KEGG   PATHWAY: cal04011
Entry
cal04011                    Pathway                                
Name
MAPK signaling pathway - yeast - Candida albicans
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
Pathway map
cal04011  MAPK signaling pathway - yeast
cal04011

Other DBs
GO: 0000165
Organism
Candida albicans [GN:cal]
Gene
CAALFM_C104050CA  MFALPHA; mating pheromone alpha [KO:K11234]
CAALFM_CR06610WA  STE2; alpha-factor pheromone receptor [KO:K11213]
CAALFM_C105620CA  STE3; Ste3p [KO:K04627]
CAALFM_C305650WA  YCK2; serine/threonine protein kinase [KO:K02218] [EC:2.7.11.1]
CAALFM_C208270CA  CaO19.2222; casein kinase [KO:K02218] [EC:2.7.11.1]
CAALFM_C208500WA  RSP5; NEDD4 family E3 ubiquitin-protein ligase [KO:K10591] [EC:2.3.2.26]
CAALFM_C505220WA  CAG1; guanine nucleotide-binding protein subunit alpha [KO:K19860]
CAALFM_C204210WA  STE4; G protein subunit beta [KO:K04536]
CAALFM_C701730CA  STE18; Ste18p [KO:K07973]
CAALFM_C502160WA  SST2; GTPase-activating protein [KO:K19838]
CAALFM_C501970CA  CDC24; Rho family guanine nucleotide exchange factor [KO:K11236]
CAALFM_C108450CA  CDC42; Rho family GTPase [KO:K04393]
CAALFM_C402000CA  RGA2; Rga2p [KO:K19839]
CAALFM_C402310WA  BEM3; Bem3p [KO:K19840]
CAALFM_C401410WA  BEM1; phosphatidylinositol-3-phosphate-binding protein [KO:K11237]
CAALFM_C502340CA  CST20; mitogen-activated protein kinase kinase kinase kinase [KO:K04409] [EC:2.7.11.1]
CAALFM_C110210CA  CLA4; serine/threonine protein kinase [KO:K19833] [EC:2.7.11.1]
CAALFM_C112960CA  BNI1; formin [KO:K11238]
CAALFM_C203770CA  STE11; mitogen-activated protein kinase kinase kinase [KO:K11228] [EC:2.7.11.25]
CAALFM_C302100WA  STE50; Ste50p [KO:K19841]
CAALFM_C604430WA  CST5; Cst5p [KO:K11239]
CAALFM_CR03900WA  HST7; mitogen-activated protein kinase kinase [KO:K11226] [EC:2.7.12.2]
CAALFM_C406480CA  CEK1; mitogen-activated serine/threonine-protein kinase [KO:K04371] [EC:2.7.11.24]
CAALFM_CR05940WA  CEK2; Cek2p [KO:K04371] [EC:2.7.11.24]
CAALFM_CR10340WA  PTP3; tyrosine protein phosphatase [KO:K19806] [EC:3.1.3.48]
CAALFM_C403890WA  PTP2; tyrosine protein phosphatase [KO:K19806] [EC:3.1.3.48]
CAALFM_C110000CA  CPP1; tyrosine/serine/threonine protein phosphatase [KO:K11240] [EC:3.1.3.48]
CAALFM_C107370CA  CPH1; homeodomain family transcription factor [KO:K11215]
CAALFM_C700890CA  MCM1; transcription factor [KO:K12412]
CAALFM_C111630CA  FUS1; Fus1p [KO:K11243]
CAALFM_C700180WA  FAR1; cyclin-dependent protein serine/threonine kinase inhibiting protein [KO:K06652]
CAALFM_CR06050WA  CDC28; cyclin-dependent serine/threonine-protein kinase [KO:K04563] [EC:2.7.11.22]
CAALFM_C304250WA  WSC1; Wsc1p [KO:K11244]
CAALFM_C602670CA  WSC2; Wsc2p [KO:K11244]
CAALFM_C203240CA  ROM2; Rho family guanine nucleotide exchange factor [KO:K19842]
CAALFM_C104480CA  TUS1; Rho family guanine nucleotide exchange factor [KO:K19843]
CAALFM_CR07090WA  STT4; 1-phosphatidylinositol 4-kinase [KO:K00888] [EC:2.7.1.67]
CAALFM_C301160WA  MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase [KO:K00889] [EC:2.7.1.68]
CAALFM_CR02860WA  RHO1; Rho family GTPase [KO:K04513]
CAALFM_C701550WA  BEM2; Bem2p [KO:K19844]
CAALFM_C700080CA  SAC7; Sac7p [KO:K19845]
CAALFM_CR00070WA  BNR1; Bnr1p [KO:K17971]
CAALFM_C304470WA  PKC1; protein kinase C [KO:K02677] [EC:2.7.11.13]
CAALFM_C112410CA  PKH2; serine/threonine protein kinase [KO:K06276] [EC:2.7.11.1]
CAALFM_C600350WA  PKH3; protein kinase [KO:K06276] [EC:2.7.11.1]
