Entry |
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Name |
p53 signaling pathway - Homo sapiens (human)
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Description |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
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Class |
Cellular Processes; Cell growth and death
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Pathway map |

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Disease |
H00409 | Type 2 diabetes mellitus |
H00896 | Lymphangioleiomyomatosis |
H00915 | Tuberous sclerosis complex |
H01007 | Choroid plexus papilloma |
H01106 | Plasminogen activator inhibitor type 1 deficiency |
H01195 | VACTERL/VATER association |
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Drug |
D11787 | Ceralasertib (USAN/INN) |
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Organism |
Homo sapiens (human) [GN: hsa]
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Gene |
1029 | CDKN2A; cyclin dependent kinase inhibitor 2A [KO:K06621] |
1026 | CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625] |
56475 | RPRM; reprimo, TP53 dependent G2 arrest mediator homolog [KO:K10128] |
1647 | GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402] |
4616 | GADD45B; growth arrest and DNA damage inducible beta [KO:K04402] |
10912 | GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402] |
355 | FAS; Fas cell surface death receptor [KO:K04390] |
55367 | PIDD1; p53-induced death domain protein 1 [KO:K10130] |
8797 | TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722] |
8795 | TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722] |
637 | BID; BH3 interacting domain death agonist [KO:K04726] |
581 | BAX; BCL2 associated X, apoptosis regulator [KO:K02159] |
5366 | PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131] |
63970 | TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1 [KO:K13773] |
10572 | SIVA1; SIVA1 apoptosis inducing factor [KO:K22744] |
596 | BCL2; BCL2 apoptosis regulator [KO:K02161] |
9540 | TP53I3; tumor protein p53 inducible protein 3 [KO:K10133] [EC:1.-.-.-] |
9538 | EI24; EI24 autophagy associated transmembrane protein [KO:K10134] |
64065 | PERP; p53 apoptosis effector related to PMP22 [KO:K10136] |
317 | APAF1; apoptotic peptidase activating factor 1 [KO:K02084] |
84883 | AIFM2; apoptosis inducing factor mitochondria associated 2 [KO:K22745] |
3486 | IGFBP3; insulin like growth factor binding protein 3 [KO:K10138] |
3479 | IGF1; insulin like growth factor 1 [KO:K05459] |
5054 | SERPINE1; serpin family E member 1 [KO:K03982] |
575 | ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596] |
5268 | SERPINB5; serpin family B member 5 [KO:K10139] |
1643 | DDB2; damage specific DNA binding protein 2 [KO:K10140] |
50484 | RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1] |
55240 | STEAP3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-] |
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Reference |
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Authors |
Levine AJ, Hu W, Feng Z. |
Title |
The P53 pathway: what questions remain to be explored? |
Journal |
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Reference |
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Authors |
Harris SL, Levine AJ. |
Title |
The p53 pathway: positive and negative feedback loops. |
Journal |
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Reference |
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Authors |
Balint E E, Vousden KH. |
Title |
Activation and activities of the p53 tumour suppressor protein. |
Journal |
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Reference |
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Authors |
Taylor WR, Stark GR. |
Title |
Regulation of the G2/M transition by p53. |
Journal |
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Reference |
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Authors |
Hofseth LJ, Hussain SP, Harris CC. |
Title |
p53: 25 years after its discovery. |
Journal |
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Reference |
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Authors |
Pietenpol JA, Stewart ZA. |
Title |
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. |
Journal |
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Reference |
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Authors |
Tokino T, Nakamura Y. |
Title |
The role of p53-target genes in human cancer. |
Journal |
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Reference |
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Authors |
Hermeking H, Benzinger A. |
Title |
14-3-3 proteins in cell cycle regulation. |
Journal |
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Reference |
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Authors |
Sherr CJ. |
Title |
Divorcing ARF and p53: an unsettled case. |
Journal |
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Reference |
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Authors |
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. |
Title |
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. |
Journal |
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Reference |
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Authors |
Resnick-Silverman L, Manfredi JJ |
Title |
Two Faces of SIVA. |
Journal |
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Reference |
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Authors |
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R |
Title |
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis. |
Journal |
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Reference |
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Authors |
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV |
Title |
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis. |
Journal |
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Reference |
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Authors |
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N |
Title |
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). |
Journal |
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Related pathway |
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KO pathway |
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