   05162 Measles
    102763670 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    102763670 (PIK3R2)
   05163 Human cytomegalovirus infection
    102763670 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102763670 (PIK3R2)
   05169 Epstein-Barr virus infection
    102763670 (PIK3R2)
   05165 Human papillomavirus infection
    102763670 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102763670 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    102763670 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102763670 (PIK3R2)
   05142 Chagas disease
    102763670 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102763670 (PIK3R2)
   05017 Spinocerebellar ataxia
    102763670 (PIK3R2)
   05020 Prion disease
    102763670 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102763670 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    102763670 (PIK3R2)
   05415 Diabetic cardiomyopathy
    102763670 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102763670 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    102763670 (PIK3R2)
   04931 Insulin resistance
    102763670 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102763670 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102763670 (PIK3R2)
   01524 Platinum drug resistance
    102763670 (PIK3R2)
   01522 Endocrine resistance
    102763670 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:myd04131]
    102763670 (PIK3R2)
Membrane trafficking [BR:myd04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102763670 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 Ribosomal_L22e SH3_2 ATG11
Other DBs
NCBI-GeneID: 102763670
NCBI-ProteinID: XP_015413199
Position
Un
AA seq 676 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQGLGVAEGSERCPQNVGWIPGL
NERTRQRGDFPGTYVEFLGPVTLARPGPRPRGPRPLPARPQEGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPPPCTDWSLSDLEQWDSAALADGIKGFLLA
LPAPLVTLEAAAEACRALRGAGPLSAGVFTERALHIHEQQTEPNPDFPALLVEKLLQEHL
EEQEVAPPALPPKPPKVKPAPAGLANGGSPPSLQDAEWYWGDISREEVNDKLRDTPDGTF
LVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQ
YNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQ
ELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRIRLNSERLKSRI
AEIHESRTKLEQELRTQALDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKIN
EWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLNGKRDGTFLIRESSQR
GCYACSVVVDGDTKHCVIYRTATGLGFAEPYNLYGSLKELVLHYQHTSLVQHNDALTVTL
AHPVRAPGPGPPPAAR
NT seq 2031 nt   +upstreamnt  +downstreamnt
atggctggcgctgagggcttccagtaccgtgcactgtacccgttccgccgggagcggcca
gaagacctggagctgttgccgggtgacgtgctggtggtgagccgggccgccctgcagggg
ctgggtgtggccgagggcagtgagcgctgcccgcagaacgtgggctggatcccgggcctc
aatgagcgaactcggcagcgcggtgacttccctggcacctacgtggagttcctggggcct
gtgaccctggcccggcctggccctcgcccccgcggcccccgcccactgcctgccaggccc
caagaggggccccctgagccaggcctcacactccctgacctacctgagcagttctcccca
cctgatgtggctcccccactgctggtaaagcttgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcccgagctgccgcccccgtgcacagactggtccctgagc
gacctagagcagtgggactcggcagccctggccgatggcatcaagggcttcctgctggca
ctgcctgcgccccttgtgacgctggaagcggctgcagaggcctgccgtgccctgcgaggt
gccggacccctcagcgcgggtgtatttactgagcgcgcactgcacatacatgagcagcag
actgagcccaaccccgacttcccagctctgctggtggagaagttgcttcaggagcacctg
gaggagcaggaggtcgcacccccagctctgccgcctaaaccacctaaagtcaagcccgcc
ccagcggggctggctaatggggggagcccaccctctctgcaggatgctgagtggtactgg
ggtgacatttccagggaggaggtgaacgacaaactccgggacacacctgacggcaccttc
ctggtccgagatgcctccagcaagattcagggagagtataccctgacccttaggaaaggt
ggaaacaacaagctaattaaggtcttccaccgtgatgggcattatggcttctcggagccg
ctcaccttctgctccgtcgtggacctcatcacccactaccgccacgagtccctggcgcag
tacaatgccaaactagacacacggctcctgtaccccgtgtccaagtaccagcaggaccag
attgtcaaggaagacagcgtggaggcagtgggcgcccagctcaaagtctaccatcagcag
taccaggacaagagccgcgagtacgaccagctctacgaggagtacacgcgcacctcccag
gagctgcagatgaagcgcaccgccatcgaggccttcaatgaaaccatcaagatcttcgaa
gagcagggccagactcaagagaagtgcagcaaggagtatttggaacgcttccggcgtgag
ggcaacgagaaggagatgcagaggatccggctgaactcagaacggctcaagtctcgcatc
gccgagatccacgagagccgcacgaagctggaacaggagctgcggacacaggccttggac
aaccgggagatcgataagcgcatgaacagcctgaagccagacctcatgcagctgcgcaag
atccgagaccagtacttggtatggctcacccagaaaggcgcccggcagaagaaaatcaac
gagtggttgggaatcaaaaatgagactgaagaccagtacgcactgatggaggatgaggat
gacctcccccaccatgaggaacgaacctggtatgtgggcaagatcaaccgcacgcaggct
gaggaaatgctgaacggcaagcgggatgggaccttcctcatccgtgagagcagccagcgg
ggctgctacgcctgctctgtggtggtggacggcgacaccaagcactgtgtcatctaccgc
acggccactggcttgggttttgcggagccttacaacctgtatgggtctctgaaggagctg
gtgctgcattaccagcacacctccctcgtgcagcacaacgatgcccttaccgtcacactg
gcgcatcccgtgcgcgccccgggccccggtccacccccggccgcccgctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (102)   
   KEGG PATHWAY (102)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (130)   

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