KEGG   PATHWAY: dme04120
dme04120                    Pathway                                

Ubiquitin mediated proteolysis - Drosophila melanogaster (fruit fly)
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dme04120  Ubiquitin mediated proteolysis

Other DBs
GO: 0016567
Drosophila melanogaster (fruit fly) [GN:dme]
Dmel_CG32744  Ubi-p5E; Ubiquitin-5E, isoform B [KO:K08770]
Dmel_CG11700  CG11700; uncharacterized protein [KO:K08770]
Dmel_CG11624  Ubi-p63E; Ubiquitin-63E, isoform D [KO:K08770]
Dmel_CG2960  RpL40; ribosomal protein L40, isoform B [KO:K02927]
Dmel_CG5271  RpS27A; ribosomal protein S27A [KO:K02977]
Dmel_CG1782  Uba1; ubiquitin activating enzyme 1, isoform C [KO:K03178] [EC:]
Dmel_CG12276  Aos1; activator of SUMO 1 [KO:K10684] [EC:]
Dmel_CG7528  Uba2; Ubiquitin-like activating enzyme 2 [KO:K10685] [EC:]
Dmel_CG13343  Uba3; Ubiquitin-like activating enzyme 3 [KO:K10686] [EC:]
Dmel_CG2013  Ubc6; ubiquitin conjugating enzyme 6, isoform C [KO:K10573] [EC:]
Dmel_CG10682  vih; vihar [KO:K06688] [EC:]
Dmel_CG7425  eff; effete, isoform B [KO:K06689] [EC:]
Dmel_CG2574  CG2574; uncharacterized protein [KO:K20217] [EC:]
Dmel_CG5440  CG5440; uncharacterized protein, isoform C [KO:K20217] [EC:]
Dmel_CG6720  Ubc2; ubiquitin conjugating enzyme 2, isoform C [KO:K20217] [EC:]
Dmel_CG40045  CG40045; uncharacterized protein, isoform A [KO:K10575] [EC:]
Dmel_CG9602  Ubc87F; ubiquitin conjugating enzyme 87F [KO:K10575] [EC:]
Dmel_CG4443  Ubc7; ubiquitin conjugating enzyme 7, isoform B [KO:K04555] [EC:]
Dmel_CG2257  UbcE2H; ubiquitin conjugating enzyme E2H, isoform B [KO:K10576] [EC:]
Dmel_CG14739  CG14739; uncharacterized protein [KO:K10576] [EC:]
Dmel_CG3018  lwr; lesswright, isoform C [KO:K10577]
Dmel_CG5823  CG5823; uncharacterized protein, isoform B [KO:K04554] [EC:]
Dmel_CG12799  Ubc84D; ubiquitin conjugating enzyme 84D [KO:K04552] [EC:]
Dmel_CG5788  Ubc10; ubiquitin conjugating enzyme 10 [KO:K04552] [EC:]
Dmel_CG17030  CG17030; uncharacterized protein [KO:K04552] [EC:]
Dmel_CG7375  UbcE2M; NEDD8-conjugating enzyme UbcE2M, isoform B [KO:K10579] [EC:]
Dmel_CG18319  ben; bendless, isoform B [KO:K10580] [EC:]
Dmel_CG3473  CG3473; uncharacterized protein, isoform B [KO:K10580] [EC:]
Dmel_CG10254  CG10254; uncharacterized protein, isoform C [KO:K10581] [EC:]
Dmel_CG2924  CG2924; uncharacterized protein, isoform E [KO:K10582] [EC:]
Dmel_CG4502  CG4502; uncharacterized protein, isoform A [KO:K10582] [EC:]
Dmel_CG7656  CG7656; uncharacterized protein, isoform F [KO:K02207] [EC:]
Dmel_CG8188  CG8188; uncharacterized protein, isoform B [KO:K10583] [EC:]
Dmel_CG7220  CG7220; uncharacterized protein, isoform E [KO:K10688] [EC:]
Dmel_CG8284  Ubc4; ubiquitin conjugating enzyme 4, isoform B [KO:K04649] [EC:]
