KEGG   PATHWAY: dme04144
Entry
dme04144                    Pathway                                

Name
Endocytosis - Drosophila melanogaster (fruit fly)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dme04144  Endocytosis
dme04144

Other DBs
GO: 0006897
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG8156  Arf51F; ADP ribosylation factor at 51F, isoform A [KO:K07941]
Dmel_CG9985  sktl; skittles, isoform B [KO:K00889] [EC:2.7.1.68]
Dmel_CG3682  PIP5K59B; phosphatidylinositol 4-phosphate 5-kinase 59B, isoform I [KO:K00889] [EC:2.7.1.68]
Dmel_CG17471  PIP4K; phosphatidylinositol 5-phosphate 4-kinase, isoform B [KO:K00889] [EC:2.7.1.68]
Dmel_CG12110  Pld; phospholipase D, isoform F [KO:K01115] [EC:3.1.4.4]
Dmel_CG18102  shi; shibire, isoform J [KO:K01528] [EC:3.6.5.5]
Dmel_CG9012  Chc; clathrin heavy chain, isoform E [KO:K04646]
Dmel_CG4260  AP-2alpha; adaptor protein complex 2, alpha subunit, isoform A [KO:K11824]
Dmel_CG7057  AP-2mu; adaptor protein complex 2, mu subunit, isoform C [KO:K11826]
Dmel_CG6056  AP-2sigma; adaptor protein complex 2, sigma subunit [KO:K11827]
Dmel_CG8224  babo; baboon, isoform C [KO:K04674] [EC:2.7.11.30]
Dmel_CG15667  Sara; smad anchor for receptor activation [KO:K04679]
Dmel_CG2262  Smox; smad on X, isoform B [KO:K23605]
Dmel_CG10079  Egfr; epidermal growth factor receptor, isoform B [KO:K04361] [EC:2.7.10.1]
Dmel_CG32134  btl; breathless, isoform B [KO:K05093] [EC:2.7.10.1]
Dmel_CG7223  htl; heartless, isoform B [KO:K05094] [EC:2.7.10.1]
Dmel_CG18402  InR; Insulin-like receptor, isoform B [KO:K05087] [EC:2.7.10.1]
Dmel_CG7037  Cbl; Cbl proto-oncogene, isoform B [KO:K04707] [EC:2.3.2.27]
Dmel_CG14296  EndoA; endophilin A, isoform C [KO:K11247]
Dmel_CG9834  EndoB; endophilin B, isoform C [KO:K11248]
Dmel_CG8604  Amph; amphiphysin, isoform B [KO:K12562]
Dmel_CG8532  lqf; liquid facets, isoform F [KO:K12471]
Dmel_CG16932  Eps-15; epidermal growth factor receptor pathway substrate clone 15, isoform D [KO:K12472]
Dmel_CG12001  spartin; spartin, isoform B [KO:K19366]
Dmel_CG42279  Nedd4; Nedd4, isoform J [KO:K10591] [EC:2.3.2.26]
Dmel_CG10961  Traf6; TNF-receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
Dmel_CG9014  CG9014; uncharacterized protein, isoform B [KO:K11981] [EC:2.3.2.27]
Dmel_CG17033  elgi; early girl, isoform B [KO:K11981] [EC:2.3.2.27]
Dmel_CG4943  Smurf; SMAD specific E3 ubiquitin protein ligase, isoform B [KO:K04678] [EC:2.3.2.26]
Dmel_CG4244  Su(dx); suppressor of deltex, isoform F [KO:K05633] [EC:2.3.2.26]
Dmel_CG9695  Dab; disabled, isoform A [KO:K12475]
Dmel_CG40129  Gprk1; G protein-coupled receptor kinase 1, isoform A [KO:K00910] [EC:2.7.11.15]
Dmel_CG17998  Gprk2; G protein-coupled receptor kinase 2, isoform B [KO:K08291] [EC:2.7.11.16]
Dmel_CG1487  krz; kurtz, isoform B [KO:K04439]
Dmel_CG1520  WASp; WASp, isoform D [KO:K23612]
Dmel_CG8978  Arpc1; Actin-related protein 2/3 complex, subunit 1, isoform A [KO:K05757]
