KEGG   PATHWAY: bmy03040
Entry
bmy03040                    Pathway                                
Name
Spliceosome - Brugia malayi (filaria)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
bmy03040  Spliceosome
bmy03040

Other DBs
GO: 0005681
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
BM_BM7768  small nuclear RNA Bm7768 [KO:K14277]
BM_BM1726  small nuclear RNA Bm1726 [KO:K14278]
BM_BM15506  small nuclear RNA Bm15506 [KO:K14280]
BM_BM4324  Bm4324; Uncharacterized protein [KO:K12811] [EC:5.6.2.7]
BM_BM13698  Bma-hel-1; putative ATP-dependent RNA helicase p47 homolog, putative [KO:K12812] [EC:5.6.2.7]
BM_BM1959  Bma-mog-4; pre-mRNA splicing factor ATP-dependent RNA helicase, putative [KO:K12813] [EC:5.6.2.6]
BM_BM4791  Bma-mog-1; Uncharacterized protein [KO:K12815] [EC:5.6.2.6]
BM_BM18101  Bm18101; Uncharacterized protein [KO:K12816]
BM_BM4870  Bm4870; Uncharacterized protein [KO:K12819]
BM_BM4476  Bma-ddx-15; Uncharacterized protein [KO:K12820] [EC:5.6.2.6]
BM_BM6235  Bma-snr-2; Uncharacterized protein [KO:K11086]
BM_BM14062  Bma-snr-3.2; Uncharacterized protein [KO:K11087]
BM_BM14071  Bma-snr-4; Uncharacterized protein [KO:K11096]
BM_BM7323  Bma-snr-1; small nuclear ribonucleoprotein Sm D3, putative [KO:K11088]
BM_BM13909  Bma-snr-6; small nuclear ribonucleoprotein E, putative [KO:K11097]
BM_BM14077  Bma-snr-5; Uncharacterized protein [KO:K11098]
BM_BM13912  Bma-snr-7; small nuclear ribonucleoprotein G, putative [KO:K11099]
BM_BM3183  Bm3183; Uncharacterized protein [KO:K11095]
BM_BM18140  Bm18140; Uncharacterized protein [KO:K12821]
BM_BM6182  Bma-rbm-25; Uncharacterized protein [KO:K12822]
BM_BM492  Bm492; Uncharacterized protein [KO:K12823] [EC:5.6.2.7]
BM_BM13700  Bma-ddx-17; RNA-dependent helicase, putative [KO:K12823] [EC:5.6.2.7]
BM_BM7628  Bm7628; FF domain containing protein [KO:K12824]
BM_BM13881  Bma-mog-2; U2 small nuclear ribonucleoprotein A, putative [KO:K11092]
BM_BM4907  Bm4907; Uncharacterized protein [KO:K11094]
BM_BM6226  Bma-prp-21; Surp module family protein [KO:K12825]
BM_BM3295  Bma-repo-1; Uncharacterized protein [KO:K12826]
BM_BM13962  Bm13962; conserved hypothetical protein,hypothetical protein [KO:K12827]
BM_BM5671  Bma-sftb-1; Splicing factor 3B subunit 1, putative [KO:K12828]
BM_BM6165  Bma-sftb-2; splicing factor 3b, subunit 2, putative [KO:K12829]
BM_BM4766  Bma-teg-4; splicing factor 3B subunit 3, putative [KO:K12830]
BM_BM2067  Bma-sap-49; Uncharacterized protein [KO:K12831]
BM_BM1827  Bma-moa-2; Uncharacterized protein [KO:K12832]
BM_BM2863  Bm2863; Uncharacterized protein [KO:K12833]
BM_BM6818  Bma-phf-5; splicing factor 3B associated 14kDa protein, putative,PHD finger-like domain protein 5A, putative [KO:K12834]
BM_BM7320  Bma-uaf-2; U2 small nuclear RNA auxiliary factor small subunit, putative [KO:K12836]
