KEGG   Oreochromis niloticus (Nile tilapia): 100709978
Entry
100709978         CDS       T06104                                 
Symbol
mthfd1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
onl  Oreochromis niloticus (Nile tilapia)
Pathway
onl00670  One carbon pool by folate
onl01100  Metabolic pathways
onl01240  Biosynthesis of cofactors
Module
onl_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:onl00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    100709978 (mthfd1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:onl04147]
    100709978 (mthfd1)
Enzymes [BR:onl01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     100709978 (mthfd1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     100709978 (mthfd1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     100709978 (mthfd1)
Exosome [BR:onl04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   100709978 (mthfd1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 100709978
NCBI-ProteinID: XP_003447800
Ensembl: ENSONIG00000012191
Position
LG19:8616876..8631016
AA seq 934 aa
MPAQIISGKEVSAQVRERLKEDVEQMKLKNPNFRPGLVVLQVGDRDDSNLYISMKLKAAA
EIGINAMHMRLPTTATEEEILHSITEVNENSSVHGLIVQLPLDSVHEINTEKITNAVAPE
KDVDGLTSINAGKLSRGDLGDCFIPCTPNGCMELIKQTGVSVAGKRAVVIGRSKIVGAPM
HDLLLWNHATVTTCHSKTADLAAEVGRADILVVGIGKAEMVKGEWIKKGAVVIDCGINHV
IDDSKSSGKRVVGDVHFQSAKEQAGFITPVPGGVGPMTVAMLMANTVLSAKRFLESHQAG
KWNISYTALNLQKPVPSDIVISRSCAAKSIDSLAREVGLLSDEVELYGKTKAKVQLTIIK
RLQSRPDGKYVVVTGITPTPLGEGKSTTTIGLAQAMGAHMKLNVFACVRQPSQGPTFGIK
GGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHEATQSDKALYNRLVP
LSGRERKFSPIQINRLKKLGIEKTEPSALTEEEINHFARLDIDPSSVTWQRVLDTNDRFL
RKITIGQSPTEKGYTREAQFDITVASEIMAVLALTSSLEDMRQRLAKMVVATSRRGDPIT
TEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSILADKIALKLVGP
EGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATIRALKMHGGGPTVTAGMPLPK
EYVEENLNLLEKGCNNMRKQIENAKHFGVPVVVAVNAFKTDTDAELDLVCTMAKAAGAFD
AVRCSHWAEGGAGAVALGEAVQKASSAPSNFKFLYDLDLPIADKIRIIAQKIYGADDIEL
LAEAQHKVALYTKQGFANLPICMAKTHLSLSHEAEKKGVPKGFILPIRDIRASVGAGFLF
PLVGTMPTIPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2805 nt   +upstreamnt  +downstreamnt
atgccagctcagatcataagcggcaaagaggtttcagcgcaggtgagggagcgtctgaag
gaggatgttgagcagatgaaacttaagaatcccaacttcaggcctggtctagtggtttta
caggttggagaccgcgatgattcaaatctgtacatcagcatgaagctcaaagcagcagca
gagattggaataaatgcaatgcatatgagacttcccacgaccgcaacagaggaggagatt
cttcatagtatcacagaggtgaacgagaactcttctgtccacggcctcatcgttcagctg
cctttagattcagtccacgaaatcaacaccgagaagatcacgaacgccgtggccccagag
aaggacgtagatggactgaccagcataaatgcggggaagctgtcccgtggggatctgggc
gactgcttcatcccctgcacgccaaatggctgcatggagttaatcaaacagacgggtgtt
tctgtggcagggaagagagcggtcgtgattgggcgcagtaagattgtgggcgcacccatg
catgatttgctgctgtggaatcacgccaccgtcaccacctgccactctaaaaccgccgat
cttgccgcagaggtgggtagagcagacatcctggttgttggtatcggaaaagcagagatg
gtaaaaggagagtggatcaagaagggagcagtggtcattgactgtggcatcaaccacgtt
atagatgacagtaaatccagcggaaagcgtgtggtgggcgacgtccattttcagtcagcc
aaagagcaggccggcttcatcacccctgtgcccggtggtgtgggaccgatgactgtggcc
atgctgatggcgaacaccgtgctgagtgcaaagcgtttcctggagagccatcaggcagga
aagtggaacatttcttacaccgcgctcaatctccaaaagccagtgccaagtgacatagtg
atttctcgctcctgcgcagccaagtccattgatagtctggccagagaagtgggattactt
tctgatgaagtagagctctatggcaagactaaggcaaaggtccagctgactatcatcaag
cgccttcagtcccggccagatggaaaatatgtagtggtcactggcattactcccactcct
ctgggtgaaggtaagagcaccacaaccatcggcctggcacaagccatgggtgctcacatg
aagctcaatgtgtttgcttgtgtccgacagccttctcagggacccacgttcggtattaaa
ggtggtgctgcaggaggtggatattctcaagttattccgatggaagagtttaatctccat
ctcactggtgacattcatgccatcacagctgccaataacttggtggcggctgctattgat
gcccgcatattccatgaagcaacccaatctgacaaggctctgtataaccgtttggtgcca
ctcagtggaagagagaggaagttctccccgatccagatcaacagactcaaaaaactggga
atagagaagacggagccttctgctctcactgaggaggagatcaaccacttcgcccgcctg
gacatcgacccaagctctgttacctggcagagagtgctggatactaatgatcgattcctg
aggaagatcacgatcggccagtcgcccactgaaaagggatacacaagagaggcccagttt
gacatcactgtggccagcgaaatcatggcggtgcttgccctcaccagcagcctggaggac
atgcggcagcgcctggctaagatggtcgtagccaccagtcggaggggagatcccatcacc
accgaggatctgggcgtgagtggcgctctgactgtgctgatgaaagatgccatcaagcca
aacctgatgcagacgttggaggggactcctgtgtttgttcatgctggcccctttgccaac
atcgcccacggaaactcatcaatcctggctgataaaattgctttgaagctggttggacct
gagggctttgtagtgacagaagctggcttcggtgctgacatcggcatggagaagttcttc
aacatcaagtgccgctactcgggcctgaggcctcatgtggtggtgttggtggcgaccatc
cgagctctaaagatgcacggaggaggaccaacagtcactgctgggatgccactgcctaag
gaatatgtggaagagaaccttaatctgctggagaagggctgcaacaacatgaggaagcag
atcgaaaatgcaaagcactttggcgtgcctgtggtggtagcagtgaatgctttcaagaca
gacacggatgctgagctggacttggtgtgcaccatggctaaagctgctggagcattcgat
gccgtgcgatgctctcactgggccgagggtggcgctggtgctgtggcacttggtgaggct
gtccagaaggcctctagcgcccctagcaacttcaagttcctgtatgatttggaccttcct
attgctgataagattcgaataattgctcagaagatctatggagcagatgatattgagctt
ctggctgaggcccaacacaaggtggcgctctacaccaagcagggattcgcgaatcttcca
atttgcatggcaaagacccacctgtcactgtcacatgaagcagaaaagaaaggtgtgccc
aaaggattcatcctgccaatcagagacatcagagccagtgtgggcgctggctttctgttc
ccgttggttggcacaatgcccaccatccctggcctccccactcggccttgtttctatgac
atcgacctggaccccgagactgaacaggtcaatggactcttctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
Protein domain (3)   
   Pfam (3)   
All databases (42)   

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