KEGG   PATHWAY: dpo04145
Entry
dpo04145                    Pathway                                

Name
Phagosome - Drosophila pseudoobscura pseudoobscura
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
dpo04145  Phagosome
dpo04145

Other DBs
GO: 0045335
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA18647  uncharacterized protein [KO:K08488]
Dpse_GA17886  uncharacterized protein, isoform A [KO:K05692]
Dpse_GA12418  uncharacterized protein [KO:K08492]
Dpse_GA20293  uncharacterized protein [KO:K08517]
Dpse_GA25944  uncharacterized protein [KO:K07887]
Dpse_GA17598  uncharacterized protein, isoform A [KO:K07889]
Dpse_GA18829  uncharacterized protein [KO:K00914] [EC:2.7.1.137]
Dpse_GA15506  uncharacterized protein [KO:K12182]
Dpse_GA11612  uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dpse_GA28953  uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dpse_GA18641  uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dpse_GA14484  uncharacterized protein, isoform A [KO:K02147]
Dpse_GA12092  uncharacterized protein [KO:K02149]
Dpse_GA20878  uncharacterized protein [KO:K02149]
Dpse_GA20975  uncharacterized protein [KO:K02149]
Dpse_GA10614  uncharacterized protein [KO:K02150]
Dpse_GA20901  Dpse_Vha14; Vha14 [KO:K02151]
Dpse_GA26491  uncharacterized protein, isoform A [KO:K02151]
Dpse_GA13911  uncharacterized protein [KO:K02151]
Dpse_GA19444  uncharacterized protein [KO:K02152]
Dpse_GA20488  uncharacterized protein [KO:K02153]
Dpse_GA13345  uncharacterized protein [KO:K02153]
Dpse_GA11753  uncharacterized protein [KO:K02153]
Dpse_GA11084  uncharacterized protein [KO:K02153]
Dpse_GA20518  uncharacterized protein [KO:K02154]
Dpse_GA11714  uncharacterized protein [KO:K02154]
Dpse_GA15764  uncharacterized protein [KO:K02154]
Dpse_GA14320  uncharacterized protein, isoform H [KO:K02154]
Dpse_GA15015  uncharacterized protein [KO:K02154]
Dpse_GA15530  uncharacterized protein [KO:K02146]
Dpse_GA18311  uncharacterized protein [KO:K02146]
Dpse_GA14464  uncharacterized protein, isoform A [KO:K02144]
Dpse_GA16335  uncharacterized protein [KO:K02155]
Dpse_GA21477  uncharacterized protein [KO:K02155]
Dpse_GA26306  uncharacterized protein [KO:K02155]
Dpse_GA25245  uncharacterized protein, isoform A [KO:K02155]
Dpse_GA26304  uncharacterized protein, isoform A [KO:K02155]
Dpse_GA20025  uncharacterized protein, isoform A [KO:K03661]
Dpse_GA26375  uncharacterized protein [KO:K03661]
Dpse_GA20777  uncharacterized protein, isoform A [KO:K03662]
Dpse_GA29225  uncharacterized protein [KO:K07897]
Dpse_GA20400  uncharacterized protein, isoform A [KO:K10413]
Dpse_GA26088  uncharacterized protein [KO:K10414]
Dpse_GA22798  uncharacterized protein, isoform H [KO:K10415]
Dpse_GA15140  uncharacterized protein, isoform A [KO:K10416]
Dpse_GA27361  uncharacterized protein [KO:K10416]
Dpse_GA15128  uncharacterized protein [KO:K07374]
Dpse_GA20973  uncharacterized protein [KO:K07374]
Dpse_GA20592  uncharacterized protein [KO:K07374]
Dpse_GA17427  uncharacterized protein, isoform A [KO:K07375]
Dpse_GA21728  uncharacterized protein [KO:K07375]
Dpse_GA27086  uncharacterized protein, isoform C [KO:K07375]
Dpse_GA27686  uncharacterized protein [KO:K07375]
Dpse_GA28334  uncharacterized protein [KO:K07375]
Dpse_GA27781  uncharacterized protein [KO:K07375]
Dpse_GA17249  uncharacterized protein [KO:K06528]
Dpse_GA19534  uncharacterized protein [KO:K00921] [EC:2.7.1.150]
Dpse_GA19805  uncharacterized protein, isoform A [KO:K13240] [EC:1.14.13.39]
Dpse_GA25021  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA23505  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA23577  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA24205  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA19520  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA21865  uncharacterized protein [KO:K10956]
Dpse_GA10096  uncharacterized protein [KO:K09481]
Dpse_GA12829  uncharacterized protein, isoform C [KO:K07342]
Dpse_GA24304  uncharacterized protein [KO:K07342]
Dpse_GA27323  uncharacterized protein [KO:K08057]
Dpse_GA26840  uncharacterized protein, isoform A [KO:K08054]
Dpse_GA14581  uncharacterized protein, isoform A [KO:K05719]
Dpse_GA23031  uncharacterized protein, isoform A [KO:K05719]
Dpse_GA10921  uncharacterized protein, isoform B [KO:K04659]
Dpse_GA32438  uncharacterized protein [KO:K04659]
Dpse_GA16473  uncharacterized protein [KO:K13885]
Dpse_GA15321  uncharacterized protein [KO:K04392]
Dpse_GA18989  uncharacterized protein [KO:K04392]
Dpse_GA21734  uncharacterized protein, isoform A [KO:K04392]
Dpse_GA23612  uncharacterized protein [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
dpo04142  Lysosome
dpo04144  Endocytosis
KO pathway
ko04145   

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