BM_BM12845  Bm12845; splicing factor U2AF35, putative [KO:K12836]
BM_BM9024  Bm9024; U2 small nuclear RNA auxiliary factor small subunit, putative [KO:K12836]
BM_BM7180  Bm7180; U2 auxiliary factor 65 kDa subunit, putative [KO:K12837]
BM_BM6624  Bma-rnp-6; Rnp, putative [KO:K12838]
BM_BM7028  Bma-smr-1; survival motor neuron domain containing protein, putative [KO:K12839]
BM_BM4547  Bma-rbm-17; Uncharacterized protein [KO:K12840]
BM_BM4565  Bm4565; G-patch domain containing protein [KO:K12841]
BM_BM2057  Bm2057; Uncharacterized protein [KO:K12842]
BM_BM6953  Bma-lsm-3; Uncharacterized protein [KO:K12622]
BM_BM3741  Bma-lsm-4; putative U6 snRNA-associated Sm-like protein LSm4, putative [KO:K12623]
BM_BM17772  Bma-lsm-5.2; Uncharacterized protein [KO:K12624]
BM_BM13910  Bma-lsm-5.1; Uncharacterized protein [KO:K12624]
BM_BM7057  Bma-lsm-6; U6 snRNA-associated Sm-like protein LSm6, putative [KO:K12625]
BM_BM13913  Bma-lsm-7; U6 snRNA-associated Sm-like protein LSm7, putative [KO:K12626]
BM_BM13915  Bma-lsm-8; Uncharacterized protein [KO:K12627]
BM_BM5081  Bma-prp-3; uncharacterized protein [KO:K12843]
BM_BM2625  Bma-prp-4; U4/U6 small nuclear ribonucleoprotein hPrp4, putative [KO:K12662]
BM_BM5454  Bma-cyn-11; peptidyl-prolyl cis-trans isomerase 11, putative [KO:K09567] [EC:5.2.1.8]
BM_BM13956  Bma-prp-31; SnoRNA binding domain containing protein [KO:K12844]
BM_BM14055  Bm14055; Uncharacterized protein [KO:K12845]
BM_BM8891  Bma-snrp-27; Uncharacterized protein [KO:K12846]
BM_BM3220  Bma-usp-39; ubiquitin thiolesterase homolog, putative [KO:K12847]
BM_BM3450  Bm3450; SART-1 family protein [KO:K11984]
BM_BM7535  Bma-snu-23; putative zinc finger protein ZK686.4 in chromosome III, putative [KO:K12848]
BM_BM3019  Bma-prp-38; GM13395p, putative [KO:K12849]
BM_BM7269  Bm7269; PRP38 family protein [KO:K12850]
BM_BM13732  Bma-eftu-2; Uncharacterized protein [KO:K12852]
BM_BM6581  Bma-snrp-200; Uncharacterized protein [KO:K12854] [EC:5.6.2.6]
BM_BM13735  Bma-prp-6; U5 snRNP-associated 102 kDa protein, putative [KO:K12855]
BM_BM13916  Bma-prp-8; Pre-mRNA splicing factor PRP8, putative [KO:K12856]
BM_BM3208  Bm3208; Biotin/lipoate A/B protein ligase family protein [KO:K12857]
BM_BM3132  Bma-ddx-23; CG10333-PA, putative [KO:K12858] [EC:5.6.2.7]
BM_BM2352  Bm2352; Uncharacterized protein [KO:K12859]
BM_BM13690  Bma-prp-19; putative 55.2 kDa Trp-Asp repeats containing protein T10F2.4 inchromosome III, putative [KO:K10599] [EC:2.3.2.27]
BM_BM3024  Bma-cdc-5L; CDC5 protein, putative [KO:K12860]
BM_BM5731  Bma-bcas-2; uncharacterized protein [KO:K12861]
BM_BM13689  Bma-plrg-1; Pre-mRNA splicing protein prp5, putative [KO:K12862]
BM_BM5709  Bma-cwc-15; Cwf15/Cwc15 cell cycle control protein [KO:K12863]
