KEGG   PATHWAY: hsa00531
Entry
hsa00531                    Pathway                                

Name
Glycosaminoglycan degradation - Homo sapiens (human)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
hsa00531  Glycosaminoglycan degradation
hsa00531

Module
hsa_M00076  Dermatan sulfate degradation [PATH:hsa00531]
hsa_M00077  Chondroitin sulfate degradation [PATH:hsa00531]
hsa_M00078  Heparan sulfate degradation [PATH:hsa00531]
hsa_M00079  Keratan sulfate degradation [PATH:hsa00531]
Network
nt06012  Glycosaminoglycan degradation
  Element
N00610  Dermatan sulfate degradation
N00615  Heparan sulfate degradation
N00623  Keratan sulfate degradation
Drug
D11812  Pabinafusp alfa (genetical recombination) (JAN)
Other DBs
GO: 0006027
Organism
Homo sapiens (human) [GN:hsa]
Gene
8692  HYAL2; hyaluronidase 2 [KO:K01197] [EC:3.2.1.35]
3373  HYAL1; hyaluronidase 1 [KO:K01197] [EC:3.2.1.35]
6677  SPAM1; sperm adhesion molecule 1 [KO:K01197] [EC:3.2.1.35]
23553  HYAL4; hyaluronidase 4 [KO:K01197] [EC:3.2.1.35]
8372  HYAL3; hyaluronidase 3 [KO:K01197] [EC:3.2.1.35]
2990  GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
3423  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
3425  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
411  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
10855  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
60495  HPSE2; heparanase 2 (inactive) [KO:K07965] [EC:3.2.1.-]
6448  SGSH; N-sulfoglucosamine sulfohydrolase [KO:K01565] [EC:3.10.1.1]
138050  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
4669  NAGLU; N-acetyl-alpha-glucosaminidase [KO:K01205] [EC:3.2.1.50]
2588  GALNS; galactosamine (N-acetyl)-6-sulfatase [KO:K01132] [EC:3.1.6.4]
2720  GLB1; galactosidase beta 1 [KO:K12309] [EC:3.2.1.23]
2799  GNS; glucosamine (N-acetyl)-6-sulfatase [KO:K01137] [EC:3.1.6.14]
3073  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
3074  HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00634  Chondroitin 4-sulfate
C00925  Heparan sulfate
G00526   
G00711   
G00872  DWA-2
G01391   
G01945   
G01977   
G02632   
G09660   
G10008   
G10505  Hyaluronic acid
G12336   
G13034   
G13035   
G13036   
G13037   
G13038   
G13039   
G13040   
G13041   
G13042   
G13043   
G13073   
G13074   
Reference
PMID:27570
  Authors
Greiling H, Stuhlsatz HW, Cantz M, Gehler J
  Title
Increased urinary excretion of keratan sulfate in fucosidosis.
  Journal
J Clin Chem Clin Biochem 16:329-34 (1978)
DOI:10.1515/cclm.1978.16.6.329
Reference
PMID:3161730
  Authors
Fuchs W, Beck M, Kresse H
  Title
Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate.
  Journal
Eur J Biochem 151:551-6 (1985)
DOI:10.1111/j.1432-1033.1985.tb09138.x
Related
pathway
hsa00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
hsa00533  Glycosaminoglycan biosynthesis - keratan sulfate
hsa00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
KO pathway
ko00531   

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