KEGG   PATHWAY: ppp03430
Entry
ppp03430                    Pathway                                
Name
Mismatch repair - Physcomitrium patens (spreading earthmoss)
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
ppp03430  Mismatch repair
ppp03430

Other DBs
GO: 0006298
Organism
Physcomitrium patens (spreading earthmoss) [GN:ppp]
Gene
112294459  uncharacterized protein LOC112294459 isoform X1 [KO:K07456]
112282139  uncharacterized protein LOC112282139 [KO:K03111]
112283083  single-stranded DNA-binding protein-like isoform X1 [KO:K03111]
112293165  uncharacterized protein LOC112293165 [KO:K03111]
112285709  DNA mismatch repair protein PMS1-like [KO:K10858]
112287819  DNA mismatch repair protein MLH1-like [KO:K08734]
112273630  DNA mismatch repair protein MSH6-like isoform X1 [KO:K08737]
112286571  DNA mismatch repair protein MSH7-like [KO:K08737]
112275272  DNA mismatch repair protein MSH2-like isoform X1 [KO:K08735]
112275975  DNA mismatch repair protein MSH3-like [KO:K08736]
112290643  DNA mismatch repair protein MLH3-like isoform X1 [KO:K08739]
112275181  replication factor C subunit 1-like isoform X1 [KO:K10754]
112279378  replication factor C subunit 2-like [KO:K10755]
112293544  replication factor C subunit 4-like [KO:K10755]
112277445  replication factor C subunit 3-like [KO:K10756]
112290299  replication factor C subunit 3-like [KO:K10756]
112290025  proliferating cell nuclear antigen [KO:K04802]
112276251  exonuclease 1-like isoform X1 [KO:K10746] [EC:3.1.-.-]
112285404  exonuclease 1-like [KO:K10746] [EC:3.1.-.-]
112276003  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
112273581  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
112289227  replication protein A 70 kDa DNA-binding subunit D-like [KO:K07466]
112277737  replication protein A 32 kDa subunit A-like [KO:K10739]
112278338  replication protein A 14 kDa subunit-like isoform X1 [KO:K10740]
112283483  DNA polymerase delta catalytic subunit-like isoform X1 [KO:K02327] [EC:2.7.7.7]
112278234  DNA polymerase delta catalytic subunit-like isoform X1 [KO:K02327] [EC:2.7.7.7]
112294650  DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
112279428  DNA polymerase delta small subunit-like isoform X1 [KO:K02328]
112278383  uncharacterized protein LOC112278383 [KO:K03504]
112280908  DNA polymerase delta subunit 4-like [KO:K03505]
112290811  DNA ligase 1-like [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   

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