Dmel_CG6303  Bruce; BIR repeat containing ubiquitin-conjugating enzyme, isoform B [KO:K10586] [EC:]
Dmel_CG6190  Ube3a; ubiquitin protein ligase E3A [KO:K10587] [EC:]
Dmel_CG5087  CG5087; uncharacterized protein, isoform B [KO:K10588] [EC:]
Dmel_CG3356  CG3356; uncharacterized protein [KO:K10589] [EC:]
Dmel_CG4943  Smurf; SMAD specific E3 ubiquitin protein ligase, isoform B [KO:K04678] [EC:]
Dmel_CG4244  Su(dx); suppressor of deltex, isoform F [KO:K05633] [EC:]
Dmel_CG42574  ctrip; circadian trip, isoform B [KO:K10590] [EC:]
Dmel_CG42279  Nedd4; Nedd4, isoform J [KO:K10591] [EC:]
Dmel_CG8184  HUWE1; HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform H [KO:K10592] [EC:]
Dmel_CG9484  hyd; hyperplastic discs, isoform A [KO:K10593] [EC:]
Dmel_CG11734  HERC2; HECT and RLD domain containing protein 2 [KO:K10595] [EC:]
Dmel_CG9153  Herc4; HECT and RLD domain containing E3 ubiquitin ligase 4, isoform C [KO:K10615] [EC:]
Dmel_CG11070  CG11070; uncharacterized protein [KO:K10596] [EC:]
Dmel_CG9934  CG9934; uncharacterized protein, isoform B [KO:K10597] [EC:]
Dmel_CG5203  STUB1; STIP1 homology and U-box containing protein 1 [KO:K09561] [EC:]
Dmel_CG7747  CG7747; uncharacterized protein [KO:K10598] [EC:]
Dmel_CG5519  Prp19; Pre-RNA processing factor 19 [KO:K10599] [EC:]
Dmel_CG2218  CG2218; uncharacterized protein, isoform B [KO:K10600]
Dmel_CG7037  Cbl; Cbl proto-oncogene, isoform B [KO:K04707] [EC:]
Dmel_CG10523  park; parkin, isoform B [KO:K04556] [EC:]
Dmel_CG9949  sina; seven in absentia, isoform C [KO:K04506] [EC:]
Dmel_CG13030  sinah; sina homologue [KO:K04506] [EC:]
Dmel_CG10961  Traf6; TNF-receptor-associated factor 6 [KO:K03175] [EC:]
Dmel_CG16947  Rchy1; ring finger and CHY zinc finger domain containing 1, isoform B [KO:K10144] [EC:]
Dmel_CG8293  Diap2; Death-associated inhibitor of apoptosis 2, isoform A [KO:K16060]
Dmel_CG12284  Diap1; Death-associated inhibitor of apoptosis 1, isoform D [KO:K16061]
Dmel_CG8068  Su(var)2-10; suppressor of variegation 2-10, isoform J [KO:K04706] [EC:2.3.2.-]
Dmel_CG1937  sip3; septin interacting protein 3, isoform B [KO:K10601] [EC:]
Dmel_CG12812  Fancl; fancl, isoform B [KO:K10606] [EC:]
Dmel_CG16982  Roc1a; regulator of cullins 1a, isoform D [KO:K03868] [EC:]
Dmel_CG16988  Roc1b; regulator of cullins 1b [KO:K03868] [EC:]
Dmel_CG1877  Cul1; cullin 1, isoform D [KO:K03347]
Dmel_CG11261  Cul6; cullin 6 [KO:K03347]
Dmel_CG16983  SkpA; SKP1-related A, isoform H [KO:K03094]
Dmel_CG12227  SkpF; SKP1-related F [KO:K03094]
Dmel_CG8881  SkpB; SKP1-related B [KO:K03094]
Dmel_CG11942  SkpE; SKP1-related E [KO:K03094]
Dmel_CG11941  SkpC; SKP1-related C [KO:K03094]
Dmel_CG12700  SkpD; SKP1-related D [KO:K03094]
