Entry |
|
Name |
HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
|
Definition |
X -> BAX -> CYCS -- APAF1 -> CASP9 -> CASP3 |
Expanded |
K21854 -> 581 -> 54205 -- 317 -> 842 -> 836 |
Class |
nt06263 Hepatocellular carcinoma
nt06131 Apoptosis (viruses and bacteria)
nt06162 Hepatitis B virus (HBV)
|
Type |
Pathogen
|
Pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
|
Gene |
581 | BAX; BCL2 associated X, apoptosis regulator |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Perturbant |
|
Reference |
|
Authors |
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK |
Title |
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria. |
Journal |
|
Reference |
|
Authors |
Gao WY, Li D, Cai DE, Huang XY, Zheng BY, Huang YH, Chen ZX, Wang XZ |
Title |
Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore. |
Journal |
|