KEGG   PATHWAY: der04144
Entry
der04144                    Pathway                                
Name
Endocytosis - Drosophila erecta
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
der04144  Endocytosis
der04144

Other DBs
GO: 0006897
Organism
Drosophila erecta [GN:der]
Gene
6546766  ADP-ribosylation factor 6 [KO:K07941]
6547602  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
6547404  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
6540960  phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
6550710  dynamin isoform X3 [KO:K01528] [EC:3.6.5.5]
6545754  clathrin light chain [KO:K04645]
6550602  clathrin heavy chain [KO:K04646]
6540801  AP-2 complex subunit alpha isoform X1 [KO:K11824]
6555175  AP-2 complex subunit mu [KO:K11826]
6553339  AP-2 complex subunit sigma [KO:K11827]
6540765  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
6547974  zinc finger FYVE domain-containing protein 9 [KO:K04679]
6550310  mothers against decapentaplegic homolog 3 [KO:K23605]
6548211  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
6545596  fibroblast growth factor receptor homolog 2 [KO:K05093] [EC:2.7.10.1]
6552001  fibroblast growth factor receptor homolog 1 [KO:K05094] [EC:2.7.10.1]
6553414  insulin-like receptor [KO:K05087] [EC:2.7.10.1]
6545674  E3 ubiquitin-protein ligase CBL-B-B [KO:K04707] [EC:2.3.2.27]
6553880  endophilin-A [KO:K11247]
6547332  endophilin-B1 isoform X1 [KO:K11248]
6546791  amphiphysin isoform X1 [KO:K12562]
6544069  epsin-2 isoform X2 [KO:K12471]
6548448  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
6551914  protein spartin isoform X2 [KO:K19366]
6546442  E3 ubiquitin-protein ligase Nedd-4 isoform X1 [KO:K10591] [EC:2.3.2.26]
6550517  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
6544884  E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
6540815  E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
6546751  E3 ubiquitin-protein ligase Smurf1 [KO:K04678] [EC:2.3.2.26]
6542319  E3 ubiquitin-protein ligase Su(dx) [KO:K05633] [EC:2.3.2.26]
6544022  protein disabled isoform X1 [KO:K12475]
6541861  G protein-coupled receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
6554722  G protein-coupled receptor kinase 2 [KO:K08291] [EC:2.7.11.16]
6554380  beta-arrestin-1 [KO:K04439]
6555101  neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
6550488  actin-related protein 2 isoform X2 [KO:K17260]
6543675  actin-related protein 3 [KO:K18584]
6542480  actin-related protein 2/3 complex subunit 1A-B [KO:K05757]
6549128  actin-related protein 2/3 complex subunit 2 [KO:K05758]
6553088  actin-related protein 2/3 complex subunit 3 [KO:K05756]
6550079  actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
6541291  actin-related protein 2/3 complex subunit 4 [KO:K05755]
6543001  actin-related protein 2/3 complex subunit 5 [KO:K05754]
6545627  heat shock 70 kDa protein cognate 1 isoform X1 [KO:K03283]
6553110  heat shock 70 kDa protein cognate 4 [KO:K03283]
6553734  heat shock 70 kDa protein cognate 2 [KO:K03283]
6553767  major heat shock 70 kDa protein Ba [KO:K03283]
6553724  major heat shock 70 kDa protein Ba [KO:K03283]
6554050  major heat shock 70 kDa protein Ba [KO:K03283]
6554051  major heat shock 70 kDa protein Ba [KO:K03283]
6554353  heat shock protein 68 [KO:K03283]
113564842  major heat shock 70 kDa protein Ba [KO:K03283]
6553763  major heat shock 70 kDa protein Ba [KO:K03283]
6550536  WASH complex subunit 4 [KO:K18465]
6544892  WASH complex subunit homolog 5 [KO:K18464]
6547093  WASH complex subunit 2 [KO:K18462]
6546891  WASH complex subunit 1 [KO:K18461]
6542295  WASH complex subunit 3 [KO:K18463]
6547739  F-actin-capping protein subunit alpha [KO:K10364]
6542656  F-actin-capping protein subunit beta [KO:K10365]
6542040  vacuolar protein sorting-associated protein 29 [KO:K18467]
6555714  vacuolar protein sorting-associated protein 26 [KO:K18466]
6548077  vacuolar protein sorting-associated protein 35 isoform X2 [KO:K18468]
6553681  sorting nexin-12 [KO:K17918]
