Entry |
|
Name |
HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
|
Definition |
NS3 -> CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3 |
Expanded |
K22273 -> 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> 836 |
Class |
nt06263 Hepatocellular carcinoma
nt06131 Apoptosis (viruses and bacteria)
nt06163 Hepatitis C virus (HCV)
|
Type |
Pathogen
|
Pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
|
Gene |
637 | BID; BH3 interacting domain death agonist |
581 | BAX; BCL2 associated X, apoptosis regulator |
578 | BAK1; BCL2 antagonist/killer 1 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Perturbant |
K22273 (NS3) | NS3; HCV serine protease NS3 |
|
Reference |
|
Authors |
Fischer R, Baumert T, Blum HE |
Title |
Hepatitis C virus infection and apoptosis. |
Journal |
|
Reference |
|
Authors |
Prikhod'ko EA, Prikhod'ko GG, Siegel RM, Thompson P, Major ME, Cohen JI |
Title |
The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities. |
Journal |
|
Reference |
|
Authors |
Lim EJ, Chin R, Angus PW, Torresi J |
Title |
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants. |
Journal |
|