KEGG   NETWORK: N00460
Entry
N00460                      Network                                
Name
HIV Vpr to WEE1-cell cycle G2M
Definition
Vpr -> WEE1 -| (CCNB+CDK1)
  Expanded
K22202 -> 7465 -| ((891,9133,85417)+983)
Class
nt06161 Human immunodeficiency virus 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
7465  WEE1; WEE1 G2 checkpoint kinase
891  CCNB1; cyclin B1
9133  CCNB2; cyclin B2
85417  CCNB3; cyclin B3
983  CDK1; cyclin dependent kinase 1
Perturbant
K22202 (Vpr)  vpr; HIV-1 virus protein R
Reference
PMID:24906315
  Authors
Bagga S, Bouchard MJ
  Title
Cell cycle regulation during viral infection.
  Journal
Methods Mol Biol 1170:165-227 (2014)
DOI:10.1007/978-1-4939-0888-2_10
Reference
PMID:18385244
  Authors
Kamata M, Watanabe N, Nagaoka Y, Chen IS
  Title
Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2.
  Journal
J Virol 82:5672-82 (2008)
DOI:10.1128/JVI.01330-07

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (5)   
Literature (2)   
   PubMed (2)   
All databases (9)   

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