KEGG   PATHWAY: bmy04120
Entry
bmy04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Brugia malayi (filaria)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
bmy04120  Ubiquitin mediated proteolysis
bmy04120

Other DBs
GO: 0016567
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
BM_BM13651  Bma-ubq-2; ubiquitin-like protein, putative [KO:K02927]
BM_BM4628  Bm4628; ubiquitin, putative [KO:K02977]
BM_BM2818  Bma-uba-1; Uncharacterized protein [KO:K03178] [EC:6.2.1.45]
BM_BM13930  Bma-aos-1; ThiF family protein [KO:K10684] [EC:6.2.1.45]
BM_BM6116  Bma-uba-2; ThiF family protein, putative [KO:K10685] [EC:6.2.1.45]
BM_BM3316  Bma-rfl-1; Ectopic membrane ruffles in embryo protein 1, putative [KO:K10686] [EC:6.2.1.64]
BM_BM13723  Bma-ubc-1; Ubiquitin-conjugating enzyme E2 1, putative [KO:K10573] [EC:2.3.2.23]
BM_BM5108  Bm5108; ubiquitin-conjugating enzyme E2-17 kDa, putative [KO:K06689] [EC:2.3.2.23]
BM_BM1509  Bma-let-70; Uncharacterized protein [KO:K06689] [EC:2.3.2.23]
BM_BM10237  Bm10237; Ubiquitin-conjugating enzyme family protein [KO:K20217] [EC:2.3.2.23]
BM_BM13724  Bma-ubc-12; Ubiquitin-conjugating enzyme family protein [KO:K10687] [EC:2.3.2.34]
BM_BM8698  Bm8698; ubiquitin-conjugating enzyme E2-19 kDa, putative [KO:K10575] [EC:2.3.2.23]
BM_BM17427  Bma-ubc-7; Uncharacterized protein [KO:K10575] [EC:2.3.2.23]
BM_BM7174  Bma-ubc-14; Uncharacterized protein [KO:K04555] [EC:2.3.2.23]
BM_BM7197  Bma-ubc-8; Ubiquitin-conjugating enzyme E2 H, putative [KO:K10576] [EC:2.3.2.23]
BM_BM13725  Bma-ubc-9; Uncharacterized protein [KO:K10577]
BM_BM3005  Bma-ubc-6; Uncharacterized protein [KO:K10578] [EC:2.3.2.23]
BM_BM10429  Bma-ubc-15; Uncharacterized protein [KO:K04554] [EC:2.3.2.23]
BM_BM13782  Bma-ubc-26; Uncharacterized protein [KO:K04554] [EC:2.3.2.23]
BM_BM13722  Bma-ubc-20; Uncharacterized protein [KO:K04649] [EC:2.3.2.23]
BM_BM8976  Bm8976; Ubiquitin-conjugating enzyme family protein [KO:K04552] [EC:2.3.2.23]
BM_BM8917  Bm8917; ubiquitin-conjugating enzyme, putative [KO:K04552] [EC:2.3.2.23]
BM_BM9167  Bma-ubc-13.2; Ubiquitin conjugating enzyme protein 13, putative [KO:K10580] [EC:2.3.2.23]
BM_BM6825  Bma-ubc-13.1; Uncharacterized protein [KO:K10580] [EC:2.3.2.23]
BM_BM3586  Bma-ubc-25; ubiquitin-conjugating enzyme E2Q, putative [KO:K10582] [EC:2.3.2.23]
BM_BM7058  Bma-ubc-3; ubiquitin conjugating enzyme protein 3, putative [KO:K02207] [EC:2.3.2.23]
BM_BM6791  Bma-ubc-16; Uncharacterized protein [KO:K10688] [EC:2.3.2.23 2.3.2.25]
BM_BM6453  Bma-oxi-1; ubiquitin-protein ligase UBE3B, putative [KO:K10588] [EC:2.3.2.26]
BM_BM3055  Bma-etc-1; conserved hypothetical protein,hypothetical protein [KO:K10589] [EC:2.3.2.26]
BM_BM6975  Bma-wwp-1; Uncharacterized protein [KO:K05633] [EC:2.3.2.26]
BM_BM7901  Bm7901; thyroid receptor interacting protein 12, putative [KO:K10590] [EC:2.3.2.26]
BM_BM7183  Bm7183; Uncharacterized protein [KO:K10591] [EC:2.3.2.26]
BM_BM7004  Bma-eel-1; Start codon is not identified, putative [KO:K10592] [EC:2.3.2.26]