Dmel_CG15800  CG15800; uncharacterized protein [KO:K03094]
Dmel_CG43089  CG43089; uncharacterized protein, isoform B [KO:K03094]
Dmel_CG3412  slmb; supernumerary limbs, isoform C [KO:K03362]
Dmel_CG9772  Skp2; S-phase kinase-associated protein 2, isoform A [KO:K03875]
Dmel_CG15010  ago; archipelago, isoform C [KO:K10260]
Dmel_CG1512  Cul2; cullin 2, isoform B [KO:K03870]
Dmel_CG9291  EloC; elongin C, isoform B [KO:K03872]
Dmel_CG4204  EloB; elongin B [KO:K03873]
Dmel_CG13221  Vhl; von Hippel-Lindau, isoform B [KO:K03871]
Dmel_CG42616  Cul3; cullin 3, isoform C [KO:K03869]
Dmel_CG3962  Keap1; Keap1, isoform A [KO:K10456]
Dmel_CG5701  RhoBTB; Rho-related BTB domain containing, isoform B [KO:K07868]
Dmel_CG8711  Cul4; cullin 4, isoform B [KO:K10609]
Dmel_CG7769  pic; piccolo [KO:K10610]
Dmel_CG6093  abo; abnormal oocyte [KO:K10571]
Dmel_CG8998  Roc2; regulator of cullins 2, isoform B [KO:K10611]
Dmel_CG1401  Cul5; cullin 5 [KO:K10612]
Dmel_CG34440  lmgA; lemming A, isoform A [KO:K03358]
Dmel_CG3060  mr; morula [KO:K03349]
Dmel_CG4274  fzy; fizzy [KO:K03363]
Dmel_CG16783  fzr2; fizzy-related 2 [KO:K03364]
Dmel_CG3000  fzr; fizzy-related, isoform A [KO:K03364]
Dmel_CG9198  shtd; shattered [KO:K03348]
Dmel_CG8610  Cdc27; cell division cycle 27, isoform B [KO:K03350]
Dmel_CG32707  APC4; anaphase promoting complex subunit 4, isoform C [KO:K03351]
Dmel_CG10850  ida; imaginal discs arrested [KO:K03352]
Dmel_CG6759  Cdc16; cell division cycle 16 [KO:K03353]
Dmel_CG14444  APC7; anaphase promoting complex subunit 7, isoform A [KO:K03354]
Dmel_CG2508  Cdc23; cell division cycle 23, isoform B [KO:K03355]
Dmel_CG31687  CG31687; uncharacterized protein, isoform B [KO:K03355]
Dmel_CG11419  APC10; anaphase promoting complex subunit 10 [KO:K03357]
Dmel_CG33981  CG33981; uncharacterized protein, isoform A [KO:K12456]
PMID:16922370 (Japanese)
Kamura T.
[Cullin-based E3 family] Japanese
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
PMID:16922408 (Japanese)
Matsuda N.
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
PMID:16922367 (Japanese)
Tokunaga F.
[E2 ubiquitin-conjugating enzymes: structures and functions]
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Nalepa G, Rolfe M, Harper JW.
Drug discovery in the ubiquitin-proteasome system.
Nat Rev Drug Discov 5:596-613 (2006)
Hsu YJ, Goodman SR.
Spectrin and ubiquitination: a review.
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Hatakeyama S, Nakayama KI.
Ubiquitylation as a quality control system for intracellular proteins.
J Biochem 134:1-8 (2003)
Lee J, Zhou P.
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Mol Cell 26:775-80 (2007)
dme03050  Proteasome
KO pathway

DBGET integrated database retrieval system