Dmel_CG10954  Arpc2; Actin-related protein 2/3 complex, subunit 2, isoform B [KO:K05758]
Dmel_CG8936  Arpc3B; Actin-related protein 2/3 complex, subunit 3B, isoform B [KO:K05756]
Dmel_CG4560  Arpc3A; Actin-related protein 2/3 complex, subunit 3A, isoform C [KO:K05756]
Dmel_CG5972  Arpc4; Actin-related protein 2/3 complex, subunit 4 [KO:K05755]
Dmel_CG9881  Arpc5; Actin-related protein 2/3 complex, subunit 5, isoform B [KO:K05754]
Dmel_CG13503  Vrp1; verprolin 1, isoform G [KO:K19475]
Dmel_CG4264  Hsc70-4; heat shock protein cognate 4, isoform G [KO:K03283]
Dmel_CG18743  Hsp70Ab; Heat-shock-protein-70Ab [KO:K03283]
Dmel_CG31366  Hsp70Aa; Heat-shock-protein-70Aa [KO:K03283]
Dmel_CG7756  Hsc70-2; heat shock protein cognate 2 [KO:K03283]
Dmel_CG5436  Hsp68; heat shock protein 68 [KO:K03283]
Dmel_CG31359  Hsp70Bb; Heat-shock-protein-70Bb [KO:K03283]
Dmel_CG5834  Hsp70Bbb [KO:K03283]
Dmel_CG31449  Hsp70Ba; Heat-shock-protein-70Ba [KO:K03283]
Dmel_CG6489  Hsp70Bc; Heat-shock-protein-70Bc [KO:K03283]
Dmel_CG8937  Hsc70-1; heat shock protein cognate 1, isoform A [KO:K03283]
Dmel_CG13957  SWIP; strumpellin and WASH-interacting protein [KO:K18465]
Dmel_CG12272  Strump; strumpellin, isoform B [KO:K18464]
Dmel_CG16742  FAM21; family with sequence similarity 21 [KO:K18462]
Dmel_CG13176  wash; washout, isoform B [KO:K18461]
Dmel_CG7429  CCDC53; Coiled-coil domain containing 53 [KO:K18463]
Dmel_CG10540  cpa; capping protein alpha [KO:K10364]
Dmel_CG17158  cpb; capping protein beta, isoform B [KO:K10365]
Dmel_CG4764  Vps29; vacuolar protein sorting 29 [KO:K18467]
Dmel_CG14804  Vps26; vacuolar protein sorting 26 [KO:K18466]
Dmel_CG5625  Vps35; vacuolar protein sorting 35, isoform A [KO:K18468]
Dmel_CG6359  Snx3; sorting nexin 3, isoform A [KO:K17918]
Dmel_CG5798  Usp8; ubiquitin specific protease 8, isoform B [KO:K11839] [EC:3.4.19.12]
Dmel_CG2224  CG2224; uncharacterized protein, isoform B [KO:K11866] [EC:3.4.19.12]
Dmel_CG5915  Rab7; Rab7, isoform B [KO:K07897]
Dmel_CG2903  Hrs; hepatocyte growth factor regulated tyrosine kinase substrate, isoform B [KO:K12182]
Dmel_CG6521  Stam; signal transducing adaptor molecule [KO:K04705]
Dmel_CG9712  TSG101; tumor susceptibility gene 101 [KO:K12183]
Dmel_CG7192  Mvb12; multivesicular body subunit 12, isoform D [KO:K12186]
Dmel_CG12770  Vps28; vacuolar protein sorting 28, isoform B [KO:K12184]
Dmel_CG1115  Vps37B; vacuolar protein sorting 37B, isoform B [KO:K12185]
Dmel_CG17828  Vsp37A; vacuolar protein sorting 37A, isoform E [KO:K12185]
Dmel_CG6637  lsn; larsen [KO:K12188]
Dmel_CG10711  Vps36; vacuolar protein sorting 36 [KO:K12190]
Dmel_CG14750  Vps25; vacuolar protein sorting 25 [KO:K12189]
Dmel_CG4071  Vps20; vacuolar protein sorting 20, isoform C [KO:K12195]
Dmel_CG8055  shrb; shrub [KO:K12194]
Dmel_CG9779  Vps24; vacuolar protein sorting 24, isoform B [KO:K12193]
Dmel_CG14542  Vps2; vacuolar protein sorting 2 [KO:K12191]
