KEGG   PATHWAY: hsa00240
Entry
hsa00240                    Pathway                                
Name
Pyrimidine metabolism - Homo sapiens (human)
Class
Metabolism; Nucleotide metabolism
Pathway map
hsa00240  Pyrimidine metabolism
hsa00240

Module
hsa_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:hsa00240]
hsa_M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:hsa00240]
hsa_M00052  Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:hsa00240]
hsa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:hsa00240]
hsa_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:hsa00240]
Drug
D00341  Hydroxyurea (USP)
D00584  Fluorouracil (JP19/USP/INN)
D00749  Leflunomide (JAN/USP/INN)
D01064  Raltitrexed (JAN/USAN/INN)
D01155  Gemcitabine hydrochloride (JAN/USP)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP19/USAN/INN)
D01309  Doxifluridine (JP19/INN)
D01370  Cladribine (JAN/USP/INN)
D01784  Carmofur (JP19/INN)
D01846  Gimeracil (JAN/INN)
D01907  Fludarabine phosphate (JAN/USP)
D02368  Gemcitabine (USAN/INN)
D03154  Brequinar sodium (USAN)
D03378  Caracemide (USAN)
D03546  Clofarabine (JAN/USAN/INN)
D04197  Floxuridine (USP/INN)
D04245  Forodesine hydrochloride (JAN/USAN)
D04964  Metesind glucuronate (USAN)
D05396  Peldesine (USAN)
D06100  Tezacitabine (USAN)
D06596  Forodesine (USAN/INN)
D07966  Fludarabine (INN)
D07974  Fluorouracil sodium salt
D10172  Teriflunomide (USAN)
D10222  Gemcitabine elaidate (USAN/INN)
D10431  Ulodesine (USAN/INN)
D10432  Ulodesine succinate (USAN)
D10803  Plevitrexed (INN)
D10963  Oleclumab (USAN/INN)
D11447  Arfolitixorin (USAN/INN)
D11890  Emvododstat (USAN)
D12373  Quemliclustat (USAN/INN)
D12387  Fosgemcitabine palabenamide (USAN/INN)
D12388  Fosifloxuridine nafalbenamide
D12401  Uliledlimab (USAN/INN)
D12465  Doxecitine (USAN/INN)
D12466  Doxribtimine (USAN/INN)
D12528  Arfolitixorin sulfate (JAN)
D13127  Vidofludimus (USAN/INN)
D13128  Vidofludimus calcium (USAN)
D13146  Mavrostobart (USAN/INN)
D13147  Pemetrexed dipotassium heptahydrate
Other DBs
GO: 0006220 0006213
Organism
Homo sapiens (human) [GN:hsa]
Gene
100526794  NT5C1B-RDH14; NT5C1B-RDH14 protein isoform 1 [KO:K01081] [EC:3.1.3.5]
10201  NME6; nucleoside diphosphate kinase 6 isoform 2 [KO:K00940] [EC:2.7.4.6]
115024  NT5C3B; 7-methylguanosine phosphate-specific 5'-nucleotidase [KO:K24242]
124583  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
129607  CMPK2; UMP-CMP kinase 2, mitochondrial isoform 1 precursor [KO:K13809] [EC:2.7.4.14]
1503  CTPS1; CTP synthase 1 isoform a [KO:K01937] [EC:6.3.4.2]
151531  UPP2; uridine phosphorylase 2 isoform a [KO:K00757] [EC:2.4.2.3]
1633  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
1635  DCTD; deoxycytidylate deaminase isoform b [KO:K01493] [EC:3.5.4.12]
1723  DHODH; dihydroorotate dehydrogenase (quinone), mitochondrial [KO:K00254] [EC:1.3.5.2]
1806  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] isoform 1 [KO:K00207] [EC:1.3.1.2]
1807  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
1841  DTYMK; thymidylate kinase isoform 1 [KO:K00943] [EC:2.7.4.9]
1854  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1 precursor [KO:K01520] [EC:3.6.1.23]
1890  TYMP; thymidine phosphorylase isoform 1 precursor [KO:K00758] [EC:2.4.2.4]
221264  AK9; adenylate kinase 9 isoform 1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
22978  NT5C2; cytosolic purine 5'-nucleotidase isoform 1 [KO:K01081] [EC:3.1.3.5]
284958  NT5DC4; 5'-nucleotidase domain-containing protein 4 isoform 2 [KO:K01081] [EC:3.1.3.5]
29922  NME7; nucleoside diphosphate kinase homolog 7 isoform a [KO:K00940] [EC:2.7.4.6]
30833  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform 1 [KO:K01081] [EC:3.1.3.5]
318  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
377841  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform 1 [KO:K01510] [EC:3.6.1.5]
4830  NME1; nucleoside diphosphate kinase A isoform b [KO:K00940] [EC:2.7.4.6]
4831  NME2; nucleoside diphosphate kinase B isoform a [KO:K00940] [EC:2.7.4.6]
4832  NME3; nucleoside diphosphate kinase 3 precursor [KO:K00940] [EC:2.7.4.6]
4833  NME4; nucleoside diphosphate kinase, mitochondrial isoform a precursor [KO:K00940] [EC:2.7.4.6]
