KEGG   PATHWAY: ams00260
Entry
ams00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Actinoplanes missouriensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ams00260  Glycine, serine and threonine metabolism
ams00260

Module
ams_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ams00260]
ams_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ams00260]
ams_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ams00260]
ams_M00621  Glycine cleavage system [PATH:ams00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Actinoplanes missouriensis [GN:ams]
Gene
AMIS_78380  putative aspartate kinase [KO:K00928] [EC:2.7.2.4]
AMIS_13440  putative aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AMIS_78370  putative aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AMIS_72250  putative homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AMIS_72170  putative homoserine kinase [KO:K00872] [EC:2.7.1.39]
AMIS_37150  putative phosphotransferase [KO:K02204] [EC:2.7.1.39]
AMIS_72260  putative threonine synthase [KO:K01733] [EC:4.2.3.1]
AMIS_77090  putative threonine synthase [KO:K01733] [EC:4.2.3.1]
AMIS_14700  putative lyase [KO:K01620] [EC:4.1.2.48]
AMIS_72010  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AMIS_4650  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AMIS_14090  putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
AMIS_76010  putative phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AMIS_10670  putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AMIS_71190  putative D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AMIS_3880  putative phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AMIS_59090  putative haloacid dehalogenase-like hydrolase [KO:K01079] [EC:3.1.3.3]
AMIS_26990  putative amine oxidoreductase [KO:K00274] [EC:1.4.3.4]
AMIS_42000  putative glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AMIS_46740  putative glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AMIS_13920  putative glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AMIS_13890  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMIS_46730  putative glycine cleavage system H protein [KO:K02437]
AMIS_51850  putative glycine cleavage system H protein [KO:K02437]
AMIS_14610  putative D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
AMIS_39880  putative D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
AMIS_6990  putative phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
AMIS_37600  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AMIS_37720  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AMIS_66490  putative FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
AMIS_66480  putative FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
AMIS_7790  putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AMIS_70860  putative cystathionine/methionine gamma-synthase/lyase [KO:K01758] [EC:4.4.1.1]
AMIS_46720  putative L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
AMIS_13380  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AMIS_69010  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AMIS_8010  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AMIS_3650  putative tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AMIS_15670  putative tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AMIS_3640  putative tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AMIS_15660  putative tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AMIS_67520  sidD; putative lysine decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ams00010  Glycolysis / Gluconeogenesis
ams00020  Citrate cycle (TCA cycle)
ams00230  Purine metabolism
ams00250  Alanine, aspartate and glutamate metabolism
ams00270  Cysteine and methionine metabolism
ams00290  Valine, leucine and isoleucine biosynthesis
ams00300  Lysine biosynthesis
ams00330  Arginine and proline metabolism
ams00460  Cyanoamino acid metabolism
ams00470  D-Amino acid metabolism
ams00564  Glycerophospholipid metabolism
ams00600  Sphingolipid metabolism
ams00620  Pyruvate metabolism
ams00630  Glyoxylate and dicarboxylate metabolism
ams00640  Propanoate metabolism
ams00680  Methane metabolism
ams00860  Porphyrin metabolism
ams00920  Sulfur metabolism
KO pathway
ko00260   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG GENES (42)   
All databases (43)   

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