KEGG   PATHWAY: dme00730
Entry
dme00730                    Pathway                                

Name
Thiamine metabolism - Drosophila melanogaster (fruit fly)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
dme00730  Thiamine metabolism
dme00730

Other DBs
GO: 0006772
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG12264  Nfs1; Nfs1 cysteine desulfurase [KO:K04487] [EC:2.8.1.7]
Dmel_CG10581  CG10581; uncharacterized protein [KO:K06928] [EC:3.6.1.15]
Dmel_CG3264  Alp8; alkaline phosphatase 8, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG3290  Alp2; alkaline phosphatase 2 [KO:K01077] [EC:3.1.3.1]
Dmel_CG3292  Alp7; alkaline phosphatase 7 [KO:K01077] [EC:3.1.3.1]
Dmel_CG8105  Alp11; alkaline phosphatase 11 [KO:K01077] [EC:3.1.3.1]
Dmel_CG10827  Alp5; alkaline phosphatase 5 [KO:K01077] [EC:3.1.3.1]
Dmel_CG1809  Alp6; alkaline phosphatase 6 [KO:K01077] [EC:3.1.3.1]
Dmel_CG16771  Alp12; alkaline phosphatase 12, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG10592  Alp10; alkaline phosphatase 10 [KO:K01077] [EC:3.1.3.1]
Dmel_CG5150  Alp9; alkaline phosphatase 9, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG5656  Alp1; alkaline phosphatase 1, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG8147  phu; phurba tashi [KO:K01077] [EC:3.1.3.1]
Dmel_CG1462  Alp4; alkaline phosphatase 4, isoform A [KO:K01077] [EC:3.1.3.1]
Dmel_CG5361  Alp13; alkaline phosphatase 13 [KO:K01077] [EC:3.1.3.1]
Dmel_CG33748  primo-1; primo-1, isoform B [KO:K14394] [EC:3.1.3.2 3.1.3.48]
Dmel_CG33747  primo-2 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
Dmel_CG31469  CG31469; uncharacterized protein [KO:K14394] [EC:3.1.3.2 3.1.3.48]
Dmel_CG14721  CG14721; uncharacterized protein, isoform B [KO:K00949] [EC:2.7.6.2]
Dmel_CG3140  Adk2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
Dmel_CG17146  Adk1; adenylate kinase 1, isoform A [KO:K00939] [EC:2.7.4.3]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
dme00010  Glycolysis / Gluconeogenesis
dme00230  Purine metabolism
dme00260  Glycine, serine and threonine metabolism
dme00270  Cysteine and methionine metabolism
dme00400  Phenylalanine, tyrosine and tryptophan biosynthesis
dme00750  Vitamin B6 metabolism
KO pathway
ko00730   

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