KEGG   PATHWAY: dgr00983
Entry
dgr00983                    Pathway                                

Name
Drug metabolism - other enzymes - Drosophila grimshawi
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
dgr00983  Drug metabolism - other enzymes
dgr00983

Organism
Drosophila grimshawi [GN:dgr]
Gene
Dgri_GH12599  GH12599 gene product from transcript GH12599-RA [KO:K00088] [EC:1.1.1.205]
Dgri_GH10300  GH10300 gene product from transcript GH10300-RA [KO:K01951] [EC:6.3.5.2]
Dgri_GH18370  GH18370 gene product from transcript GH18370-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH10460  GH10460 gene product from transcript GH10460-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH10448  GH10448 gene product from transcript GH10448-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH19388  GH19388 gene product from transcript GH19388-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH19389  GH19389 gene product from transcript GH19389-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH19396  GH19396 gene product from transcript GH19396-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH18200  GH18200 gene product from transcript GH18200-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH19390  GH19390 gene product from transcript GH19390-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH19391  GH19391 gene product from transcript GH19391-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH19392  GH19392 gene product from transcript GH19392-RA [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Dgri_GH13806  GH13806 gene product from transcript GH13806-RA [KO:K01519] [EC:3.6.1.-]
Dgri_GH15533  GH15533 gene product from transcript GH15533-RA [KO:K01044] [EC:3.1.1.1]
Dgri_GH10674  GH10674 gene product from transcript GH10674-RA [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
Dgri_GH11213  GH11213 gene product from transcript GH11213-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH10546  GH10546 gene product from transcript GH10546-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH20997  GH20997 gene product from transcript GH20997-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH11567  GH11567 gene product from transcript GH11567-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH10101  GH10101 gene product from transcript GH10101-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH18173  GH18173 gene product from transcript GH18173-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH10731  GH10731 gene product from transcript GH10731-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH11568  GH11568 gene product from transcript GH11568-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH16953  GH16953 gene product from transcript GH16953-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH20333  GH20333 gene product from transcript GH20333-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH20037  GH20037 gene product from transcript GH20037-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH20036  GH20036 gene product from transcript GH20036-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH20035  GH20035 gene product from transcript GH20035-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH10545  GH10545 gene product from transcript GH10545-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH18740  GH18740 gene product from transcript GH18740-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH13698  GH13698 gene product from transcript GH13698-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH10547  GH10547 gene product from transcript GH10547-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH11566  GH11566 gene product from transcript GH11566-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH18172  GH18172 gene product from transcript GH18172-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH19421  GH19421 gene product from transcript GH19421-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH19422  GH19422 gene product from transcript GH19422-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH19423  GH19423 gene product from transcript GH19423-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH24981  GH24981 gene product from transcript GH24981-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH10108  GH10108 gene product from transcript GH10108-RA [KO:K00699] [EC:2.4.1.17]
Dgri_GH22628  GH22628 gene product from transcript GH22628-RA [KO:K01195] [EC:3.2.1.31]
Dgri_GH22627  GH22627 gene product from transcript GH22627-RA [KO:K01195] [EC:3.2.1.31]
Dgri_GH11513  GH11513 gene product from transcript GH11513-RA [KO:K01489] [EC:3.5.4.5]
Dgri_GH11514  GH11514 gene product from transcript GH11514-RA [KO:K01489] [EC:3.5.4.5]
Dgri_GH11515  GH11515 gene product from transcript GH11515-RA [KO:K01489] [EC:3.5.4.5]
Dgri_GH17755  GH17755 gene product from transcript GH17755-RA [KO:K00207] [EC:1.3.1.2]
