KEGG   PATHWAY: dme03040
Entry
dme03040                    Pathway                                

Name
Spliceosome - Drosophila melanogaster (fruit fly)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
dme03040  Spliceosome
dme03040

Other DBs
GO: 0005681
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CR31341  snRNA:U1:95Ca; small nuclear RNA U1 at 95C a [KO:K14276]
Dmel_CR31854  snRNA:U2:34ABb; small nuclear RNA U2 at 34AB b [KO:K14277]
Dmel_CR31850  snRNA:U2:34ABa; small nuclear RNA U2 at 34AB a [KO:K14277]
Dmel_CR33788  snRNA:U2:34ABc; small nuclear RNA U2 at 34AB c [KO:K14277]
Dmel_CR32882  snRNA:U2:38ABa; small nuclear RNA U2 at 38AB a [KO:K14277]
Dmel_CR32913  snRNA:U2:14B; small nuclear RNA U2 at 14B [KO:K14277]
Dmel_CR32878  snRNA:U2:38ABb; small nuclear RNA U2 at 38AB b [KO:K14277]
Dmel_CR31625  snRNA:U4:39B; small nuclear RNA U4 at 39B [KO:K14278]
Dmel_CR32879  snRNA:U4:38AB; small nuclear RNA U4 at 38AB [KO:K14278]
Dmel_CR32881  snRNA:U5:38ABa; small nuclear RNA U5 at 38AB a [KO:K14279]
Dmel_CR32880  snRNA:U5:38ABb; small nuclear RNA U5 at 38AB b [KO:K14279]
Dmel_CR32914  snRNA:U5:14B; small nuclear RNA U5 at 14B [KO:K14279]
Dmel_CR31379  snRNA:U6:96Aa; small nuclear RNA U6 at 96A a [KO:K14280]
Dmel_CR32867  snRNA:U6:96Ab; small nuclear RNA U6 at 96A b [KO:K14280]
Dmel_CR31539  snRNA:U6:96Ac; small nuclear RNA U6 at 96A c [KO:K14280]
Dmel_CG6227  CG6227; uncharacterized protein [KO:K12811] [EC:3.6.4.13]
Dmel_CG7269  Hel25E; helicase at 25E, isoform A [KO:K12812] [EC:3.6.4.13]
Dmel_CG10689  l(2)37Cb; lethal (2) 37Cb [KO:K12813] [EC:3.6.4.13]
Dmel_CG32604  l(1)G0007; lethal (1) G0007, isoform A [KO:K12815] [EC:3.6.4.13]
Dmel_CG6015  CG6015; uncharacterized protein [KO:K12816]
Dmel_CG6011  Prp18; Prp18 [KO:K12817]
Dmel_CG8241  pea; peanuts [KO:K12818] [EC:3.6.4.13]
Dmel_CG1420  Slu7; Slu7 [KO:K12819]
Dmel_CG11107  Dhx15; DEAH-box helicase 15, isoform B [KO:K12820] [EC:3.6.4.13]
Dmel_CG5352  SmB; small ribonucleoprotein particle protein SmB [KO:K11086]
Dmel_CG10753  SmD1; small ribonucleoprotein particle protein SmD1 [KO:K11087]
Dmel_CG1249  SmD2; small ribonucleoprotein particle protein SmD2 [KO:K11096]
Dmel_CG8427  SmD3; small ribonucleoprotein particle protein SmD3 [KO:K11088]
Dmel_CG18591  SmE; small ribonucleoprotein particle protein SmE [KO:K11097]
Dmel_CG16792  SmF; small ribonucleoprotein particle protein SmF [KO:K11098]
Dmel_CG9742  SNRPG; small nuclear ribonucleoprotein G, isoform B [KO:K11099]
Dmel_CG8749  snRNP-U1-70K; small ribonucleoprotein particle U1 subunit 70K, isoform C [KO:K11093]
Dmel_CG5454  snRNP-U1-C; small ribonucleoprotein particle U1 subunit C [KO:K11095]
Dmel_CG3542  CG3542; uncharacterized protein [KO:K12821]
Dmel_CG4119  CG4119; uncharacterized protein, isoform B [KO:K12822]
Dmel_CG10077  CG10077; uncharacterized protein, isoform D [KO:K12823] [EC:3.6.4.13]
Dmel_CG10279  Rm62; Rm62, isoform A [KO:K12823] [EC:3.6.4.13]
Dmel_CG10777  mahe; maheshvara, isoform C [KO:K12823] [EC:3.6.4.13]
Dmel_CG14443  CG14443; uncharacterized protein [KO:K12823] [EC:3.6.4.13]