6553489  ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
6555348  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
6555071  ras-related protein Rab-7a [KO:K07897]
6543096  hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
6543285  signal transducing adapter molecule 1 [KO:K04705]
6543627  tumor susceptibility gene 101 protein [KO:K12183]
6550271  multivesicular body subunit 12A isoform X2 [KO:K12186]
6543327  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
6555806  vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
6552296  vacuolar protein sorting-associated protein 37B [KO:K12185]
6554378  vacuolar-sorting protein SNF8 [KO:K12188]
6545564  vacuolar protein-sorting-associated protein 36 [KO:K12190]
6540921  vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189]
6546679  charged multivesicular body protein 6-A [KO:K12195]
6541040  charged multivesicular body protein 4c isoform X2 [KO:K12194]
6552091  charged multivesicular body protein 3 [KO:K12193]
6554408  charged multivesicular body protein 2a [KO:K12191]
6544045  charged multivesicular body protein 2b-B [KO:K12192]
6545925  charged multivesicular body protein 7 [KO:K15053]
6550218  vacuolar protein sorting-associated protein 4B [KO:K12196]
6545684  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
6546006  charged multivesicular body protein 1b [KO:K12197]
6546192  charged multivesicular body protein 5 [KO:K12198]
6544847  IST1 homolog isoform X1 [KO:K19476]
6554389  programmed cell death 6-interacting protein [KO:K12200]
6555255  cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
6542499  sorting nexin-2 [KO:K17917]
6541142  sorting nexin-32 isoform X2 [KO:K17920]
6544189  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
6548768  ras-like GTP-binding protein Rho1 [KO:K04513]
6541139  ras-related protein Rab-5B [KO:K07889]
6547815  rab GTPase-binding effector protein 1 [KO:K12480]
6542179  rabenosyn-5 [KO:K12481]
6554641  RUN and FYVE domain-containing protein 2 isoform X2 [KO:K12482]
6553741  EH domain-containing protein 1 [KO:K12483]
6551995  vacuolar protein sorting-associated protein 45 [KO:K12479]
6550367  ras-related protein Rab-10 [KO:K07903]
6545858  ras-related protein Rab-8A [KO:K07901]
6550373  ras-related protein Rab-35 [KO:K07876]
6553557  ras-related protein Rab-11A [KO:K07904]
6550236  nucleolar and coiled-body phosphoprotein 1 isoform X1 [KO:K12484]
6548646  kinesin heavy chain [KO:K10396]
6545705  rab11 family-interacting protein 4B isoform X3 [KO:K12485]
6550139  partitioning defective 3 homolog isoform X4 [KO:K04237]
6549770  partitioning defective protein 6 [KO:K06093]
6548974  atypical protein kinase C isoform X6 [KO:K06069] [EC:2.7.11.13]
6550501  cdc42 homolog [KO:K04393]
6542533  stromal membrane-associated protein 2 [KO:K12486]
6547354  ARF GTPase-activating protein GIT2 [KO:K12487]
6541269  arfGAP with SH3 domain, ANK repeat and PH domain-containing protein isoform X1 [KO:K12488]
6554777  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12489]
6540778  centaurin-gamma-1A isoform X2 [KO:K12491]
6545183  ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
6544239  ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
6555136  uncharacterized protein LOC6555136 [KO:K12494]
6546173  IQ motif and SEC7 domain-containing protein 1 isoform X2 [KO:K12495]
6548876  cytohesin-3 isoform X2 [KO:K18441]
6540931  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
6546841  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
6544260  ADP-ribosylation factor 1 [KO:K07937]
6555885  ADP-ribosylation factor 2 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
der04070  Phosphatidylinositol signaling system
der04130  SNARE interactions in vesicular transport
der04142  Lysosome
der04350  TGF-beta signaling pathway
KO pathway
ko04144   

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Genome (1)   
   KEGG GENOME (1)   
Gene (125)   
   KEGG GENES (125)   
All databases (126)   

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