KEGG   PATHWAY: hsa04110
Entry
hsa04110                    Pathway                                
Name
Cell cycle - Homo sapiens (human)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
hsa04110  Cell cycle
hsa04110

Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
nt06509  DNA replication
nt06512  Chromosome cohesion and segregation
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00091  p27-Cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00455  CDC25-Cell cycle G2/M
N00459  WEE1-Cell cycle G2/M
N00493  Spindle assembly checkpoint signaling
N00499  ATR-p21-Cell cycle G2/M
N00536  MDM2-p21-Cell cycle G1/S
N01468  DNA replication licensing
N01482  Cohesin loading
N01483  Cohesin acetylation
N01484  Establishment of cohesion
N01485  Cohesin dissociation in prophase
N01486  Cohesin dissociation in anaphase
N01529  Recruitment and formation of the MCC
N01533  Disassembly of MCC
Drug
D05988  Tacedinaline (USAN/INN)
D06320  Vorinostat (JAN/USAN)
D06637  Romidepsin (JAN/USAN/INN)
D08870  Belinostat (USAN/INN)
D09338  Entinostat (JAN/USAN/INN)
D09357  Mocetinostat dihydrobromide (USAN)
D09604  Dinaciclib (USAN/INN)
D09641  Mocetinostat (USAN/INN)
D10019  Panobinostat lactate (JAN)
D10060  Abexinostat (USAN)
D10084  Abexinostat hydrochloride (USAN)
D10154  Rigosertib (USAN)
D10155  Rigosertib sodium (JAN/USAN)
D10182  Volasertib (USAN)
D10183  Volasertib trihydrochloride (USAN)
D10319  Panobinostat (USAN/INN)
D10321  Quisinostat (USAN/INN)
D10322  Quisinostat hydrochloride (USAN)
D10372  Palbociclib (JAN/USAN)
D10397  Rabusertib (USAN/INN)
D10652  Palbociclib isethionate (USAN)
D10688  Abemaciclib (JAN/USAN/INN)
D10883  Ribociclib (USAN/INN)
D10977  Remetinostat (USAN/INN)
D10979  Ribociclib succinate (USAN)
D10993  Tucidinostat (JAN/USAN/INN)
D11130  Trilaciclib (USAN/INN)
D11148  Berzosertib (USAN/INN)
D11182  Tinostamustine (USAN/INN)
D11206  Prexasertib (USAN/INN)
D11319  Fimepinostat (USAN/INN)
D11361  Adavosertib (USAN)
D11442  Nanatinostat (USAN)
D11455  Lerociclib (USAN)
D11458  Onvansertib (USAN)
D11459  Onvansertib fumarate (USAN)
D11599  Zotiraciclib (USAN)
D11600  Zotiraciclib citrate (USAN)
D11787  Ceralasertib (JAN/USAN/INN)
D11987  Trilaciclib dihydrochloride
D12176  Simurosertib (USAN/INN)
D12304  Elraglusib (USAN)
D12321  Camonsertib (USAN)
D12394  Inobrodib (USAN)
D12551  Bocodepsin (USAN)
D12552  Bocodepsin besylate (USAN)
D12601  Tegtociclib (USAN)
D12828  Risvodetinib (USAN/INN)
D12829  Risvodetinib succinate (USAN)
D12834  Atirmociclib (USAN)
D12882  Tuvusertib (USAN/INN)
D12924  Pocenbrodib (USAN/INN)
D12925  Pocenbrodib hydrochloride (USAN)
D12946  Certociclib (USAN)
D13010  Lartesertib (USAN/INN)
D13021  Resminostat (INN)
D13244  Monzosertib hydrochloride (JAN)
Other DBs
GO: 0000278
Organism
Homo sapiens (human) [GN:hsa]
Gene
1017  CDK2; cyclin-dependent kinase 2 isoform 1 [KO:K02206] [EC:2.7.11.22]
1019  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
1021  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
1022  CDK7; cyclin-dependent kinase 7 isoform 1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
1026  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform 1 [KO:K06625]
1027  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
10274  STAG1; cohesin subunit SA-1 [KO:K06671]
1028  CDKN1C; cyclin-dependent kinase inhibitor 1C isoform a [KO:K09993]
1029  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform p16INK4a [KO:K06621]
1030  CDKN2B; cyclin-dependent kinase 4 inhibitor B isoform 1 [KO:K04685]
1031  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
1032  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
10393  ANAPC10; anaphase-promoting complex subunit 10 isoform 1 [KO:K03357]
10403  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
10459  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
10735  STAG2; cohesin subunit SA-2 isoform b [KO:K06671]
10744  PTTG2; securin-2 [KO:K06635]
10912  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
10926  DBF4; protein DBF4 homolog A isoform 1 [KO:K06629]
10971  YWHAQ; 14-3-3 protein theta [KO:K16197]
1111  CHEK1; serine/threonine-protein kinase Chk1 isoform 1 [KO:K02216] [EC:2.7.11.1]
11200  CHEK2; serine/threonine-protein kinase Chk2 isoform a [KO:K06641] [EC:2.7.11.1]
113130  CDCA5; sororin isoform 1 [KO:K17390]
114799  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
119504  ANAPC16; anaphase-promoting complex subunit 16 isoform 1 [KO:K25229]
1387  CREBBP; CREB-binding protein isoform a [KO:K04498] [EC:2.3.1.48]
