KEGG   PATHWAY: egr04120
Entry
egr04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Eucalyptus grandis (rose gum)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
egr04120  Ubiquitin mediated proteolysis
egr04120

Other DBs
GO: 0016567
Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104435738  polyubiquitin [KO:K08770]
120287604  polyubiquitin [KO:K08770]
120292994  polyubiquitin 3 isoform X1 [KO:K08770]
120293006  polyubiquitin-like [KO:K08770]
104414208  polyubiquitin [KO:K08770]
104437441  ubiquitin-60S ribosomal protein L40 [KO:K02927]
104425627  ubiquitin-60S ribosomal protein L40 [KO:K02927]
104435729  ubiquitin [KO:K02977]
104435709  ubiquitin [KO:K02977]
104433524  ubiquitin-40S ribosomal protein S27a [KO:K02977]
104432622  ubiquitin-activating enzyme E1 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
104422383  ubiquitin-activating enzyme E1 1-like isoform X1 [KO:K03178] [EC:6.2.1.45]
104426142  SUMO-activating enzyme subunit 1A [KO:K10684] [EC:6.2.1.45]
104453355  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
104414871  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
104419225  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
104419230  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
104433606  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
104421800  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
104421489  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
104453430  ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:2.3.2.23]
104419641  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
104450384  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
104442151  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
104445784  ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:2.3.2.23]
104443966  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
104424465  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
104441683  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
104433783  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
104420906  ubiquitin-conjugating enzyme E2 14 isoform X1 [KO:K10575] [EC:2.3.2.23]
120285857  ubiquitin-conjugating enzyme E2 14 [KO:K10575] [EC:2.3.2.23]
104443824  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:2.3.2.23]
104426286  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
104426283  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
120289912  ubiquitin-conjugating enzyme E2 6-like [KO:K10576] [EC:2.3.2.23]
104457307  SUMO-conjugating enzyme SCE1 [KO:K10577]
104447870  SUMO-conjugating enzyme SCE1 isoform X1 [KO:K10577]
104450726  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
104422891  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
104426110  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
120290045  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
104456845  NEDD8-conjugating enzyme Ubc12 isoform X2 [KO:K10579] [EC:2.3.2.34]
104418816  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
104448533  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
104450088  ubiquitin-conjugating enzyme E2 35 [KO:K10580] [EC:2.3.2.23]
104452063  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
104418963  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
104448439  probable ubiquitin-conjugating enzyme E2 25 isoform X1 [KO:K10581] [EC:2.3.2.24]
104441012  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
104417548  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
104417549  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
120288729  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
120294864  LOW QUALITY PROTEIN: putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
104425416  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
104419696  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
104438724  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
104434102  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
104435823  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
104418939  E3 ubiquitin-protein ligase UPL3 isoform X1 [KO:K10590] [EC:2.3.2.26]
104449197  E3 ubiquitin-protein ligase UPL2 isoform X2 [KO:K10592] [EC:2.3.2.26]
104449116  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
104419398  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
104425689  E3 ubiquitin-protein ligase CHIP isoform X2 [KO:K09561] [EC:2.3.2.27]
104418441  peptidyl-prolyl cis-trans isomerase CYP65 isoform X1 [KO:K10598] [EC:5.2.1.8]
104414429  pre-mRNA-processing factor 19 homolog 1 isoform X1 [KO:K10599] [EC:2.3.2.27]
104437722  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
104446060  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
104422131  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
104454548  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
104443358  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
104432973  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
104426965  WD repeat-containing protein RUP2 [KO:K10143] [EC:2.3.2.27]
104424712  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
104441439  E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
104442933  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
104425770  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
104437739  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
104436934  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
104421229  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
104456826  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
120286333  E3 ubiquitin-protein ligase RZFP34-like [KO:K10144] [EC:2.3.2.27]
104443932  E4 SUMO-protein ligase PIAL2 [KO:K04706] [EC:2.3.2.-]
104424282  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X1 [KO:K10601] [EC:2.3.2.27]
104437993  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
104436408  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
104439002  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
104415121  cullin-1 [KO:K03347]
104425941  LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
104425962  cullin-1 isoform X1 [KO:K03347]
104426047  cullin-1 isoform X1 [KO:K03347]
104434733  cullin-1 isoform X1 [KO:K03347]
104426051  cullin-1 isoform X2 [KO:K03347]
104415119  LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
104448856  SKP1-like protein 1B [KO:K03094]
104422792  SKP1-like protein 1B [KO:K03094]
104422794  SKP1-like protein 1B [KO:K03094]
104444261  SKP1-like protein 1B [KO:K03094]
104418954  SKP1-like protein 11 [KO:K03094]
104418953  SKP1-like protein 1A [KO:K03094]
104418952  SKP1-like protein 1A [KO:K03094]
104418955  SKP1-like protein 1A [KO:K03094]
104418956  SKP1-like protein 1A [KO:K03094]
104420786  SKP1-like protein 1B [KO:K03094]
104419631  SKP1-like protein 1B isoform X1 [KO:K03094]
104419632  SKP1-like protein 1B [KO:K03094]
104419633  SKP1-like protein 1B [KO:K03094]
120291307  SKP1-like protein 1A [KO:K03094]
104449651  F-box protein SKP2A [KO:K03875]
104438620  elongin-C [KO:K03872]
120292136  elongin-C-like [KO:K03872]
104437500  polyubiquitin [KO:K03873]
104433618  LOW QUALITY PROTEIN: cullin-3B [KO:K03869]
104433620  cullin-3B [KO:K03869]
104444840  cullin-4 [KO:K10609]
104417802  LOW QUALITY PROTEIN: DNA damage-binding protein 1 [KO:K10610]
104415814  DNA damage-binding protein 1 [KO:K10610]
104432651  LOW QUALITY PROTEIN: protein DAMAGED DNA-BINDING 2 [KO:K10140]
104447788  WD repeat-containing protein ATCSA-1 isoform X1 [KO:K10570]
104444547  light-mediated development protein DET1 [KO:K10571]
104424946  anaphase-promoting complex subunit 11 [KO:K03358]
104418132  anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
104450300  LOW QUALITY PROTEIN: cell division cycle 20.1, cofactor of APC complex [KO:K03363]
104437388  cell division cycle 20.1, cofactor of APC complex [KO:K03363]
104437473  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
104439612  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
104454306  protein FIZZY-RELATED 3 [KO:K03364]
104441819  protein FIZZY-RELATED 2 [KO:K03364]
104454403  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
104441056  cell division cycle protein 27 homolog B [KO:K03350]
104436576  cell division cycle protein 27 homolog B isoform X1 [KO:K03350]
104442430  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
104428397  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 4-like [KO:K03351]
104435036  anaphase-promoting complex subunit 4-like [KO:K03351]
104442267  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
104448550  anaphase-promoting complex subunit 6 [KO:K03353]
104425820  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
104423048  anaphase-promoting complex subunit 8 isoform X1 [KO:K03355]
104434296  anaphase-promoting complex subunit 8-like isoform X1 [KO:K03355]
104419730  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
egr03050  Proteasome
KO pathway
ko04120   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (139)   
   KEGG GENES (139)   
All databases (140)   

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