BM_BM3863  Bma-ubr-5; ubiquitin--protein ligase EDD, putative [KO:K10593] [EC:2.3.2.26]
BM_BM6671  Bma-herc-1; conserved hypothetical protein,hypothetical protein [KO:K10615] [EC:2.3.2.26]
BM_BM5604  Bma-ufd-2; U-box domain containing protein [KO:K10597] [EC:2.3.2.27]
BM_BM4594  Bma-cyn-4; cyclophilin-type peptidyl-prolyl cis-trans isomerase-4, Bmcyp-4 [KO:K10598] [EC:5.2.1.8]
BM_BM13690  Bma-prp-19; putative 55.2 kDa Trp-Asp repeats containing protein T10F2.4 inchromosome III, putative [KO:K10599] [EC:2.3.2.27]
BM_BM5061  Bma-sli-1; signal transduction protein CBL-B, putative [KO:K04707] [EC:2.3.2.27]
BM_BM6403  Bma-siah-1; Uncharacterized protein [KO:K04506] [EC:2.3.2.27]
BM_BM9906  Bm9906; Uncharacterized protein [KO:K10143] [EC:2.3.2.27]
BM_BM4400  Bma-sel-11; conserved hypothetical protein,hypothetical protein [KO:K10601] [EC:2.3.2.27]
BM_BM14000  Bma-rbx-1; hyperosmotic protein 21, putative [KO:K03868] [EC:2.3.2.32]
BM_BM6609  Bm6609; S-phase kinase-associated protein 1A, putative [KO:K03094]
BM_BM6611  Bm6611; S-phase kinase-associated protein SKR-1, putative [KO:K03094]
BM_BM4966  Bma-lin-23; WD domain, G-beta repeat containing protein [KO:K03362]
BM_BM4408  Bma-sel-10; F-box domain containing protein [KO:K10260]
BM_BM18118  Bm18118; Uncharacterized protein [KO:K10260]
BM_BM10829  Bma-cul-2; Uncharacterized protein [KO:K03870]
BM_BM7166  Bma-elc-1; transcription elongation factor B polypeptide 1, putative [KO:K03872]
BM_BM6512  Bma-elb-1; Uncharacterized protein [KO:K03873]
BM_BM7268  Bma-cul-3; Uncharacterized protein [KO:K03869]
BM_BM7571  Bma-mel-26; Uncharacterized protein [KO:K03876]
BM_BM4110  Bma-cul-4; Cullin family protein [KO:K10609]
BM_BM5114  Bma-ddb-1; Uncharacterized protein [KO:K10610]
BM_BM8942  Bm8942; Uncharacterized protein [KO:K10570]
BM_BM12912  Bm12912; Uncharacterized protein [KO:K10571]
BM_BM5321  Bma-rbx-2; RING finger protein, putative [KO:K10611]
BM_BM7563  Bma-cul-5; Uncharacterized protein [KO:K10612]
BM_BM12903  Bma-apc-11.2; Uncharacterized protein [KO:K03358]
BM_BM4844  Bma-apc-2; Anaphase-promoting complex subunit 2-like [KO:K03349]
BM_BM7431  Bma-fzy-1; cell division cycle protein 20 homolog (p55CDC), putative [KO:K03363]
BM_BM7664  Bma-fzr-1; Uncharacterized protein [KO:K03364]
BM_BM6268  Bma-mat-2; meiotic check point regulator protein, putative [KO:K03348]
BM_BM8218  Bm8218; Uncharacterized protein [KO:K03352]
BM_BM7450  Bma-emb-27; Uncharacterized protein [KO:K03353]
BM_BM8019  Bm8019; TPR Domain containing protein [KO:K03354]
BM_BM3261  Bma-mat-3; Uncharacterized protein [KO:K03355]
BM_BM6670  Bm6670; Uncharacterized protein [KO:K03357]
BM_BM14669  Bm14669; anaphase promoting complex subunit 13, putative [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
bmy03050  Proteasome
KO pathway
ko04120   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (70)   
   KEGG GENES (70)   
All databases (71)   

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