4907  NT5E; 5'-nucleotidase isoform 1 preproprotein [KO:K19970] [EC:3.1.3.5]
50484  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform 1 [KO:K10808] [EC:1.17.4.1]
51020  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
51251  NT5C3A; cytosolic 5'-nucleotidase 3A isoform 1 [KO:K24242]
5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
51727  CMPK1; UMP-CMP kinase isoform c [KO:K13800] [EC:2.7.4.14]
51733  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
54963  UCKL1; uridine-cytidine kinase-like 1 isoform 1 [KO:K00876] [EC:2.7.1.48]
56474  CTPS2; CTP synthase 2 [KO:K01937] [EC:6.3.4.2]
56953  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform 4 precursor [KO:K01081] [EC:3.1.3.5]
6240  RRM1; ribonucleoside-diphosphate reductase large subunit isoform 1 [KO:K10807] [EC:1.17.4.1]
6241  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform 2 [KO:K10808] [EC:1.17.4.1]
654364  NME1-NME2; NME1-NME2 protein [KO:K00940] [EC:2.7.4.6]
7083  TK1; thymidine kinase, cytosolic isoform 1 [KO:K00857] [EC:2.7.1.21]
7084  TK2; thymidine kinase 2, mitochondrial isoform 1 precursor [KO:K00857] [EC:2.7.1.21]
7298  TYMS; thymidylate synthase isoform 1 [KO:K00560] [EC:2.1.1.45]
7371  UCK2; uridine-cytidine kinase 2 isoform 1 [KO:K00876] [EC:2.7.1.48]
7372  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
7378  UPP1; uridine phosphorylase 1 isoform a [KO:K00757] [EC:2.4.2.3]
790  CAD; multifunctional protein CAD isoform 1 [KO:K11540] [EC:6.3.5.5 2.1.3.2 3.5.2.3]
79077  DCTPP1; dCTP pyrophosphatase 1 [KO:K16904] [EC:3.6.1.12]
81602  CDADC1; cytidine and dCMP deaminase domain-containing protein 1 isoform 1 [KO:K28865]
83549  UCK1; uridine-cytidine kinase 1 isoform a [KO:K00876] [EC:2.7.1.48]
84618  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
8623  ASMTL; probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 1 [KO:K25435]
93034  NT5C1B; cytosolic 5'-nucleotidase 1B isoform 1 [KO:K01081] [EC:3.1.3.5]
953  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform 1 [KO:K01510] [EC:3.6.1.5]
955  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform 1 [KO:K01511] [EC:3.6.1.6]
956  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform 1 [KO:K01510] [EC:3.6.1.5]
957  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor [KO:K01511] [EC:3.6.1.6]
9583  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform a [KO:K12305] [EC:3.6.1.6]
978  CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
Compound
C00015  UDP
C00039  DNA
C00046  RNA
C00055  CMP
C00063  CTP
C00064  L-Glutamine
C00075  UTP
C00086  Urea
C00099  beta-Alanine
C00105  UMP
C00106  Uracil
C00112  CDP
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00169  Carbamoyl phosphate
C00178  Thymine
C00214  Thymidine
C00222  3-Oxopropanoate
C00239  dCMP
C00295  Orotate
C00299  Uridine
C00337  (S)-Dihydroorotate
C00363  dTDP
C00364  dTMP
C00365  dUMP
C00380  Cytosine
C00383  Malonate
C00429  5,6-Dihydrouracil
C00438  N-Carbamoyl-L-aspartate
C00458  dCTP
C00459  dTTP
C00460  dUTP
C00475  Cytidine
C00526  Deoxyuridine
C00672  2-Deoxy-D-ribose 1-phosphate
C00705  dCDP
C00813  Barbiturate
C00881  Deoxycytidine
C00941  3',5'-Cyclic CMP
C01013  3-Hydroxypropanoate
C01103  Orotidine 5'-phosphate
C01168  Pseudouridine 5'-phosphate
C01205  (R)-3-Amino-2-methylpropanoate
C01346  dUDP
C01368  3'-UMP
C01563  Carbamate
C02067  Pseudouridine
C02170  Methylmalonate
C02354  2',3'-Cyclic CMP
C02355  2',3'-Cyclic UMP
C02376  5-Methylcytosine
C02642  3-Ureidopropionate
C03997  5-Hydroxymethyldeoxycytidylate
C05281  5-Methylbarbiturate
C05822  3'-CMP
C06198  P1,P4-Bis(5'-uridyl) tetraphosphate
C11038  2'-Deoxy-5-hydroxymethylcytidine-5'-diphosphate
C11039  2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate
C15607  3-Oxo-3-ureidopropanoate
C20231  (Z)-3-Ureidoacrylate peracid
C20249  (Z)-3-Peroxyaminoacrylate
C20253  Aminoacrylate
C20254  Ureidoacrylate
C20846  3-Oxo-3-ureidoisobutyrate
C21028  (R)-5,6-Dihydrothymine
C21029  (R)-3-Ureidoisobutyrate
C22509  3',5'-Cyclic UMP
Related
pathway
hsa00030  Pentose phosphate pathway
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00410  beta-Alanine metabolism
KO pathway
ko00240   

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