Dmel_CG4618  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
Dmel_CG5498  CG5498; uncharacterized protein [KO:K15053]
Dmel_CG6842  Vps4; vacuolar protein sorting 4, isoform B [KO:K12196]
Dmel_CG7967  Vta1; vesicle trafficking 1 [KO:K12199]
Dmel_CG4108  Chmp1; charged multivesicular body protein 1, isoform B [KO:K12197]
Dmel_CG6259  Vps60; vacuolar protein sorting 60, isoform B [KO:K12198]
Dmel_CG10103  Ist1; Ist1, isoform B [KO:K19476]
Dmel_CG12876  ALiX; ALG-2 interacting protein X [KO:K12200]
Dmel_CG31072  Lerp; lysosomal enzyme receptor protein, isoform E [KO:K06564]
Dmel_CG2774  Snx1; sorting nexin 1, isoform B [KO:K17917]
Dmel_CG8282  Snx6; sorting nexin 6, isoform B [KO:K17920]
Dmel_CG7524  Src64B; Src oncogene at 64B, isoform D [KO:K05704] [EC:2.7.10.2]
Dmel_CG8416  Rho1; Rho1, isoform A [KO:K04513]
Dmel_CG3664  Rab5; Rab5, isoform G [KO:K07889]
Dmel_CG4030  Rbpn-5; Rabaptin-5 [KO:K12480]
Dmel_CG8506  Rbsn-5; Rabenosyn-5 [KO:K12481]
Dmel_CG6148  Past1; putative achaete scute target 1, isoform B [KO:K12483]
Dmel_CG8228  Vps45; vacuolar protein sorting 45 [KO:K12479]
Dmel_CG17060  Rab10; Rab10 [KO:K07903]
Dmel_CG8287  Rab8; Rab8, isoform B [KO:K07901]
Dmel_CG9575  Rab35; Rab35, isoform B [KO:K07876]
Dmel_CG5771  Rab11; Rab11, isoform B [KO:K07904]
Dmel_CG6606  Rip11; Rab11 interacting protein, isoform B [KO:K12484]
Dmel_CG7765  Khc; kinesin heavy chain [KO:K10396]
Dmel_CG33991  nuf; nuclear fallout, isoform F [KO:K12485]
Dmel_CG5055  baz; bazooka, isoform B [KO:K04237]
Dmel_CG5884  par-6; par-6, isoform A [KO:K06093]
Dmel_CG42783  aPKC; atypical protein kinase C, isoform C [KO:K06069] [EC:2.7.11.13]
Dmel_CG12530  Cdc42; Cdc42, isoform C [KO:K04393]
Dmel_CG8243  CG8243; uncharacterized protein [KO:K12486]
Dmel_CG16728  Git; G protein-coupled receptor kinase interacting ArfGAP [KO:K12487]
Dmel_CG30372  Asap; ArfGAP with SH3 domain, ankyrin repeat and PH domain, isoform B [KO:K12488]
Dmel_CG6742  CenB1A; centaurin beta 1A, isoform A [KO:K12489]
Dmel_CG31811  CenG1A; centaurin gamma 1A, isoform B [KO:K12491]
Dmel_CG4237  ArfGAP1; ADP-ribosylation factor GTPase activating protein 1, isoform B [KO:K12492]
Dmel_CG6838  ArfGAP3; ADP-ribosylation factor GTPase activating protein 3, isoform C [KO:K12493]
Dmel_CG31158  Efa6; exchange factor for Arf 6, isoform H [KO:K12494]
Dmel_CG32434  siz; schizo, isoform C [KO:K12495]
Dmel_CG11628  step; steppke, isoform C [KO:K18441]
Dmel_CG7578  Sec71; secretory 71 [KO:K18442]
Dmel_CG8487  garz; gartenzwerg, isoform C [KO:K18443]
Dmel_CG8385  Arf79F; ADP ribosylation factor at 79F, isoform F [KO:K07937]
Dmel_CG11027  Arf102F; ADP ribosylation factor at 102F, isoform B [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dme04070  Phosphatidylinositol signaling system
dme04130  SNARE interactions in vesicular transport
dme04142  Lysosome
dme04350  TGF-beta signaling pathway
KO pathway
ko04144   

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