Dmel_CG42724  CG42724; uncharacterized protein, isoform G [KO:K12824]
Dmel_CG3606  caz; cabeza, isoform B [KO:K13098]
Dmel_CG1406  U2A; U2A [KO:K11092]
Dmel_CG4528  snf; sans fille [KO:K11094]
Dmel_CG16941  Sf3a1; splicing factor 3a subunit 1 [KO:K12825]
Dmel_CG10754  Sf3a2; splicing factor 3a subunit 2 [KO:K12826]
Dmel_CG2925  noi; noisette [KO:K12827]
Dmel_CG2807  Sf3b1; splicing factor 3b subunit 1, isoform B [KO:K12828]
Dmel_CG3605  Sf3b2; splicing factor 3b subunit 2, isoform B [KO:K12829]
Dmel_CG13900  Sf3b3; splicing factor 3b subunit 3, isoform A [KO:K12830]
Dmel_CG3780  Spx; spliceosomal protein on the X [KO:K12831]
Dmel_CG11985  Sf3b5; splicing factor 3b subunit 5 [KO:K12832]
Dmel_CG13298  Sf3b6; splicing factor 3b subunit 6 [KO:K12833]
Dmel_CG9548  Phf5a; PHD finger protein 5a [KO:K12834]
Dmel_CG6418  CG6418; uncharacterized protein [KO:K12835] [EC:3.6.4.13]
Dmel_CG3582  U2af38; U2 small nuclear riboprotein auxiliary factor 38, isoform B [KO:K12836]
Dmel_CG9998  U2af50; U2 small nuclear riboprotein auxiliary factor 50, isoform D [KO:K12837]
Dmel_CG3162  LS2; large subunit 2 [KO:K12837]
Dmel_CG12085  hfp; half pint, isoform A [KO:K12838]
Dmel_CG17454  CG17454; uncharacterized protein, isoform A [KO:K12839]
Dmel_CG17540  Spf45; Spf45, isoform C [KO:K12840]
Dmel_CG33522  scaf6; SR-related CTD associated factor 6, isoform A [KO:K12841]
Dmel_CG9346  CG9346; uncharacterized protein [KO:K12842]
Dmel_CG10418  CG10418; uncharacterized protein [KO:K12621]
Dmel_CG31184  LSm3; like Sm 3, isoform B [KO:K12622]
Dmel_CG17768  CG17768; uncharacterized protein, isoform A [KO:K12623]
Dmel_CG6610  CG6610; uncharacterized protein, isoform B [KO:K12624]
Dmel_CG9344  CG9344; uncharacterized protein [KO:K12625]
Dmel_CG13277  LSm7; like Sm 7, isoform B [KO:K12626]
Dmel_CG2021  CG2021; uncharacterized protein [KO:K12627]
Dmel_CG7757  Prp3; precursor RNA processing 3, isoform A [KO:K12843]
Dmel_CG6322  U4-U6-60K; U4-U6 small nuclear riboprotein factor 60K [KO:K12662]
Dmel_CG17266  CG17266; uncharacterized protein, isoform B [KO:K09567] [EC:5.2.1.8]
Dmel_CG6876  Prp31; Pre-mRNA processing factor 31 [KO:K12844]
Dmel_CG3949  hoip; hoi-polloi, isoform B [KO:K12845]
Dmel_CG18426  ytr; yantar, isoform B [KO:K12846]
Dmel_CG7288  Usp39; ubiquitin specific protease 39 [KO:K12847]
Dmel_CG6686  CG6686; uncharacterized protein, isoform B [KO:K11984]
Dmel_CG11586  CG11586; uncharacterized protein, isoform B [KO:K12848]
Dmel_CG30342  Prp38; pre-mRNA processing factor 38 [KO:K12849]
Dmel_CG1622  CG1622; uncharacterized protein, isoform B [KO:K12850]
Dmel_CG4849  CG4849; uncharacterized protein [KO:K12852]
Dmel_CG5931  l(3)72Ab; lethal (3) 72Ab [KO:K12854] [EC:3.6.4.13]
Dmel_CG6841  CG6841; uncharacterized protein, isoform B [KO:K12855]
Dmel_CG8877  Prp8; pre-mRNA processing factor 8 [KO:K12856]
Dmel_CG3436  CG3436; uncharacterized protein, isoform C [KO:K12857]
Dmel_CG10333  CG10333; uncharacterized protein [KO:K12858] [EC:3.6.4.13]
Dmel_CG3058  Dim1; Dim1 [KO:K12859]
