KEGG   PATHWAY: egr00790
Entry
egr00790                    Pathway                                
Name
Folate biosynthesis - Eucalyptus grandis (rose gum)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
egr00790  Folate biosynthesis
egr00790

Module
egr_M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:egr00790]
egr_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:egr00790]
Other DBs
GO: 0046656
Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104456513  GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
104450368  uncharacterized protein LOC104450368 [KO:K01113] [EC:3.1.3.1]
104452735  dihydroneopterin aldolase 1 [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
104449881  folate synthesis bifunctional protein, mitochondrial [KO:K13941] [EC:2.7.6.3 2.5.1.15]
104453306  bifunctional dihydrofolate reductase-thymidylate synthase [KO:K13998] [EC:1.5.1.3 2.1.1.45]
104444539  folylpolyglutamate synthase isoform X3 [KO:K01930] [EC:6.3.2.17]
104422545  folylpolyglutamate synthase [KO:K01930] [EC:6.3.2.17]
104424477  dihydrofolate synthetase isoform X1 [KO:K20457] [EC:6.3.2.12]
108954044  probable gamma-glutamyl hydrolase 3 [KO:K01307] [EC:3.4.19.9]
104448563  gamma-glutamyl hydrolase 2 [KO:K01307] [EC:3.4.19.9]
104448560  gamma-glutamyl hydrolase 2 [KO:K01307] [EC:3.4.19.9]
104451569  gamma-glutamyl hydrolase 2-like [KO:K01307] [EC:3.4.19.9]
104448570  gamma-glutamyl hydrolase 2-like [KO:K01307] [EC:3.4.19.9]
104415759  bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
104455114  LOW QUALITY PROTEIN: bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
104452860  bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
104422521  LOW QUALITY PROTEIN: monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
120295914  bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic-like [KO:K14652] [EC:4.1.99.12 3.5.4.25]
104454208  aminodeoxychorismate synthase, chloroplastic isoform X1 [KO:K13950] [EC:2.6.1.85]
104437761  LOW QUALITY PROTEIN: D-amino-acid transaminase, chloroplastic [KO:K18482] [EC:4.1.3.38]
104448487  D-amino-acid transaminase, chloroplastic [KO:K18482] [EC:4.1.3.38]
104416142  (+)-neomenthol dehydrogenase [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
104427637  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
104444811  pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial isoform X2 [KO:K01724] [EC:4.2.1.96]
104450236  probable pterin-4-alpha-carbinolamine dehydratase, chloroplastic [KO:K01724] [EC:4.2.1.96]
104433357  GTP 3',8-cyclase, mitochondrial [KO:K03639] [EC:4.1.99.22]
104443356  cyclic pyranopterin monophosphate synthase, mitochondrial isoform X1 [KO:K03637] [EC:4.6.1.17]
104421443  molybdopterin synthase catalytic subunit [KO:K03635] [EC:2.8.1.12]
120289058  molybdopterin synthase catalytic subunit-like [KO:K03635] [EC:2.8.1.12]
104421393  molybdopterin biosynthesis protein CNX1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
104448676  molybdenum cofactor sulfurase [KO:K15631] [EC:2.8.1.9]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
egr00230  Purine metabolism
egr00400  Phenylalanine, tyrosine and tryptophan biosynthesis
egr00670  One carbon pool by folate
KO pathway
ko00790   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG GENES (31)   
All databases (32)   

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