KEGG   PATHWAY: rno05330Help
Entry
rno05330                    Pathway                                

Name
Allograft rejection - Rattus norvegicus (rat)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune diseases
BRITE hierarchy
Pathway map
rno05330  Allograft rejection
rno05330

Ortholog table
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24737  RT1-EC2; RT1 class Ib, locus EC2 [KO:K06751]
24747  RT1-M3-1; RT1 class Ib, locus M3, gene 1 [KO:K06751]
24748  RT1-N1; RT1 class Ib, locus N1 [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24973  RT1-A1; RT1 class Ia, locus A1 [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 [KO:K06751]
24977  RT1-Cl; RT1 class Ib, locus Cl [KO:K06751]
24988  RT1-M2; RT1 class Ib, locus M2 [KO:K06751]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 [KO:K06751]
309603  RT1-CE1; RT1 class I, locus1 [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 [KO:K06751]
309627  RT1-A3; RT1 class I, locus A3 [KO:K06751]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 [KO:K06751]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 [KO:K06751]
368153  RT1-CE7; RT1 class I, locus CE7 [KO:K06751]
414270  RT1-CE14; RT1 class I, locus CE14 [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 [KO:K06751]
414787  RT1-M10-1; RT1 class I, locus M10, gene 1 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
406194  RT1-T18; RT1 class Ib, locus T18 [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 [KO:K06751]
309584  RT1-M4; RT1 class Ib, locus M4 [KO:K06751]
360323  RT1-N2; RT1 class Ib, locus N2 [KO:K06751]
100188935  RT1-A; RT1 class I, locus A [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  RT1-M1-5; RT1 class I, M1, gene 5 [KO:K06751]
102546590  HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
499400  RT1-M5; RT1 class Ib, locus M5 [KO:K06751]
100362949  TRAV14S2; mCG140239-like [KO:K10784]
688340  T-cell receptor alpha chain V region PHDS58-like [KO:K10784]
25408  Cd80; Cd80 molecule [KO:K05412]
56822  Cd86; CD86 molecule [KO:K05413]
25660  Cd28; Cd28 molecule [KO:K06470]
84405  Il12a; interleukin 12A [KO:K05406]
64546  Il12b; interleukin 12B [KO:K05425]
25385  Faslg; Fas ligand [KO:K04389]
246097  Fas; Fas cell surface death receptor [KO:K04390]
50669  Prf1; perforin 1 [KO:K07818]
171528  Gzmb; granzyme B [KO:K01353] [EC:3.4.21.79]
100361468  Gzmbl2; Granzyme B-like 2 [KO:K01353] [EC:3.4.21.79]
294274  RT1-DMa; RT1 class II, locus DMa [KO:K06752]
294273  RT1-DMb; RT1 class II, locus DMb [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha [KO:K06752]
294269  RT1-Da; RT1 class II, locus Da [KO:K06752]
294270  RT1-Db1; RT1 class II, locus Db1 [KO:K06752]
309621  RT1-Ba; RT1 class II, locus Ba [KO:K06752]
309622  RT1-Bb; RT1 class II, locus Bb [KO:K06752]
365542  RT1-DOb; RT1 class II, locus DOb [KO:K06752]
688090  Bb; similar to RT1 class II histocompatibility antigen, B-1 beta chain precursor (RT1.B-beta(1)) [KO:K06752]
100911800  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
108348072  class II histocompatibility antigen, M alpha chain [KO:K06752]
108348139  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
116562  Il2; interleukin 2 [KO:K05429]
84349  Cd40lg; CD40 ligand [KO:K03161]
171369  Cd40; CD40 molecule [KO:K03160]
25712  Ifng; interferon gamma [KO:K04687]
24835  Tnf; tumor necrosis factor [KO:K03156]
103694380  tumor necrosis factor [KO:K03156]
287287  Il4; interleukin 4 [KO:K05430]
24497  Il5; interleukin 5 [KO:K05428]
25325  Il10; interleukin 10 [KO:K05443]
691714  RGD1565478; similar to Immunoglobulin heavy chain (gamma polypeptide) [KO:K06856]
Compound
C00533  Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002
KO pathway
ko05330   

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