Dmel_CG5519  Prp19; Pre-RNA processing factor 19 [KO:K10599] [EC:2.3.2.27]
Dmel_CG6905  Cdc5; cell division cycle 5, isoform B [KO:K12860]
Dmel_CG4980  BCAS2; BCAS2 [KO:K12861]
Dmel_CG1796  Tango4; transport and golgi organization 4 [KO:K12862]
Dmel_CG12135  c12.1; c12.1 [KO:K12863]
Dmel_CG11964  CG11964; uncharacterized protein [KO:K12864]
Dmel_CG4264  Hsc70-4; heat shock protein cognate 4, isoform G [KO:K03283]
Dmel_CG18743  Hsp70Ab; Heat-shock-protein-70Ab [KO:K03283]
Dmel_CG31366  Hsp70Aa; Heat-shock-protein-70Aa [KO:K03283]
Dmel_CG7756  Hsc70-2; heat shock protein cognate 2 [KO:K03283]
Dmel_CG5436  Hsp68; heat shock protein 68 [KO:K03283]
Dmel_CG31359  Hsp70Bb; Heat-shock-protein-70Bb [KO:K03283]
Dmel_CG5834  Hsp70Bbb [KO:K03283]
Dmel_CG31449  Hsp70Ba; Heat-shock-protein-70Ba [KO:K03283]
Dmel_CG6489  Hsp70Bc; Heat-shock-protein-70Bc [KO:K03283]
Dmel_CG8937  Hsc70-1; heat shock protein cognate 1, isoform A [KO:K03283]
Dmel_CG11820  PQBP1; Poly-glutamine tract binding protein 1 [KO:K12865]
Dmel_CG2685  CG2685; uncharacterized protein [KO:K12866]
Dmel_CG8264  Bx42; Bx42, isoform B [KO:K06063]
Dmel_CG6197  fand; fandango [KO:K12867]
Dmel_CG12343  CG12343; uncharacterized protein [KO:K12868]
Dmel_CG3193  crn; crooked neck [KO:K12869]
Dmel_CG9667  CG9667; uncharacterized protein, isoform B [KO:K12870]
Dmel_CG13892  Cypl; Cyclophilin-like [KO:K12733] [EC:5.2.1.8]
Dmel_CG4886  cyp33; cyclophilin-33 [KO:K09564] [EC:5.2.1.8]
Dmel_CG15525  CG15525; uncharacterized protein [KO:K12871]
Dmel_CG14641  CG14641; uncharacterized protein [KO:K12872]
Dmel_CG1639  l(1)10Bb; lethal (1) 10Bb [KO:K12873]
Dmel_CG31368  CG31368; uncharacterized protein, isoform C [KO:K12874]
Dmel_CG10473  Acn; acinus, isoform C [KO:K12875]
Dmel_CG7483  CG7483; uncharacterized protein [KO:K13025] [EC:3.6.4.13]
Dmel_CG8781  tsu; tsunagi [KO:K12876]
Dmel_CG9401  mago; mago nashi [KO:K12877]
Dmel_CG2031  Hpr1; Hpr1 [KO:K12878]
Dmel_CG31671  tho2; tho2, isoform C [KO:K12879]
Dmel_CG9615  tex; tex [KO:K12880]
Dmel_CG1101  Ref1; RNA and export factor binding protein 1 [KO:K12881]
Dmel_CG17031  Ref2; RNA and export factor binding protein 2, isoform B [KO:K12881]
Dmel_CG7035  Cbp80; cap binding protein 80, isoform B [KO:K12882]
Dmel_CG7907  CG7907; uncharacterized protein, isoform B [KO:K12882]
Dmel_CG12357  Cbp20; cap binding protein 20 [KO:K12883]
Dmel_CG9983  Hrb98DE; heterogeneous nuclear ribonucleoprotein at 98DE, isoform B [KO:K12741]
Dmel_CG12749  Hrb87F; heterogeneous nuclear ribonucleoprotein at 87F, isoform C [KO:K12741]
Dmel_CG13425  HnRNP-K; heterogeneous nuclear ribonucleoprotein K, isoform E [KO:K12886]
Dmel_CG6987  SF2; splicing factor 2, isoform B [KO:K12890]
Dmel_CG5442  SC35; SR family splicing factor SC35, isoform C [KO:K12891]
Dmel_CG10851  B52; B52, isoform O [KO:K12893]
Dmel_CG10203  x16; x16 splicing factor, isoform B [KO:K12896]
Dmel_CG10128  tra2; transformer 2, isoform A [KO:K12897]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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