151648  SGO1; shugoshin 1 isoform EF [KO:K11580]
157570  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
1647  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1 [KO:K04402]
1663  DDX11; ATP-dependent DNA helicase DDX11 isoform 3 [KO:K11273] [EC:5.6.2.7]
168448  CDC14C; dual specificity protein phosphatase CDC14C [KO:K06639] [EC:3.1.3.16 3.1.3.48]
1869  E2F1; transcription factor E2F1 [KO:K17454]
1870  E2F2; transcription factor E2F2 [KO:K09389]
1871  E2F3; transcription factor E2F3 isoform 1 [KO:K06620]
1874  E2F4; transcription factor E2F4 [KO:K04682]
1875  E2F5; transcription factor E2F5 isoform 1 [KO:K04682]
2033  EP300; histone acetyltransferase p300 isoform 1 [KO:K04498] [EC:2.3.1.48]
23047  PDS5B; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
23063  WAPL; wings apart-like protein homolog isoform 1 [KO:K25163]
23244  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform 1 [KO:K11267]
23383  MAU2; MAU2 chromatid cohesion factor homolog [KO:K11266]
23594  ORC6; origin recognition complex subunit 6 [KO:K02608]
23595  ORC3; origin recognition complex subunit 3 isoform 2 [KO:K02605]
246184  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
25  ABL1; tyrosine-protein kinase ABL1 isoform a [KO:K06619] [EC:2.7.10.2]
25836  NIPBL; nipped-B-like protein isoform A [KO:K06672]
25847  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
25906  ANAPC15; anaphase-promoting complex subunit 15 isoform b [KO:K25228]
26271  FBXO5; F-box only protein 5 isoform a [KO:K10292]
27085  MTBP; mdm2-binding protein [KO:K26116]
27127  SMC1B; structural maintenance of chromosomes protein 1B isoform 1 [KO:K06636]
2810  SFN; 14-3-3 protein sigma [KO:K06644]
2932  GSK3B; glycogen synthase kinase-3 beta isoform 2 [KO:K03083] [EC:2.7.11.26]
29882  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
29945  ANAPC4; anaphase-promoting complex subunit 4 isoform 2 [KO:K03351]
3065  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
3066  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
4085  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
4087  SMAD2; mothers against decapentaplegic homolog 2 isoform 1 [KO:K04500]
4088  SMAD3; mothers against decapentaplegic homolog 3 isoform 1 [KO:K23605]
4089  SMAD4; mothers against decapentaplegic homolog 4 isoform a [KO:K04501]
4171  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
4172  MCM3; DNA replication licensing factor MCM3 isoform 1 [KO:K02541] [EC:5.6.2.3]
4173  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
4174  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
4175  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
4176  MCM7; DNA replication licensing factor MCM7 isoform 1 [KO:K02210] [EC:5.6.2.3]
4193  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform 2 [KO:K06643] [EC:2.3.2.27]
4609  MYC; myc proto-oncogene protein isoform 1 [KO:K04377]
4616  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
472  ATM; serine-protein kinase ATM isoform a [KO:K04728] [EC:2.7.11.1]
494551  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
4998  ORC1; origin recognition complex subunit 1 isoform 1 [KO:K02603]
4999  ORC2; origin recognition complex subunit 2 [KO:K02604]
5000  ORC4; origin recognition complex subunit 4 isoform 1 [KO:K02606]
5001  ORC5; origin recognition complex subunit 5 isoform 1 [KO:K02607]
5111  PCNA; proliferating cell nuclear antigen [KO:K04802]
51343  FZR1; fizzy-related protein homolog isoform 1 [KO:K03364]
51433  ANAPC5; anaphase-promoting complex subunit 5 isoform a [KO:K03352]
51434  ANAPC7; anaphase-promoting complex subunit 7 isoform a [KO:K03354]
51529  ANAPC11; anaphase-promoting complex subunit 11 isoform 2 [KO:K03358]
5347  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
545  ATR; serine/threonine-protein kinase ATR isoform 1 [KO:K06640] [EC:2.7.11.1]
546  ATRX; transcriptional regulator ATRX isoform 1 [KO:K10779]
5515  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1 [KO:K04382] [EC:3.1.3.16]
5516  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
5518  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1 [KO:K03456]
5519  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a [KO:K03456]
5525  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1 [KO:K11584]
5526  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
5527  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a [KO:K11584]
5528  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1 [KO:K11584]
5529  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a [KO:K11584]