Dgri_GH20890  GH20890 gene product from transcript GH20890-RA [KO:K01464] [EC:3.5.2.2]
Dgri_GH20891  GH20891 gene product from transcript GH20891-RA [KO:K01464] [EC:3.5.2.2]
Dgri_GH15883  GH15883 gene product from transcript GH15883-RA [KO:K01464] [EC:3.5.2.2]
Dgri_GH21956  GH21956 gene product from transcript GH21956-RA [KO:K01431] [EC:3.5.1.6]
Dgri_GH19395  GH19395 gene product from transcript GH19395-RA [KO:K00757] [EC:2.4.2.3]
Dgri_GH19384  GH19384 gene product from transcript GH19384-RA [KO:K00757] [EC:2.4.2.3]
Dgri_GH19373  GH19373 gene product from transcript GH19373-RA [KO:K00757] [EC:2.4.2.3]
Dgri_GH21395  GH21395 gene product from transcript GH21395-RA [KO:K00876] [EC:2.7.1.48]
Dgri_GH18807  GH18807 gene product from transcript GH18807-RA [KO:K00876] [EC:2.7.1.48]
Dgri_GH23167  GH23167 gene product from transcript GH23167-RA [KO:K13421] [EC:2.4.2.10 4.1.1.23]
Dgri_GH18143  GH18143 gene product from transcript GH18143-RA [KO:K13800] [EC:2.7.4.14]
Dgri_GH13371  GH13371 gene product from transcript GH13371-RA [KO:K10807] [EC:1.17.4.1]
Dgri_GH20400  GH20400 gene product from transcript GH20400-RA [KO:K10808] [EC:1.17.4.1]
Dgri_GH18934  GH18934 gene product from transcript GH18934-RA [KO:K00940] [EC:2.7.4.6]
Dgri_GH14091  GH14091 gene product from transcript GH14091-RA [KO:K00940] [EC:2.7.4.6]
Dgri_GH19407  GH19407 gene product from transcript GH19407-RA [KO:K00940] [EC:2.7.4.6]
Dgri_GH11937  GH11937 gene product from transcript GH11937-RA [KO:K00940] [EC:2.7.4.6]
Dgri_GH10478  GH10478 gene product from transcript GH10478-RA [KO:K01520] [EC:3.6.1.23]
Dgri_GH13103  GH13103 gene product from transcript GH13103-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH17521  GH17521 gene product from transcript GH17521-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH12207  GH12207 gene product from transcript GH12207-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH21668  GH21668 gene product from transcript GH21668-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH21669  GH21669 gene product from transcript GH21669-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH15974  GH15974 gene product from transcript GH15974-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH21671  GH21671 gene product from transcript GH21671-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20396  GH20396 gene product from transcript GH20396-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH13569  GH13569 gene product from transcript GH13569-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20218  GH20218 gene product from transcript GH20218-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH21620  GH21620 gene product from transcript GH21620-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH13113  GH13113 gene product from transcript GH13113-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH22936  GH22936 gene product from transcript GH22936-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH17734  GH17734 gene product from transcript GH17734-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH24640  GH24640 gene product from transcript GH24640-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH24641  GH24641 gene product from transcript GH24641-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20197  GH20197 gene product from transcript GH20197-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20186  GH20186 gene product from transcript GH20186-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20548  GH20548 gene product from transcript GH20548-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20559  GH20559 gene product from transcript GH20559-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH12904  GH12904 gene product from transcript GH12904-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH13568  GH13568 gene product from transcript GH13568-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH20570  GH20570 gene product from transcript GH20570-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH17520  GH17520 gene product from transcript GH17520-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH18970  GH18970 gene product from transcript GH18970-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH21542  GH21542 gene product from transcript GH21542-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH19714  GH19714 gene product from transcript GH19714-RA [KO:K00799] [EC:2.5.1.18]
Dgri_GH18587  GH18587 gene product from transcript GH18587-RA [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP17/USP/INN)
D00346  Isoniazid (JP17/USP/INN)
D00584  Fluorouracil (JP17/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP17/USAN/INN)
D01309  Doxifluridine (JP17/INN)
D01784  Carmofur (JP17/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   

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