BM_BM3611  Bma-hsp-1; Uncharacterized protein [KO:K03283]
BM_BM5892  Bma-pqbp-1.1; WW domain containing protein [KO:K12865]
BM_BM3805  Bm3805; Uncharacterized protein [KO:K12866]
BM_BM6051  Bma-skp-1; putative 60.2 kDa protein T27F2.1 in chromosome V, putative [KO:K06063]
BM_BM13935  Bma-syf-1; Uncharacterized protein [KO:K12867]
BM_BM18058  Bma-syf-2.2; Uncharacterized protein [KO:K12868]
BM_BM13922  Bm13922; Uncharacterized protein [KO:K12869]
BM_BM4297  Bma-isy-1; Isy1-like splicing family protein [KO:K12870]
BM_BM2572  Bma-cyn-12; cyclophilin-type peptidyl-prolyl cis-trans isomerase-12, Bmcyp-12 [KO:K12733] [EC:5.2.1.8]
BM_BM7319  Bma-cyn-13; Uncharacterized protein [KO:K09564] [EC:5.2.1.8]
BM_BM7017  Bm7017; zgc:101038 protein, putative [KO:K12871]
BM_BM14057  Bma-bud-31; G10 protein homolog, putative [KO:K12873]
BM_BM7158  Bma-emb-4; conserved hypothetical protein,hypothetical protein [KO:K12874]
BM_BM13697  Bm13697; ATP-dependent helicase DDX48, putative [KO:K13025] [EC:5.6.2.7]
BM_BM5285  Bma-rnp-4; Uncharacterized protein [KO:K12876]
BM_BM5312  Bma-mag-1; Uncharacterized protein [KO:K12877]
BM_BM5500  Bma-thoc-1; Uncharacterized protein [KO:K12878]
BM_BM2239  Bma-thoc-2; conserved hypothetical protein,hypothetical protein [KO:K12879]
BM_BM3777  Bma-thoc-3; conserved hypothetical protein,hypothetical protein [KO:K12880]
BM_BM10327  Bm10327; RNA and export factor binding protein 2, putative [KO:K12881]
BM_BM3810  Bma-ncbp-1.2; Uncharacterized protein [KO:K12882]
BM_BM10285  Bma-ncbp-1.1; ncbp1-prov protein-like [KO:K12882]
BM_BM3604  Bma-ncbp-2; nuclear cap binding protein subunit 2, putative [KO:K12883]
BM_BM12801  Bm12801; RNA recognition motif domain containing protein [KO:K12741]
BM_BM4012  Bma-hrp-1.2; Uncharacterized protein [KO:K12741]
BM_BM12863  Bma-hrpk-1.1; Uncharacterized protein [KO:K12886]
BM_BM3607  Bma-hrpk-1.2; KH domain containing protein [KO:K12886]
BM_BM9558  Bma-hrpk-1.3; Uncharacterized protein [KO:K12886]
BM_BM9635  Bma-rsp-3.1; Uncharacterized protein [KO:K12890]
BM_BM7293  Bma-rsp-3.2; Uncharacterized protein [KO:K12890]
BM_BM17395  Bma-rsp-3.3; Uncharacterized protein [KO:K12890]
BM_BM3114  Bma-rsp-4; putative RNA-binding protein T28D9.2 in chromosome II, putative [KO:K12891]
BM_BM10359  Bma-rsp-5; putative RNA-binding protein T28D9.2 in chromosome II, putative [KO:K12893]
BM_BM6124  Bm6124; Uncharacterized protein [KO:K12893]
BM_BM8919  Bm8919; RNA recognition motif domain containing protein [KO:K12897]
BM_BM2855  Bm2855; RNA recognition motif domain containing protein [KO:K12897]
BM_BM11036  Bm11036; RNA recognition motif domain containing protein [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (111)   
   KEGG GENES (111)   
All databases (112)   

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