KEGG   PATHWAY: sma00010
Entry
sma00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Streptomyces avermitilis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
sma00010  Glycolysis / Gluconeogenesis
sma00010

Module
sma_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sma00010]
sma_M00002  Glycolysis, core module involving three-carbon compounds [PATH:sma00010]
sma_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sma00010]
sma_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sma00010]
Other DBs
GO: 0006096 0006094
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_6074  glkA1; glucokinase [KO:K00845] [EC:2.7.1.2]
SAVERM_1476  putative ROK-family transcriptional regulator [KO:K00845] [EC:2.7.1.2]
SAVERM_1980  putative carbohydrate kinase [KO:K00845] [EC:2.7.1.2]
SAVERM_3940  putative ROK-family transcriptional regulator [KO:K00845] [EC:2.7.1.2]
SAVERM_6302  pgi2; putative glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SAVERM_1770  pgi1; putative glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SAVERM_7123  pfkA3; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.11 2.7.1.90]
SAVERM_2822  pfkA1; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.11 2.7.1.90]
SAVERM_6083  pfkA2; 6-phosphofructokinase [KO:K21071] [EC:2.7.1.11 2.7.1.90]
SAVERM_3215  glpX; putative fructose-1,6-bisphosphatase II [KO:K02446] [EC:3.1.3.11]
SAVERM_4523  fbaA; putative fructose 1,6-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
SAVERM_1445  gatY; putative tagatose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
SAVERM_6298  tpiA; putative triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
SAVERM_6296  gap2; glyceraldehyde-3-phosphate dehydrogenase (sensitive to pentalenolactone) [KO:K00134] [EC:1.2.1.12]
SAVERM_2990  gap1; glyceraldehyde-3-phosphate dehydrogenase (insensitive to pentalenolactone) [KO:K00134] [EC:1.2.1.12]
SAVERM_6297  pgk; putative phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
SAVERM_3979  gpmA1; putative 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SAVERM_3533  eno; putative enolase [KO:K01689] [EC:4.2.1.11]
SAVERM_6217  pykA2; putative pyruvate kinase [KO:K00873] [EC:2.7.1.40]
SAVERM_2825  pykA1; putative pyruvate kinase [KO:K00873] [EC:2.7.1.40]
SAVERM_5654  ppdK; putative pyruvate phosphate dikinase [KO:K01006] [EC:2.7.9.1]
SAVERM_6020  aceE2; putative pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
SAVERM_5800  aceE1; putative pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
SAVERM_4362  bkdA; putative 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) E1-alpha chain [KO:K00161] [EC:1.2.4.1]
SAVERM_4376  bkdF; putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit [KO:K00161] [EC:1.2.4.1]
SAVERM_4363  bkdB; putative 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) E1-beta chain [KO:K00162] [EC:1.2.4.1]
SAVERM_4377  bkdG; putative branched-chain alpha keto acid dehydrogenase E1 beta subunit [KO:K00162] [EC:1.2.4.1]
SAVERM_4364  bkdC; putative dihydrolipoamide acyltransferase [KO:K00627] [EC:2.3.1.12]
SAVERM_4378  bkdH; putative dihydrolipoamide acyltransferase component [KO:K00627] [EC:2.3.1.12]
SAVERM_6024  lpdA1; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_2154  lpdA2; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_4877  korA; putative 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit [KO:K00174] [EC:1.2.7.3 1.2.7.11]
SAVERM_4876  korB; putative 2-oxoglutarate ferredoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11]
SAVERM_339  ldhA; putative lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
SAVERM_5871  putative dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
SAVERM_3833  adhA6; putative alcohol dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
SAVERM_1141  adhA1; putative alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1]
SAVERM_1357  adhA2; putative alcohol dehydrogenase [KO:K00001] [EC:1.1.1.1]
SAVERM_7169  putative dehydrogenase [KO:K00001] [EC:1.1.1.1]
SAVERM_5335  putative oxidoreductase [KO:K00001] [EC:1.1.1.1]
SAVERM_3314  adhA4; putative NADP-dependent alcohol dehydrogenase [KO:K13979] [EC:1.1.1.2]
SAVERM_6595  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_4650  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_2579  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_1187  aldH; putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_3347  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_5852  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_7177  thcA; putative aldehyde dehydrogenase [KO:K00138] [EC:1.2.1.-]
SAVERM_4599  acsA1; putative acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SAVERM_2031  acsA4; putative acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SAVERM_3828  putative pimeloyl-CoA synthetase [KO:K24012] [EC:6.2.1.13]
SAVERM_5782  galM2; putative aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
SAVERM_5766  galM1; putative aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
SAVERM_4521  hypothetical protein [KO:K01785] [EC:5.1.3.3]
SAVERM_803  pgmA; putative phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
SAVERM_3209  ppgK; putative polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63]
SAVERM_3287  pckA; putative phosphoenolpyruvate carboxykinase [KO:K01596] [EC:4.1.1.32]
SAVERM_1754  bglA1; putative 6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
SAVERM_5380  bglA2; putative 6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
SAVERM_6975  ptsA; putative phosphoenolpyruvate-dependent sugar phosphotransferase [KO:K02777] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
sma00020  Citrate cycle (TCA cycle)
sma00030  Pentose phosphate pathway
sma00500  Starch and sucrose metabolism
sma00620  Pyruvate metabolism
sma00640  Propanoate metabolism
KO pathway
ko00010   

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