55869  HDAC8; histone deacetylase 8 isoform 1 [KO:K11405] [EC:3.5.1.98]
5591  PRKDC; DNA-dependent protein kinase catalytic subunit isoform 1 [KO:K06642] [EC:2.7.11.1]
57082  KNL1; outer kinetochore KNL1 complex subunit KNL1 isoform 1 [KO:K11542]
5885  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
5925  RB1; retinoblastoma-associated protein isoform 1 [KO:K06618]
5933  RBL1; retinoblastoma-like protein 1 isoform a [KO:K04681]
5934  RBL2; retinoblastoma-like protein 2 isoform 1 [KO:K16332]
595  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
64682  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
6500  SKP1; S-phase kinase-associated protein 1 isoform b [KO:K03094]
6502  SKP2; S-phase kinase-associated protein 2 isoform 1 [KO:K03875]
699  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1 [KO:K02178] [EC:2.7.11.1]
701  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
7027  TFDP1; transcription factor Dp-1 [KO:K04683]
7029  TFDP2; transcription factor Dp-2 isoform 2 [KO:K09392]
7040  TGFB1; transforming growth factor beta-1 proprotein preproprotein [KO:K13375]
7042  TGFB2; transforming growth factor beta-2 proprotein isoform 2 preproprotein [KO:K13376]
7043  TGFB3; transforming growth factor beta-3 proprotein isoform 1 preproprotein [KO:K13377]
7157  TP53; cellular tumor antigen p53 isoform a [KO:K04451]
7272  TTK; dual specificity protein kinase TTK isoform 1 [KO:K08866] [EC:2.7.12.1]
7465  WEE1; wee1-like protein kinase isoform 1 [KO:K06632] [EC:2.7.11.1]
7529  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
7531  YWHAE; 14-3-3 protein epsilon [KO:K06630]
7532  YWHAG; 14-3-3 protein gamma [KO:K16198]
7533  YWHAH; 14-3-3 protein eta [KO:K16198]
7534  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
7709  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform 2 [KO:K10500]
80174  DBF4B; protein DBF4 homolog B isoform 1 [KO:K06629]
81620  CDT1; DNA replication factor Cdt1 [KO:K10727]
8243  SMC1A; structural maintenance of chromosomes protein 1A isoform 1 [KO:K06636]
8317  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
8318  CDC45; cell division control protein 45 homolog isoform 2 [KO:K06628]
8379  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform a [KO:K06679]
8454  CUL1; cullin-1 [KO:K03347]
85417  CCNB3; G2/mitotic-specific cyclin-B3 isoform 3 [KO:K21771]
8555  CDC14B; dual specificity protein phosphatase CDC14B isoform 2 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
8556  CDC14A; dual specificity protein phosphatase CDC14A isoform 1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
8697  CDC23; cell division cycle protein 23 homolog [KO:K03355]
8881  CDC16; cell division cycle protein 16 homolog isoform 1 [KO:K03353]
890  CCNA2; cyclin-A2 [KO:K06627]
8900  CCNA1; cyclin-A1 [KO:K06627]
891  CCNB1; G2/mitotic-specific cyclin-B1 isoform 1 [KO:K05868]
894  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
896  CCND3; G1/S-specific cyclin-D3 isoform 2 [KO:K10152]
898  CCNE1; G1/S-specific cyclin-E1 isoform 1 [KO:K06626]
902  CCNH; cyclin-H isoform 1 [KO:K06634]
90381  TICRR; treslin isoform 2 [KO:K26117]
9088  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1 [KO:K06633] [EC:2.7.11.1]
9126  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
9133  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
9134  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
9184  BUB3; mitotic checkpoint protein BUB3 isoform a [KO:K02180]
9212  AURKB; aurora kinase B isoform 1 [KO:K11479] [EC:2.7.11.1]
9232  PTTG1; securin [KO:K06635]
9319  TRIP13; pachytene checkpoint protein 2 homolog isoform 1 [KO:K22399]
9587  MAD2L1BP; MAD2L1-binding protein isoform 2 [KO:K26093]
9700  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
983  CDK1; cyclin-dependent kinase 1 isoform 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
990  CDC6; cell division control protein 6 homolog [KO:K02213]
991  CDC20; cell division cycle protein 20 homolog [KO:K03363]
993  CDC25A; M-phase inducer phosphatase 1 isoform a [KO:K06645] [EC:3.1.3.48]
994  CDC25B; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:3.1.3.48]
995  CDC25C; M-phase inducer phosphatase 3 isoform a [KO:K05867] [EC:3.1.3.48]
996  CDC27; cell division cycle protein 27 homolog isoform 2 [KO:K03350]
9978  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
hsa03030  DNA replication
hsa04010  MAPK signaling pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04210  Apoptosis
KO pathway
ko04110   

  All links  
No link information was found.
DBGET integrated database retrieval system