CAALFM_C702990WA  BCK1; mitogen-activated protein kinase kinase kinase [KO:K11229] [EC:2.7.11.25]
CAALFM_C205780CA  MKK2; mitogen-activated protein kinase kinase [KO:K08294] [EC:2.7.12.2]
CAALFM_C112620WA  SPA2; Spa2p [KO:K19846]
CAALFM_CR00120CA  MKC1; mitogen-activated serine/threonine-protein kinase [KO:K04464] [EC:2.7.11.24]
CAALFM_C401260WA  RLM1; Rlm1p [KO:K09265]
CAALFM_CR00850CA  GSL2; Gsl2p [KO:K00706] [EC:2.4.1.34]
CAALFM_C102420CA  GSC1; 1,3-beta-glucan synthase [KO:K00706] [EC:2.4.1.34]
CAALFM_C105600WA  GSL1; Gsl1p [KO:K00706] [EC:2.4.1.34]
CAALFM_C208630CA  CaO19.3613; hypothetical protein [KO:K15174]
CAALFM_C101790WA  SWI4; SBF complex DNA-binding subunit [KO:K06649]
CAALFM_C108670WA  SWI6; transcriptional regulator [KO:K06648]
CAALFM_C300800WA  MIH1; putative tyrosine protein phosphatase [KO:K02555] [EC:3.1.3.48]
CAALFM_C201410CA  CLB2; B-type cyclin [KO:K23469]
CAALFM_C109140CA  SSU81; osmosensor [KO:K11246]
CAALFM_C108310WA  OPY2; Opy2p [KO:K19850]
CAALFM_CR01000CA  SLN1; Sln1p [KO:K11231] [EC:2.7.13.3]
CAALFM_C107240WA  YPD1; Ypd1p [KO:K11232]
CAALFM_C113930WA  SSK1; mitogen-activated protein kinase kinase kinase [KO:K11233]
CAALFM_C405030CA  SSK2; mitogen-activated protein kinase kinase kinase [KO:K11230] [EC:2.7.11.25]
CAALFM_C306070CA  PBS2; mitogen-activated protein kinase kinase [KO:K11227] [EC:2.7.12.2]
CAALFM_C203330CA  HOG1; mitogen-activated protein kinase [KO:K04441] [EC:2.7.11.24]
CAALFM_C109260CA  PTC1; type 2C protein phosphatase [KO:K19704] [EC:3.1.3.16]
CAALFM_C101390CA  CaO19.3328; hypothetical protein [KO:K19815]
CAALFM_C210240WA  GPD1; glycerol-3-phosphate dehydrogenase (NAD(+)) [KO:K00006] [EC:1.1.1.8]
CAALFM_C602010CA  GPD2; Gpd2p [KO:K00006] [EC:1.1.1.8]
CAALFM_C108940CA  MSN4; stress-responsive transcriptional activator [KO:K09468]
CAALFM_C106810WA  CAT1; catalase A [KO:K03781] [EC:1.11.1.6]
CAALFM_C103770WA  SKO1; Sko1p [KO:K09051]
CAALFM_C307020WA  SSN6; transcription regulator [KO:K06665]
CAALFM_C100060WA  TUP1; chromatin-silencing transcriptional regulator [KO:K06666]
CAALFM_C603240WA  CaO19.5611; methylglyoxal reductase (NADPH-dependent) [KO:K17741] [EC:1.1.1.283]
CAALFM_C502860CA  GRP2; Grp2p [KO:K17741] [EC:1.1.1.283]
CAALFM_C206720WA  GRE2; Gre2p [KO:K17741] [EC:1.1.1.283]
CAALFM_CR01810CA  CaO19.2581; hypothetical protein [KO:K17741] [EC:1.1.1.283]
CAALFM_C205560WA  CaO19.6868; hypothetical protein [KO:K17741] [EC:1.1.1.283]
CAALFM_C206710WA  CaO19.3151; hypothetical protein [KO:K17741] [EC:1.1.1.283]
CAALFM_C502840CA  HSL1; protein kinase [KO:K02515] [EC:2.7.11.-]
CAALFM_C110010CA  SWE1; tyrosine protein kinase [KO:K03114] [EC:2.7.11.1]
CAALFM_C103220CA  BMH1; 14-3-3 family protein [KO:K06630]
CAALFM_C304530CA  TEC1; Tec1p [KO:K09448]
Reference
PMID:15690603
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
PMID:15944456
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
PMID:22174182
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
PMID:17875410
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
PMID:23028184
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
PMID:22219507
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
PMID:17604854
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003
KO pathway
ko04011   

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Genome (1)   
   KEGG GENOME (1)   
Gene (85)   
   KEGG GENES (85)   
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