KEGG   PATHWAY: hsa00030Help
Entry
hsa00030                    Pathway                                

Name
Pentose phosphate pathway - Homo sapiens (human)
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
hsa00030  Pentose phosphate pathway
hsa00030

Ortholog table
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:hsa00030]
hsa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:hsa00030]
hsa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:hsa00030]
hsa_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:hsa00030]
Network
N00311  NADPH generation
Disease
H00196  Phosphoribosylpyrophosphate synthetase superactivity
H00668  Anemia due to disorders of glutathione metabolism
H00946  Arts syndrome
H01111  Cortisone reductase deficiency
H01135  Ribose 5-phosphate isomerase deficiency
H01189  Transaldolase deficiency
H01375  Glucose 6-phosphate dehydrogenase deficiency
H01952  Glycogen storage disease type XII
Other DBs
BSID: 82928
GO: 0006098
Organism
Homo sapiens (human) [GN:hsa]
Gene
2821  GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
2539  G6PD; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.363 1.1.1.49]
25796  PGLS; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
9563  H6PD; hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase [KO:K13937] [EC:3.1.1.31 1.1.1.47]
5226  PGD; phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.343 1.1.1.44]
6120  RPE; ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]
729020  RPEL1; ribulose-5-phosphate-3-epimerase like 1 [KO:K01783] [EC:5.1.3.1]
7086  TKT; transketolase [KO:K00615] [EC:2.2.1.1]
84076  TKTL2; transketolase like 2 [KO:K00615] [EC:2.2.1.1]
8277  TKTL1; transketolase like 1 [KO:K00615] [EC:2.2.1.1]
6888  TALDO1; transaldolase 1 [KO:K00616] [EC:2.2.1.2]
22934  RPIA; ribose 5-phosphate isomerase A [KO:K01807] [EC:5.3.1.6]
51071  DERA; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
64080  RBKS; ribokinase [KO:K00852] [EC:2.7.1.15]
5236  PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
55276  PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.7 5.4.2.2]
221823  PRPS1L1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
5634  PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
5631  PRPS1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]
9104  RGN; regucalcin [KO:K01053] [EC:3.1.1.17]
414328  IDNK; IDNK, gluconokinase [KO:K00851] [EC:2.7.1.12]
132158  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
230  ALDOC; aldolase, fructose-bisphosphate C [KO:K01623] [EC:4.1.2.13]
226  ALDOA; aldolase, fructose-bisphosphate A [KO:K01623] [EC:4.1.2.13]
229  ALDOB; aldolase, fructose-bisphosphate B [KO:K01623] [EC:4.1.2.13]
2203  FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
8789  FBP2; fructose-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
5213  PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
5214  PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
5211  PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
(map 3)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 4)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
KO pathway
ko00030   

DBGET integrated database retrieval system